{"id":"https://openalex.org/W2889341833","doi":"https://doi.org/10.1093/eurheartj/ehy565.p2861","title":"P2861A systematic review and meta-analysis of anti-cytokine therapies targeting IL-1 and TNF- A in myocardial infarction and heart failure","display_name":"P2861A systematic review and meta-analysis of anti-cytokine therapies targeting IL-1 and TNF- A in myocardial infarction and heart failure","publication_year":2018,"publication_date":"2018-08-01","ids":{"openalex":"https://openalex.org/W2889341833","doi":"https://doi.org/10.1093/eurheartj/ehy565.p2861","mag":"2889341833"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/ehy565.p2861","doi":"https://doi.org/10.1093/eurheartj/ehy565.p2861","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehy565.p2861","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10044/1/83684","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086296922","display_name":"Mona Panahi","orcid":"https://orcid.org/0000-0001-7977-9317","observed_orcids":["https://orcid.org/0000-0001-7977-9317"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Panahi","raw_affiliation_strings":["Imperial College London, National Heart and Lung Instutute, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, National Heart and Lung Instutute, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061827835","display_name":"Angelos Papanikolaou","orcid":"https://orcid.org/0000-0002-1245-6596","observed_orcids":["https://orcid.org/0000-0002-1245-6596"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Papanikolaou","raw_affiliation_strings":["Imperial College London, National Heart and Lung Instutute, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, National Heart and Lung Instutute, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H Khan","raw_affiliation_strings":["Imperial College Healthcare NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College Healthcare NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113537962","display_name":"Azam Torabi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Torabi","raw_affiliation_strings":["Imperial College Healthcare NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College Healthcare NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017160240","display_name":"John G.F. Cleland","orcid":"https://orcid.org/0000-0002-1471-7016","observed_orcids":["https://orcid.org/0000-0002-1471-7016","https://orcid.org/0000-0002-8635-1009"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J G F Cleland","raw_affiliation_strings":["Imperial College Healthcare NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College Healthcare NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014497968","display_name":"Nimai Vadgama","orcid":"https://orcid.org/0000-0001-7862-6247","observed_orcids":["https://orcid.org/0000-0001-7862-6247"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N Vadgama","raw_affiliation_strings":["Imperial College London, National Heart and Lung Instutute, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, National Heart and Lung Instutute, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042049867","display_name":"Nadia A Rosenthal","orcid":"https://orcid.org/0000-0002-7599-7365","observed_orcids":["https://orcid.org/0000-0002-7599-7365"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N A Rosenthal","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine, United States of America","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055266997","display_name":"Si\u00e2n E. Harding","orcid":"https://orcid.org/0000-0002-3651-6354","observed_orcids":["https://orcid.org/0000-0002-3651-6354"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Harding","raw_affiliation_strings":["Imperial College London, National Heart and Lung Instutute, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, National Heart and Lung Instutute, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047655077","display_name":"Susanne Sattler","orcid":"https://orcid.org/0000-0001-9932-4109","observed_orcids":["https://orcid.org/0000-0001-9932-4109"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Sattler","raw_affiliation_strings":["Imperial College London, National Heart and Lung Instutute, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, National Heart and Lung Instutute, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5240,"currency":"EUR","value_usd":5922},"apc_paid":null,"fwci":0.0465,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.11285714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"39","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-cytokine-therapy","display_name":"anti-cytokine therapy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9710000157356262},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9950000047683716},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9890000224113464},{"id":"https://openalex.org/keywords/post-infarction-heart-failure","display_name":"post-infarction heart failure","score":0.7329999804496765},{"id":"https://openalex.org/keywords/ventricular-remodeling","display_name":"ventricular