{"id":"https://openalex.org/W2889564529","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e14521","title":"Selective histone deacetylase inhibition augments melanoma immunotherapy.","display_name":"Selective histone deacetylase inhibition augments melanoma immunotherapy.","publication_year":2016,"publication_date":"2016-05-20","ids":{"openalex":"https://openalex.org/W2889564529","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e14521","mag":"2889564529"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2016.34.15_suppl.e14521","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e14521","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.15_suppl.e14521","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104110292","display_name":"Andressa S. Laino","orcid":"https://orcid.org/0000-0002-4435-1342","observed_orcids":["https://orcid.org/0000-0002-4435-1342"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andressa Sodre Laino","raw_affiliation_strings":["NYU Medical Center2, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Medical Center2, New York, NY;","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067364305","display_name":"David Michael Woods","orcid":"https://orcid.org/0000-0002-6328-8107","observed_orcids":["https://orcid.org/0000-0002-6328-8107"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Michael Woods","raw_affiliation_strings":["NYU Langone Medical Center2, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Langone Medical Center2, New York, NY;","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033965725","display_name":"Amod A. Sarnaik","orcid":"https://orcid.org/0000-0002-2337-5898","observed_orcids":["https://orcid.org/0000-0002-2337-5898"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amod Sarnaik","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL;","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110477505","display_name":"Steven N. Quayle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146766","display_name":"Acetylon Pharmaceuticals (United States)","ror":"https://ror.org/04re20p56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Quayle3","raw_affiliation_strings":["Acetylon Pharmaceuticals, Inc.3, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acetylon Pharmaceuticals, Inc.3, Boston, MA;","institution_ids":["https://openalex.org/I4210146766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103729912","display_name":"Simon S. Jones","orcid":"https://orcid.org/0009-0008-8557-8536","observed_orcids":["https://orcid.org/0009-0008-8557-8536"]},"institutions":[{"id":"https://openalex.org/I4210146766","display_name":"Acetylon Pharmaceuticals (United States)","ror":"https://ror.org/04re20p56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon S. Jones3","raw_affiliation_strings":["Acetylon Pharmaceuticals Inc.3, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acetylon Pharmaceuticals Inc.3, Boston, MA;","institution_ids":["https://openalex.org/I4210146766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108222207","display_name":"Eduardo M. Sotomayor","orcid":"https://orcid.org/0009-0009-5081-3855","observed_orcids":["https://orcid.org/0009-0009-5081-3855"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo M. Sotomayor","raw_affiliation_strings":["H. Lee Moffitt Cancer Center &amp; Research Institute, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center &amp; Research Institute, Tampa, FL;","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047177507","display_name":"Jeffrey S. Weber","orcid":"https://orcid.org/0000-0002-4962-2957","observed_orcids":["https://orcid.org/0000-0002-4962-2957"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey S. Weber","raw_affiliation_strings":["NYU Langone Medical Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Langone Medical Center, New York, NY;","institution_ids":["https://openalex.org/I4210086933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"15_suppl","first_page":"e14521","last_page":"e14521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.07440000027418137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.045499999076128006,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac6","display_name":"HDAC6","score":0.8090000152587891},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.6700000166893005},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8339999914169312},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.8289999961853027},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.5180000066757202},{"id":"https://openalex.org/keywords/th1-th2-cytokines","display_name":"Th1/Th2 cytokines","score":0.8799999952316284},{"id":"https://openalex.org/keywords/central-memory-t-cells","display_name":"central memory T cells","score":0.9449999928474426},{"id":"https://openalex.org/keywords/t-cell-mediated-cytotoxicity","display_name":"T cell cytotoxicity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7210000157356262},{"id":"https://openalex.org/keywords/inducible-t-cell-costimulator","display_name":"ICOS","score":0.7300000190734863},{"id":"https://openalex.org/keywords/cd69","display_name":"CD69","score":0.9240000247955322},{"id":"https://openalex.org/keywords/epigenetic-modulation","display_name":"epigenetic