{"id":"https://openalex.org/W2889410772","doi":"https://doi.org/10.1186/s12985-018-1042-3","title":"Neutralizing antibodies against porcine epidemic diarrhea virus block virus attachment and internalization","display_name":"Neutralizing antibodies against porcine epidemic diarrhea virus block virus attachment and internalization","publication_year":2018,"publication_date":"2018-08-30","ids":{"openalex":"https://openalex.org/W2889410772","doi":"https://doi.org/10.1186/s12985-018-1042-3","mag":"2889410772","pmid":"https://pubmed.ncbi.nlm.nih.gov/30165871"},"language":"en","primary_location":{"id":"doi:10.1186/s12985-018-1042-3","doi":"https://doi.org/10.1186/s12985-018-1042-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12985-018-1042-3","pdf_url":null,"source":{"id":"https://openalex.org/S115714813","display_name":"Virology Journal","issn_l":"1743-422X","issn":["1743-422X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12985-018-1042-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029731396","display_name":"Lang Gong","orcid":"https://orcid.org/0000-0003-0745-0031","observed_orcids":["https://orcid.org/0000-0003-0745-0031"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lang Gong","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101707186","display_name":"Ying Ling Lin","orcid":"https://orcid.org/0000-0002-2793-5741","observed_orcids":["https://orcid.org/0000-0002-2793-5741"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Lin","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110605696","display_name":"Jianru Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianru Qin","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090636497","display_name":"Qianniu Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianniu Li","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109450783","display_name":"Chunyi Xue","orcid":"https://orcid.org/0009-0006-2070-3936","observed_orcids":["https://orcid.org/0009-0006-2070-3936"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunyi Xue","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China. xuechy@mail.sysu.edu.cn","State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China. xuechy@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059797825","display_name":"Yongchang Cao","orcid":"https://orcid.org/0000-0002-0311-5474","observed_orcids":["https://orcid.org/0000-0002-0311-5474"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongchang Cao","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China. caoych@mail.sysu.edu.cn","State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China. caoych@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5059797825","https://openalex.org/A5109450783"],"corresponding_institution_ids":["https://openalex.org/I157773358"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":4.4962,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.94529934,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"133","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porcine-epidemic-diarrhea-virus","display_name":"porcine epidemic diarrhea virus","score":1.0},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.9810000061988831},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8930000066757202},{"id":"https://openalex.org/keywords/spike-protein","display_name":"spike protein","score":0.7910000085830688},{"id":"https://openalex.org/keywords/receptor-binding-domain","display_name":"receptor binding domain","score":0.8489999771118164},{"id":"https://openalex.org/keywords/virus-attachment","display_name":"viral attachment","score":0.7860000133514404},{"id":"https://openalex.org/keywords/virus-internalization","display_name":"viral internalization","score":0.8500000238418579},{"id":"https://openalex.org/keywords/virus-entry-inhibition","display_name":"viral entry inhibition","score":0.5630000233650208},{"id":"https://openalex.org/keywords/conformational-epitopes","display_name":"conformational epitopes","score":0.8389999866485596},{"id":"https://openalex.org/keywords/swine-coronavirus","display_name":"swine coronavirus","score":0.5389999747276306},{"id":"https://openalex.org/keywords/vero-e6-cells","display_name":"Vero E6 cells","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C2775862345","wikidata":"https://www.wikidata.org/wiki/Q16023751","display_name":"Porcine epidemic diarrhea virus","level":3,"score":0.939399778842926},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8887120485305786},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.8227443099021912},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7686275243759155},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7419229745864868},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6673259735107422},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6207724809646606},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6076640486717224},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.5071680545806885},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.48939934372901917},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.48784327507019043},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3231660723686218},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.2768760919570923},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09817272424697876},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.05671313405036926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.054615676403045654},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.053465574979782104},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053485","descriptor_name":"Porcine epidemic diarrhea virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053485","descriptor_name":"Porcine epidemic diarrhea virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053485","descriptor_name":"Porcine epidemic diarrhea virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053585","descriptor_name":"Virus