{"id":"https://openalex.org/W2889596303","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e22178","title":"Gut microbiome alterations in breast cancer survivors with cancer-related fatigue.","display_name":"Gut microbiome alterations in breast cancer survivors with cancer-related fatigue.","publication_year":2018,"publication_date":"2018-05-20","ids":{"openalex":"https://openalex.org/W2889596303","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e22178","mag":"2889596303"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2018.36.15_suppl.e22178","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e22178","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.15_suppl.e22178","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060981830","display_name":"Alexandre Chan","orcid":"https://orcid.org/0000-0003-4391-4219","observed_orcids":["https://orcid.org/0000-0003-4391-4219"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Alexandre Chan","raw_affiliation_strings":["Department of Pharmacy, National University of Singapore, Singapore, Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, National University of Singapore, Singapore, Singapore;","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110574102","display_name":"Maung Shwe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Maung Shwe","raw_affiliation_strings":["Department of Pharmacy, National University of Singapore, Singapore, Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, National University of Singapore, Singapore, Singapore;","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036433805","display_name":"Samantha An Qi Koh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58236372","display_name":"Ngee Ann Polytechnic","ror":"https://ror.org/01w953x65","country_code":"SG","type":"education","lineage":["https://openalex.org/I58236372"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Samantha An Qi Koh","raw_affiliation_strings":["School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore;","institution_ids":["https://openalex.org/I58236372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029964973","display_name":"Congju Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58236372","display_name":"Ngee Ann Polytechnic","ror":"https://ror.org/01w953x65","country_code":"SG","type":"education","lineage":["https://openalex.org/I58236372"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Congju Zhu","raw_affiliation_strings":["School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore;","institution_ids":["https://openalex.org/I58236372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034796412","display_name":"Yi Shan Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58236372","display_name":"Ngee Ann Polytechnic","ror":"https://ror.org/01w953x65","country_code":"SG","type":"education","lineage":["https://openalex.org/I58236372"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yi Shan Chan","raw_affiliation_strings":["School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore;","institution_ids":["https://openalex.org/I58236372"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Si Hui Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58236372","display_name":"Ngee Ann Polytechnic","ror":"https://ror.org/01w953x65","country_code":"SG","type":"education","lineage":["https://openalex.org/I58236372"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Si Hui Tan","raw_affiliation_strings":["School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore;","institution_ids":["https://openalex.org/I58236372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002912763","display_name":"Xiao Jun Ang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58236372","display_name":"Ngee Ann Polytechnic","ror":"https://ror.org/01w953x65","country_code":"SG","type":"education","lineage":["https://openalex.org/I58236372"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Xiao Jun Ang","raw_affiliation_strings":["School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore;","institution_ids":["https://openalex.org/I58236372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071054146","display_name":"Wei Quan Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58236372","display_name":"Ngee Ann Polytechnic","ror":"https://ror.org/01w953x65","country_code":"SG","type":"education","lineage":["https://openalex.org/I58236372"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wei Quan Lee","raw_affiliation_strings":["School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore;","institution_ids":["https://openalex.org/I58236372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020984275","display_name":"Wei Wei Thwe Khine","orcid":"https://orcid.org/0000-0002-7805-9024","observed_orcids":["https://orcid.org/0000-0002-7805-9024"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wei Wei Thwe Khine","raw_affiliation_strings":["Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore;","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059167717","display_name":"Yuan Kun Lee","orcid":"https://orcid.org/0000-0002-3884-4706","observed_orcids":["https://orcid.org/0000-0002-3884-4706"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yuan Kun Lee","raw_affiliation_strings":["Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore;","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039870258","display_name":"Quek Choon Lau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58236372","display_name":"Ngee Ann Polytechnic","ror":"https://ror.org/01w953x65","country_code":"SG","type":"education","lineage":["https://openalex.org/I58236372"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Quek Choon Lau","raw_affiliation_strings":["School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore, Singapore;","institution_ids":["https://openalex.org/I58236372"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"15_suppl","first_page":"e22178","last_page":"e22178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cancer-related-fatigue","display_name":"cancer-related