{"id":"https://openalex.org/W2888065392","doi":"https://doi.org/10.1172/jci.insight.99007","title":"BDNF inhibits neurodegenerative disease\u2013associated asparaginyl endopeptidase activity via phosphorylation by AKT","display_name":"BDNF inhibits neurodegenerative disease\u2013associated asparaginyl endopeptidase activity via phosphorylation by AKT","publication_year":2018,"publication_date":"2018-08-22","ids":{"openalex":"https://openalex.org/W2888065392","doi":"https://doi.org/10.1172/jci.insight.99007","mag":"2888065392","pmid":"https://pubmed.ncbi.nlm.nih.gov/30135302","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6141178"},"language":"en","primary_location":{"id":"doi:10.1172/jci.insight.99007","doi":"https://doi.org/10.1172/jci.insight.99007","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.99007","pdf_url":"http://insight.jci.org/articles/view/99007/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://insight.jci.org/articles/view/99007/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100713041","display_name":"Zhi-Hao Wang","orcid":"https://orcid.org/0000-0002-2517-8679","observed_orcids":["https://orcid.org/0000-0002-2517-8679"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zhi-Hao Wang","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA","Department of Pathophysiology, Key Laboratory of Ministry of Education of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Pathophysiology, Key Laboratory of Ministry of Education of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033795683","display_name":"Wanqiang Wu","orcid":"https://orcid.org/0000-0002-3199-6934","observed_orcids":["https://orcid.org/0000-0002-3199-6934"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Wanqiang Wu","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA","Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070887856","display_name":"Seong Su Kang","orcid":"https://orcid.org/0000-0002-2517-9962","observed_orcids":["https://orcid.org/0000-0002-2517-9962","https://orcid.org/0000-0003-0278-7372"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seong Su Kang","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100373211","display_name":"Xia Liu","orcid":"https://orcid.org/0000-0002-0180-2166","observed_orcids":["https://orcid.org/0000-0002-0180-2166"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xia Liu","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA","Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009542446","display_name":"Zhiping Wu","orcid":"https://orcid.org/0009-0006-2666-0754","observed_orcids":["https://orcid.org/0009-0006-2666-0754","https://orcid.org/0000-0002-5554-3681"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiping Wu","raw_affiliation_strings":["Departments of Structural Biology and Developmental Neurobiology, St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Structural Biology and Developmental Neurobiology, St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005061089","display_name":"Junmin Peng","orcid":"https://orcid.org/0000-0003-0472-7648","observed_orcids":["https://orcid.org/0000-0003-0472-7648","https://orcid.org/0000-0002-4043-8475"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junmin Peng","raw_affiliation_strings":["Departments of Structural Biology and Developmental Neurobiology, St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Structural Biology and Developmental Neurobiology, St. Jude Proteomics Facility, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107483233","display_name":"Shan Ping Yu","orcid":"https://orcid.org/0000-0003-1335-1398","observed_orcids":["https://orcid.org/0000-0003-1335-1398"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shan Ping Yu","raw_affiliation_strings":["Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056072835","display_name":"Fredric P. Manfredsson","orcid":"https://orcid.org/0000-0001-5802-5487","observed_orcids":["https://orcid.org/0000-0001-5802-5487"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fredric P. Manfredsson","raw_affiliation_strings":["Department of Translational Science & Molecular Medicine, Michigan State University, Grand Rapids, Michigan, USA"],"raw_orcid":"https://orcid.org/0000-0001-5802-5487","affiliations":[{"raw_affiliation_string":"Department of Translational Science & Molecular Medicine, Michigan State University, Grand Rapids, Michigan, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103111631","display_name":"Ivette M. Sandoval","orcid":"https://orcid.org/0000-0002-0191-4395","observed_orcids":["https://orcid.org/0000-0002-0191-4395"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivette M. Sandoval","raw_affiliation_strings":["Department of Translational Science & Molecular Medicine, Michigan State University, Grand