Attachment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053585","descriptor_name":"Virus Attachment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053585","descriptor_name":"Virus Attachment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12985-018-1042-3","doi":"https://doi.org/10.1186/s12985-018-1042-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12985-018-1042-3","pdf_url":null,"source":{"id":"https://openalex.org/S115714813","display_name":"Virology Journal","issn_l":"1743-422X","issn":["1743-422X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology Journal","raw_type":"journal-article"},{"id":"pmid:30165871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30165871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology journal","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5075571","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6117962","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6117962","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6117962","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Virol J","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5506f06db6524114ba2f9362ccdd8a69","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5506f06db6524114ba2f9362ccdd8a69","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Virology Journal, Vol 15, Iss 1, Pp 1-9 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12985-018-1042-3","doi":"https://doi.org/10.1186/s12985-018-1042-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12985-018-1042-3","pdf_url":null,"source":{"id":"https://openalex.org/S115714813","display_name":"Virology Journal","issn_l":"1743-422X","issn":["1743-422X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1707497546","display_name":null,"funder_award_id":"2016YFD0500101)","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1554543951","https://openalex.org/W1966561205","https://openalex.org/W1968016411","https://openalex.org/W1979615660","https://openalex.org/W1991879923","https://openalex.org/W2016457570","https://openalex.org/W2020389051","https://openalex.org/W2027518730","https://openalex.org/W2029627660","https://openalex.org/W2030522563","https://openalex.org/W2045028967","https://openalex.org/W2045356077","https://openalex.org/W2060554496","https://openalex.org/W2064350446","https://openalex.org/W2064778609","https://openalex.org/W2075944727","https://openalex.org/W2086955313","https://openalex.org/W2094023848","https://openalex.org/W2120544171","https://openalex.org/W2120857679","https://openalex.org/W2131859684","https://openalex.org/W2132898347","https://openalex.org/W2148270110","https://openalex.org/W2160752203","https://openalex.org/W2165907695","https://openalex.org/W2262289299","https://openalex.org/W2288515996","https://openalex.org/W2408838502","https://openalex.org/W2428313270","https://openalex.org/W2493146871","https://openalex.org/W2498036824","https://openalex.org/W2543966974","https://openalex.org/W2603416299","https://openalex.org/W2604114683","https://openalex.org/W2609048818","https://openalex.org/W2615042921","https://openalex.org/W2655519188","https://openalex.org/W2726784030","https://openalex.org/W2739332273","https://openalex.org/W4245636680","https://openalex.org/W6740119310"],"related_works":["https://openalex.org/W2060284918","https://openalex.org/W2014442749","https://openalex.org/W2070226647","https://openalex.org/W4221034833","https://openalex.org/W2973009367","https://openalex.org/W2889410772","https://openalex.org/W2615042921","https://openalex.org/W2070200459","https://openalex.org/W3006766558","https://openalex.org/W2888659845"],"abstract_inverted_index":{"BACKGROUND:":[0],"Porcine":[1],"epidemic":[2],"diarrhea":[3],"virus":[4,49,153,179,193],"(PEDV)":[5],"is":[6,35,44],"emerging":[7],"as":[8,37,203],"a":[9,14,204],"pathogenic":[10],"coronavirus":[11],"that":[12,98,173,188],"causes":[13],"huge":[15],"economic":[16],"burden":[17],"to":[18,69,94,112,124,128,197,206],"the":[19,24,31,38,45,71,75,80,114,162,166,208],"swine":[20],"industry.":[21],"Interaction":[22],"of":[23,41,48,74,82,117,156,165],"viral":[25,76],"spike":[26,77],"(S)":[27],"surface":[28],"glycoprotein":[29],"with":[30,132],"host":[32],"cell":[33,89],"receptor":[34],"recognized":[36],"first":[39],"step":[40],"infection":[42,154,194],"and":[43,78,106,159,176],"main":[46],"determinant":[47],"tropism.":[50],"The":[51,185],"mechanisms":[52],"by":[53,195],"which":[54,157,200],"neutralizing":[55,65,133,190],"antibodies":[56,66,140],"inhibit":[57],"PEDV":[58,64,85,126,167,189],"have":[59],"not":[60],"been":[61],"defined.":[62],"Isolating":[63],"are":[67],"crucial":[68],"identifying":[70],"receptor-binding":[72,209],"domains":[73],"elucidating":[79],"mechanism":[81],"protection":[83],"against":[84],"infection.":[86],"METHODS:":[87],"B":[88],"hybridoma":[90,96,142],"technique":[91],"was":[92,122],"used":[93,111],"generate":[95],"cells":[97,131],"secrete":[99],"specific":[100],"antibodies.":[101],"E.coli":[102],"prokaryotic":[103],"expression":[104,108],"system":[105,109],"Bac-to-Bac":[107],"were":[110],"identify":[113],"target":[115],"protein":[116],"each":[118],"monoclonal":[119,139],"antibody.":[120,134],"qPCR":[121,170],"performed":[123],"analyze":[125],"binding":[127,196],"Vero":[129,182],"E6":[130],"RESULTS:":[135],"We":[136],"identified":[137],"10":[138],"using":[141],"technology.":[143],"Remarkably,":[144],"4":[145],"mAbs":[146],"(designed":[147],"2G8,":[148],"2B11,":[149],"3D9,":[150],"1E3)":[151],"neutralized":[152],"potently,":[155],"2B11":[158,175],"1E3":[160],"targeted":[161],"conformational":[163],"epitope":[164],"S":[168],"protein.":[169],"results":[171],"showed":[172],"both":[174],"2G8":[177],"blocked":[178],"entry":[180],"into":[181],"cells.":[183],"CONCLUSION:":[184],"data":[186],"suggested":[187],"antibody":[191],"inhibited":[192],"infectious":[198],"virions,":[199],"could":[201],"work":[202],"tool":[205],"find":[207],"domains.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}