{"id":"https://openalex.org/W2887797769","doi":"https://doi.org/10.21037/apc.2018.07.03","title":"Current and emerging radiotherapy strategies for pancreatic adenocarcinoma: stereotactic, intensity modulated and particle radiotherapy","display_name":"Current and emerging radiotherapy strategies for pancreatic adenocarcinoma: stereotactic, intensity modulated and particle radiotherapy","publication_year":2018,"publication_date":"2018-08-01","ids":{"openalex":"https://openalex.org/W2887797769","doi":"https://doi.org/10.21037/apc.2018.07.03","mag":"2887797769","pmid":"https://pubmed.ncbi.nlm.nih.gov/30198024","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6124686"},"language":"en","primary_location":{"id":"doi:10.21037/apc.2018.07.03","doi":"https://doi.org/10.21037/apc.2018.07.03","is_oa":true,"landing_page_url":"https://doi.org/10.21037/apc.2018.07.03","pdf_url":null,"source":{"id":"https://openalex.org/S4210198234","display_name":"Annals of Pancreatic Cancer","issn_l":"2616-2741","issn":["2616-2741"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Pancreatic Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.21037/apc.2018.07.03","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052290457","display_name":"Sweet Ping Ng","orcid":"https://orcid.org/0000-0003-1721-0680","observed_orcids":["https://orcid.org/0000-0003-1721-0680"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sweet Ping Ng","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026500137","display_name":"Eugene Jon Koay","orcid":"https://orcid.org/0000-0001-7675-3461","observed_orcids":["https://orcid.org/0000-0001-7675-3461"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene J. Koay","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.551,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.69107051,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":null,"first_page":"22","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.698199987411499,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.698199987411499,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.2858999967575073,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/locally-advanced-pancreatic-cancer","display_name":"locally advanced pancreatic cancer","score":0.9440000057220459},{"id":"https://openalex.org/keywords/stereotactic-body-radiation-therapy","display_name":"stereotactic body radiotherapy","score":0.9700000286102295},{"id":"https://openalex.org/keywords/intensity-modulated-radiotherapy","display_name":"intensity-modulated radiotherapy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/particle-therapy","display_name":"particle therapy","score":0.8560000061988831},{"id":"https://openalex.org/keywords/conformal-radiotherapy","display_name":"conformal radiotherapy","score":0.6890000104904175},{"id":"https://openalex.org/keywords/high-dose-radiotherapy","display_name":"high-dose radiotherapy","score":0.7210000157356262},{"id":"https://openalex.org/keywords/normal-tissue-dose-constraints","display_name":"normal tissue dose constraints","score":0.7039999961853027},{"id":"https://openalex.org/keywords/radiation-toxicity","display_name":"radiation toxicity","score":0.7559999823570251},{"id":"https://openalex.org/keywords/survival-outcomes","display_name":"survival outcomes","score":0.5870000123977661},{"id":"https://openalex.org/keywords/biologically-equivalent-dose","display_name":"biologically equivalent dose","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.8110181093215942},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.786933183670044},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.556631863117218},{"id":"https://openalex.org/C2778418280","wikidata":"https://www.wikidata.org/wiki/Q38276304","display_name":"Particle therapy","level":3,"score":0.49962615966796875},{"id":"https://openalex.org/C147976105","wikidata":"https://www.wikidata.org/wiki/Q945733","display_name":"Particle radiation","level":4,"score":0.46136870980262756},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.45592737197875977},{"id":"https://openalex.org/C155806632","wikidata":"https://www.wikidata.org/wiki/Q5299253","display_name":"Dose fractionation","level":3,"score":0.449301540851593},{"id":"https://openalex.org/C2775908122","wikidata":"https://www.wikidata.org/wiki/Q3070621","display_name":"External beam radiotherapy","level":4,"score":0.4292573928833008},{"id":"https://openalex.org/C2992393070","wikidata":"https://www.wikidata.org/wiki/Q973234","display_name":"Stereotactic