{"id":"https://openalex.org/W2889089744","doi":"https://doi.org/10.1038/s41419-018-0934-x","title":"Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity","display_name":"Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity","publication_year":2018,"publication_date":"2018-08-30","ids":{"openalex":"https://openalex.org/W2889089744","doi":"https://doi.org/10.1038/s41419-018-0934-x","mag":"2889089744","pmid":"https://pubmed.ncbi.nlm.nih.gov/30166531","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6117318"},"language":"en","primary_location":{"id":"doi:10.1038/s41419-018-0934-x","doi":"https://doi.org/10.1038/s41419-018-0934-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-018-0934-x","pdf_url":"https://www.nature.com/articles/s41419-018-0934-x.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41419-018-0934-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038960531","display_name":"Ni Ni Moe Myint","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ni Ni Moe Myint","raw_affiliation_strings":["Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013477531","display_name":"Ajay Mark Verma","orcid":"https://orcid.org/0000-0002-6432-3357","observed_orcids":["https://orcid.org/0000-0002-6432-3357"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ajay M. Verma","raw_affiliation_strings":["University of Leicester, University Hospital of Leicester, Leicester, LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leicester, University Hospital of Leicester, Leicester, LE2 7LX, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002930240","display_name":"Daniel Fern\u00e1ndez-Garc\u00eda","orcid":"https://orcid.org/0000-0002-4438-9666","observed_orcids":["https://orcid.org/0000-0002-4438-9666"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel Fernandez-Garcia","raw_affiliation_strings":["Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110770026","display_name":"Panchali B. Sarmah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Panchali Sarmah","raw_affiliation_strings":["Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045328655","display_name":"Patrick S. Tarpey","orcid":"https://orcid.org/0000-0002-2042-4543","observed_orcids":["https://orcid.org/0000-0002-2042-4543"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patrick S. Tarpey","raw_affiliation_strings":["Wellcome Sanger Institute, Hinxton, CB10 1SA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Sanger Institute, Hinxton, CB10 1SA, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081105504","display_name":"Saif Sattar Al-Aqbi","orcid":"https://orcid.org/0000-0001-5333-7350","observed_orcids":["https://orcid.org/0000-0001-5333-7350"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I47229656","display_name":"University of Kufa","ror":"https://ror.org/02dwrdh81","country_code":"IQ","type":"education","lineage":["https://openalex.org/I47229656"]}],"countries":["GB","IQ"],"is_corresponding":false,"raw_author_name":"Saif Sattar Al-Aqbi","raw_affiliation_strings":["Department of Pathology and Poultry Diseases, Faculty of Veterinary Medicine, University of Kufa, Kufa, Iraq","Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Poultry Diseases, Faculty of Veterinary Medicine, University of Kufa, Kufa, Iraq","institution_ids":["https://openalex.org/I47229656"]},{"raw_affiliation_string":"Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028379678","display_name":"Hong Cai","orcid":"https://orcid.org/0000-0002-2711-9461","observed_orcids":["https://orcid.org/0000-0002-2711-9461","https://orcid.org/0009-0002-8023-1206"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hong Cai","raw_affiliation_strings":["Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015272467","display_name":"Ricky M. Trigg","orcid":"https://orcid.org/0000-0001-9329-9344","observed_orcids":["https://orcid.org/0000-0001-9329-9344"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ricky Trigg","raw_affiliation_strings":["Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK"],"raw_orcid":"https://orcid.org/0000-0001-9329-9344","affiliations":[{"raw_affiliation_string":"Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111932243","display_name":"Kevin West","orcid":"https://orcid.org/0000-0002-8621-9446","observed_orcids":["https://orcid.org/0000-0002-8621-9446"]},"institutions":[{"id":"https://openalex.org/I2801415944","display_name":"Kettering General Hospital","ror":"https://ror.org/032kmqj66","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801415944","https://openalex.org/I4210167175"]},{"id":"https://openalex.org/I4210167175","display_name":"Kettering General Hospital NHS Trust","ror":"https://ror.org/05xh7ac43","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210167175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin West","raw_affiliation_strings":["Kettering General Hospital NHS Foundation Trust, Kettering, NN16 8UZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kettering General Hospital NHS Foundation Trust, Kettering, NN16 8UZ, UK","institution_ids":["https://openalex.org/I2801415944","https://openalex.org/I4210167175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031111647","display_name":"Lynne M. Howells","orcid":"https://orcid.org/0000-0001-5560-765X","observed_orcids":["https://orcid.org/0000-0001-5560-765X"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lynne