{"id":"https://openalex.org/W2889615651","doi":"https://doi.org/10.1134/s1819712418030030","title":"Exosome Drug Delivery through the Blood\u2013Brain Barrier: Experimental Approaches and Potential Applications","display_name":"Exosome Drug Delivery through the Blood\u2013Brain Barrier: Experimental Approaches and Potential Applications","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2889615651","doi":"https://doi.org/10.1134/s1819712418030030","mag":"2889615651"},"language":"en","primary_location":{"id":"doi:10.1134/s1819712418030030","doi":"https://doi.org/10.1134/s1819712418030030","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1819712418030030","pdf_url":null,"source":{"id":"https://openalex.org/S115587109","display_name":"Neurochemical Journal","issn_l":"1819-7124","issn":["1819-7124","1819-7132"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058412543","display_name":"Tatiana A. Druzhkova","orcid":"https://orcid.org/0000-0002-5031-1187","observed_orcids":["https://orcid.org/0000-0002-5031-1187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. A. Druzhkova","raw_affiliation_strings":["Solov\u2019ev Scientific and Practical Psychoneurological Center, Moscow Department of Healthcare, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Solov\u2019ev Scientific and Practical Psychoneurological Center, Moscow Department of Healthcare, Moscow, Russia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009707379","display_name":"Alexander A. Yakovlev","orcid":"https://orcid.org/0000-0003-2546-5130","observed_orcids":["https://orcid.org/0000-0003-2546-5130"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210156060","display_name":"Institute of Higher Nervous Activity and Neurophysiology","ror":"https://ror.org/057n4xq60","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210115279","https://openalex.org/I4210156060"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"A. A. Yakovlev","raw_affiliation_strings":["Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia","Solov\u2019ev Scientific and Practical Psychoneurological Center, Moscow Department of Healthcare, Moscow, Russia","ul. Butlerova, 5a, Moscow, 117485, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210156060"]},{"raw_affiliation_string":"Solov\u2019ev Scientific and Practical Psychoneurological Center, Moscow Department of Healthcare, Moscow, Russia","institution_ids":[]},{"raw_affiliation_string":"ul. Butlerova, 5a, Moscow, 117485, Russia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009707379"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210156060"],"apc_list":null,"apc_paid":null,"fwci":1.1707,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.77421883,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"12","issue":"3","first_page":"195","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9120000004768372},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.8069999814033508},{"id":"https://openalex.org/keywords/exosome-engineering","display_name":"exosome engineering","score":0.7910000085830688},{"id":"https://openalex.org/keywords/exosome-modification","display_name":"exosome modification","score":0.828000009059906},{"id":"https://openalex.org/keywords/drug-delivery-to-the-brain","display_name":"brain drug delivery","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.9285272359848022},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.9057481288909912},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.7589573860168457},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.6408364772796631},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.5634781122207642},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5490109324455261},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4077179431915283},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.40034544467926025},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35403692722320557},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3513537049293518},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3163362741470337},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.265749990940094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22608721256256104},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.13265976309776306},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.12451356649398804},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.11339622735977173},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05903854966163635},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1134/s1819712418030030","doi":"https://doi.org/10.1134/s1819712418030030","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1819712418030030","pdf_url":null,"source":{"id":"https://openalex.org/S115587109","display_name":"Neurochemical Journal","issn_l":"1819-7124","issn":["1819-7124","1819-7132"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1721689174","https://openalex.org/W1970130496","https://openalex.org/W1975088956","https://openalex.org/W1992176533","https://openalex.org/W2005154332","https://openalex.org/W2016963246","https://openalex.org/W2020438602","https://openalex.org/W2036161137","https://openalex.org/W2046677279","https://openalex.org/W2059895668","https://openalex.org/W2066234893","https://openalex.org/W2080418767","https://openalex.org/W2085898732","https://openalex.org/W2091250479","https://openalex.org/W2094305477","https://openalex.org/W2109298880","https://openalex.org/W2121354606","https://openalex.org/W2124304994","https://openalex.org/W2151079805","https://openalex.org/W2164322384","https://openalex.org/W2166846320","https://openalex.org/W2168120562","https://openalex.org/W2207291742","https://openalex.org/W2253028130","https://openalex.org/W2288838295","https://openalex.org/W2406609064","https://openalex.org/W2465939084","https://openalex.org/W2476696777","https://openalex.org/W2527897220","https://openalex.org/W2607139744","https://openalex.org/W2736233594","https://openalex.org/W2761425229","https://openalex.org/W7098400432"],"related_works":["https://openalex.org/W7172421198","https://openalex.org/W4414168683","https://openalex.org/W7141247596","https://openalex.org/W4310832405","https://openalex.org/W4412066527","https://openalex.org/W4410894805","https://openalex.org/W4410049494","https://openalex.org/W7160329416","https://openalex.org/W4408339893","https://openalex.org/W3184807600"],"abstract_inverted_index":{"This":[0],"review":[1],"discusses":[2],"the":[3,12,24,41,64],"current":[4],"experimental":[5,57],"data":[6],"on":[7,18],"targeted":[8],"drug":[9,20,61],"delivery":[10,21,62],"through":[11,63],"blood\u2013brain":[13],"barrier":[14],"(BBB).":[15],"We":[16],"focus":[17],"exosome":[19,60],"and":[22,36,47,75],"examine":[23],"unique":[25],"biological":[26],"structure":[27],"of":[28,49,56,59,73],"exosomes,":[29],"which":[30],"allows":[31],"them":[32],"to":[33,40,45],"pack,":[34],"store,":[35],"deliver":[37],"various":[38],"molecules":[39],"brain.":[42],"Various":[43],"approaches":[44],"modification":[46],"engineering":[48],"exosomes":[50,74],"are":[51,79],"reviewed":[52],"with":[53,69],"an":[54],"analysis":[55],"studies":[58],"BBB.":[65],"The":[66],"problems":[67],"associated":[68],"potential":[70],"clinical":[71],"uses":[72],"their":[76],"possible":[77],"solutions":[78],"discussed.":[80]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-09-27T00:00:00"}
