{"id":"https://openalex.org/W2888190898","doi":"https://doi.org/10.3357/amhp.4913.2018","title":"Retrospective Evaluation of Clinical Symptoms Due to Mild Hypobaric Hypoxia Exposure in Microgravity","display_name":"Retrospective Evaluation of Clinical Symptoms Due to Mild Hypobaric Hypoxia Exposure in Microgravity","publication_year":2018,"publication_date":"2018-08-21","ids":{"openalex":"https://openalex.org/W2888190898","doi":"https://doi.org/10.3357/amhp.4913.2018","mag":"2888190898","pmid":"https://pubmed.ncbi.nlm.nih.gov/30126511"},"language":"en","primary_location":{"id":"doi:10.3357/amhp.4913.2018","doi":"https://doi.org/10.3357/amhp.4913.2018","is_oa":false,"landing_page_url":"https://doi.org/10.3357/amhp.4913.2018","pdf_url":null,"source":{"id":"https://openalex.org/S2764403496","display_name":"Aerospace Medicine and Human Performance","issn_l":"2375-6314","issn":["2375-6314","2375-6322"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316708","host_organization_name":"Aerospace Medical Association","host_organization_lineage":["https://openalex.org/P4310316708"],"host_organization_lineage_names":["Aerospace Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aerospace Medicine and Human Performance","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071745669","display_name":"James H. Wessel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James H. Wessel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011892879","display_name":"Caroline M. Schaefer","orcid":"https://orcid.org/0000-0003-1898-0644","observed_orcids":["https://orcid.org/0000-0003-1898-0644"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caroline M. Schaefer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075096256","display_name":"Moriah S. Thompson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moriah S. Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020185877","display_name":"Jason R. Norcross","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason R. Norcross","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009263173","display_name":"Omar S. Bekdash","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Omar S. Bekdash","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5041,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.6434588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"89","issue":"9","first_page":"792","last_page":"797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14214","display_name":"Space Exploration and Technology","score":0.08820000290870667,"subfield":{"id":"https://openalex.org/subfields/2202","display_name":"Aerospace Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11968","display_name":"High Altitude and Hypoxia","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microgravity","display_name":"microgravity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/space-shuttle","display_name":"Space Shuttle","score":0.8600000143051147},{"id":"https://openalex.org/keywords/extravehicular-activity","display_name":"extravehicular activity","score":0.8349999785423279},{"id":"https://openalex.org/keywords/denitrogenation","display_name":"denitrogenation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/astronaut-health","display_name":"astronaut health","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6661636829376221},{"id":"https://openalex.org/C23161992","wikidata":"https://www.wikidata.org/wiki/Q2922301","display_name":"Hum","level":3,"score":0.6416072249412537},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5284340977668762},{"id":"https://openalex.org/C6439246","wikidata":"https://www.wikidata.org/wiki/Q3332475","display_name":"Aviation medicine","level":2,"score":0.5246493816375732},{"id":"https://openalex.org/C3017916928","wikidata":"https://www.wikidata.org/wiki/Q105688","display_name":"Tissue hypoxia","level":3,"score":0.4467664957046509},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4263398051261902},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3879627287387848},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.37465327978134155},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.30089902877807617},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.24497351050376892},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1627882421016693},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12499046325683594},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.11839672923088074},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0759735107421875},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C554144382","wikidata":"https://www.wikidata.org/wiki/Q213156","display_name":"Performance art","level":2,"score":0.0},{"id":"https://openalex.org/C52119013","wikidata":"https://www.wikidata.org/wiki/Q50637","display_name":"Art