{"id":"https://openalex.org/W2889634379","doi":"https://doi.org/10.1159/000493226","title":"C. Elegans Fatty Acid Two-Hydroxylase Regulates Intestinal Homeostasis by Affecting Heptadecenoic Acid Production","display_name":"C. Elegans Fatty Acid Two-Hydroxylase Regulates Intestinal Homeostasis by Affecting Heptadecenoic Acid Production","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2889634379","doi":"https://doi.org/10.1159/000493226","mag":"2889634379","pmid":"https://pubmed.ncbi.nlm.nih.gov/30184537"},"language":"en","primary_location":{"id":"doi:10.1159/000493226","doi":"https://doi.org/10.1159/000493226","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000493226","pdf_url":"https://www.karger.com/Article/Pdf/493226","source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.karger.com/Article/Pdf/493226","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023177145","display_name":"Yuanbao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanbao Li","raw_affiliation_strings":["Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100749809","display_name":"Chunxia Wang","orcid":"https://orcid.org/0000-0003-4550-5208","observed_orcids":["https://orcid.org/0000-0003-4550-5208"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunxia Wang","raw_affiliation_strings":["Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028139857","display_name":"Yikai Huang","orcid":"https://orcid.org/0009-0005-1259-3004","observed_orcids":["https://orcid.org/0009-0005-1259-3004"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yikai Huang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Soochow University Medical College, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Soochow University Medical College, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038349031","display_name":"Rong Fu","orcid":"https://orcid.org/0000-0002-5140-5951","observed_orcids":["https://orcid.org/0000-0002-5140-5951"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Fu","raw_affiliation_strings":["Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057495128","display_name":"Hanxi Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanxi Zheng","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Soochow University Medical College, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Soochow University Medical College, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065716081","display_name":"Yi Zhu","orcid":"https://orcid.org/0000-0001-7115-2544","observed_orcids":["https://orcid.org/0000-0001-7115-2544"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Zhu","raw_affiliation_strings":["Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071090981","display_name":"Xiaoruo Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoruo Shi","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Soochow University Medical College, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Soochow University Medical College, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062419384","display_name":"Prashanth K. Padakanti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prashanth\u00a0K. Padakanti","raw_affiliation_strings":["Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA","Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029519704","display_name":"Zhude Tu","orcid":"https://orcid.org/0000-0003-0325-835X","observed_orcids":["https://orcid.org/0000-0003-0325-835X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhude Tu","raw_affiliation_strings":["Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA","Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021354628","display_name":"Xiong Su","orcid":"https://orcid.org/0000-0001-8998-1826","observed_orcids":["https://orcid.org/0000-0001-8998-1826"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xiong Su","raw_affiliation_strings":["Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA","Department of Biochemistry and Molecular Biology, Soochow University Medical College, Suzhou, China","Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Soochow University Medical College, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071877234","display_name":"Huimin Zhang","orcid":"https://orcid.org/0000-0002-2167-9644","observed_orcids":["https://orcid.org/0000-0002-2167-9644"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huimin Zhang","raw_affiliation_strings":["Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1785,"currency":"EUR","value_usd":1925},"apc_paid":{"value":1785,"currency":"EUR","value_usd":1925},"fwci":0.7065,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.66960465,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"49","issue":"3","first_page":"947","last_page":"960"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.5386000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.5386000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.3668999969959259,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fatty-acid-2-hydroxylase","display_name":"FA2H","score":0.9589999914169312},{"id":"https://openalex.org/keywords/intestinal-homeostasis","display_name":"intestinal