{"id":"https://openalex.org/W2889795290","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e16514","title":"Clinical activity of ONC201 in metastatic castrate resistant prostate cancer (mCRPC).","display_name":"Clinical activity of ONC201 in metastatic castrate resistant prostate cancer (mCRPC).","publication_year":2016,"publication_date":"2016-05-20","ids":{"openalex":"https://openalex.org/W2889795290","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e16514","mag":"2889795290"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2016.34.15_suppl.e16514","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e16514","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.15_suppl.e16514","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071773606","display_name":"Mark N. Stein","orcid":"https://orcid.org/0000-0002-0853-3640","observed_orcids":["https://orcid.org/0000-0002-0853-3640","https://orcid.org/0000-0002-2573-4911"]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark N. Stein","raw_affiliation_strings":["Rutgers Cancer Institute of New Jersey, New Brunswick, NJ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers Cancer Institute of New Jersey, New Brunswick, NJ;","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090739964","display_name":"Howard L. Kaufman","orcid":"https://orcid.org/0000-0003-1131-004X","observed_orcids":["https://orcid.org/0000-0003-1131-004X","https://orcid.org/0000-0003-3538-4166"]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Kaufman","raw_affiliation_strings":["Rutgers Cancer Institute of New Jersey, New Brunswick, NJ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers Cancer Institute of New Jersey, New Brunswick, NJ;","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060699951","display_name":"Cyril H. Benes","orcid":"https://orcid.org/0000-0002-8751-9707","observed_orcids":["https://orcid.org/0000-0002-8751-9707"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cyril Benes","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055837818","display_name":"Martin Stogniew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128844","display_name":"Oncoceutics (United States)","ror":"https://ror.org/032rwz169","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Stogniew","raw_affiliation_strings":["Oncoceutics, Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncoceutics, Philadelphia, PA;","institution_ids":["https://openalex.org/I4210128844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036916387","display_name":"Wolfgang Oster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128844","display_name":"Oncoceutics (United States)","ror":"https://ror.org/032rwz169","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wolfgang Oster","raw_affiliation_strings":["Oncoceutics, Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncoceutics, Philadelphia, PA;","institution_ids":["https://openalex.org/I4210128844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008547275","display_name":"Joshua E. Allen","orcid":"https://orcid.org/0000-0002-6835-1128","observed_orcids":["https://orcid.org/0000-0002-6835-1128"]},"institutions":[{"id":"https://openalex.org/I4210128844","display_name":"Oncoceutics (United States)","ror":"https://ror.org/032rwz169","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua E. Allen","raw_affiliation_strings":["Oncoceutics, Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncoceutics, Philadelphia, PA;","institution_ids":["https://openalex.org/I4210128844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063899863","display_name":"Bruce George Haffty","orcid":"https://orcid.org/0000-0002-9597-6019","observed_orcids":["https://orcid.org/0000-0002-9597-6019"]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce George Haffty","raw_affiliation_strings":["Rutgers Cancer Institute of New Jersey, New Brunswick, NJ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers Cancer Institute of New Jersey, New Brunswick, NJ;","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104110678","display_name":"Joseph R. Bertino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph R. Bertino","raw_affiliation_strings":["Rutgers Cancer Institute of New Jersey, New Brunswick, NJ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers Cancer Institute of New Jersey, New Brunswick, NJ;","institution_ids":["https://openalex.org/I4390039325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"15_suppl","first_page":"e16514","last_page":"e16514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/onc201","display_name":"ONC201","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":0.8489999771118164},{"id":"https://openalex.org/keywords/integrated-stress-response","display_name":"integrated stress response","score":0.9789999723434448},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.7319999933242798},{"id":"https://openalex.org/keywords/small-molecule-drugs","display_name":"small molecule