{"id":"https://openalex.org/W2889765659","doi":"https://doi.org/10.1182/bloodadvances.2018020560","title":"Induced pluripotent stem cell\u2013based mapping of \u03b2-globin expression throughout human erythropoietic development","display_name":"Induced pluripotent stem cell\u2013based mapping of \u03b2-globin expression throughout human erythropoietic development","publication_year":2018,"publication_date":"2018-08-14","ids":{"openalex":"https://openalex.org/W2889765659","doi":"https://doi.org/10.1182/bloodadvances.2018020560","mag":"2889765659","pmid":"https://pubmed.ncbi.nlm.nih.gov/30108108","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6093724"},"language":"en","primary_location":{"id":"doi:10.1182/bloodadvances.2018020560","doi":"https://doi.org/10.1182/bloodadvances.2018020560","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2018020560","pdf_url":null,"source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1182/bloodadvances.2018020560","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033724435","display_name":"Kim Vanuytsel","orcid":"https://orcid.org/0000-0002-8872-0736","observed_orcids":["https://orcid.org/0000-0002-8872-0736"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim Vanuytsel","raw_affiliation_strings":["Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center, Boston, MA","Section of Hematology and Medical Oncology, School of Medicine, Boston University, Boston, MA; and"],"raw_orcid":"https://orcid.org/0000-0002-8872-0736","affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center, Boston, MA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]},{"raw_affiliation_string":"Section of Hematology and Medical Oncology, School of Medicine, Boston University, Boston, MA; and","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054523867","display_name":"Taylor M. Matte","orcid":"https://orcid.org/0000-0002-7796-7485","observed_orcids":["https://orcid.org/0000-0002-7796-7485"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taylor Matte","raw_affiliation_strings":["Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center, Boston, MA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Amy Leung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Leung","raw_affiliation_strings":["Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center, Boston, MA","Section of Hematology and Medical Oncology, School of Medicine, Boston University, Boston, MA; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center, Boston, MA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]},{"raw_affiliation_string":"Section of Hematology and Medical Oncology, School of Medicine, Boston University, Boston, MA; and","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015623054","display_name":"Zaw Htut Naing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zaw Htut Naing","raw_affiliation_strings":["Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center, Boston, MA","Section of Hematology and Medical Oncology, School of Medicine, Boston University, Boston, MA; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center, Boston, MA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]},{"raw_affiliation_string":"Section of Hematology and Medical Oncology, School of Medicine, Boston University, Boston, MA; and","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104072195","display_name":"Tasha A. Morrison","orcid":"https://orcid.org/0000-0002-6403-9364","observed_orcids":["https://orcid.org/0000-0002-6403-9364"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tasha Morrison","raw_affiliation_strings":["Section of Hematology and Medical Oncology, School of Medicine, Boston University, Boston, MA; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology and Medical Oncology, School of Medicine, Boston University, Boston, MA; and","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044458439","display_name":"David H.K. Chui","orcid":"https://orcid.org/0000-0002-1475-7309","observed_orcids":["https://orcid.org/0000-0002-1475-7309"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. K. Chui","raw_affiliation_strings":["Section of Hematology and Medical Oncology, School of Medicine, Boston University, Boston, MA; and"],"raw_orcid":"https://orcid.org/0000-0002-1475-7309","affiliations":[{"raw_affiliation_string":"Section of Hematology and Medical Oncology, School of Medicine, Boston University, Boston, MA; and","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065128454","display_name":"Martin H. Steinberg","orcid":"https://orcid.org/0000-0001-8800-8020","observed_orcids":["https://orcid.org/0000-0001-8800-8020"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin H. Steinberg","raw_affiliation_strings":["Section of Hematology and Medical Oncology, School of Medicine, Boston University, Boston, MA; and"],"raw_orcid":"https://orcid.org/0000-0001-8800-8020","affiliations":[{"raw_affiliation_string":"Section of Hematology and Medical Oncology, School of Medicine, Boston University, Boston, MA; and","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062891826","display_name":"George