{"id":"https://openalex.org/W28881979","doi":null,"title":"Diuretic-induced CNS magnesium alteration and digoxin intoxication.","display_name":"Diuretic-induced CNS magnesium alteration and digoxin intoxication.","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W28881979","mag":"28881979","pmid":"https://pubmed.ncbi.nlm.nih.gov/3244283"},"language":"en","primary_location":{"id":"pmid:3244283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3244283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnesium","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008620674","display_name":"Brooke Alexander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B S Alexander","raw_affiliation_strings":["Department of Pharmacology, Howard University, Washington, D.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Howard University, Washington, D.C","institution_ids":["https://openalex.org/I137853757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008620674"],"corresponding_institution_ids":["https://openalex.org/I137853757"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.00317329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"4","first_page":"210","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12280","display_name":"Magnesium in Health and Disease","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12280","display_name":"Magnesium in Health and Disease","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diuretics","display_name":"diuretics","score":0.8299999833106995},{"id":"https://openalex.org/keywords/thiazide-diuretics","display_name":"thiazide diuretics","score":0.7879999876022339},{"id":"https://openalex.org/keywords/hydrochlorothiazide","display_name":"hydrochlorothiazide","score":0.9380000233650208},{"id":"https://openalex.org/keywords/chlorothiazide","display_name":"chlorothiazide","score":0.9639999866485596},{"id":"https://openalex.org/keywords/bendroflumethiazide","display_name":"bendroflumethiazide","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chlorthalidone","display_name":"chlorthalidone","score":0.9850000143051147},{"id":"https://openalex.org/keywords/methyclothiazide","display_name":"methyclothiazide","score":0.9639999866485596},{"id":"https://openalex.org/keywords/metolazone","display_name":"metolazone","score":1.0},{"id":"https://openalex.org/keywords/hypomagnesemia","display_name":"hypomagnesemia","score":0.7319999933242798},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9179999828338623},{"id":"https://openalex.org/keywords/medulla-oblongata","display_name":"medulla oblongata","score":0.996999979019165},{"id":"https://openalex.org/keywords/digoxin-intoxication","display_name":"digoxin intoxication","score":0.8849999904632568},{"id":"https://openalex.org/keywords/magnesium-supplementation","display_name":"magnesium supplementation","score":0.46000000834465027},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2780361556","wikidata":"https://www.wikidata.org/wiki/Q423930","display_name":"Hydrochlorothiazide","level":3,"score":0.8737825155258179},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7675214409828186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7096949219703674},{"id":"https://openalex.org/C2779918671","wikidata":"https://www.wikidata.org/wiki/Q200656","display_name":"Diuretic","level":2,"score":0.6747846603393555},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6116381883621216},{"id":"https://openalex.org/C2777707475","wikidata":"https://www.wikidata.org/wiki/Q422222","display_name":"Digoxin","level":3,"score":0.5501410365104675},{"id":"https://openalex.org/C2779660313","wikidata":"https://www.wikidata.org/wiki/Q2603363","display_name":"Chlorothiazide","level":3,"score":0.42486634850502014},{"id":"https://openalex.org/C2780437262","wikidata":"https://www.wikidata.org/wiki/Q665843","display_name":"Thiazide","level":3,"score":0.42381733655929565},{"id":"https://openalex.org/C2776492347","wikidata":"https://www.wikidata.org/wiki/Q210697","display_name":"Hypermagnesemia","level":4,"score":0.41423502564430237},{"id":"https://openalex.org/C543218039","wikidata":"https://www.wikidata.org/wiki/Q660","display_name":"Magnesium","level":2,"score":0.3474910855293274},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30221569538116455},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.13064342737197876},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.10515201091766357},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2776183862","wikidata":"https://www.wikidata.org/wiki/Q3771629","display_name":"Hypomagnesemia","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001539","descriptor_name":"Bendroflumethiazide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004077","descriptor_name":"Digoxin","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":true},{"descriptor_ui":"D004232","descriptor_name":"Diuretics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006852","descriptor_name":"Hydrochlorothiazide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008275","descriptor_name":"Magnesium Deficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049993","descriptor_name":"Sodium Chloride Symporter Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3244283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3244283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnesium","raw_type":"Journal Article"},{"id":"mag:28881979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3244283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1935838690","https://openalex.org/W1995452282","https://openalex.org/W2004053049","https://openalex.org/W2008929650","https://openalex.org/W2040846244","https://openalex.org/W2045218416","https://openalex.org/W2046847841","https://openalex.org/W2058046532","https://openalex.org/W2069552222","https://openalex.org/W2096890121","https://openalex.org/W2098290597","https://openalex.org/W2100556411","https://openalex.org/W2101851144","https://openalex.org/W2108150542","https://openalex.org/W2110496823","https://openalex.org/W2117078302","https://openalex.org/W2119341498","https://openalex.org/W2119862467","https://openalex.org/W2120572720","https://openalex.org/W2132168166","https://openalex.org/W2138019504","https://openalex.org/W2146738944","https://openalex.org/W2149916722","https://openalex.org/W2154865814","https://openalex.org/W2155513557","https://openalex.org/W2160972508","https://openalex.org/W2166348468","https://openalex.org/W2167792187","https://openalex.org/W2192091774","https://openalex.org/W2220159479","https://openalex.org/W2303875941","https://openalex.org/W2387215428","https://openalex.org/W2418179447","https://openalex.org/W2500004684"],"related_works":["https://openalex.org/W4232342259","https://openalex.org/W2074257744","https://openalex.org/W1975735599","https://openalex.org/W2063791649","https://openalex.org/W2159813375","https://openalex.org/W2966863417","https://openalex.org/W2437649376","https://openalex.org/W2028652849","https://openalex.org/W2404957690","https://openalex.org/W2314008329"],"abstract_inverted_index":{"Male":[0],"Wistar":[1],"rats":[2],"were":[3,197],"injected":[4],"intraperitoneally":[5],"for":[6],"3":[7],"consecutive":[8],"days":[9],"with":[10,170],"hydrochlorothiazide":[11],"(HCTZ;":[12],"15":[13,25],"mg/kg),":[14,18,22,26],"chlorothiazide":[15],"(CTZ;":[16],"100":[17],"bendroflumethiazide":[19],"(BFTZ;":[20],"1.5":[21,34],"chlorthalidone":[23],"(CHLOR;":[24],"methyclothiazide":[27],"(METH;":[28],"1.0":[29],"mg/kg)":[30],"or":[31],"metolazone":[32],"(MET;":[33],"mg/kg).":[35],"Magnesium":[36],"content":[37],"was":[38,54,68,91,116],"measured":[39],"in":[40,60,87,141,148,167,176,194,217],"the":[41,61,88,218],"hypothalamus,":[42],"medulla":[43,156],"oblongata,":[44],"cerebral":[45],"cortex,":[46],"heart,":[47,66],"skeletal":[48,63],"muscle":[49,64],"and":[50,65,74,107,132,155],"serum.":[51],"Although":[52],"there":[53,67,90,115],"no":[55],"consistent":[56],"alteration":[57],"of":[58,82,191,203,206,215],"Mg":[59,140,147,216],"serum,":[62],"a":[69,79,92,117],"significant":[70],"effect":[71],"on":[72,139],"hypothalamic":[73],"medullary":[75],"Mg.":[76,207],"Compared":[77],"to":[78,221],"control":[80],"value":[81],"17.20":[83],"+/-":[84],"1.24":[85],"mEg/kg":[86],"hypothamus":[89],"decrease":[93,118],"by":[94,119,200],"HCTZ":[95,120,171],"(26%;":[96,157],"p":[97,103,110,122,128,135,151,158,185],"less":[98,104,111,123,129,136,152,159,186],"than":[99,105,112,124,130,137,153,160,175,187],"0.01),":[100,125],"CTZ":[101,126],"(24%;":[102],"0.01)":[106,131,138,154],"BFTZ":[108,133],"(30%;":[109,127],"0.01).":[113,161,188],"Similarly,":[114],"(22%;":[121],"(25%;":[134],"medulla.":[142],"In":[143],"contrast":[144],"MET":[145],"increases":[146],"hypothalamus":[149],"(31%;":[150],"Furthermore,":[162],"digoxin":[163,179,192,222],"infusion":[164],"(0.051":[165],"ml/min)":[166],"animals":[168,177,196],"pretreated":[169],"induced":[172],"arrhythmias":[173],"earlier":[174],"receiving":[178],"alone":[180],"(30":[181],"vs.":[182],"60":[183],"min;":[184],"The":[189],"effects":[190],"toxicity":[193],"HCTZ-pretreated":[195],"partially":[198],"reversed":[199],"CNS":[201,219],"administration":[202],"50":[204],"micrograms":[205],"These":[208],"findings":[209],"strongly":[210],"suggest":[211],"that":[212],"thiazide-induced":[213],"depletion":[214],"predisposes":[220],"intoxication.":[223]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}