{"id":"https://openalex.org/W2889570909","doi":"https://doi.org/10.1186/s13045-018-0664-7","title":"Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development","display_name":"Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development","publication_year":2018,"publication_date":"2018-09-19","ids":{"openalex":"https://openalex.org/W2889570909","doi":"https://doi.org/10.1186/s13045-018-0664-7","mag":"2889570909","pmid":"https://pubmed.ncbi.nlm.nih.gov/30231931","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6146601"},"language":"en","primary_location":{"id":"doi:10.1186/s13045-018-0664-7","doi":"https://doi.org/10.1186/s13045-018-0664-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-018-0664-7","pdf_url":"https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-018-0664-7","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology &amp; Oncology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2889570909"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-018-0664-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014942475","display_name":"Guoshuang Shen","orcid":"https://orcid.org/0000-0002-9381-8658","observed_orcids":["https://orcid.org/0000-0002-9381-8658"]},"institutions":[{"id":"https://openalex.org/I4210086866","display_name":"Qinghai University Affiliated Hospital","ror":"https://ror.org/000j1tr86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086866"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoshuang Shen","raw_affiliation_strings":["Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China","institution_ids":["https://openalex.org/I4210086866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037906632","display_name":"Fangchao Zheng","orcid":"https://orcid.org/0000-0002-2640-544X","observed_orcids":["https://orcid.org/0000-0002-2640-544X"]},"institutions":[{"id":"https://openalex.org/I4210086866","display_name":"Qinghai University Affiliated Hospital","ror":"https://ror.org/000j1tr86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086866"]},{"id":"https://openalex.org/I4210159744","display_name":"Weifang Chinese Medicine Hospital","ror":"https://ror.org/05mfqj750","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159744"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangchao Zheng","raw_affiliation_strings":["Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China","Shouguang Hospital of Traditional Chinese Medicine, Weifang, 262700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China","institution_ids":["https://openalex.org/I4210086866"]},{"raw_affiliation_string":"Shouguang Hospital of Traditional Chinese Medicine, Weifang, 262700, China","institution_ids":["https://openalex.org/I4210159744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049059298","display_name":"Dengfeng Ren","orcid":"https://orcid.org/0000-0002-4544-9528","observed_orcids":["https://orcid.org/0000-0002-4544-9528"]},"institutions":[{"id":"https://openalex.org/I4210086866","display_name":"Qinghai University Affiliated Hospital","ror":"https://ror.org/000j1tr86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086866"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dengfeng Ren","raw_affiliation_strings":["Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China","institution_ids":["https://openalex.org/I4210086866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101478862","display_name":"Feng Du","orcid":"https://orcid.org/0000-0002-3709-1933","observed_orcids":["https://orcid.org/0000-0002-3709-1933"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Du","raw_affiliation_strings":["Peking University Cancer Hospital and Institute, Beijing, 100142, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University Cancer Hospital and Institute, Beijing, 100142, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104067176","display_name":"Qiuxia Dong","orcid":"https://orcid.org/0000-0002-7759-0091","observed_orcids":["https://orcid.org/0000-0002-7759-0091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiuxia Dong","raw_affiliation_strings":["The Fifth People's Hospital of Qinghai Province, Xining, 810000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fifth People's Hospital of Qinghai Province, Xining, 810000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441384","display_name":"Ziyi Wang","orcid":"https://orcid.org/0000-0003-1884-8053","observed_orcids":["https://orcid.org/0000-0003-1884-8053","https://orcid.org/0009-0001-1456-577X"]},"institutions":[{"id":"https://openalex.org/I4210086866","display_name":"Qinghai University Affiliated Hospital","ror":"https://ror.org/000j1tr86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086866"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyi Wang","raw_affiliation_strings":["Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China","institution_ids":["https://openalex.org/I4210086866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101979022","display_name":"Fuxing Zhao","orcid":"https://orcid.org/0009-0000-1317-1368","observed_orcids":["https://orcid.org/0009-0000-1317-1368"]},"institutions":[{"id":"https://openalex.org/I4210086866","display_name":"Qinghai University Affiliated Hospital","ror":"https://ror.org/000j1tr86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086866"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fuxing Zhao","raw_affiliation_strings":["Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China","institution_ids":["https://openalex.org/I4210086866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000274948","display_name":"Raees