{"id":"https://openalex.org/W2888382467","doi":"https://doi.org/10.1093/glycob/cwy078","title":"Active site complementation and hexameric arrangement in the GH family 29; a structure\u2013function study of \u03b1-l-fucosidase isoenzyme 1 from Paenibacillus thiaminolyticus","display_name":"Active site complementation and hexameric arrangement in the GH family 29; a structure\u2013function study of \u03b1-l-fucosidase isoenzyme 1 from Paenibacillus thiaminolyticus","publication_year":2018,"publication_date":"2018-08-22","ids":{"openalex":"https://openalex.org/W2888382467","doi":"https://doi.org/10.1093/glycob/cwy078","mag":"2888382467","pmid":"https://pubmed.ncbi.nlm.nih.gov/30544181"},"language":"en","primary_location":{"id":"doi:10.1093/glycob/cwy078","doi":"https://doi.org/10.1093/glycob/cwy078","is_oa":true,"landing_page_url":"https://doi.org/10.1093/glycob/cwy078","pdf_url":"https://academic.oup.com/glycob/article-pdf/29/1/59/27118557/cwy078.pdf","source":{"id":"https://openalex.org/S188363740","display_name":"Glycobiology","issn_l":"0959-6658","issn":["0959-6658","1460-2423"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glycobiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/glycob/article-pdf/29/1/59/27118557/cwy078.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062602231","display_name":"Ter\u00e9zia Kova\u013aov\u00e1","orcid":"https://orcid.org/0000-0002-0144-2463","observed_orcids":["https://orcid.org/0000-0002-0144-2463"]},"institutions":[{"id":"https://openalex.org/I4210099114","display_name":"Czech Academy of Sciences, Institute of Biotechnology","ror":"https://ror.org/00wzqmx94","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210099114"]},{"id":"https://openalex.org/I9073902","display_name":"University of Chemistry and Technology, Prague","ror":"https://ror.org/05ggn0a85","country_code":"CZ","type":"education","lineage":["https://openalex.org/I9073902"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Ter\u00e9zia Kova\u013eov\u00e1","raw_affiliation_strings":["Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic","Laboratory of Structure and Function of Biomolecules, Institute of Biotechnology of the Czech Academy of Sciences, v.v.i., Biocev, Vestec, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0002-0144-2463","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic","institution_ids":["https://openalex.org/I9073902"]},{"raw_affiliation_string":"Laboratory of Structure and Function of Biomolecules, Institute of Biotechnology of the Czech Academy of Sciences, v.v.i., Biocev, Vestec, Czech Republic","institution_ids":["https://openalex.org/I4210099114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007943730","display_name":"T. Kova\u013a","orcid":"https://orcid.org/0000-0002-2836-3765","observed_orcids":["https://orcid.org/0000-0002-2836-3765"]},"institutions":[{"id":"https://openalex.org/I4210099114","display_name":"Czech Academy of Sciences, Institute of Biotechnology","ror":"https://ror.org/00wzqmx94","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210099114"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Tom\u00e1\u0161 Kova\u013e","raw_affiliation_strings":["Laboratory of Structure and Function of Biomolecules, Institute of Biotechnology of the Czech Academy of Sciences, v.v.i., Biocev, Vestec, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structure and Function of Biomolecules, Institute of Biotechnology of the Czech Academy of Sciences, v.v.i., Biocev, Vestec, Czech Republic","institution_ids":["https://openalex.org/I4210099114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060295172","display_name":"Eva Bene\u0161ov\u00e1","orcid":"https://orcid.org/0000-0002-3696-3517","observed_orcids":["https://orcid.org/0000-0002-3696-3517"]},"institutions":[{"id":"https://openalex.org/I9073902","display_name":"University of Chemistry and Technology, Prague","ror":"https://ror.org/05ggn0a85","country_code":"CZ","type":"education","lineage":["https://openalex.org/I9073902"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Eva Bene\u0161ov\u00e1","raw_affiliation_strings":["Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic","institution_ids":["https://openalex.org/I9073902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053183971","display_name":"Patricie