{"id":"https://openalex.org/W2889653294","doi":"https://doi.org/10.1038/s41598-018-32691-w","title":"Effect of Vitis vinifera hydroalcoholic extract against oxaliplatin neurotoxicity: in vitro and in vivo evidence","display_name":"Effect of Vitis vinifera hydroalcoholic extract against oxaliplatin neurotoxicity: in vitro and in vivo evidence","publication_year":2018,"publication_date":"2018-09-19","ids":{"openalex":"https://openalex.org/W2889653294","doi":"https://doi.org/10.1038/s41598-018-32691-w","mag":"2889653294","pmid":"https://pubmed.ncbi.nlm.nih.gov/30254294","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6156221"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-32691-w","doi":"https://doi.org/10.1038/s41598-018-32691-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-32691-w","pdf_url":"https://www.nature.com/articles/s41598-018-32691-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-32691-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060512635","display_name":"Laura Micheli","orcid":"https://orcid.org/0000-0001-8834-5801","observed_orcids":["https://orcid.org/0000-0001-8834-5801"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Micheli","raw_affiliation_strings":["Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Florence, Viale Gaetano Pieraccini 6, 50139, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Florence, Viale Gaetano Pieraccini 6, 50139, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001995416","display_name":"Luisa Mattoli","orcid":"https://orcid.org/0000-0002-5566-8919","observed_orcids":["https://orcid.org/0000-0002-5566-8919"]},"institutions":[{"id":"https://openalex.org/I4210125802","display_name":"Aboca (Italy)","ror":"https://ror.org/03f5nqa05","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210125802"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luisa Mattoli","raw_affiliation_strings":["Aboca S.p.A. Societ\u00e0 Agricola, Localit\u00e0 Aboca, Sansepolcro, Arezzo, 52100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aboca S.p.A. Societ\u00e0 Agricola, Localit\u00e0 Aboca, Sansepolcro, Arezzo, 52100, Italy","institution_ids":["https://openalex.org/I4210125802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060293043","display_name":"Anna Maidecchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125802","display_name":"Aboca (Italy)","ror":"https://ror.org/03f5nqa05","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210125802"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Maidecchi","raw_affiliation_strings":["Aboca S.p.A. Societ\u00e0 Agricola, Localit\u00e0 Aboca, Sansepolcro, Arezzo, 52100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aboca S.p.A. Societ\u00e0 Agricola, Localit\u00e0 Aboca, Sansepolcro, Arezzo, 52100, Italy","institution_ids":["https://openalex.org/I4210125802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013590235","display_name":"Alessandra Pacini","orcid":"https://orcid.org/0000-0002-4098-7626","observed_orcids":["https://orcid.org/0000-0002-4098-7626"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Pacini","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, Anatomy and Histology Section, University of Florence, Florence, Largo Brambilla 1, 50134, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, Anatomy and Histology Section, University of Florence, Florence, Largo Brambilla 1, 50134, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017358008","display_name":"Carla Ghelardini","orcid":"https://orcid.org/0000-0001-9856-8144","observed_orcids":["https://orcid.org/0000-0001-9856-8144"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carla Ghelardini","raw_affiliation_strings":["Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Florence, Viale Gaetano Pieraccini 6, 50139, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Florence, Viale Gaetano Pieraccini 6, 50139, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049261961","display_name":"Lorenzo Di Cesare Mannelli","orcid":"https://orcid.org/0000-0001-8374-4432","observed_orcids":["https://orcid.org/0000-0001-8374-4432"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Lorenzo Di Cesare Mannelli","raw_affiliation_strings":["Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Florence, Viale Gaetano Pieraccini 6, 50139, Italy. lorenzo.mannelli@unifi.it","Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Florence, Viale Gaetano Pieraccini 6, 50139, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8374-4432","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Florence, Viale Gaetano Pieraccini 6, 50139, Italy. lorenzo.mannelli@unifi.it","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Florence, Viale Gaetano Pieraccini 6, 