homeostasis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/sphingolipid-biosynthesis","display_name":"sphingolipid biosynthesis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/peroxisomes","display_name":"peroxisomes","score":0.6539999842643738},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.8169999718666077},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8629999756813049},{"id":"https://openalex.org/keywords/growth-retardation","display_name":"growth retardation","score":0.671999990940094},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tissue-specific-gene-function","display_name":"tissue-specific gene function","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.5844965577125549},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5257771015167236},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5031582713127136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.450765460729599},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.41972601413726807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3876357972621918}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005229","descriptor_name":"Fatty Acids, Monounsaturated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005229","descriptor_name":"Fatty Acids, Monounsaturated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005229","descriptor_name":"Fatty Acids, Monounsaturated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020675","descriptor_name":"Peroxisomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020675","descriptor_name":"Peroxisomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020675","descriptor_name":"Peroxisomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1159/000493226","doi":"https://doi.org/10.1159/000493226","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000493226","pdf_url":"https://www.karger.com/Article/Pdf/493226","source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},{"id":"pmid:30184537","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30184537","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-8134","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/7128","pdf_url":"https://digitalcommons.wustl.edu/open_access_pubs/7128","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},{"id":"pmh:oai:europepmc.org:5410889","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6428043","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6428043","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6428043","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Physiol Biochem","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4395862a82b04cc98b259e594c446a09","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4395862a82b04cc98b259e594c446a09","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular Physiology and Biochemistry, Vol 49, Iss 3, Pp 947-960 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1159/000493226","doi":"https://doi.org/10.1159/000493226","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000493226","pdf_url":"https://www.karger.com/Article/Pdf/493226","source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G151374072","display_name":null,"funder_award_id":"P30-DK056341","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3029184898","display_name":"METABOLIC FUNCTIONS OF ADIPOCYTE PEROXISOMES","funder_award_id":"R01DK097608","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3925926572","display_name":"\u80f6\u539f\u86cb\u767d\u7f51\u7edc\u8c03\u63a7\u4e0a\u76ae\u7ec6\u80de\u56fa\u6709\u514d\u75ab\u5e94\u7b54\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"31670912","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G9000865705","display_name":"Caenorhabditis Genetics Center","funder_award_id":"P40OD010440","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326182","display_name":"Six Talent Peaks Project in Jiangsu