J. Murphy","orcid":"https://orcid.org/0000-0003-3464-793X","observed_orcids":["https://orcid.org/0000-0003-3464-793X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George J. Murphy","raw_affiliation_strings":["Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center, Boston, MA","Section of Hematology and Medical Oncology, School of Medicine, Boston University, Boston, MA; and"],"raw_orcid":"https://orcid.org/0000-0003-3464-793X","affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center, Boston, MA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]},{"raw_affiliation_string":"Section of Hematology and Medical Oncology, School of Medicine, Boston University, Boston, MA; and","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":0.8727,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.70801704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2","issue":"15","first_page":"1998","last_page":"2011"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7006999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7006999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.19529999792575836,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.038100000470876694,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-globin-expression","display_name":"beta-globin expression","score":0.8830000162124634},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/erythroid-maturation","display_name":"erythroid maturation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/definitive-erythropoiesis","display_name":"definitive erythropoiesis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/erythroblasts","display_name":"erythroblasts","score":0.7120000123977661},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9430000185966492},{"id":"https://openalex.org/keywords/ribosomal-proteins","display_name":"ribosomal proteins","score":0.8669999837875366},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.800000011920929},{"id":"https://openalex.org/keywords/beta-thalassemia","display_name":"beta-thalassemia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/disease-modeling","display_name":"disease modeling","score":0.7820000052452087},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7161396741867065},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6923172473907471},{"id":"https://openalex.org/C125996951","wikidata":"https://www.wikidata.org/wiki/Q412234","display_name":"Globin","level":3,"score":0.6289595365524292},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6099296808242798},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5530411601066589},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.49898242950439453},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4588838219642639},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.435266375541687},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34419435262680054},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3145565986633301},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2726283669471741}],"mesh":[{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004900","descriptor_name":"Erythroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004900","descriptor_name":"Erythroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055544","descriptor_name":"beta-Globins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1182/bloodadvances.2018020560","doi":"https://doi.org/10.1182/bloodadvances.2018020560","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2018020560","pdf_url":null,"source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5041036","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6093724","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6093724","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6093724","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Adv","raw_type":"Text"},{"id":"pmid:30108108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30108108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood advances","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:90f65c6905b545d187d63ae96104ade0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/90f65c6905b545d187d63ae96104ade0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood Advances, Vol 2, Iss 15, Pp 1998-2011 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1182/bloodadvances.2018020560","doi":"https://doi.org/10.1182/bloodadvances.2018020560","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2018020560","pdf_url":null,"source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2728508562","display_name":"Mechanisms of cis-acting HbF regulation in sickle cell anemia","funder_award_id":"R01HL133350","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4113691723","display_name":"Defining the Role of the AHR in Blood Cell Specifications","funder_award_id":"R01ES025409","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6582750909","display_name":"Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells","funder_award_id":"U01HL107443","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G846748634","display_name":"Research Training in Blood Diseases and