Vodi\u010dkov\u00e1","orcid":"https://orcid.org/0000-0002-2441-5038","observed_orcids":["https://orcid.org/0000-0002-2441-5038"]},"institutions":[{"id":"https://openalex.org/I9073902","display_name":"University of Chemistry and Technology, Prague","ror":"https://ror.org/05ggn0a85","country_code":"CZ","type":"education","lineage":["https://openalex.org/I9073902"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Patricie Vodi\u010dkov\u00e1","raw_affiliation_strings":["Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic","institution_ids":["https://openalex.org/I9073902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068377776","display_name":"Vojt\u011bch Spiwok","orcid":"https://orcid.org/0000-0001-8108-2033","observed_orcids":["https://orcid.org/0000-0001-8108-2033"]},"institutions":[{"id":"https://openalex.org/I9073902","display_name":"University of Chemistry and Technology, Prague","ror":"https://ror.org/05ggn0a85","country_code":"CZ","type":"education","lineage":["https://openalex.org/I9073902"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Vojt\u011bch Spiwok","raw_affiliation_strings":["Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic","institution_ids":["https://openalex.org/I9073902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008856972","display_name":"Petra Lipovov\u00e1","orcid":"https://orcid.org/0000-0003-2275-3479","observed_orcids":["https://orcid.org/0000-0003-2275-3479"]},"institutions":[{"id":"https://openalex.org/I9073902","display_name":"University of Chemistry and Technology, Prague","ror":"https://ror.org/05ggn0a85","country_code":"CZ","type":"education","lineage":["https://openalex.org/I9073902"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Petra Lipovov\u00e1","raw_affiliation_strings":["Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic","institution_ids":["https://openalex.org/I9073902"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060080928","display_name":"Jan Dohn\u00e1lek","orcid":"https://orcid.org/0000-0002-8083-7980","observed_orcids":["https://orcid.org/0000-0002-8083-7980"]},"institutions":[{"id":"https://openalex.org/I4210099114","display_name":"Czech Academy of Sciences, Institute of Biotechnology","ror":"https://ror.org/00wzqmx94","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210099114"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jan Dohn\u00e1lek","raw_affiliation_strings":["Laboratory of Structure and Function of Biomolecules, Institute of Biotechnology of the Czech Academy of Sciences, v.v.i., Biocev, Vestec, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structure and Function of Biomolecules, Institute of Biotechnology of the Czech Academy of Sciences, v.v.i., Biocev, Vestec, Czech Republic","institution_ids":["https://openalex.org/I4210099114"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062602231"],"corresponding_institution_ids":["https://openalex.org/I4210099114","https://openalex.org/I9073902"],"apc_list":{"value":4208,"currency":"EUR","value_usd":4756},"apc_paid":null,"fwci":0.6801,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.70347003,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"1","first_page":"59","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.4392000138759613,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.4392000138759613,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.4154999852180481,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.05180000141263008,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paenibacillus-thiaminolyticus","display_name":"Paenibacillus thiaminolyticus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/transglycosylation","display_name":"transglycosylation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.6790000200271606},{"id":"https://openalex.org/keywords/maltose-binding","display_name":"maltose binding","score":0.8399999737739563},{"id":"https://openalex.org/keywords/carbohydrate-binding-site","display_name":"carbohydrate-binding site","score":0.871999979019165},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.6000000238418579},{"id":"https://openalex.org/keywords/optimal-ph","display_name":"pH optimum","score":0.656000018119812},{"id":"https://openalex.org/keywords/chromogenic-substrates","display_name":"chromogenic substrates","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7595871686935425},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.7279574871063232},{"id":"https://openalex.org/C7927669","wikidata":"https://www.wikidata.org/wiki/Q898529","display_name":"Protein