{"id":"https://openalex.org/W2889529485","doi":"https://doi.org/10.21767/2573-5349.100022","title":"Translational Research on Amyotrophic Lateral Sclerosis (ALS): The Preclinical SOD1 Mouse Model","display_name":"Translational Research on Amyotrophic Lateral Sclerosis (ALS): The Preclinical SOD1 Mouse Model","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2889529485","doi":"https://doi.org/10.21767/2573-5349.100022","mag":"2889529485"},"language":"en","primary_location":{"id":"doi:10.21767/2573-5349.100022","doi":"https://doi.org/10.21767/2573-5349.100022","is_oa":true,"landing_page_url":"https://doi.org/10.21767/2573-5349.100022","pdf_url":"http://translational-neuroscience.imedpub.com/translational-research-on-amyotrophiclateral-sclerosis-als-the-preclinical-sod1mouse-model.pdf","source":{"id":"https://openalex.org/S4210205532","display_name":"Journal of Translational Neurosciences","issn_l":"2573-5349","issn":["2573-5349"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Neurosciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://translational-neuroscience.imedpub.com/translational-research-on-amyotrophiclateral-sclerosis-als-the-preclinical-sod1mouse-model.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Maria Mina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210093138","display_name":"Biomedical Research Foundation of the Academy of Athens","ror":"https://ror.org/00gban551","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210093138"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Maria Mina","raw_affiliation_strings":["Center of Basic Research , Biomedical Research Foundation of the Academy of Athens , 4 Soranou Ephessiou Str. , 11527 , Athens , Greece","Department of Basic Sciences , Faculty of Nursing , University of Athens , 123 Papadiamantopoulou Str. , 11527 , Athens , Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Basic Research , Biomedical Research Foundation of the Academy of Athens , 4 Soranou Ephessiou Str. , 11527 , Athens , Greece","institution_ids":["https://openalex.org/I4210093138"]},{"raw_affiliation_string":"Department of Basic Sciences , Faculty of Nursing , University of Athens , 123 Papadiamantopoulou Str. , 11527 , Athens , Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045755998","display_name":"Eleni Konsolaki","orcid":"https://orcid.org/0000-0001-7248-4989","observed_orcids":["https://orcid.org/0000-0001-7248-4989"]},"institutions":[{"id":"https://openalex.org/I4210093138","display_name":"Biomedical Research Foundation of the Academy of Athens","ror":"https://ror.org/00gban551","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210093138"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni Konsolaki","raw_affiliation_strings":["Center of Basic Research , Biomedical Research Foundation of the Academy of Athens , 4 Soranou Ephessiou Str. , 11527 , Athens , Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Basic Research , Biomedical Research Foundation of the Academy of Athens , 4 Soranou Ephessiou Str. , 11527 , Athens , Greece","institution_ids":["https://openalex.org/I4210093138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085578416","display_name":"Laskaro Zagoraiou","orcid":"https://orcid.org/0000-0003-4757-6077","observed_orcids":["https://orcid.org/0000-0003-4757-6077"]},"institutions":[{"id":"https://openalex.org/I4210093138","display_name":"Biomedical Research Foundation of the Academy of Athens","ror":"https://ror.org/00gban551","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210093138"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Laskaro Zagoraiou","raw_affiliation_strings":["Center of Basic Research , Biomedical Research Foundation of the Academy of Athens , 4 Soranou Ephessiou Str. , 11527 , Athens , Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Basic Research , Biomedical Research Foundation of the Academy of Athens , 4 Soranou Ephessiou Str. , 11527 , Athens , Greece","institution_ids":["https://openalex.org/I4210093138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085578416"],"corresponding_institution_ids":["https://openalex.org/I4210093138"],"apc_list":null,"apc_paid":null,"fwci":0.5054,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.65910847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"03","issue":"03","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/superoxide-dismutase-1","display_name":"superoxide dismutase 1","score":0.8650000095367432},{"id":"https://openalex.org/keywords/familial-amyotrophic-lateral-sclerosis","display_name":"familial ALS","score":0.8420000076293945},{"id":"https://openalex.org/keywords/sporadic-als","display_name":"sporadic