history","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000337","descriptor_name":"Aerospace Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003665","descriptor_name":"Decompression Sickness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013026","descriptor_name":"Space Flight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014893","descriptor_name":"Weightlessness","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3357/amhp.4913.2018","doi":"https://doi.org/10.3357/amhp.4913.2018","is_oa":false,"landing_page_url":"https://doi.org/10.3357/amhp.4913.2018","pdf_url":null,"source":{"id":"https://openalex.org/S2764403496","display_name":"Aerospace Medicine and Human Performance","issn_l":"2375-6314","issn":["2375-6314","2375-6322"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316708","host_organization_name":"Aerospace Medical Association","host_organization_lineage":["https://openalex.org/P4310316708"],"host_organization_lineage_names":["Aerospace Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aerospace Medicine and Human Performance","raw_type":"journal-article"},{"id":"pmid:30126511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30126511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aerospace medicine and human performance","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3173412465","https://openalex.org/W2529786956","https://openalex.org/W7211964934","https://openalex.org/W831879317","https://openalex.org/W3213211041","https://openalex.org/W194599919","https://openalex.org/W7019088818","https://openalex.org/W7023845334","https://openalex.org/W2018471914","https://openalex.org/W3133243315"],"abstract_inverted_index":{"INTRODUCTION:":[0],"A":[1,109,220],"habitat":[2],"atmosphere":[3,60],"of":[4,23,36,46,61,85,111,148,166,210,232,262],"34%":[5],"oxygen":[6],"(O2)":[7],"and":[8,64,102],"66%":[9],"nitrogen":[10],"(N2)":[11],"at":[12,67,99,104,125,158],"8.2":[13],"psia":[14,69,101,106,127,142,160,202],"(56.5":[15],"kPa)":[16],"is":[17,39,213],"proposed":[18],"to":[19,41,77,93,207,245,266],"minimize":[20],"the":[21,97,140,177,187,200,225],"risk":[22],"decompression":[24],"sickness":[25],"during":[26,44,121,186],"extravehicular":[27],"activity.":[28],"The":[29],"resulting":[30],"inspired":[31],"O2":[32,63],"partial":[33],"pressure":[34],"(PIo2)":[35],"128":[37],"mmHg":[38,212],"similar":[40,221],"that":[42,51],"experienced":[43],"portions":[45],"41":[47],"Space":[48],"Shuttle":[49],"missions":[50],"used":[52,92],"a":[53,83,146,208],"\"staged\"":[54],"denitrogenation":[55],"(prebreathe)":[56],"protocol":[57],"with":[58,118,145,181,198,241],"an":[59],"26.5%":[62],"73.5%":[65],"N2":[66],"10.2":[68,100,141,201],"(70.3":[70],"kPa).":[71,108],"We":[72],"evaluated":[73],"symptoms":[74,115,119,170,194,264],"possibly":[75],"linked":[76],"mild":[78,238,267],"hypoxia":[79,114,239,269],"in":[80,96,228,271],"astronauts":[81],"breathing":[82],"PIo2":[84,209],"127":[86,211],"mmHg.":[87],"METHODS:":[88],"Environmental":[89],"data":[90],"were":[91,116,133,155,195],"determine":[94],"time":[95,103],"shuttle":[98,123,226],"14.7":[105,126,159],"(101.3":[107],"total":[110],"14":[112],"possible":[113,233],"compared":[117,180],"collected":[120],"normoxic":[122,188],"operations":[124],"using":[128],"logistic":[129],"regression.":[130],"RESULTS:":[131],"There":[132,154],"134.1":[134],"d":[135,157],"(788.8":[136],"person":[137,162],"days)":[138],"under":[139,176],"staged":[143,178],"condition":[144,179],"mean":[147],"3.17":[149],"\u00b1":[150],"2.2":[151],"SD":[152],"d/mission.":[153],"258.81":[156],"(2192.95":[161],"days).":[163],"An":[164],"average":[165],"4.31":[167],"potentially":[168],"hypoxia-related":[169,234],"per":[171,183],"mission":[172,184],"day":[173,185],"was":[174],"documented":[175],"4.08":[182],"condition.":[189,203],"Logistic":[190],"regression":[191],"showed":[192],"no":[193,229],"significantly":[196],"associated":[197],"just":[199],"DISCUSSION:":[204],"Chronic":[205],"exposure":[206,223,270],"well-tolerated":[214],"by":[215],"healthy":[216],"humans":[217],"on":[218,224],"Earth.":[219],"short-duration":[222],"resulted":[227],"increased":[230],"reporting":[231],"symptoms.":[235],"However,":[236],"chronic":[237],"interactions":[240],"physiological":[242],"changes":[243],"due":[244,265],"microgravity":[246],"adaptations":[247],"remain":[248],"unclear.Wessel":[249],"JH":[250],"III,":[251],"Schaefer":[252],"CM,":[253],"Thompson":[254],"MS,":[255],"Norcross":[256],"JR,":[257],"Bekdash":[258],"OS.":[259],"Retrospective":[260],"evaluation":[261],"clinical":[263],"hypobaric":[268],"microgravity.":[272],"Aerosp":[273],"Med":[274],"Hum":[275],"Perform.":[276],"2018;":[277],"89(9):792-797.":[278]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-31T00:00:00"}