quaternary structure","level":4,"score":0.5810180306434631},{"id":"https://openalex.org/C2780302934","wikidata":"https://www.wikidata.org/wiki/Q14905580","display_name":"Fucosidase","level":4,"score":0.5521718263626099},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.538644552230835},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.5236836671829224},{"id":"https://openalex.org/C196032511","wikidata":"https://www.wikidata.org/wiki/Q375795","display_name":"Glycoside hydrolase","level":3,"score":0.5071494579315186},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5054821968078613},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5049174427986145},{"id":"https://openalex.org/C13426554","wikidata":"https://www.wikidata.org/wiki/Q416019","display_name":"Glycoconjugate","level":2,"score":0.49415305256843567},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.49302002787590027},{"id":"https://openalex.org/C2777762822","wikidata":"https://www.wikidata.org/wiki/Q5507035","display_name":"Fucosyltransferase","level":3,"score":0.4677453339099884},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.45604777336120605},{"id":"https://openalex.org/C2779240490","wikidata":"https://www.wikidata.org/wiki/Q7632163","display_name":"Substrate analog","level":4,"score":0.44083666801452637},{"id":"https://openalex.org/C128463046","wikidata":"https://www.wikidata.org/wiki/Q22315590","display_name":"Chromogenic","level":2,"score":0.4169577658176422},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.41301584243774414},{"id":"https://openalex.org/C2776841590","wikidata":"https://www.wikidata.org/wiki/Q66589589","display_name":"Fucose","level":3,"score":0.3396250605583191},{"id":"https://openalex.org/C2778173381","wikidata":"https://www.wikidata.org/wiki/Q66589593","display_name":"Galactose","level":2,"score":0.2595733404159546},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.1938905417919159},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.15643584728240967},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005644","descriptor_name":"alpha-L-Fucosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005644","descriptor_name":"alpha-L-Fucosidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056507","descriptor_name":"Paenibacillus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D056507","descriptor_name":"Paenibacillus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/glycob/cwy078","doi":"https://doi.org/10.1093/glycob/cwy078","is_oa":true,"landing_page_url":"https://doi.org/10.1093/glycob/cwy078","pdf_url":"https://academic.oup.com/glycob/article-pdf/29/1/59/27118557/cwy078.pdf","source":{"id":"https://openalex.org/S188363740","display_name":"Glycobiology","issn_l":"0959-6658","issn":["0959-6658","1460-2423"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glycobiology","raw_type":"journal-article"},{"id":"pmid:30544181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30544181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glycobiology","raw_type":"Journal Article"},{"id":"pmh:oai:bib-pubdb1.desy.de:425972","doi":null,"is_oa":true,"landing_page_url":"https://bib-pubdb1.desy.de/search?p=id:%22PUBDB-2019-03515%22","pdf_url":"https://bib-pubdb1.desy.de/search?p=id:%22PUBDB-2019-03515%22","source":{"id":"https://openalex.org/S4306401365","display_name":"Desy publication database (The Deutsches Elektronen-Synchrotron)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801876189","host_organization_name":"Deutsches Elektronen-Synchrotron DESY","host_organization_lineage":["https://openalex.org/I2801876189"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Glycobiology 29, 59-73 (2018). doi:10.1093/glycob/cwy078","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/glycob/cwy078","doi":"https://doi.org/10.1093/glycob/cwy078","is_oa":true,"landing_page_url":"https://doi.org/10.1093/glycob/cwy078","pdf_url":"https://academic.oup.com/glycob/article-pdf/29/1/59/27118557/cwy078.pdf","source":{"id":"https://openalex.org/S188363740","display_name":"Glycobiology","issn_l":"0959-6658","issn":["0959-6658","1460-2423"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glycobiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2888382467.pdf","grobid_xml":"https://content.openalex.org/works/W2888382467.