Ahmad","orcid":"https://orcid.org/0000-0002-9975-5213","observed_orcids":["https://orcid.org/0000-0002-9975-5213","https://orcid.org/0009-0009-3396-5136"]},"institutions":[{"id":"https://openalex.org/I4210086866","display_name":"Qinghai University Affiliated Hospital","ror":"https://ror.org/000j1tr86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086866"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Raees Ahmad","raw_affiliation_strings":["Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China","institution_ids":["https://openalex.org/I4210086866"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055003664","display_name":"Jiuda Zhao","orcid":"https://orcid.org/0000-0002-1266-8943","observed_orcids":["https://orcid.org/0000-0002-1266-8943"]},"institutions":[{"id":"https://openalex.org/I4210086866","display_name":"Qinghai University Affiliated Hospital","ror":"https://ror.org/000j1tr86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086866"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiuda Zhao","raw_affiliation_strings":["Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China. jiudazhao@126.com","Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China. jiudazhao@126.com","institution_ids":["https://openalex.org/I4210086866"]},{"raw_affiliation_string":"Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China","institution_ids":["https://openalex.org/I4210086866"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055003664"],"corresponding_institution_ids":["https://openalex.org/I4210086866"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":5.3952,"has_fulltext":true,"cited_by_count":685,"citation_normalized_percentile":{"value":0.98320611,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"120","last_page":"120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anlotinib","display_name":"anlotinib","score":1.0},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8550000190734863},{"id":"https://openalex.org/keywords/vegfr","display_name":"VEGFR","score":0.8140000104904175},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-receptor","display_name":"fibroblast growth factor receptor","score":0.9810000061988831},{"id":"https://openalex.org/keywords/pdgfr","display_name":"PDGFR","score":0.9950000047683716},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.9909999966621399},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9509999752044678},{"id":"https://openalex.org/keywords/soft-tissue-sarcoma","display_name":"soft tissue sarcoma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/metastatic-renal-cell-carcinoma","display_name":"metastatic renal cell carcinoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/third-line-therapy","display_name":"third-line therapy","score":0.8080000281333923},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9520000219345093},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6729999780654907},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7416834831237793},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.6606687903404236},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.6296647787094116},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5946094393730164},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.5791851878166199},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.5644828081130981},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5177909135818481},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5103799700737},{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.4666101336479187},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.4653191566467285},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.45592406392097473},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.42132487893104553},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.419028639793396},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35916373133659363},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3569486737251282},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.27342110872268677},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20364752411842346},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.2010512351989746},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.19277969002723694},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s13045-018-0664-7","doi":"https://doi.org/10.1186/s13045-018-0664-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-018-0664-7","pdf_url":"https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-018-0664-7","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology &amp; Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5098251","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6146601","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30231931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30231931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hematology & oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6146601","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6146601/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Hematol Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:020266eff90340c3ac425e27a241126d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/020266eff90340c3ac425e27a241126d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-11 (2018)","raw_type":"article"},{"id":"doi:10.60692/qc5ze-b6158","doi":"https://doi.org/10.60692/qc5ze-b6158","is_oa":true,"landing_page_url":"https://doi.org/10.60692/qc5ze-b6158","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/yhean-7gv20","doi":"https://doi.org/10.60692/yhean-7gv20","is_oa":true,"landing_page_url":"https://doi.org/10.60692/yhean-7gv20","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s13045-018-0664-7","doi":"https://doi.org/10.1186/s13045-018-0664-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-018-0664-7","pdf_url":"https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-018-0664-7","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology &amp; Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2889570909.pdf","grobid_xml":"https://content.openalex.org/works/W2889570909.