Province","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2889634379.pdf"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1944127002","https://openalex.org/W1965910933","https://openalex.org/W1967299835","https://openalex.org/W1977180164","https://openalex.org/W1977203758","https://openalex.org/W1982035848","https://openalex.org/W1988466138","https://openalex.org/W1990300902","https://openalex.org/W1992727272","https://openalex.org/W2007118279","https://openalex.org/W2011859788","https://openalex.org/W2019308540","https://openalex.org/W2019396114","https://openalex.org/W2027634841","https://openalex.org/W2036134806","https://openalex.org/W2036727412","https://openalex.org/W2053254030","https://openalex.org/W2058605720","https://openalex.org/W2084043096","https://openalex.org/W2097860556","https://openalex.org/W2098923623","https://openalex.org/W2101400941","https://openalex.org/W2106367815","https://openalex.org/W2115059753","https://openalex.org/W2115803302","https://openalex.org/W2120350838","https://openalex.org/W2125613745","https://openalex.org/W2134390983","https://openalex.org/W2152980478","https://openalex.org/W2153079301","https://openalex.org/W2227275386","https://openalex.org/W2343111445","https://openalex.org/W2912527368"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W2151865869","https://openalex.org/W1951304285"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"The":[1,98,175],"hydroxylation":[2],"of":[3,14,41,69,95,125,150,196,208,226,238,248,266,286,297,306,313,329,339],"fatty":[4,15,23,44,107],"acids":[5],"at":[6,141],"the":[7,11,38,61,66,71,126,167,171,182,193,197,201,227,236,261,284,295,309,326,330],"C-2":[8],"position":[9],"is":[10,29,139,163],"first":[12],"step":[13],"acid":[16,27,33,45,108,251,257],"\u03b1-oxidation":[17],"and":[18,43,63,82,92,112,145,158,221,263,276,311,321,344],"generates":[19],"sphingolipids":[20],"containing":[21],"2-hydroxy":[22],"acyl":[24],"moieties.":[25],"Fatty":[26,32],"2-hydroxylation":[28,46],"catalyzed":[30],"by":[31,132],"2-hydroxylase":[34],"(FA2H)":[35],"enzyme.":[36,79],"However,":[37],"precise":[39],"roles":[40],"FA2H":[42,78,340],"in":[47,109,146,154,166,188,235,283],"whole":[48],"cell":[49],"homeostasis":[50,328],"still":[51],"remain":[52,245],"unclear.":[53],"METHODS:":[54],"Here":[55],"we":[56,204],"utilize":[57],"Caenorhabditis":[58],"elegans":[59,137],"as":[60,215,217,292,294],"model":[62],"systemically":[64],"investigate":[65],"physiological":[67],"functions":[68,312,341],"FATH-1/C25A1.5,":[70],"highly":[72,281],"conserved":[73],"worm":[74],"homolog":[75],"for":[76,308,349],"mammalian":[77],"Immunostaining,":[80],"dye-staining":[81],"translational":[83],"fusion":[84],"reporters":[85],"were":[86,117],"used":[87],"to":[88,104,119,192,317],"visualize":[89],"FATH-1":[90,121,138,161,183,275],"protein":[91,319],"a":[93,232],"variety":[94],"subcellular":[96,202,264],"structures.":[97],"\"click":[99,176],"chemistry\"":[100,177],"method":[101],"was":[102,130],"employed":[103],"label":[105],"2-OH":[106],"vivo.":[110],"Global":[111],"tissue-specific":[113],"RNAi":[114],"knockdown":[115,268],"experiments":[116],"performed":[118],"inactivate":[120],"function.":[122],"Lipid":[123,224],"analysis":[124,225],"fath-1":[127,151,209,228,267],"deficient":[128,229],"mutants":[129],"achieved":[131],"mass":[133],"spectrometry.":[134],"RESULTS:":[135],"C.":[136],"expressed":[140],"most":[142,147],"developmental":[143],"stages":[144],"tissues.":[148],"Loss":[149],"expression":[152,210],"results":[153],"severe":[155],"growth":[156],"retardation":[157],"shortened":[159],"lifespan.":[160],"function":[162],"crucially":[164],"required":[165],"intestine":[168],"but":[169,254],"not":[170,255],"epidermis":[172],"with":[173],"stereospecificity.":[174],"labeling":[178],"technique":[179],"showed":[180],"that":[181,206,274],"metabolites":[184],"are":[185,280],"mainly":[186],"enriched":[187],"membrane":[189],"structures":[190],"preferable":[191],"apical":[194,222],"side":[195],"intestinal":[198,331],"cells.":[199,332],"At":[200],"level,":[203],"found":[205],"loss":[207],"inhibits":[211],"lipid":[212],"droplets":[213],"formation,":[214],"well":[216,293],"selectively":[218],"disrupts":[219],"peroxisomes":[220],"endosomes.":[223],"animals":[230],"revealed":[231,273],"significant":[233],"reduction":[234],"content":[237],"heptadecenoic":[239,250],"acid,":[240],"while":[241],"other":[242],"major":[243],"FAs":[244,315],"unaffected.":[246],"Feeding":[247],"exogenous":[249],"(C17:":[252],"1),":[253,259],"oleic":[256],"(C18:":[258],"rescues":[260],"global":[262],"defects":[265],"worms.":[269],"CONCLUSION:":[270],"Our":[271],"study":[272],"its":[277],"catalytic":[278],"products":[279],"specific":[282],"context":[285],"chirality,":[287],"C-chain":[288],"length,":[289],"spatial":[290],"distribution,":[291],"types":[296],"cellular":[298,327],"organelles":[299],"they":[300],"affect.":[301],"Such":[302],"an":[303],"unexpected":[304],"degree":[305],"specificity":[307],"synthesis":[310],"hydroxylated":[314],"helps":[316],"regulate":[318],"transport":[320],"fat":[322],"metabolism,":[323],"therefore":[324],"maintaining":[325],"These":[333],"findings":[334],"may":[335],"help":[336],"our":[337],"understanding":[338],"across":[342],"species,":[343],"offer":[345],"potential":[346],"therapeutical":[347],"targets":[348],"treating":[350],"FA2H-related":[351],"diseases.":[352]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