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1036232568","https://openalex.org/W1529784093","https://openalex.org/W1647233635","https://openalex.org/W1965301687","https://openalex.org/W1967751551","https://openalex.org/W1976223991","https://openalex.org/W1977290627","https://openalex.org/W1980850294","https://openalex.org/W1985288339","https://openalex.org/W1988437166","https://openalex.org/W1988966516","https://openalex.org/W1994439434","https://openalex.org/W1994915593","https://openalex.org/W1996185349","https://openalex.org/W2005921260","https://openalex.org/W2019410656","https://openalex.org/W2019526197","https://openalex.org/W2022673202","https://openalex.org/W2035503835","https://openalex.org/W2037891557","https://openalex.org/W2049924291","https://openalex.org/W2053575361","https://openalex.org/W2055043387","https://openalex.org/W2070268560","https://openalex.org/W2076261290","https://openalex.org/W2084971027","https://openalex.org/W2085407365","https://openalex.org/W2091075510","https://openalex.org/W2098943363","https://openalex.org/W2106121486","https://openalex.org/W2106982904","https://openalex.org/W2108921801","https://openalex.org/W2110808180","https://openalex.org/W2113058396","https://openalex.org/W2113964973","https://openalex.org/W2117946498","https://openalex.org/W2122559203","https://openalex.org/W2122927972","https://openalex.org/W2124026197","https://openalex.org/W2127322768","https://openalex.org/W2128956666","https://openalex.org/W2132629607","https://openalex.org/W2144998676","https://openalex.org/W2146080841","https://openalex.org/W2147874841","https://openalex.org/W2149170646","https://openalex.org/W2154714625","https://openalex.org/W2156608719","https://openalex.org/W2159211495","https://openalex.org/W2168974130","https://openalex.org/W2180229411","https://openalex.org/W2316641879","https://openalex.org/W2521535507"],"related_works":["https://openalex.org/W4210440979","https://openalex.org/W6981850031","https://openalex.org/W7056534050","https://openalex.org/W4211097574","https://openalex.org/W1491017239","https://openalex.org/W2113058396","https://openalex.org/W1984827054","https://openalex.org/W4413053462","https://openalex.org/W4400097153","https://openalex.org/W7155367483"],"abstract_inverted_index":{"\u03b1-l-Fucosidase":[0],"isoenzyme":[1],"1":[2],"from":[3,20,65],"bacterium":[4],"Paenibacillus":[5],"thiaminolyticus":[6],"is":[7,47],"a":[8,38,49,63,85,91,101,106,127],"member":[9],"of":[10,17,23,34,58,73,87,93,116,124,129,139,153,160,186],"the":[11,30,54,74,81,88,117,140,148,151,158,161,172,175],"glycoside":[12],"hydrolase":[13],"family":[14],"GH29":[15],"capable":[16,123],"cleaving":[18],"l-fucose":[19],"nonreducing":[21],"termini":[22],"oligosaccharides":[24,121],"and":[25,100,122],"glycoconjugates.":[26],"Here":[27],"we":[28],"present":[29],"first":[31,55],"crystal":[32,176],"structure":[33,177],"this":[35,43,70],"protein":[36,46],"revealing":[37,53],"novel":[39],"quaternary":[40],"state":[41],"within":[42],"family.":[44,71],"The":[45,109],"in":[48,69,80,165,174,184],"unique":[50],"hexameric":[51],"assembly":[52],"observed":[56],"case":[57],"active":[59,113],"site":[60],"complementation":[61],"by":[62],"residue":[64,77,142],"an":[66,96],"adjacent":[67],"monomer":[68],"Mutation":[72,138],"complementing":[75,141],"tryptophan":[76],"caused":[78],"changes":[79],"catalytic":[82],"properties":[83],"including":[84,132],"shift":[86],"pH":[89],"optimum,":[90],"change":[92],"affinity":[94],"to":[95,171],"artificial":[97],"chromogenic":[98,136],"substrate":[99,145],"decreased":[102],"reaction":[103],"rate":[104],"for":[105,150],"natural":[107],"substrate.":[108],"wild-type":[110],"enzyme":[111,173],"was":[112],"on":[114,126],"most":[115],"tested":[118],"naturally":[119],"occurring":[120],"transglycosylation":[125,154],"variety":[128],"acceptor":[130,155],"molecules,":[131],"saccharides,":[133],"alcohols":[134],"or":[135],"substrates.":[137],"changed":[143],"neither":[144],"specificity":[146],"nor":[147],"preference":[149],"type":[152],"molecule;":[156],"however,":[157],"yields":[159],"reactions":[162],"were":[163],"lower":[164],"both":[166],"cases.":[167],"Maltose":[168],"molecules":[169],"bound":[170],"identified":[178],"surface":[179],"carbohydrate-binding":[180],"sites,":[181],"possibly":[182],"participating":[183],"binding":[185],"larger":[187],"oligosaccharides.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-08-31T00:00:00"}