modulation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5510905981063843},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5348732471466064},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.5300295948982239},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5235537886619568},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4860544502735138},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4771789312362671},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46612098813056946},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.465692400932312},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.45038747787475586},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4352429211139679},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.4349014163017273},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.39843547344207764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29848697781562805},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.22993668913841248},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.12367194890975952},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2016.34.15_suppl.e14521","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e14521","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.15_suppl.e14521","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5299999713897705,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2918515594","https://openalex.org/W2339751426","https://openalex.org/W1612846967","https://openalex.org/W2331369838","https://openalex.org/W2546851777","https://openalex.org/W7034435570","https://openalex.org/W6921097537","https://openalex.org/W2407985146","https://openalex.org/W2739921892","https://openalex.org/W84014473"],"abstract_inverted_index":{"e14521":[0],"Background:":[1],"Histone":[2],"deacetylases":[3],"(HDACs)":[4],"are":[5],"epigenetic":[6],"modulators":[7],"and":[8,56,96,113,115,120,156,186,202,207,216,220,239,255,282,311,325],"regulate":[9],"gene":[10,131],"expression.":[11],"The":[12],"impact":[13,167],"of":[14,32,53,92,111,117,136,171,197,235,270,289,304],"the":[15,30,198],"HDAC6":[16],"selective":[17,157],"inhibitor":[18],"ACY1215":[19,74,139,151,194,243,264,296,316,320],"was":[20,79,107,126,143,152],"explored":[21],"on":[22,128,145,168],"immune":[23],"cell":[24,94,105,163,251,313,323],"biology,":[25],"with":[26,73,165,293,307,331],"novel":[27],"implications":[28],"for":[29,130],"treatment":[31],"melanoma":[33,57,114,172,217],"patient":[34,218],"T":[35,44,93,104,141,162,174,222,274,312,322],"cells":[36,45,52,142,175,223,275],"ex":[37,71,225,328],"vivo":[38,72,226,329],"prior":[39],"to":[40],"adoptive":[41],"transfer.":[42],"Methods:":[43],"were":[46,63,69,87,99],"obtained":[47],"from":[48,65,249],"peripheral":[49],"blood":[50],"mononuclear":[51],"healthy":[54,215],"donors":[55],"patients.":[58],"Tumor":[59],"infiltrating":[60],"lymphocytes":[61],"(TILs)":[62],"isolated":[64],"surgical":[66],"biopsies.":[67],"Cells":[68],"treated":[70,140,265,297,317],"or":[75],"DMSO":[76,137,294],"control.":[77],"Viability":[78],"addressed":[80],"by":[81,89,101,109,214,233],"MTS":[82],"colorimetric":[83],"assay.":[84],"Cytokine":[85],"levels":[86,191,269],"evaluated":[88],"Luminex.":[90],"Expression":[91],"markers":[95,200],"IFN\u03b3/CD107a":[97,271],"production":[98,179],"assessed":[100],"flow":[102],"cytometry.":[103],"cytotoxicity":[106,284],"determined":[108,232],"co-culture":[110],"TILs":[112,129,247,266],"analysis":[116,300],"annexin":[118],"V":[119],"propidium":[121],"iodide.":[122],"Affymetrix":[123],"based":[124,144],"microarray":[125],"performed":[127],"expression":[132,196,234,303],"analysis.":[133],"Statistical":[134],"significance":[135],"vs":[138,277,286,295],"paired,":[146],"two-tailed,":[147],"student\u2019s":[148],"t-test.":[149],"Results:":[150],"unique":[153],"among":[154],"pan":[155],"HDAC":[158],"inhibitors":[159],"in":[160,258,315],"modulating":[161],"function,":[164],"minimal":[166],"viability.":[169],"Treatment":[170],"patient-derived":[173],"reduced":[176],"Th2":[177],"cytokine":[178,190],"(IL-4,":[180],"IL-6,":[181],"IL-10;":[182],"p":[183,261,279],"<":[184,205,229,262,280],"0.01)":[185],"maintained":[187],"Th1":[188],"effector":[189],"(IFN\u03b3,":[192],"IL-2).":[193],"increased":[195,244,302],"activation/costimulatory":[199],"CD69":[201],"ICOS":[203],"(p":[204,228],"0.05),":[206,230,281],"enhanced":[208,283],"a":[209],"central":[210,245],"memory":[211,246,314],"phenotype":[212],"expressed":[213],"CD4":[219],"CD8":[221,273],"during":[224,327],"expansion":[227],"as":[231],"CD45RO,":[236],"CD45RA,":[237],"CD62L":[238],"CCR7.":[240],"In":[241],"fact,":[242],"derived":[248],"multiple":[250],"preparations":[252],"(e.g.":[253],"pre":[254],"post":[256],"rapid":[257],"vitro":[259],"expansion;":[260],"0.05).":[263],"exhibited":[267],"higher":[268],"expressing":[272],"(50%":[276,285],"35%,":[278],"70%":[287],"killing":[288],"HLA":[290],"matched":[291],"targets":[292],"TILs).":[298],"Microarray":[299],"revealed":[301],"genes":[305],"associated":[306],"an":[308],"inflammatory":[309],"response":[310],"TILs.":[318],"Conclusions:":[319],"augmented":[321],"proliferation":[324],"function":[326],"expansion,":[330],"possible":[332],"translatable":[333],"clinical":[334],"implications.":[335]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-09-27T00:00:00"}