{"id":"https://openalex.org/W2889171823","doi":"https://doi.org/10.1038/s41388-018-0479-6","title":"mTOR mediates a mechanism of resistance to chemotherapy and defines a rational combination strategy to treat KRAS-mutant lung cancer","display_name":"mTOR mediates a mechanism of resistance to chemotherapy and defines a rational combination strategy to treat KRAS-mutant lung cancer","publication_year":2018,"publication_date":"2018-08-31","ids":{"openalex":"https://openalex.org/W2889171823","doi":"https://doi.org/10.1038/s41388-018-0479-6","mag":"2889171823","pmid":"https://pubmed.ncbi.nlm.nih.gov/30171261"},"language":"en","primary_location":{"id":"doi:10.1038/s41388-018-0479-6","doi":"https://doi.org/10.1038/s41388-018-0479-6","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41388-018-0479-6","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.7892/boris.120511","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056864152","display_name":"Shun\u2010Qing Liang","orcid":"https://orcid.org/0000-0003-4664-6029","observed_orcids":["https://orcid.org/0000-0003-4664-6029"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Shun-Qing Liang","raw_affiliation_strings":["Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103151189","display_name":"Elias D. B\u00fchrer","orcid":"https://orcid.org/0000-0002-2200-9781","observed_orcids":["https://orcid.org/0000-0002-2200-9781","https://orcid.org/0000-0001-5678-9395"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Elias D. B\u00fchrer","raw_affiliation_strings":["Tumor Immunology, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Immunology, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075579285","display_name":"Sabina Berezowska","orcid":"https://orcid.org/0000-0001-5442-9791","observed_orcids":["https://orcid.org/0000-0001-5442-9791","https://orcid.org/0000-0003-1158-5641"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sabina Berezowska","raw_affiliation_strings":["Institute of Pathology, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080089616","display_name":"Thomas M. Marti","orcid":"https://orcid.org/0000-0003-3005-220X","observed_orcids":["https://orcid.org/0000-0003-3005-220X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas M. Marti","raw_affiliation_strings":["Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103144272","display_name":"Duo Xu","orcid":"https://orcid.org/0000-0002-4691-1761","observed_orcids":["https://orcid.org/0000-0002-4691-1761"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Duo Xu","raw_affiliation_strings":["Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland","Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003855653","display_name":"Laur\u00e8ne Froment","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Laur\u00e8ne Froment","raw_affiliation_strings":["Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084929058","display_name":"Haitang Yang","orcid":"https://orcid.org/0000-0002-8732-5910","observed_orcids":["https://orcid.org/0000-0002-8732-5910"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Haitang Yang","raw_affiliation_strings":["Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland","Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071210426","display_name":"Sean R. R. Hall","orcid":"https://orcid.org/0000-0003-3561-7329","observed_orcids":["https://orcid.org/0000-0003-3561-7329"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sean R. R. Hall","raw_affiliation_strings":["Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032572194","display_name":"Erik Vassella","orcid":"https://orcid.org/0000-0001-7982-8713","observed_orcids":["https://orcid.org/0000-0001-7982-8713"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Erik Vassella","raw_affiliation_strings":["Institute of Pathology, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100697708","display_name":"Yang Zhang","orcid":"https://orcid.org/0000-0001-8592-5800","observed_orcids":["https://orcid.org/0000-0001-8592-5800"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Zhang Yang","raw_affiliation_strings":["Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland","Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064896227","display_name":"Gregor Jan Kocher","orcid":"https://orcid.org/0000-0001-6531-2919","observed_orcids":["https://orcid.org/0000-0001-6531-2919"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gregor J. Kocher","raw_affiliation_strings":["Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001322287","display_name":"Michael A. Amrein","orcid":"https://orcid.org/0000-0002-0378-8070","observed_orcids":["https://orcid.org/0000-0002-0378-8070"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michael A. Amrein","raw_affiliation_strings":["Tumor Immunology, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Immunology, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013509037","display_name":"Carsten Riether","orcid":"https://orcid.org/0000-0001-7512-513X","observed_orcids":["https://orcid.org/0000-0001-7512-513X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Carsten Riether","raw_affiliation_strings":["Department of Medical Oncology, Inselspital, Bern University Hospital, Bern, Switzerland","Tumor Immunology, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-7512-513X","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Inselspital, Bern University Hospital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Tumor Immunology, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034361476","display_name":"Adrian F. Ochsenbein","orcid":"https://orcid.org/0000-0003-1773-5436","observed_orcids":["https://orcid.org/0000-0003-1773-5436"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Adrian F. Ochsenbein","raw_affiliation_strings":["Department of Medical Oncology, Inselspital, Bern University Hospital, Bern, Switzerland","Tumor Immunology, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Inselspital, Bern University Hospital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Tumor Immunology, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056509936","display_name":"Ralph Alexander Schmid","orcid":"https://orcid.org/0000-0003-0699-079X","observed_orcids":["https://orcid.org/0000-0003-0699-079X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Ralph