Rapids, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Science & Molecular Medicine, Michigan State University, Grand Rapids, Michigan, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029551526","display_name":"Xuebo Liu","orcid":"https://orcid.org/0000-0001-6370-2868","observed_orcids":["https://orcid.org/0000-0001-6370-2868"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xuebo Liu","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA","Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100733753","display_name":"Jian\u2010Zhi Wang","orcid":"https://orcid.org/0000-0003-3569-9715","observed_orcids":["https://orcid.org/0000-0003-3569-9715"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian-Zhi Wang","raw_affiliation_strings":["Department of Pathophysiology, Key Laboratory of Ministry of Education of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Key Laboratory of Ministry of Education of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073266870","display_name":"Keqiang Ye","orcid":"https://orcid.org/0000-0002-7657-8154","observed_orcids":["https://orcid.org/0000-0002-7657-8154"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Keqiang Ye","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5073266870","https://openalex.org/A5100733753"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I47720641"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":{"value":4100,"currency":"USD","value_usd":4100},"fwci":3.4306,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.92956064,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.949999988079071},{"id":"https://openalex.org/keywords/asparaginyl-endopeptidase","display_name":"asparaginyl endopeptidase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tau-cleavage","display_name":"tau cleavage","score":0.9200000166893005},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.8849999904632568},{"id":"https://openalex.org/keywords/synaptic-dysfunction","display_name":"synaptic dysfunction","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7799999713897705},{"id":"https://openalex.org/keywords/lysosomal-translocation","display_name":"lysosomal translocation","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.8070098161697388},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6531949639320374},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5448692440986633},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.47465187311172485},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4645167887210846},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.43490657210350037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4107182025909424},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36945438385009766},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2440243661403656},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.20534461736679077},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0943082869052887}],"mesh":[{"descriptor_ui":"D000099240","descriptor_name":"Asparaginyl Endopeptidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061251","descriptor_name":"Primary Cell Culture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci.insight.99007","doi":"https://doi.org/10.1172/jci.insight.99007","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.99007","pdf_url":"http://insight.jci.org/articles/view/99007/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5099082","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6141178","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6141178","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6141178","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"Text"},{"id":"pmid:30135302","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30135302","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI insight","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci.insight.99007","doi":"https://doi.org/10.1172/jci.insight.99007","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.99007","pdf_url":"http://insight.jci.org/articles/view/99007/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3616039601","display_name":"RNA splicing dysfunction in Alzheimer's disease","funder_award_id":"R01AG047928","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7378477626","display_name":"Molecular Regulation of AEP during Ageing","funder_award_id":"RF1AG051538","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8302563558","display_name":null,"funder_award_id":"No. 81528007","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2888065392.pdf","grobid_xml":"https://content.openalex.org/works/W2888065392.