M. Howells","raw_affiliation_strings":["Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060639360","display_name":"Anne Thomas","orcid":"https://orcid.org/0000-0003-1998-3134","observed_orcids":["https://orcid.org/0000-0003-1998-3134"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anne Thomas","raw_affiliation_strings":["Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058052872","display_name":"Karen Brown","orcid":"https://orcid.org/0000-0002-5217-1501","observed_orcids":["https://orcid.org/0000-0002-5217-1501"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karen Brown","raw_affiliation_strings":["Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075679677","display_name":"David S. Guttery","orcid":"https://orcid.org/0000-0003-0418-580X","observed_orcids":["https://orcid.org/0000-0003-0418-580X"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David S. Guttery","raw_affiliation_strings":["Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK"],"raw_orcid":"https://orcid.org/0000-0003-0418-580X","affiliations":[{"raw_affiliation_string":"Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069435197","display_name":"Baljit Singh","orcid":"https://orcid.org/0000-0002-7987-7336","observed_orcids":["https://orcid.org/0000-0002-7987-7336","https://orcid.org/0000-0002-2064-2356"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Baljit Singh","raw_affiliation_strings":["University of Leicester, University Hospital of Leicester, Leicester, LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leicester, University Hospital of Leicester, Leicester, LE2 7LX, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058569272","display_name":"Howard Pringle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Howard J. Pringle","raw_affiliation_strings":["Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080415325","display_name":"Ultan McDermott","orcid":"https://orcid.org/0000-0001-9032-4700","observed_orcids":["https://orcid.org/0000-0001-9032-4700"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ultan McDermott","raw_affiliation_strings":["Wellcome Sanger Institute, Hinxton, CB10 1SA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Sanger Institute, Hinxton, CB10 1SA, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066575183","display_name":"Jacqui Shaw","orcid":"https://orcid.org/0000-0003-4227-503X","observed_orcids":["https://orcid.org/0000-0003-4227-503X"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jacqui A. Shaw","raw_affiliation_strings":["Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084273562","display_name":"Alessandro Rufini","orcid":"https://orcid.org/0000-0002-5855-655X","observed_orcids":["https://orcid.org/0000-0002-5855-655X"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alessandro Rufini","raw_affiliation_strings":["Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK. ar230@le.ac.uk","Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK. ar230@le.ac.uk","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK","institution_ids":["https://openalex.org/I153648349"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5084273562"],"corresponding_institution_ids":["https://openalex.org/I153648349"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":1.3567,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.77468308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"9","issue":"9","first_page":"894","last_page":"894"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.8989999890327454},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.8690000176429749},{"id":"https://openalex.org/keywords/genetic-heterogeneity","display_name":"genetic heterogeneity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/early-detection-of-colorectal-cancer","display_name":"early detection of colorectal cancer","score":0.703000009059906},{"id":"https://openalex.org/keywords/apc-mutation","display_name":"APC mutation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/mismatch-repair-genes","display_name":"mismatch repair genes","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tumor-mutation-detection","display_name":"tumor mutation detection","score":0.46299999952316284},{"id":"https://openalex.org/keywords/colorectal-cancer-screening","display_name":"colorectal cancer screening","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.735181450843811},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7135055065155029},{"id":"https://openalex.org/C48126324","wikidata":"https://www.wikidata.org/wiki/Q5276136","display_name":"Digital polymerase chain reaction","level":4,"score":0.6606448292732239},{"id":"https://openalex.org/C152110520","wikidata":"https://www.wikidata.org/wiki/Q14225730","display_name":"Cell-free fetal