remodeling","score":0.8399999737739563},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/major-adverse-cardiac-events","display_name":"major adverse cardiac events","score":0.753000020980835},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8059999942779541},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.777999997138977},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9834942817687988},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7468134760856628},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7223491668701172},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.552286684513092},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5518074631690979},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.48595917224884033},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44512248039245605},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.43551862239837646},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.36444661021232605}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/eurheartj/ehy565.p2861","doi":"https://doi.org/10.1093/eurheartj/ehy565.p2861","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehy565.p2861","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/83684","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/83684","pdf_url":"http://hdl.handle.net/10044/1/83684","source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European-Society-of-Cardiology Congress","raw_type":"Conference Paper"}],"best_oa_location":{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/83684","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/83684","pdf_url":"http://hdl.handle.net/10044/1/83684","source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European-Society-of-Cardiology Congress","raw_type":"Conference Paper"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2889341833.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2884458063","https://openalex.org/W7034169832","https://openalex.org/W2794439438","https://openalex.org/W2064483592","https://openalex.org/W2012576732","https://openalex.org/W2118590314","https://openalex.org/W2072602078","https://openalex.org/W3086485795","https://openalex.org/W7166433736","https://openalex.org/W2056098567"],"abstract_inverted_index":{"Background:":[0],"Acute":[1],"and":[2,8,29,73,88,101,130,156,165,180,203,218,224],"chronic":[3],"inflammation":[4],"influence":[5],"cardiac":[6,175],"healing":[7],"remodelling":[9],"following":[10,32],"a":[11,70,193],"myocardial":[12],"infarction":[13],"(MI),":[14],"which":[15],"may":[16],"result":[17],"in":[18,55,128,132,141],"heart":[19,59],"failure":[20,60],"(HF).":[21],"Numerous":[22],"pre-clinical":[23],"studies":[24],"have":[25,38,43],"reported":[26],"increased":[27],"morphological":[28],"functional":[30],"recovery":[31],"immune-modulatory":[33],"interventions.":[34],"Some":[35],"clinical":[36,76,122],"trials":[37,80,123,152],"been":[39,44],"conducted":[40],"but":[41],"outcomes":[42],"inconsistent.":[45],"Purpose:":[46],"To":[47],"assess":[48],"the":[49,133,210],"benefits":[50],"of":[51,65,75,147,169,172],"targeting":[52],"inflammatory":[53],"cytokines":[54],"post-MI":[56],"patients":[57,142],"with":[58,106,124],"or":[61,144],"at":[62,145],"high":[63],"risk":[64,146,168,215],"developing":[66,148],"HF":[67],"by":[68],"performing":[69],"systematic":[71],"review":[72],"meta-analysis":[74],"trials.":[77],"Methods:":[78],"Clinical":[79],"using":[81,112,185,209],"cytokine":[82],"modulation":[83],"were":[84,104,118,163,183,207,226],"identified":[85],"searching":[86],"PUBMED":[87],"clinicaltrials.gov.":[89],"The":[90,150,214],"search":[91],"terms:":[92],"\u201ccytokines\u201d,":[93],"\u201cinterleukin\u201d,":[94],"\u201cmyocardial":[95],"infarction\u201d,":[96],"\u201cventricular":[97],"remodelling\u201d,":[98],"\u201cischemia":[99],"reperfusion\u201d":[100],"\u201cheart":[102],"failure\u201d":[103],"combined":[105],"string":[107],"terms":[108],"for":[109,167,222],"each":[110],"intervention":[111],"simple":[113],"Boolean":[114],"connectors.":[115],"Inclusion":[116],"criteria":[117],"randomised":[119],"placebo":[120],"controlled":[121],"comparable":[125],"outcomes,":[126],"written":[127],"English":[129],"published":[131],"last":[134],"50":[135],"years":[136],"to":[137,187],"target":[138],"immunological":[139],"factors":[140],"with,":[143],"HF.":[149],"selected":[151],"targeted":[153],"interleukin-1":[154],"(IL-1),":[155],"tumour":[157],"necrosis":[158],"factor-alpha":[159],"(TNF-\u03b1).":[160],"Trial":[161],"characteristics":[162],"extracted,":[164],"assessed":[166],"bias.":[170],"Data":[171],"major":[173],"adverse":[174],"events":[176],"(MACE)":[177],"including":[178],"MI":[179],"mortality":[181,223],"rates":[182],"pooled":[184],"MedCalc":[186],"calculate":[188],"heterogeneity.":[189],"Following":[190],"heterogeneity":[191],"assessment,":[192],"random":[194,200],"effects":[195],"model":[196],"was":[197],"implemented.":[198],"Pooled":[199],"effects,":[201],"p-values":[202],"95%":[204],"confidence":[205,219],"intervals":[206,220],"calculated":[208],"Dersimonian":[211],"Laird":[212],"method.":[213],"ratio":[216],"(RR)":[217],"(CI)":[221],"MACE":[225],"calculated.":[227]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-09-07T00:00:00"}