50139, Italy","institution_ids":["https://openalex.org/I45084792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049261961"],"corresponding_institution_ids":["https://openalex.org/I45084792"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.3569,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.84116045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"14364","last_page":"14364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.03720000013709068,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grapevine","display_name":"grapevine","score":0.9810000061988831},{"id":"https://openalex.org/keywords/grape-leaf-extract","display_name":"grape leaf extract","score":0.6570000052452087},{"id":"https://openalex.org/keywords/oxaliplatin-neurotoxicity","display_name":"oxaliplatin neurotoxicity","score":0.9269999861717224},{"id":"https://openalex.org/keywords/chemotherapy-induced-peripheral-neuropathy","display_name":"chemotherapy-induced peripheral neuropathy","score":0.8659999966621399},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.781000018119812},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.7870000004768372},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":1.0},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.765999972820282},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":0.8600000143051147},{"id":"https://openalex.org/keywords/drg","display_name":"DRG","score":0.4880000054836273},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.9580000042915344},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.885780930519104},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.8214490413665771},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6843204498291016},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6228111386299133},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5776075124740601},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5220220685005188},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4721030294895172},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4333706200122833},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.4183065593242645},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.4118342101573944},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39149773120880127},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3063162565231323},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.28514426946640015},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25745826959609985},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2516292333602905},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16959890723228455},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.12044891715049744},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10163208842277527},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000438","descriptor_name":"Alcohols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009252","descriptor_name":"NADPH Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016660","descriptor_name":"NAD(P)H Dehydrogenase (Quinone)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D027843","descriptor_name":"Vitis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-018-32691-w","doi":"https://doi.org/10.1038/s41598-018-32691-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-32691-w","pdf_url":"https://www.nature.com/articles/s41598-018-32691-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5105449","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6156221","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30254294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30254294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6156221","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6156221/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:flore.unifi.it:2158/1137826","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2158/1137826","pdf_url":"https://flore.unifi.it/bitstream/2158/1137826/1/Sci%20Rep%202018.pdf","source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:c97de1c9c9f84ca0b8ce81d0cb96d967","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c97de1c9c9f84ca0b8ce81d0cb96d967","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-32691-w","doi":"https://doi.org/10.1038/s41598-018-32691-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-32691-w","pdf_url":"https://www.nature.com/articles/s41598-018-32691-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320322648","display_name":"Universit\u00e0 degli Studi di Firenze","ror":"https://ror.org/04jr1s763"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2889653294.pdf","grobid_xml":"https://content.openalex.org/works/W2889653294.