{"id":"https://openalex.org/W2889253271","doi":"https://doi.org/10.1021/acs.biomac.8b00885","title":"Multifunctional Enzyme Packaging and Catalysis in the Q\u03b2 Protein Nanoparticle","display_name":"Multifunctional Enzyme Packaging and Catalysis in the Q\u03b2 Protein Nanoparticle","publication_year":2018,"publication_date":"2018-08-30","ids":{"openalex":"https://openalex.org/W2889253271","doi":"https://doi.org/10.1021/acs.biomac.8b00885","mag":"2889253271","pmid":"https://pubmed.ncbi.nlm.nih.gov/30160482"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biomac.8b00885","doi":"https://doi.org/10.1021/acs.biomac.8b00885","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biomac.8b00885","pdf_url":null,"source":{"id":"https://openalex.org/S11629336","display_name":"Biomacromolecules","issn_l":"1525-7797","issn":["1525-7797","1526-4602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065194939","display_name":"Jason D. Fiedler","orcid":"https://orcid.org/0000-0001-7736-4484","observed_orcids":["https://orcid.org/0000-0001-7736-4484"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason D. Fiedler","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016393651","display_name":"Maxwell R. Fishman","orcid":"https://orcid.org/0000-0003-1890-4596","observed_orcids":["https://orcid.org/0000-0003-1890-4596"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maxwell R. Fishman","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019407143","display_name":"Steven D. Brown","orcid":"https://orcid.org/0000-0002-9281-3898","observed_orcids":["https://orcid.org/0000-0002-9281-3898"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven D. Brown","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034918803","display_name":"Jolene L. Lau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jolene Lau","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032114980","display_name":"M. G. Finn","orcid":"https://orcid.org/0000-0001-8247-3108","observed_orcids":["https://orcid.org/0000-0001-8247-3108"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. G. Finn","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States","School of Chemistry and Biochemistry, School of Biological Sciences, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, Georgia 30332, United States"],"raw_orcid":"https://orcid.org/0000-0001-8247-3108","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"School of Chemistry and Biochemistry, School of Biological Sciences, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, Georgia 30332, United States","institution_ids":["https://openalex.org/I130701444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032114980"],"corresponding_institution_ids":["https://openalex.org/I123431417","https://openalex.org/I130701444"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.8603,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.83544669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"19","issue":"10","first_page":"3945","last_page":"3957"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3781999945640564,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3781999945640564,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.1598999947309494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.09749999642372131,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzyme-encapsulation","display_name":"enzyme encapsulation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/capsid-protein","display_name":"capsid protein","score":0.5590000152587891},{"id":"https://openalex.org/keywords/enzyme-protection","display_name":"enzyme protection","score":0.5019999742507935},{"id":"https://openalex.org/keywords/protein-display","display_name":"protein display","score":0.5690000057220459},{"id":"https://openalex.org/keywords/nanoparticle-yield","display_name":"nanoparticle yield","score":0.597000002861023},{"id":"https://openalex.org/keywords/multifunctional-nanoparticles","display_name":"multifunctional nanoparticles","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6750706434249878},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.6124868988990784},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6002277135848999},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.584713339805603},{"id":"https://openalex.org/C69118441","wikidata":"https://www.wikidata.org/wiki/Q2941663","display_name":"Enzyme catalysis","level":3,"score":0.533463180065155},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.400859534740448},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.37730494141578674},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.33296459913253784},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2935749292373657},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2686445116996765},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08585524559020996}],"mesh":[{"descriptor_ui":"D000446","descriptor_name":"Aldehyde-Lyases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000446","descriptor_name":"Aldehyde-Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000446","descriptor_name":"Aldehyde-Lyases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015694","descriptor_name":"Gene Products, rev","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015694","descriptor_name":"Gene Products, rev","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015694","descriptor_name":"Gene Products, rev","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019065","descriptor_name":"Virus Assembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043525","descriptor_name":"Cytosine Deaminase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043525","descriptor_name":"Cytosine Deaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043525","descriptor_name":"Cytosine