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1507777154","https://openalex.org/W1520589118","https://openalex.org/W1590012920","https://openalex.org/W1680217275","https://openalex.org/W1963500709","https://openalex.org/W1965134160","https://openalex.org/W1968973248","https://openalex.org/W1979125012","https://openalex.org/W1979205386","https://openalex.org/W1981782246","https://openalex.org/W1986152555","https://openalex.org/W1987647111","https://openalex.org/W1995069132","https://openalex.org/W1996194036","https://openalex.org/W1996893328","https://openalex.org/W2000083942","https://openalex.org/W2000209446","https://openalex.org/W2003502313","https://openalex.org/W2004932952","https://openalex.org/W2007355134","https://openalex.org/W2011301103","https://openalex.org/W2012561426","https://openalex.org/W2021770702","https://openalex.org/W2026077861","https://openalex.org/W2026538105","https://openalex.org/W2027105008","https://openalex.org/W2029322891","https://openalex.org/W2033985997","https://openalex.org/W2035521611","https://openalex.org/W2037892763","https://openalex.org/W2043028475","https://openalex.org/W2047731623","https://openalex.org/W2051343450","https://openalex.org/W2057249855","https://openalex.org/W2057889532","https://openalex.org/W2063849763","https://openalex.org/W2066110504","https://openalex.org/W2067249462","https://openalex.org/W2071610467","https://openalex.org/W2090560687","https://openalex.org/W2103126447","https://openalex.org/W2110442840","https://openalex.org/W2127012092","https://openalex.org/W2133301540","https://openalex.org/W2138745251","https://openalex.org/W2139565721","https://openalex.org/W2140243281","https://openalex.org/W2144838450","https://openalex.org/W2146224411","https://openalex.org/W2149707290","https://openalex.org/W2149937665","https://openalex.org/W2151986987","https://openalex.org/W2152165298","https://openalex.org/W2160919644","https://openalex.org/W2168787545","https://openalex.org/W2170013728","https://openalex.org/W2192805543","https://openalex.org/W2419157048","https://openalex.org/W2599676172","https://openalex.org/W2615571115","https://openalex.org/W2730498479","https://openalex.org/W2747562354","https://openalex.org/W2747851831","https://openalex.org/W2936022182","https://openalex.org/W2944707665","https://openalex.org/W2959131130","https://openalex.org/W2959271239"],"related_works":["https://openalex.org/W2026077861","https://openalex.org/W2342980355","https://openalex.org/W2730498479","https://openalex.org/W4406881318","https://openalex.org/W3009785240","https://openalex.org/W2003502313","https://openalex.org/W2936022182","https://openalex.org/W3162976883","https://openalex.org/W2014747345","https://openalex.org/W2520032704"],"abstract_inverted_index":{"AEP":[0,40,65,71,97,171],"is":[1,68,72],"an":[2],"age-dependent":[3],"lysosomal":[4,53],"asparaginyl":[5],"endopeptidase":[6],"that":[7,37,160],"cleaves":[8,81],"numerous":[9],"substrates":[10],"including":[11],"tau":[12,83,92,120,124],"and":[13,15,50,55,74,84,98,123,129,146],"\u03b1-synuclein":[14,94,143],"mediates":[16],"their":[17],"pathological":[18],"roles":[19],"in":[20,62],"neurodegenerative":[21,63,167],"diseases.":[22],"However,":[23],"the":[24,77,87,158,164],"molecular":[25],"mechanism":[26],"regulating":[27],"this":[28],"critical":[29],"protease":[30],"remains":[31],"incompletely":[32],"understood.":[33],"Here,":[34],"we":[35],"show":[36],"Akt":[38,173],"phosphorylates":[39],"on":[41],"residue":[42],"T322":[43,66],"upon":[44],"brain-derived":[45],"neurotrophic":[46],"factor":[47],"(BDNF)":[48],"treatment":[49],"triggers":[51],"its":[52],"translocation":[54],"inactivation.":[56],"When":[57],"BDNF":[58,161],"levels":[59],"are":[60],"reduced":[61],"diseases,":[64],"phosphorylation":[67,103],"attenuated.":[69],"Consequently,":[70],"activated":[73],"translocates":[75],"into":[76,115,138],"cytoplasm,":[78],"where":[79],"it":[80],"both":[82],"\u03b1-synuclein.":[85],"Remarkably,":[86],"unphosphorylated":[88],"T322A":[89,137],"mutant":[90,106],"increases":[91],"or":[93],"cleavage":[95,122,145],"by":[96,169],"augments":[99],"cell":[100],"death,":[101],"whereas":[102],"mimetic":[104],"T322E":[105,114],"represses":[107],"these":[108],"effects.":[109],"Interestingly,":[110],"viral":[111,134],"injection":[112],"of":[113,136,166],"Tau":[116],"P301S":[117],"mice":[118,141],"antagonizes":[119],"N368":[121],"pathologies,":[125],"rescuing":[126],"synaptic":[127],"dysfunction":[128],"cognitive":[130],"deficits.":[131],"By":[132],"contrast,":[133],"administration":[135],"young":[139],"\u03b1-SNCA":[140],"elicits":[142],"N103":[144],"promotes":[147],"dopaminergic":[148],"neuronal":[149],"loss,":[150],"facilitating":[151],"motor":[152],"defects.":[153],"Therefore,":[154],"our":[155],"findings":[156],"support":[157],"notion":[159],"contributes":[162],"to":[163],"pathogenesis":[165],"diseases":[168],"suppressing":[170],"via":[172],"phosphorylation.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-08-31T00:00:00"}