DNA","level":5,"score":0.5880410671234131},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5614212155342102},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.5408904552459717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5178080797195435},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48278987407684326},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4703555107116699},{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.44616618752479553},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44583016633987427},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42645758390426636},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.42302969098091125},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4228825867176056},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.397185355424881},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3552074432373047},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24138444662094116},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14264193177223206},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.13702544569969177},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.1244300901889801},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.0},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073890","descriptor_name":"Liquid Biopsy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025601","descriptor_name":"Adenomatous Polyposis Coli Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1038/s41419-018-0934-x","doi":"https://doi.org/10.1038/s41419-018-0934-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-018-0934-x","pdf_url":"https://www.nature.com/articles/s41419-018-0934-x.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5072277","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6117318","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6117318","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6117318","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"},{"id":"pmid:30166531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30166531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:air.unimi.it:2434/945235","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2434/945235","pdf_url":"https://air.unimi.it/bitstream/2434/945235/2/cDNA%20paper.pdf","source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:cee0e231f00d45f0aa2a1db414204498","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/cee0e231f00d45f0aa2a1db414204498","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death and Disease, Vol 9, Iss 9, Pp 1-16 (2018)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/10215278","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Circulating_tumor_DNA_in_patients_with_colorectal_adenomas_assessment_of_detectability_and_genetic_heterogeneity_/10215278","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/10231634","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Circulating_tumor_DNA_in_patients_with_colorectal_adenomas_assessment_of_detectability_and_genetic_heterogeneity_/10231634","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:lra.le.ac.uk:2381/42944","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/42944","pdf_url":null,"source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:lra.le.ac.uk:2381/45311","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/45311","pdf_url":null,"source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/285808","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/285808","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.33152","doi":"https://doi.org/10.17863/cam.33152","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.33152","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1038/s41419-018-0934-x","doi":"https://doi.org/10.1038/s41419-018-0934-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-018-0934-x","pdf_url":"https://www.nature.com/articles/s41419-018-0934-x.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7400000095367432,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1006845473","display_name":null,"funder_award_id":"13462","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G2195134385","display_name":null,"funder_award_id":"C325/A15575","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G4668805537","display_name":null,"funder_award_id":"2013 RIF","funder_id":"https://openalex.org/F4320311543","funder_display_name":"Pancreatic Cancer UK"},{"id":"https://openalex.org/G5036984571","display_name":null,"funder_award_id":"23464","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6349119567","display_name":null,"funder_award_id":"20276","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6480194853","display_name":null,"funder_award_id":"A15575","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G768853933","display_name":null,"funder_award_id":"13101","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320311543","display_name":"Pancreatic Cancer UK","ror":"https://ror.org/04ad7pn51"},{"id":"https://openalex.org/F4320315632","display_name":"Hope Against Cancer","ror":"https://ror.org/02qp25s05"},{"id":"https://openalex.org/F4320315740","display_name":"Cancer Prevention Research Trust","ror":"https://ror.org/05vwgqw53"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2889089744.pdf","grobid_xml":"https://content.openalex.org/works/W2889089744.