{"id":"https://openalex.org/W2889112262","doi":"https://doi.org/10.1055/s-0038-1644630","title":"G PROTEIN REGULATORS OF PHOSPHOLIPASE C AND ADENYLATE CYCLASE IN PLATELETS","display_name":"G PROTEIN REGULATORS OF PHOSPHOLIPASE C AND ADENYLATE CYCLASE IN PLATELETS","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2889112262","doi":"https://doi.org/10.1055/s-0038-1644630","mag":"2889112262"},"language":"en","primary_location":{"id":"doi:10.1055/s-0038-1644630","doi":"https://doi.org/10.1055/s-0038-1644630","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1644630","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066987101","display_name":"Lawrence F. Brass","orcid":"https://orcid.org/0000-0003-0093-8886","observed_orcids":["https://orcid.org/0000-0003-0093-8886"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L F Brass","raw_affiliation_strings":["Dept. of Medicine, Pathology and Pharmacology, University of Pennsylvania, Philadelphia, PA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Medicine, Pathology and Pharmacology, University of Pennsylvania, Philadelphia, PA, U.S.A","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083596355","display_name":"David R. Manning","orcid":"https://orcid.org/0000-0002-2541-9030","observed_orcids":["https://orcid.org/0000-0002-2541-9030"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D R Manning","raw_affiliation_strings":["Dept. of Medicine, Pathology and Pharmacology, University of Pennsylvania, Philadelphia, PA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Medicine, Pathology and Pharmacology, University of Pennsylvania, Philadelphia, PA, U.S.A","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084359914","display_name":"Mar\u00edlyn J. Woolkal\u00eds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M J Woolkalis","raw_affiliation_strings":["Dept. of Medicine, Pathology and Pharmacology, University of Pennsylvania, Philadelphia, PA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Medicine, Pathology and Pharmacology, University of Pennsylvania, Philadelphia, PA, U.S.A","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34195402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7300000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7300000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.25290000438690186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-alpha-subunit","display_name":"G protein alpha subunit","score":0.5260000228881836},{"id":"https://openalex.org/keywords/gi","display_name":"Gi","score":0.39500001072883606},{"id":"https://openalex.org/keywords/pertussis-toxin","display_name":"pertussis toxin","score":0.7770000100135803},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.8870000243186951},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9769999980926514},{"id":"https://openalex.org/keywords/polyphosphoinositide-hydrolysis","display_name":"polyphosphoinositide hydrolysis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/inositol-trisphosphate","display_name":"inositol trisphosphate","score":0.9010000228881836},{"id":"https://openalex.org/keywords/diacylglycerol","display_name":"diacylglycerol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.5799999833106995},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.7250000238418579},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.8740000128746033},{"id":"https://openalex.org/keywords/platelet-activating-factor","display_name":"platelet-activating factor","score":0.9860000014305115},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.8259999752044678},{"id":"https://openalex.org/keywords/thromboxane","display_name":"thromboxane","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.8871197700500488},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.760177731513977},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.6728493571281433},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.6613233089447021},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6177036166191101},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.5655161738395691},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.5480145215988159},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.4819888472557068},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4708558917045593},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.4432026743888855},{"id":"https://openalex.org/C2777582894","wikidata":"https://www.wikidata.org/wiki/Q137103","display_name":"Bordetella