{"id":"https://openalex.org/W2888754368","doi":"https://doi.org/10.1056/nejme1810855","title":"Lorcaserin \u2014 Elixir or Liability?","display_name":"Lorcaserin \u2014 Elixir or Liability?","publication_year":2018,"publication_date":"2018-08-26","ids":{"openalex":"https://openalex.org/W2888754368","doi":"https://doi.org/10.1056/nejme1810855","mag":"2888754368","pmid":"https://pubmed.ncbi.nlm.nih.gov/30145932"},"language":"en","primary_location":{"id":"doi:10.1056/nejme1810855","doi":"https://doi.org/10.1056/nejme1810855","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejme1810855","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049720282","display_name":"Julie R. Ingelfinger","orcid":"https://orcid.org/0000-0001-9039-2703","observed_orcids":["https://orcid.org/0000-0001-9039-2703"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie R. Ingelfinger","raw_affiliation_strings":["From Tufts University School of Medicine, Boston, and Maine Medical Center Research Institute, Scarborough (C.J.R.)","Tufts University School of Medicine, Boston, and Maine Medical Center Research Institute, Scarborough"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Tufts University School of Medicine, Boston, and Maine Medical Center Research Institute, Scarborough (C.J.R.)","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210146345"]},{"raw_affiliation_string":"Tufts University School of Medicine, Boston, and Maine Medical Center Research Institute, Scarborough","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210146345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047044979","display_name":"Clifford james Rosen","orcid":"https://orcid.org/0000-0003-3436-8199","observed_orcids":["https://orcid.org/0000-0003-3436-8199"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford J. Rosen","raw_affiliation_strings":["From Tufts University School of Medicine, Boston, and Maine Medical Center Research Institute, Scarborough (C.J.R.)","Tufts University School of Medicine, Boston, and Maine Medical Center Research Institute, Scarborough"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Tufts University School of Medicine, Boston, and Maine Medical Center Research Institute, Scarborough (C.J.R.)","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210146345"]},{"raw_affiliation_string":"Tufts University School of Medicine, Boston, and Maine Medical Center Research Institute, Scarborough","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210146345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"379","issue":"12","first_page":"1174","last_page":"1175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10569","display_name":"Bariatric Surgery and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lorcaserin","display_name":"lorcaserin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/appetite-suppressants","display_name":"appetite suppressants","score":0.8479999899864197},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.8349999785423279},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.8040000200271606},{"id":"https://openalex.org/keywords/long-term-safety","display_name":"long-term safety","score":0.6159999966621399},{"id":"https://openalex.org/keywords/bariatric-surgery","display_name":"bariatric surgery","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9088846445083618},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.7767403721809387},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.6452975869178772},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6258885860443115},{"id":"https://openalex.org/C2780616401","wikidata":"https://www.wikidata.org/wiki/Q1133673","display_name":"Cornerstone","level":2,"score":0.5902944803237915},{"id":"https://openalex.org/C103472402","wikidata":"https://www.wikidata.org/wiki/Q5362035","display_name":"Elixir (programming language)","level":2,"score":0.4892832934856415},{"id":"https://openalex.org/C34320749","wikidata":"https://www.wikidata.org/wiki/Q17087302","display_name":"Weight management","level":4,"score":0.4523393511772156},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3638002872467041},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3536572754383087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16627776622772217},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejme1810855","doi":"https://doi.org/10.1056/nejme1810855","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejme1810855","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:30145932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30145932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W2001562531","https://openalex.org/W2123931921","https://openalex.org/W2148287957","https://openalex.org/W2148449799","https://openalex.org/W2590664415","https://openalex.org/W2888628330","https://openalex.org/W4238441644"],"related_works":["https://openalex.org/W2970240541","https://openalex.org/W7117254214","https://openalex.org/W1916498323","https://openalex.org/W4292497841","https://openalex.org/W2897440390","https://openalex.org/W2937815752","https://openalex.org/W2067683566","https://openalex.org/W3080118574","https://openalex.org/W41468882","https://openalex.org/W2021924845"],"abstract_inverted_index":{"More":[0],"than":[1,13,35],"1.9":[2],"billion":[3],"adults":[4,38],"worldwide":[5],"(39%)":[6],"are":[7,17,39,91],"overweight;":[8],"of":[9,37,45,54,98],"these":[10],"adults,":[11],"more":[12,34],"650":[14],"million":[15],"(13%)":[16],"obese,":[18],"according":[19],"to":[20,81],"the":[21,26,52,88,95],"World":[22],"Health":[23],"Organization.":[24],"In":[25],"United":[27],"States":[28],"alone,":[29],"recent":[30],"studies":[31],"suggest":[32],"that":[33,68],"40%":[36],"obese.1":[40],"A":[41],"nonpharmacologic":[42],"approach":[43],"consisting":[44],"exercise,":[46],"diet,":[47],"and":[48,72,83],"behavior":[49],"modification":[50],"remains":[51],"cornerstone":[53],"treatment.2":[55],"However,":[56],"many":[57],"affected":[58],"patients":[59,89],"cannot":[60],"lose":[61],"or":[62],"maintain":[63,84],"their":[64,93],"weight":[65,85],"loss":[66],"with":[67],"approach.":[69],"Hence,":[70],"medical":[71],"surgical":[73],"options":[74],"(e.g.,":[75],"bariatric":[76],"surgery)":[77],"have":[78],"been":[79],"developed":[80],"reduce":[82],"loss.":[86],"Among":[87],"who":[90],"considering":[92],"options,":[94],"long-term":[96],"safety":[97],"any":[99],".":[100,101,102]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-31T00:00:00"}