drugs","score":0.531000018119812},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.6050000190734863},{"id":"https://openalex.org/keywords/stable-disease","display_name":"stable disease","score":0.5669999718666077},{"id":"https://openalex.org/keywords/psa-decline","display_name":"PSA decline","score":0.6029999852180481},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9254814386367798},{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.8032832145690918},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7431255578994751},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.6026806235313416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5681198239326477},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5668553709983826},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.564896285533905},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4816935956478119},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4317360520362854},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3648480772972107},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.25767019391059875},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.09273406863212585}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2016.34.15_suppl.e16514","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e16514","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.15_suppl.e16514","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2741897432","https://openalex.org/W4282938890","https://openalex.org/W2602334924","https://openalex.org/W2479291038","https://openalex.org/W2794978585","https://openalex.org/W2484042796","https://openalex.org/W2487613987","https://openalex.org/W4401280037","https://openalex.org/W2600944061","https://openalex.org/W4391427908"],"abstract_inverted_index":{"e16514":[0],"Background:":[1],"Proteasome":[2],"inhibitors":[3],"that":[4,45,60,77,282,292],"induce":[5],"the":[6,41,66,78,121,140,151,155,259,264],"integrated":[7,42],"stress":[8,43],"response":[9,44],"are":[10],"effective":[11,81],"in":[12,24,28,49,82,133,146,154,218,263,287],"preclinical":[13,50,141],"models":[14],"of":[15,40,65,111,144,195,223,267,294],"hormone-refractory":[16,83],"prostate":[17,25,61,128,159,288],"cancer":[18,26,52,62,84,129,160,289],"and":[19,76,92,188,198,225,258,291,303,308],"have":[20,174],"induced":[21],"objective":[22],"responses":[23],"patients":[27,130,153,161,173,290],"early":[29],"phase":[30,103,123,156],"clinical":[31],"trials.":[32],"ONC201":[33,72,88,112,145,167,196,224,283],"is":[34,63,80,262,284,301],"a":[35,134,215,240],"PERK-independent":[36],"small":[37],"molecule":[38],"inducer":[39],"has":[46,58],"compelling":[47],"efficacy":[48],"advanced":[51],"models.":[53],"In":[54,86],"vitro":[55],"sensitivity":[56,142],"profiling":[57],"determined":[59],"one":[64],"most":[67],"sensitive":[68],"tumor":[69],"types":[70],"to":[71],"among":[73],"solid":[74,147],"tumors":[75],"drug":[79,270],"cells.":[85],"addition,":[87],"shows":[89],"excellent":[90],"tolerability":[91],"can":[93],"be":[94],"given":[95],"orally":[96,114],"with":[97,184,210,232,243],"infrequent":[98],"dosing":[99,297],"regimens.":[100],"Methods:":[101],"A":[102,205,236,250],"I":[104],"dose":[105,135],"escalation":[106],"trial":[107,312],"recently":[108],"established":[109],"625mg":[110,166],"administered":[113],"every":[115,168],"three":[116,169],"weeks":[117],"(one":[118],"cycle)":[119],"as":[120],"recommended":[122],"II":[124],"dose.":[125],"Metastatic":[126],"castration-resistant":[127],"were":[131],"enriched":[132],"expansion":[136],"cohort":[137],"based":[138],"on":[139,200,227],"profile":[143],"tumors.":[148],"Results:":[149],"Of":[150],"28":[152],"I,":[157],"5":[158],"(age":[162],"range":[163],"62-90)":[164],"received":[165],"weeks;":[170],"currently,":[171],"4":[172,230,248],"recieved":[175],"at":[176],"least":[177],"2":[178,221,256],"cycles.":[179,249],"One":[180],"patient":[181,207,238,252,261],"previously":[182,208],"treated":[183,209],"sipuleucel-t,":[185,211],"abiraterone,":[186,212],"enzalutamide,":[187,213],"docetaxel":[189],"exhibited":[190,239],"stable":[191,234,245],"disease":[192,246],"after":[193,220,229,247,255],"initiation":[194],"therapy":[197,300],"remained":[199],"study":[201,228],"for":[202],"6":[203],"months.":[204],"second":[206],"had":[214,253],"25%":[216],"decline":[217],"PSA":[219],"cycles":[222,231,257],"remains":[226],"radiographically":[233],"disease.":[235],"third":[237],"mixed":[241],"response,":[242],"overall":[244],"fourth":[251],"progression":[254],"fifth":[260],"first":[265],"cycle":[266],"treatment.":[268],"No":[269],"related":[271],"toxicity":[272],">":[273],"grade":[274],"1":[275],"was":[276],"observed.":[277],"Conclusions:":[278],"These":[279],"results":[280],"suggest":[281],"clinically":[285],"active":[286],"investigation":[293],"more":[295],"frequent":[296],"and/or":[298],"combination":[299],"warranted":[302],"enabled":[304],"by":[305],"its":[306],"safety":[307],"pharmacokinetic/pharmacodynamic":[309],"profile.":[310],"Clinical":[311],"information:":[313],"NCT02324621.":[314]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2018-09-27T00:00:00"}