pertussis","level":3,"score":0.4370936155319214},{"id":"https://openalex.org/C78297661","wikidata":"https://www.wikidata.org/wiki/Q10760862","display_name":"Phosphoinositide phospholipase C","level":4,"score":0.4299119710922241},{"id":"https://openalex.org/C161473406","wikidata":"https://www.wikidata.org/wiki/Q24719569","display_name":"Gi alpha subunit","level":4,"score":0.4128972291946411},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3745708465576172},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2781486213207245},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1884298026561737},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0038-1644630","doi":"https://doi.org/10.1055/s-0038-1644630","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1644630","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1568427873","https://openalex.org/W1608917238","https://openalex.org/W2075948115","https://openalex.org/W2889400974","https://openalex.org/W2081891738","https://openalex.org/W1524540558","https://openalex.org/W2888911847","https://openalex.org/W2066555820","https://openalex.org/W111835263","https://openalex.org/W2402488588"],"abstract_inverted_index":{"The":[0,160],"hydrolysis":[1,81,237],"of":[2,66,140,150,162,168,291],"polyphosphoinositides":[3],"(PI)":[4],"by":[5,27,59,72,85,153,172,178,193,212,227],"phospholipase":[6,319],"C":[7,320],"during":[8],"platelet":[9,196,313],"activation":[10],"produces":[11],"two":[12,271],"key":[13],"intracellular":[14],"messengers,":[15],"inositol":[16],"triphosphate":[17],"and":[18,71,124,184,195,211,257,301,307],"diacylglycerol.":[19],"This":[20],"process":[21],"is":[22,43],"thought":[23],"to":[24,34,45,68,282,286,327],"be":[25,83],"regulated":[26],"a":[28,104,109,126,138,252,311],"guanine":[29],"nucleotide":[30],"binding":[31],"protein":[32,92,107,130,152,157,268,306],"referred":[33],"as":[35],"Gp.":[36],"Although":[37],"the":[38,64,88,136,143,155,166,173,228,246,265,289,304,328],"evidence":[39],"that":[40,77,245,299,309],"Gp":[41,67,102,256,283,302],"exists":[42],"compelling,":[44],"date":[46],"it":[47,98],"has":[48,56],"not":[49,220],"been":[50,57],"isolated.":[51],"Uncertainty":[52],"about":[53],"its":[54],"identity":[55],"compounded":[58],"variations":[60],"between":[61],"tissues":[62],"in":[63,260],"susceptibility":[65],"pertussis":[69,78,89,122],"toxin":[70,123],"reconstitution":[73],"studies":[74],"which":[75,93,133,180,199,214,232],"show":[76],"toxin-inhibited":[79],"PI":[80,187,202,222,236],"can":[82],"restored":[84],"purified":[86,137],"Gi,":[87],"toxin-sensitive":[90,169,235],"G":[91,106,156,329],"inhibits":[94],"adenylate":[95,316],"cyclase.":[96],"Therefore,":[97,294],"remains":[99],"unclear":[100],"whether":[101,310],"represents":[103],"new":[105],"or":[108,284,318,321],"second":[110],"role":[111],"for":[112],"Gj.":[113],"When":[114],"platelets":[115,144],"permeabilized":[116],"with":[117,121,135,145,165,273],"saponin":[118],"were":[119],"incubated":[120],"32P-NAD,":[125],"single":[127],"42":[128,247,266],"kDa":[129,248,267],"was":[131,176,190,225],"32P-ADP-ribosylated":[132],"co-migrated":[134],"subunit":[139],"Gi.":[141],"Preincubating":[142],"an":[146],"agonist":[147,314],"inhibited":[148,181,192,215,239],"labeling":[149,290],"this":[151],"dissociating":[154],"into":[158,270],"subunits.":[159],"extent":[161],"inhibition":[163],"correlated":[164],"number":[167],"functions":[170],"caused":[171,185,200,234],"agonist.":[174],"Labeling":[175,189,224],"abolished":[177],"thrombin,":[179],"cAMP":[182,209,216,240],"formation":[183,210],"toxin-inhibitable":[186,201],"hydrolysis.":[188,223],"partially":[191],"vasopressin":[194],"activating":[197],"factor,":[198],"hydrolysis,":[203],"but":[204,218],"had":[205],"no":[206],"effect":[207],"on":[208],"epinephrine,":[213],"formation,":[217],"did":[219],"cause":[221],"unaffected":[226],"TxA2":[229],"analog":[230],"U46619,":[231],"neither":[233],"nor":[238],"formation.":[241],"These":[242],"observations":[243],"suggest":[244,297],"band":[249,269],"may":[250],"contain":[251],"subunits":[253],"from":[254],"both":[255,292,322],"Gi":[258,287],"and,":[259],"fact,":[261],"2D":[262],"electrophoresis":[263],"resolved":[264],"proteins":[272],"distinct":[274],"pi.":[275],"However,":[276],"those":[277],"agonists":[278],"linked":[279],"functionally":[280],"only":[281,285],"decreased":[288],"proteins.":[293],"our":[295],"data":[296],"(1)":[298],"Gj":[300],"are":[303],"same":[305],"(2)":[308],"aiven":[312],"affects":[315],"cyclase":[317],"depends":[323],"upon":[324],"factors":[325],"extrinsic":[326],"protein.":[330]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2018-09-07T00:00:00"}