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W109839135","https://openalex.org/W1914351667","https://openalex.org/W1976111569","https://openalex.org/W1982603620","https://openalex.org/W1983466841","https://openalex.org/W1988290769","https://openalex.org/W1991472738","https://openalex.org/W1994924949","https://openalex.org/W2001258296","https://openalex.org/W2004645532","https://openalex.org/W2005786362","https://openalex.org/W2010873488","https://openalex.org/W2031698999","https://openalex.org/W2052154128","https://openalex.org/W2060833449","https://openalex.org/W2071251869","https://openalex.org/W2089135124","https://openalex.org/W2090222306","https://openalex.org/W2090424364","https://openalex.org/W2090562908","https://openalex.org/W2100856319","https://openalex.org/W2103441770","https://openalex.org/W2103547637","https://openalex.org/W2105643290","https://openalex.org/W2107721849","https://openalex.org/W2113414502","https://openalex.org/W2116805592","https://openalex.org/W2117753040","https://openalex.org/W2117906597","https://openalex.org/W2119263822","https://openalex.org/W2119938514","https://openalex.org/W2122080063","https://openalex.org/W2125129322","https://openalex.org/W2129136620","https://openalex.org/W2130243293","https://openalex.org/W2135900256","https://openalex.org/W2151464048","https://openalex.org/W2152823722","https://openalex.org/W2154397429","https://openalex.org/W2158548262","https://openalex.org/W2159609271","https://openalex.org/W2165083157","https://openalex.org/W2168861223","https://openalex.org/W2171237493","https://openalex.org/W2186699971","https://openalex.org/W2262414037","https://openalex.org/W2269331124","https://openalex.org/W2284361446","https://openalex.org/W2460179076","https://openalex.org/W2563137730","https://openalex.org/W2586629973","https://openalex.org/W2586862787","https://openalex.org/W2587883867","https://openalex.org/W2590954301","https://openalex.org/W2594373254","https://openalex.org/W2608738563","https://openalex.org/W2719863564","https://openalex.org/W2749817636","https://openalex.org/W2753109313","https://openalex.org/W2774464097","https://openalex.org/W2783674487","https://openalex.org/W2798041799","https://openalex.org/W4235857807","https://openalex.org/W4247053599"],"related_works":["https://openalex.org/W2768827395","https://openalex.org/W4406628610","https://openalex.org/W4404425972","https://openalex.org/W4407930851","https://openalex.org/W4391298490","https://openalex.org/W3021188695","https://openalex.org/W4386038178","https://openalex.org/W7133824809","https://openalex.org/W4379282707","https://openalex.org/W2890890344"],"abstract_inverted_index":{"Improving":[0],"early":[1],"detection":[2,31,42,116],"of":[3,32,44,89,101,108,117,127,154,187],"colorectal":[4],"cancer":[5,18,80,210],"(CRC)":[6],"is":[7,110],"a":[8,79,111,125,183],"key":[9],"public":[10],"health":[11],"priority":[12],"as":[13,78,164],"adenomas":[14,130,155,190],"and":[15,58,95,131,139,156,167,191,234],"stage":[16],"I":[17],"can":[19],"be":[20,238],"treated":[21],"with":[22,129,241,246],"minimally":[23],"invasive":[24],"procedures.":[25],"Population":[26],"screening":[27,67],"strategies":[28],"based":[29,50],"on":[30,51],"occult":[33],"blood":[34],"in":[35,177],"the":[36,87,97,193,202,232,247],"feces":[37],"have":[38],"contributed":[39],"to":[40,55,65,85,114,143,195,228,237],"enhance":[41,115],"rates":[43],"localized":[45],"disease,":[46,91],"but":[47],"new":[48],"approaches":[49],"genetic":[52,99,221],"analyses":[53],"able":[54],"increase":[56],"specificity":[57],"sensitivity":[59],"could":[60],"provide":[61],"additional":[62],"advantages":[63],"compared":[64],"current":[66,248],"methodologies.":[68],"Recently,":[69],"circulating":[70],"cell-free":[71],"DNA":[72,230],"(cfDNA)":[73],"has":[74],"received":[75],"much":[76],"attention":[77],"biomarker":[81],"for":[82],"its":[83],"ability":[84],"monitor":[86],"progression":[88],"advanced":[90],"predict":[92],"tumor":[93],"recurrence":[94],"reflect":[96],"complex":[98],"heterogeneity":[100],"cancers.":[102],"Here,":[103],"we":[104,123,147,181,213],"tested":[105],"whether":[106],"analysis":[107],"cfDNA":[109],"viable":[112],"tool":[113],"colon":[118,217],"adenomas.":[119],"To":[120],"address":[121],"this,":[122],"assessed":[124],"cohort":[126],"patients":[128],"healthy":[132],"controls":[133],"using":[134],"droplet":[135],"digital":[136],"PCR":[137],"(ddPCR)":[138],"mutation-specific":[140],"assays":[141],"targeted":[142,150],"trunk":[144],"mutations.":[145],"Additionally,":[146],"performed":[148],"multiregional,":[149],"next-generation":[151],"sequencing":[152],"(NGS)":[153],"unmasked":[157],"extensive":[158,220],"heterogeneity,":[159,222],"affecting":[160],"known":[161],"drivers":[162],"such":[163],"APC,":[165],"KRAS":[166],"mismatch":[168],"repair":[169],"(MMR)":[170],"genes.":[171],"However,":[172],"tumor-related":[173,197],"mutations":[174],"were":[175],"undetectable":[176],"patients'":[178],"plasma.":[179],"Finally,":[180],"employed":[182],"preclinical":[184],"mouse":[185],"model":[186],"Apc-driven":[188],"intestinal":[189],"confirmed":[192],"inability":[194],"identify":[196],"alterations":[198],"via":[199],"cfDNA,":[200],"despite":[201],"enhanced":[203],"disease":[204],"burden":[205],"displayed":[206],"by":[207],"this":[208],"experimental":[209],"model.":[211],"Therefore,":[212],"conclude":[214],"that":[215,223],"benign":[216],"lesions":[218],"display":[219],"they":[224],"are":[225,235],"not":[226],"prone":[227],"release":[229],"into":[231],"circulation":[233],"unlikely":[236],"reliably":[239],"detected":[240],"liquid":[242],"biopsies,":[243],"at":[244],"least":[245],"technologies.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-09-07T00:00:00"}