fatigue","score":0.9240000247955322},{"id":"https://openalex.org/keywords/breast-cancer-survivors","display_name":"breast cancer survivors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/early-breast-cancer","display_name":"early breast cancer","score":0.8190000057220459},{"id":"https://openalex.org/keywords/fatigue-severity","display_name":"fatigue severity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/bacteroides","display_name":"Bacteroides","score":0.9010000228881836},{"id":"https://openalex.org/keywords/ruminococcus","display_name":"Ruminococcus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/streptococcus","display_name":"Streptococcus","score":0.9850000143051147},{"id":"https://openalex.org/keywords/prevotella","display_name":"Prevotella","score":1.0},{"id":"https://openalex.org/keywords/butyricimonas","display_name":"Butyricimonas","score":0.8569999933242798},{"id":"https://openalex.org/keywords/lactobacillus","display_name":"Lactobacillus","score":0.8999999761581421},{"id":"https://openalex.org/keywords/megasphaera","display_name":"Megasphaera","score":0.8410000205039978},{"id":"https://openalex.org/keywords/neurocognitive-function","display_name":"neurocognitive function","score":0.8980000019073486},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C2780423288","wikidata":"https://www.wikidata.org/wiki/Q7242440","display_name":"Prevotella","level":3,"score":0.8463155627250671},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7005127668380737},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6794296503067017},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6721457242965698},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5716451406478882},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5204482078552246},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.4789469838142395},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.4630318880081177},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4378967583179474},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3722968101501465},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3441474139690399},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29825079441070557},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28232526779174805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21850386261940002},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13579818606376648},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.09591424465179443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2018.36.15_suppl.e22178","doi":"https://doi.org/10.1200/jco.2018.36.15_suppl.e22178","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.15_suppl.e22178","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4311128568","https://openalex.org/W7125672498","https://openalex.org/W4393986067","https://openalex.org/W3135599602","https://openalex.org/W4405590060","https://openalex.org/W4396626244","https://openalex.org/W2571252045","https://openalex.org/W3125431677","https://openalex.org/W3093115823","https://openalex.org/W7221829115"],"abstract_inverted_index":{"e22178":[0],"Background:":[1],"Recent":[2],"studies":[3,227],"have":[4],"shown":[5],"that":[6,131,244],"alterations":[7],"in":[8,43,50,147,168,250],"the":[9,19,24,41,66,87,101,107,112,208,216,251],"gut":[10,25,44,108,211],"microbiome":[11,26,45,109,212],"are":[12,213],"associated":[13,214],"with":[14,80,126,149,170,199,215,228],"chronic":[15],"fatigue":[16,29,48,69,172,177,219],"syndrome.":[17],"However,":[18],"correlation":[20],"between":[21],"composition":[22],"of":[23,52,58,111,133,140,161,186,202,210,218,223,238,255],"and":[27,47,83,137,142,163,179,192,241,253],"cancer-related":[28],"(CRF)":[30],"has":[31],"not":[32],"been":[33],"well":[34],"established.":[35],"In":[36],"this":[37],"study,":[38],"we":[39],"evaluated":[40],"changes":[42],"profiles":[46],"severity":[49,57,217],"survivors":[51,62,119,148,169,222],"breast":[53,60,117,224],"cancer.":[54,225],"Methods:":[55],"Fatigue":[56],"early-stage":[59,116],"cancer":[61,118],"was":[63,98],"assessed":[64],"using":[65,86,100],"validated":[67],"multidimensional":[68],"symptom":[70],"inventory":[71],"\u2013":[72],"short":[73],"form":[74],"(MFSI-SF).":[75],"Stool":[76],"samples":[77],"were":[78,120,145,166,195],"collected,":[79],"DNA":[81,91],"purified":[82],"library":[84],"prepared":[85],"Next":[88],"\u00ae":[89],"Ultra":[90],"Library":[92],"Preparation":[93],"Kit.":[94],"16s":[95],"rRNA":[96],"sequencing":[97],"performed":[99],"Illumina":[102],"HiSeq":[103],"sequencer":[104],"to":[105,153,174,197],"reveal":[106],"profile":[110],"survivors.":[113,203],"Results:":[114],"Thirty":[115],"recruited":[121],"(mean":[122],"age\u00b1SD:":[123],"52.7\u00b18.7":[124],"years),":[125],"56.7%":[127],"regularly":[128],"consumed":[129],"diets":[130],"consist":[132],"probiotics.":[134],"A":[135],"1.7-fold":[136],"3.2-fold":[138],"increase":[139],"Bacteroides":[141],"Ruminococcus":[143],"species":[144,165,194],"found":[146,167,196],"severe":[150,171],"fatigue,":[151],"compared":[152,173],"patients":[154],"without":[155,176],"fatigue.":[156],"Conversely,":[157],"significantly":[158],"lower":[159],"abundance":[160,185],"Streptococcus":[162],"Prevotella":[164],"those":[175],"(4-fold":[178],"5.3-fold":[180],"less":[181],"abundance,":[182],"respectively).":[183],"Relative":[184],"Butyricimonas,":[187],"Prevotella,":[188],"Streptococcus,":[189],"Bacillus,":[190],"Lactobacillus":[191],"Megasphaera":[193],"correlate":[198],"neurocognitive":[200],"ability":[201],"Conclusions:":[204],"Our":[205],"results":[206],"showed":[207],"compositions":[209],"experienced":[220],"by":[221],"Further":[226],"larger":[229],"cohort":[230],"may":[231],"provide":[232],"greater":[233],"insights":[234],"for":[235],"future":[236],"development":[237],"novel":[239],"biomarkers":[240],"dietary":[242],"interventions":[243],"would":[245],"play":[246],"a":[247],"crucial":[248],"role":[249],"detection":[252],"alleviation":[254],"CRF.":[256]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2018-09-27T00:00:00"}