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1233276","https://openalex.org/W43269249","https://openalex.org/W1500817860","https://openalex.org/W1502721826","https://openalex.org/W1569310189","https://openalex.org/W1570620904","https://openalex.org/W1600417207","https://openalex.org/W1888470382","https://openalex.org/W1937006093","https://openalex.org/W1963663378","https://openalex.org/W1965814531","https://openalex.org/W1968746748","https://openalex.org/W1969104779","https://openalex.org/W1970930356","https://openalex.org/W1971045589","https://openalex.org/W1973839513","https://openalex.org/W1980450602","https://openalex.org/W1983107467","https://openalex.org/W1992372874","https://openalex.org/W1998106503","https://openalex.org/W2000224895","https://openalex.org/W2001685570","https://openalex.org/W2007350931","https://openalex.org/W2007389646","https://openalex.org/W2008119263","https://openalex.org/W2017319763","https://openalex.org/W2020691193","https://openalex.org/W2022442206","https://openalex.org/W2025968906","https://openalex.org/W2030515433","https://openalex.org/W2035062443","https://openalex.org/W2036868154","https://openalex.org/W2051300373","https://openalex.org/W2053497350","https://openalex.org/W2059008374","https://openalex.org/W2059839512","https://openalex.org/W2059994807","https://openalex.org/W2061214727","https://openalex.org/W2066322182","https://openalex.org/W2066582161","https://openalex.org/W2073688363","https://openalex.org/W2080382070","https://openalex.org/W2082980766","https://openalex.org/W2083687646","https://openalex.org/W2092211307","https://openalex.org/W2101160724","https://openalex.org/W2110032138","https://openalex.org/W2121368761","https://openalex.org/W2121836743","https://openalex.org/W2126949422","https://openalex.org/W2138090475","https://openalex.org/W2140441724","https://openalex.org/W2149603226","https://openalex.org/W2168611380","https://openalex.org/W2169946736","https://openalex.org/W2170475716","https://openalex.org/W2171949783","https://openalex.org/W2173726680","https://openalex.org/W2259471424","https://openalex.org/W2324025901","https://openalex.org/W2747068608","https://openalex.org/W4242057663","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2270615539","https://openalex.org/W7135191779","https://openalex.org/W2996692624","https://openalex.org/W2586695568","https://openalex.org/W2082980766","https://openalex.org/W2537923145","https://openalex.org/W7042523814","https://openalex.org/W4281808922","https://openalex.org/W1892859852","https://openalex.org/W2023444263"],"abstract_inverted_index":{"Abstract":[0],"Oxaliplatin":[1,69],"treatment":[2],"is":[3,21],"associated":[4],"with":[5,65,139],"the":[6,30,72,81,86,124,140,157,192,195,199],"development":[7],"of":[8,16,25,34,50,85,98,108,156,181,201],"a":[9,22,43,95,152],"dose-limiting":[10],"painful":[11],"neuropathy":[12,41,99],"impairing":[13],"patient\u2019s":[14],"quality":[15],"life.":[17],"Since":[18],"oxidative":[19,206],"unbalance":[20],"relevant":[23],"mechanism":[24],"oxaliplatin":[26,66,102,144,213],"neurotoxicity,":[27],"we":[28],"assessed":[29],"potential":[31],"antioxidant":[32],"properties":[33],"Vitis":[35,51,113,158,203],"vinifera":[36,52,114,159,204],"extract":[37,49,115,160,196],"in":[38,59,71,80,94,132,145,185,191],"reducing":[39],"oxaliplatin-induced":[40],"as":[42],"valuable":[44],"therapeutic":[45],"opportunity.":[46],"A":[47],"hydroalcoholic":[48],"red":[53],"leaf":[54],"was":[55,78,92],"characterized":[56],"and":[57,83,103,129,168,173,178,188,208],"tested":[58],"primary":[60],"rat":[61,96,133],"astrocyte":[62],"cells":[63],"treated":[64],"(100":[67],"\u03bcM).":[68],"lethality":[70],"human":[73],"adenocarcinoma":[74],"cell":[75],"line":[76],"HT-29":[77,146],"evaluated":[79],"absence":[82],"presence":[84],"extract.":[87],"In":[88,149],"vivo,":[89],"pain":[90,210],"hypersensitivity":[91,170],"measured":[93],"model":[97],"induced":[100],"by":[101,143],"ex":[104],"vivo":[105],"molecular":[106],"targets":[107],"redox":[109],"balance":[110],"were":[111,183],"studied.":[112],"(50":[116],"\u03bcg":[117],"mL\u22121,":[118],"4":[119],"h":[120],"incubation)":[121],"significantly":[122,165,197],"reduced":[123,205],"oxaliplatin-dependent":[125],"superoxide":[126],"anion":[127],"increase":[128],"lipid":[130],"peroxidation":[131],"astrocytes":[134],"but":[135],"did":[136],"not":[137],"interfere":[138],"mortality":[141],"elicited":[142],"cancer":[147],"cells.":[148],"oxaliplatin-treated":[150],"rats,":[151],"repeated":[153],"daily":[154],"administration":[155],"(300":[161],"mg":[162],"kg\u22121,":[163],"p.o.)":[164],"prevented":[166],"mechanical":[167],"thermal":[169],"to":[171],"noxious":[172,175],"non":[174],"stimuli.":[176],"mRNA":[177],"protein":[179],"levels":[180],"Nrf2":[182],"normalized":[184],"spinal":[186,193],"cord":[187],"DRGs.":[189],"Moreover,":[190],"cord,":[194],"decreased":[198],"activation":[200],"astrocytes.":[202],"damages":[207],"relieved":[209],"without":[211],"influencing":[212],"anti-cancer":[214],"activity.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-09-27T00:00:00"}