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W772589830","https://openalex.org/W1965804113","https://openalex.org/W1974903221","https://openalex.org/W1974903851","https://openalex.org/W2012978969","https://openalex.org/W2048747154","https://openalex.org/W2052874737","https://openalex.org/W2053237929","https://openalex.org/W2087898932","https://openalex.org/W2095657951","https://openalex.org/W2099088585","https://openalex.org/W2101776780","https://openalex.org/W2103689170","https://openalex.org/W2107230638","https://openalex.org/W2111237964","https://openalex.org/W2111851685","https://openalex.org/W2112129582","https://openalex.org/W2118880688","https://openalex.org/W2119501407","https://openalex.org/W2122956665","https://openalex.org/W2132951626","https://openalex.org/W2133354058","https://openalex.org/W2133365073","https://openalex.org/W2139120013","https://openalex.org/W2140980839","https://openalex.org/W2147663823","https://openalex.org/W2147834058","https://openalex.org/W2149456801","https://openalex.org/W2152715911","https://openalex.org/W2153331460","https://openalex.org/W2157262448","https://openalex.org/W2160120519","https://openalex.org/W2162225483","https://openalex.org/W2162424705","https://openalex.org/W2168076926","https://openalex.org/W2172208023","https://openalex.org/W2206853573","https://openalex.org/W2394893668","https://openalex.org/W2413552560","https://openalex.org/W2419095525","https://openalex.org/W2508822337","https://openalex.org/W2511218030","https://openalex.org/W2528424364","https://openalex.org/W2558408743","https://openalex.org/W2663694575","https://openalex.org/W2675862164","https://openalex.org/W2741694214","https://openalex.org/W2756743534","https://openalex.org/W2767554548","https://openalex.org/W2767929170","https://openalex.org/W2768001377","https://openalex.org/W2773039266","https://openalex.org/W2780585767","https://openalex.org/W2791602004","https://openalex.org/W2791667474","https://openalex.org/W2793605704","https://openalex.org/W2794211762","https://openalex.org/W2795758525","https://openalex.org/W2890685438","https://openalex.org/W2891312861","https://openalex.org/W2891509796","https://openalex.org/W2891802601","https://openalex.org/W2891856000","https://openalex.org/W2892340162","https://openalex.org/W2942710068","https://openalex.org/W4250935139","https://openalex.org/W4285097283"],"related_works":["https://openalex.org/W3032195772","https://openalex.org/W3163990763","https://openalex.org/W2571298662","https://openalex.org/W2969136866","https://openalex.org/W4281794380","https://openalex.org/W3029521844","https://openalex.org/W3139427320","https://openalex.org/W3206942369","https://openalex.org/W2791602004","https://openalex.org/W2810290331"],"abstract_inverted_index":{"Anlotinib":[0,112],"is":[1,135],"a":[2,46,82,91,155],"new,":[3],"orally":[4],"administered":[5],"tyrosine":[6,141,149],"kinase":[7,142],"inhibitor":[8],"that":[9,97,138,144,168],"targets":[10],"vascular":[11],"endothelial":[12],"growth":[13,18,23],"factor":[14,19,24],"receptor":[15,20],"(VEGFR),":[16],"fibroblast":[17],"(FGFR),":[21],"platelet-derived":[22],"receptors":[25],"(PDGFR),":[26],"and":[27,41,73,124,147,177],"c-kit.":[28],"Compared":[29],"to":[30,137,167],"the":[31,61,70,101,173,183],"effect":[32],"of":[33,60,66,133,139,159,169,180,185],"placebo,":[34],"it":[35],"improved":[36],"both":[37],"progression-free":[38],"survival":[39,43],"(PFS)":[40],"overall":[42],"(OS)":[44],"in":[45,50,104,117],"phase":[47,93],"III":[48],"trial":[49,95],"patients":[51,86,105,118],"with":[52,87,106,119],"advanced":[53,88,107,120],"non-small-cell":[54],"lung":[55],"cancer":[56,62],"(NSCLC),":[57],"despite":[58],"progression":[59],"after":[63],"two":[64],"lines":[65],"prior":[67],"treatments.":[68],"Recently,":[69],"China":[71],"Food":[72],"Drug":[74],"Administration":[75],"(CFDA)":[76],"approved":[77],"single":[78],"agent":[79],"anlotinib":[80,98,134,153,181],"as":[81],"third-line":[83],"treatment":[84,184],"for":[85,182],"NSCLC.":[89],"Moreover,":[90],"randomized":[92],"IIB":[94],"demonstrated":[96],"significantly":[99,156],"prolonged":[100],"median":[102],"PFS":[103],"soft":[108],"tissue":[109],"sarcoma":[110],"(STS).":[111],"also":[113],"showed":[114],"promising":[115],"efficacy":[116],"medullary":[121],"thyroid":[122],"carcinoma":[123,128],"metastatic":[125],"renal":[126],"cell":[127],"(mRCC).":[129],"The":[130],"tolerability":[131],"profile":[132],"similar":[136],"other":[140,148],"inhibitors":[143],"target":[145],"VEGFR":[146],"kinase-mediated":[150],"pathways;":[151],"however,":[152],"has":[154],"lower":[157],"incidence":[158],"grade":[160],"3":[161],"or":[162],"higher":[163],"side":[164],"effects":[165],"compared":[166],"sunitinib.":[170],"We":[171],"review":[172],"rationale,":[174],"clinical":[175],"evidence,":[176],"future":[178],"perspectives":[179],"multiple":[186],"cancers.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":73},{"year":2025,"cited_by_count":129},{"year":2024,"cited_by_count":126},{"year":2023,"cited_by_count":110},{"year":2022,"cited_by_count":110},{"year":2021,"cited_by_count":74},{"year":2020,"cited_by_count":40},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-09-27T00:00:00"}