ALS","score":0.8550000190734863},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.8550000190734863},{"id":"https://openalex.org/keywords/motor-neuron-disease","display_name":"motor neuron disease","score":0.9120000004768372},{"id":"https://openalex.org/keywords/als-pathogenesis","display_name":"ALS pathogenesis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/clinical-trial-design","display_name":"clinical trial design","score":0.9750000238418579}],"concepts":[{"id":"https://openalex.org/C2777615887","wikidata":"https://www.wikidata.org/wiki/Q15328137","display_name":"SOD1","level":4,"score":0.9651710987091064},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.9607439637184143},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6434752345085144},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.6350321173667908},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5898785591125488},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5597798824310303},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.47541147470474243},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4370483458042145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43336430191993713},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.428536057472229},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4136989712715149},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3462446331977844},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33358335494995117},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2871886193752289}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21767/2573-5349.100022","doi":"https://doi.org/10.21767/2573-5349.100022","is_oa":true,"landing_page_url":"https://doi.org/10.21767/2573-5349.100022","pdf_url":"http://translational-neuroscience.imedpub.com/translational-research-on-amyotrophiclateral-sclerosis-als-the-preclinical-sod1mouse-model.pdf","source":{"id":"https://openalex.org/S4210205532","display_name":"Journal of Translational Neurosciences","issn_l":"2573-5349","issn":["2573-5349"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Neurosciences","raw_type":"journal-article"},{"id":"pmh:oai:HAL:hal-03639948v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-03639948","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Translational Neurosciences, 2018","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.21767/2573-5349.100022","doi":"https://doi.org/10.21767/2573-5349.100022","is_oa":true,"landing_page_url":"https://doi.org/10.21767/2573-5349.100022","pdf_url":"http://translational-neuroscience.imedpub.com/translational-research-on-amyotrophiclateral-sclerosis-als-the-preclinical-sod1mouse-model.pdf","source":{"id":"https://openalex.org/S4210205532","display_name":"Journal of Translational Neurosciences","issn_l":"2573-5349","issn":["2573-5349"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Neurosciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321916","display_name":"State Scholarships Foundation","ror":"https://ror.org/023z3dm33"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2889529485.pdf","grobid_xml":"https://content.openalex.org/works/W2889529485.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W1547758273","https://openalex.org/W1571682533","https://openalex.org/W1590729586","https://openalex.org/W1619082318","https://openalex.org/W1732461177","https://openalex.org/W1915809219","https://openalex.org/W1940519961","https://openalex.org/W1951356720","https://openalex.org/W1967105697","https://openalex.org/W1970380641","https://openalex.org/W1972431103","https://openalex.org/W1974032274","https://openalex.org/W1976162312","https://openalex.org/W1978119802","https://openalex.org/W1993730622","https://openalex.org/W1998143624","https://openalex.org/W1998289889","https://openalex.org/W2001221763","https://openalex.org/W2001287092","https://openalex.org/W2002104055","https://openalex.org/W2003337850","https://openalex.org/W2003618511","https://openalex.org/W2005900086","https://openalex.org/W2007395718","https://openalex.org/W2008522537","https://openalex.org/W2011029903","https://openalex.org/W2011396520","https://openalex.org/W2012851706","https://openalex.org/W2022367303","https://openalex.org/W2022925950","https://openalex.org/W2023556666","https://openalex.org/W2024882157","https://openalex.org/W2028765046","https://openalex.org/W2031700674","https://openalex.org/W2032162800","https://openalex.org/W2032288008","https://openalex.org/W2034531487","https://openalex.org/W2036693225","https://openalex.org/W2040751146","https://openalex.org/W2041258699","https://openalex.org/W2042637324","https://openalex.org/W2048813950","https://openalex.org/W2050626075","https://openalex.org/W2053863700","https://openalex.org/W2067847915","https://openalex.org/W2070086306","https://openalex.org/W2070243481","https://openalex.org/W2072413533","https://openalex.org/W2072978915","https://openalex.org/W2072981065","https://openalex.org/W2074726646","https://openalex.org/W2078068644","https://openalex.org/W2080964315","https://openalex.org/W2084016719","https://openalex.org/W2084561728","https://openalex.org/W2085054042","https://openalex.org/W2087656730","https://openalex.org/W2093791199","https://openalex.org/W2099071260","https://openalex.org/W2106430667","https://openalex.org/W2107660300","https://openalex.org/W2107768418","https://openalex.org/W2110284480","https://openalex.org/W2110289399","https://openalex.org/W2112343021","https://openalex.org/W2124976615","https://openalex.org/W2125606478","https://openalex.org/W2128206335","https://openalex.org/W2128815118","https://openalex.org/W2132166526","https://openalex.org/W2139560421","https://openalex.org/W2139956925","https://openalex.org/W2149497936","https://openalex.org/W2150095505","https://openalex.org/W2150430904","https://openalex.org/W2150523249","https://openalex.org/W2154844537","https://openalex.org/W2154945114","https://openalex.org/W2162589295","https://openalex.org/W2164817302","https://openalex.org/W2166043619","https://openalex.org/W2167386605","https://openalex.org/W2169895464","https://openalex.org/W2187620259","https://openalex.org/W2189443629","https://openalex.org/W2240151290","https://openalex.org/W2290753804","https://openalex.org/W2296809607","https://openalex.org/W2338545563","https://openalex.org/W2340195634","https://openalex.org/W2374979046","https://openalex.org/W2398515656","https://openalex.org/W2518689955","https://openalex.org/W2556818673","https://openalex.org/W2616124858","https://openalex.org/W4253140965","https://openalex.org/W4319308344","https://openalex.org/W4365799132"],"related_works":["https://openalex.org/W2164665289","https://openalex.org/W2037225117","https://openalex.org/W1990422584","https://openalex.org/W1603760473","https://openalex.org/W2078818999","https://openalex.org/W2082012193","https://openalex.org/W2158719727","https://openalex.org/W2105740443","https://openalex.org/W3201201595","https://openalex.org/W2043095629"],"abstract_inverted_index":{"Amyotrophic":[0],"Lateral":[1],"Sclerosis":[2],"(ALS)":[3],"is":[4,12,194],"the":[5,16,36,40,68,71,75,83,103,110,118,123,131,151,154,158,186,199,202],"most":[6],"common":[7],"motor":[8,22],"neuron":[9],"disease":[10,41,76],"and":[11,20,27,42,54,78,96,144,160,176],"clinically":[13],"defined":[14],"by":[15],"degeneration":[17],"of":[18,31,39,48,70,94,100,130,157,191,201],"upper":[19],"lower":[21],"neurons,":[23],"leading":[24],"to":[25,98,106,149],"paralysis":[26],"premature":[28],"death.":[29],"10%":[30],"ALS":[32,61,133,174,207],"patients":[33],"suffer":[34],"from":[35],"familial":[37],"form":[38],"research":[43,166],"has":[44,169],"revealed":[45],"a":[46],"number":[47],"responsible":[49],"mutations":[50,63],"in":[51,74,82,109,142,147,206],"specific":[52],"genes":[53],"loci.":[55],"Transgenic":[56],"mouse":[57,136,204],"models":[58,137,205],"carrying":[59],"human":[60,132],"related":[62],"have":[64,138,183],"been":[65,139],"generated":[66],"for":[67,92,188],"study":[69],"mechanisms":[72],"involved":[73,108],"pathogenesis":[77],"putative":[79],"therapies.":[80],"Mutations":[81],"Cu/":[84],"Zn":[85],"superoxide":[86],"dismutase":[87],"1":[88],"(SOD1)":[89],"gene,":[90],"accounting":[91],"20%":[93],"fALS":[95],"up":[97],"5%":[99],"sALS,":[101],"were":[102],"first":[104,119],"identified":[105],"be":[107],"disease.":[111],"In":[112,164,178],"this":[113,167],"review,":[114],"we":[115],"focus":[116],"on":[117],"transgenic":[120],"model":[121,168],"used,":[122],"SOD1":[124,135,203],"mouse,":[125],"which":[126],"recapitulates":[127],"many":[128],"symptoms":[129],"pathology.":[134],"extensively":[140],"studied":[141],"basic":[143,165],"translational":[145,179],"research,":[146,180],"order":[148],"unravel":[150],"underlying":[152],"mechanisms,":[153],"early":[155],"signs":[156],"disorder":[159],"potential":[161],"therapeutic":[162],"interventions.":[163],"provided":[170],"valuable":[171],"information":[172],"about":[173],"causes":[175],"progression.":[177],"encouraging":[181],"results":[182],"emerged,":[184],"but":[185],"need":[187],"better":[189],"design":[190],"clinical":[192],"trials":[193],"evident.":[195],"This":[196],"review":[197],"presents":[198],"impact":[200],"investigation.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2025-10-10T00:00:00"}