Deaminase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064251","descriptor_name":"Multifunctional Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064251","descriptor_name":"Multifunctional Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064251","descriptor_name":"Multifunctional Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.biomac.8b00885","doi":"https://doi.org/10.1021/acs.biomac.8b00885","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biomac.8b00885","pdf_url":null,"source":{"id":"https://openalex.org/S11629336","display_name":"Biomacromolecules","issn_l":"1525-7797","issn":["1525-7797","1526-4602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"journal-article"},{"id":"pmid:30160482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30160482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3155357159","display_name":null,"funder_award_id":"GM101421","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3235954759","display_name":null,"funder_award_id":"EB015663","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G6974717172","display_name":"Genetic and Chemically Programmed Nanoparticles for Prodrug Therapy","funder_award_id":"R01GM101421","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320333240","display_name":"Skaggs Institute for Chemical Biology, Scripps Research Institute","ror":null},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W59452175","https://openalex.org/W1490146132","https://openalex.org/W1531535965","https://openalex.org/W1575463246","https://openalex.org/W1581252490","https://openalex.org/W1606573610","https://openalex.org/W1879610971","https://openalex.org/W1947975057","https://openalex.org/W1963593450","https://openalex.org/W1965767348","https://openalex.org/W1974013202","https://openalex.org/W1976305171","https://openalex.org/W1981738421","https://openalex.org/W1984180361","https://openalex.org/W1984328540","https://openalex.org/W1985115408","https://openalex.org/W1994744496","https://openalex.org/W1996320633","https://openalex.org/W2002759609","https://openalex.org/W2007344686","https://openalex.org/W2014403527","https://openalex.org/W2018249439","https://openalex.org/W2023125705","https://openalex.org/W2026894454","https://openalex.org/W2028756389","https://openalex.org/W2028940349","https://openalex.org/W2029584311","https://openalex.org/W2029621223","https://openalex.org/W2034351729","https://openalex.org/W2036096376","https://openalex.org/W2044054419","https://openalex.org/W2048466999","https://openalex.org/W2051714526","https://openalex.org/W2054487627","https://openalex.org/W2063465346","https://openalex.org/W2068345651","https://openalex.org/W2071115424","https://openalex.org/W2073474141","https://openalex.org/W2075122957","https://openalex.org/W2079670884","https://openalex.org/W2083146987","https://openalex.org/W2094458696","https://openalex.org/W2094979671","https://openalex.org/W2097245634","https://openalex.org/W2100431738","https://openalex.org/W2104220374","https://openalex.org/W2107711132","https://openalex.org/W2107898312","https://openalex.org/W2116066140","https://openalex.org/W2118607669","https://openalex.org/W2126467730","https://openalex.org/W2127473737","https://openalex.org/W2131994408","https://openalex.org/W2141720296","https://openalex.org/W2147068023","https://openalex.org/W2148046164","https://openalex.org/W2160719116","https://openalex.org/W2164498356","https://openalex.org/W2192981192","https://openalex.org/W2249095822","https://openalex.org/W2259198909","https://openalex.org/W2269808005","https://openalex.org/W2284750113","https://openalex.org/W2317947423","https://openalex.org/W2329476392","https://openalex.org/W2334151637","https://openalex.org/W2406900093","https://openalex.org/W2612037504","https://openalex.org/W2740071739","https://openalex.org/W2743518333","https://openalex.org/W2804007336","https://openalex.org/W2822366101","https://openalex.org/W4235687893"],"related_works":["https://openalex.org/W2075122957","https://openalex.org/W4288010079","https://openalex.org/W1994744496","https://openalex.org/W2088961410","https://openalex.org/W2327604072","https://openalex.org/W2807441022","https://openalex.org/W4367021645","https://openalex.org/W4244186737","https://openalex.org/W7117474031","https://openalex.org/W2024497111"],"abstract_inverted_index":{"The":[0,56,107],"simultaneous":[1],"expression":[2],"in":[3,51],"Escherichia":[4],"coli":[5],"cells":[6],"of":[7,31,36,44,93,105,135,158],"the":[8,28,37,42,63,83,90,101,122,133,137,155],"Q\u03b2":[9],"virus-like":[10],"particle":[11],"(VLP)":[12],"capsid":[13],"protein":[14,16,119,142,160],"and":[15,53,66,96,124,139,145,165],"\"cargo\"":[17],"tagged":[18],"with":[19,33,48,162],"a":[20,151],"positively":[21],"charged":[22],"Rev":[23],"peptide":[24],"sequence":[25],"leads":[26],"to":[27,74,82,111],"spontaneous":[29],"self-assembly":[30,91],"VLPs":[32,115],"multiple":[34],"copies":[35],"cargo":[38],"inside.":[39],"We":[40,77],"report":[41],"packaging":[43,84,103],"four":[45],"new":[46],"enzymes":[47,58,126],"potential":[49],"applications":[50],"medicine":[52],"chemical":[54],"manufacturing.":[55],"captured":[57],"are":[59,67],"active":[60],"while":[61],"inside":[62],"nanoparticle":[64,146],"shell":[65],"protected":[68],"from":[69],"environmental":[70],"conditions":[71],"that":[72,86,116],"lead":[73],"free-enzyme":[75],"destruction.":[76],"also":[78],"describe":[79],"genetic":[80],"modifications":[81],"scheme":[85],"shed":[87],"light":[88],"on":[89,121],"mechanism":[92],"this":[94],"system":[95],"allow":[97],"indirect":[98],"control":[99],"over":[100],"internal":[102],"density":[104],"cargo.":[106],"technology":[108],"was":[109],"extended":[110],"create,":[112],"via":[113],"self-assembly,":[114],"simultaneously":[117],"display":[118],"ligands":[120],"exterior":[123],"contain":[125],"within.":[127],"Inverse":[128],"relationships":[129],"were":[130],"observed":[131],"between":[132],"size":[134],"both":[136],"packaged":[138],"externally":[140],"displayed":[141],"or":[143],"domains":[144],"yield.":[147],"These":[148],"results":[149],"provide":[150],"general":[152],"method":[153],"for":[154],"rapid":[156],"creation":[157],"robust":[159],"nanoparticles":[161],"desired":[163],"catalytic":[164],"targeting":[166],"functionalities.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-09-07T00:00:00"}