Resources","funder_award_id":"T32HL007501","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1588611448","https://openalex.org/W1937332911","https://openalex.org/W1964955179","https://openalex.org/W1969483592","https://openalex.org/W1970141199","https://openalex.org/W1971128326","https://openalex.org/W1974742081","https://openalex.org/W1976747229","https://openalex.org/W1991412538","https://openalex.org/W2002768599","https://openalex.org/W2008982471","https://openalex.org/W2010074780","https://openalex.org/W2010743526","https://openalex.org/W2011687861","https://openalex.org/W2015017933","https://openalex.org/W2032487911","https://openalex.org/W2032951893","https://openalex.org/W2033737798","https://openalex.org/W2040576499","https://openalex.org/W2042982622","https://openalex.org/W2044354693","https://openalex.org/W2047036934","https://openalex.org/W2049017883","https://openalex.org/W2053790363","https://openalex.org/W2070050178","https://openalex.org/W2075024026","https://openalex.org/W2077007919","https://openalex.org/W2081391072","https://openalex.org/W2094954217","https://openalex.org/W2098407640","https://openalex.org/W2100543326","https://openalex.org/W2100681150","https://openalex.org/W2115864156","https://openalex.org/W2141881890","https://openalex.org/W2144859693","https://openalex.org/W2150394682","https://openalex.org/W2150409084","https://openalex.org/W2155090266","https://openalex.org/W2155733789","https://openalex.org/W2166675510","https://openalex.org/W2168967248","https://openalex.org/W2169456326","https://openalex.org/W2174761822","https://openalex.org/W2258559315","https://openalex.org/W2343956310","https://openalex.org/W2345356016","https://openalex.org/W2504220050","https://openalex.org/W2535629412","https://openalex.org/W2557493485","https://openalex.org/W2570296070","https://openalex.org/W2572921361","https://openalex.org/W2616279709","https://openalex.org/W2728938210","https://openalex.org/W2743753720","https://openalex.org/W2750394087","https://openalex.org/W2779616042","https://openalex.org/W2792799981","https://openalex.org/W6682351906","https://openalex.org/W6702824930"],"related_works":["https://openalex.org/W4241303033","https://openalex.org/W1977889349","https://openalex.org/W2543148822","https://openalex.org/W2570296070","https://openalex.org/W2580247177","https://openalex.org/W2144859693","https://openalex.org/W1981563366","https://openalex.org/W2980097008","https://openalex.org/W2807162541","https://openalex.org/W2538887050"],"abstract_inverted_index":{"Robust":[0],"\u03b2-globin":[1,41,49,59],"expression":[2,60,166,215],"in":[3,33,39,65,108,159,178,189,211],"erythroid":[4,98,142,182],"cells":[5,11,84,110,114,146,155],"derived":[6],"from":[7],"induced":[8],"pluripotent":[9],"stem":[10],"(iPSCs)":[12],"increases":[13],"the":[14,45,56,88,91,127,170,181,190],"resolution":[15],"with":[16,74,144,151],"which":[17],"red":[18,195],"blood":[19,196],"cell":[20,25,197],"disorders":[21],"such":[22],"as":[23],"sickle":[24],"disease":[26,224],"and":[27,85,93,105,184,216,226],"\u03b2":[28],"thalassemia":[29],"can":[30],"be":[31,176],"modeled":[32],"vitro.":[34],"To":[35],"better":[36],"quantify":[37],"efforts":[38],"augmenting":[40],"expression,":[42],"we":[43],"report":[44],"creation":[46],"of":[47,58,90,96,102,123,129,141,167,169,180,186,194,213],"a":[48,117,139,157],"reporter":[50],"iPSC":[51],"line":[52],"that":[53,81,112,202],"allows":[54],"for":[55,87,162,223],"mapping":[57],"throughout":[61],"human":[62],"erythropoietic":[63],"development":[64],"real":[66],"time":[67],"at":[68],"single-cell":[69,75],"resolution.":[70],"Coupling":[71],"this":[72,133],"tool":[73],"RNA":[76],"sequencing":[77],"(scRNAseq)":[78],"identified":[79,138,174],"features":[80],"distinguish":[82],"\u03b2-globin-expressing":[83,145,154],"allowed":[86],"dissection":[89],"developmental":[92,134],"maturational":[94],"statuses":[95],"iPSC-derived":[97,205],"lineage":[99],"cells.":[100],"Coexpression":[101],"embryonic,":[103],"fetal,":[104],"adult":[106],"globins":[107],"individual":[109],"indicated":[111],"these":[113],"correspond":[115],"to":[116,175],"yolk":[118],"sac":[119],"erythromyeloid":[120],"progenitor":[121],"program":[122],"hematopoietic":[124],"development,":[125],"representing":[126],"onset":[128],"definitive":[130],"erythropoiesis.":[131],"Within":[132],"program,":[135],"scRNAseq":[136],"analysis":[137],"gradient":[140],"maturation,":[143],"showing":[147],"increased":[148,165],"maturation.":[149,198],"Compared":[150],"other":[152],"cells,":[153],"showed":[156],"reduction":[158],"transcripts":[160],"coding":[161],"ribosomal":[163],"proteins,":[164],"members":[168],"ubiquitin-proteasome":[171],"system":[172],"recently":[173],"involved":[177,188],"remodeling":[179],"proteome,":[183],"upregulation":[185],"genes":[187],"dynamic":[191],"translational":[192],"control":[193],"These":[199],"findings":[200],"emphasize":[201],"definitively":[203],"patterned":[204],"erythroblasts":[206],"resemble":[207],"their":[208,221],"postnatal":[209],"counterparts":[210],"terms":[212],"gene":[214],"essential":[217],"biological":[218],"processes,":[219],"confirming":[220],"potential":[222],"modeling":[225],"regenerative":[227],"medicine":[228],"applications.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-09-27T00:00:00"}