A. Schmid","raw_affiliation_strings":["Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland. Ralph.Schmid@insel.ch","Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland. Ralph.Schmid@insel.ch","Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland. Ralph.Schmid@insel.ch","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland. Ralph.Schmid@insel.ch","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039127180","display_name":"Ren\u2010Wang Peng","orcid":"https://orcid.org/0000-0003-1199-6520","observed_orcids":["https://orcid.org/0000-0003-1199-6520"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Ren-Wang Peng","raw_affiliation_strings":["Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland. Renwang.Peng@insel.ch","Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland. Renwang.Peng@insel.ch","Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland. Renwang.Peng@insel.ch","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland. Renwang.Peng@insel.ch","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Division of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039127180","https://openalex.org/A5056509936"],"corresponding_institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"],"apc_list":{"value":5990,"currency":"USD","value_usd":5990},"apc_paid":null,"fwci":2.0292,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.88122557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"38","issue":"5","first_page":"622","last_page":"636"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.5781000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.5781000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.38350000977516174,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9300000071525574},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.777999997138977},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9599999785423279},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.847000002861023},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.492000013589859},{"id":"https://openalex.org/keywords/oncogenic-kras","display_name":"oncogenic KRAS","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.9323163628578186},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6904581785202026},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6803497672080994},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6301603317260742},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.619275689125061},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5717500448226929},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5312281250953674},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4830227792263031},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2548081874847412},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2542598843574524},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1684914529323578},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.1557338535785675},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05287700891494751}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41388-018-0479-6","doi":"https://doi.org/10.1038/s41388-018-0479-6","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41388-018-0479-6","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmid:30171261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30171261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"pmh:doi:10.7892/boris.120511","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/60122","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"pmh:oai:boris.unibe.ch:120511","doi":null,"is_oa":false,"landing_page_url":"https://boris.unibe.ch/120511/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.7892/boris.120511","doi":"https://doi.org/10.7892/boris.120511","is_oa":true,"landing_page_url":"https://doi.org/10.7892/boris.120511","pdf_url":null,"source":{"id":"https://openalex.org/S7407053152","display_name":"Open Access CRIS of the University of Bern","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.7892/boris.120511","doi":"https://doi.org/10.7892/boris.120511","is_oa":true,"landing_page_url":"https://doi.org/10.7892/boris.120511","pdf_url":null,"source":{"id":"https://openalex.org/S7407053152","display_name":"Open Access CRIS of the University of Bern","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W903460745","https://openalex.org/W1504621038","https://openalex.org/W1853810791","https://openalex.org/W1974969947","https://openalex.org/W1976767579","https://openalex.org/W1982288880","https://openalex.org/W1986525211","https://openalex.org/W1993450184","https://openalex.org/W1993737062","https://openalex.org/W2001999652","https://openalex.org/W2002226709","https://openalex.org/W2013335096","https://openalex.org/W2021012077","https://openalex.org/W2022881840","https://openalex.org/W2026635246","https://openalex.org/W2027146979","https://openalex.org/W2037139573","https://openalex.org/W2042619042","https://openalex.org/W2048351900","https://openalex.org/W2050146483","https://openalex.org/W2059333451","https://openalex.org/W2062983115","https://openalex.org/W2064627550","https://openalex.org/W2072693879","https://openalex.org/W2073759100","https://openalex.org/W2075614768","https://openalex.org/W2077945404","https://openalex.org/W2080100938","https://openalex.org/W2081990599","https://openalex.org/W2094454542","https://openalex.org/W2109093911","https://openalex.org/W2115074961","https://openalex.org/W2126496132","https://openalex.org/W2135131549","https://openalex.org/W2135925682","https://openalex.org/W2136076059","https://openalex.org/W2147168993","https://openalex.org/W2149528253","https://openalex.org/W2153096480","https://openalex.org/W2159588477","https://openalex.org/W2159714906","https://openalex.org/W2161249280","https://openalex.org/W2180481128","https://openalex.org/W2405571000","https://openalex.org/W2474854223","https://openalex.org/W2605757478","https://openalex.org/W4238567307"],"related_works":["https://openalex.org/W2972930003","https://openalex.org/W2973796265","https://openalex.org/W4410271814","https://openalex.org/W2886542533","https://openalex.org/W2749893104","https://openalex.org/W4417335947","https://openalex.org/W2810382969","https://openalex.org/W2992304306","https://openalex.org/W4362544221","https://openalex.org/W2117584564"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-09-07T00:00:00"}