radiotherapy","level":4,"score":0.41585487127304077},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38154110312461853},{"id":"https://openalex.org/C2780387249","wikidata":"https://www.wikidata.org/wiki/Q973234","display_name":"Radiosurgery","level":3,"score":0.3789653182029724},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3755897283554077},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3217032253742218},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28673261404037476},{"id":"https://openalex.org/C2777416452","wikidata":"https://www.wikidata.org/wiki/Q896687","display_name":"Brachytherapy","level":3,"score":0.25849103927612305},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.05168360471725464},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.0},{"id":"https://openalex.org/C35048267","wikidata":"https://www.wikidata.org/wiki/Q587553","display_name":"Charged particle","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.21037/apc.2018.07.03","doi":"https://doi.org/10.21037/apc.2018.07.03","is_oa":true,"landing_page_url":"https://doi.org/10.21037/apc.2018.07.03","pdf_url":null,"source":{"id":"https://openalex.org/S4210198234","display_name":"Annals of Pancreatic Cancer","issn_l":"2616-2741","issn":["2616-2741"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Pancreatic Cancer","raw_type":"journal-article"},{"id":"pmid:30198024","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30198024","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of pancreatic cancer","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5076967","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6124686","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6124686","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6124686","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ann Pancreat Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.21037/apc.2018.07.03","doi":"https://doi.org/10.21037/apc.2018.07.03","is_oa":true,"landing_page_url":"https://doi.org/10.21037/apc.2018.07.03","pdf_url":null,"source":{"id":"https://openalex.org/S4210198234","display_name":"Annals of Pancreatic Cancer","issn_l":"2616-2741","issn":["2616-2741"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Pancreatic Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2258116482","display_name":"Center for Immunotherapeutic Transport Oncophysics","funder_award_id":"U54CA210181","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6911098835","display_name":"Imaging and Molecular Correlates of Progression in Cystic Neoplasms of the Pancreas","funder_award_id":"U01CA196403","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000908439","display_name":"Clinical Validation Center for Early Detection of Pancreatic Cancer","funder_award_id":"U01CA200468","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1563283949","https://openalex.org/W1980367758","https://openalex.org/W1991517423","https://openalex.org/W1999946563","https://openalex.org/W2015575263","https://openalex.org/W2017461673","https://openalex.org/W2035281362","https://openalex.org/W2048787455","https://openalex.org/W2050957719","https://openalex.org/W2068359620","https://openalex.org/W2071442044","https://openalex.org/W2085562092","https://openalex.org/W2086454079","https://openalex.org/W2101102721","https://openalex.org/W2101345979","https://openalex.org/W2108063732","https://openalex.org/W2108708599","https://openalex.org/W2115701552","https://openalex.org/W2119914737","https://openalex.org/W2128410323","https://openalex.org/W2146974261","https://openalex.org/W2160450044","https://openalex.org/W2160994657","https://openalex.org/W2196287118","https://openalex.org/W2212687827","https://openalex.org/W2259646680","https://openalex.org/W2319701188","https://openalex.org/W2335313798","https://openalex.org/W2346921980","https://openalex.org/W2430002790","https://openalex.org/W2471637668","https://openalex.org/W2570618306","https://openalex.org/W2595551151","https://openalex.org/W2767594246"],"related_works":["https://openalex.org/W3026142237","https://openalex.org/W4414114797","https://openalex.org/W2790027553","https://openalex.org/W2940497959","https://openalex.org/W2798389324","https://openalex.org/W3085816397","https://openalex.org/W4312783330","https://openalex.org/W7204122687","https://openalex.org/W2975439693","https://openalex.org/W4310603792"],"abstract_inverted_index":{"The":[0,62],"role":[1],"of":[2,39,43,68,76],"radiotherapy":[3,23,45,92,125],"for":[4,89,110,129],"locally":[5],"advanced":[6],"pancreatic":[7],"cancer":[8],"(LAPC)":[9],"is":[10],"unclear":[11],"based":[12],"on":[13,36],"studies":[14],"that":[15,122],"used":[16],"conventional":[17],"doses":[18,42,75,95,116],"and":[19,53,60,70,102],"fractionation":[20],"schedules.":[21],"Modern":[22],"techniques":[24,126],"have":[25],"not":[26],"been":[27],"studied":[28],"in":[29],"depth,":[30],"however.":[31],"We":[32],"reviewed":[33],"the":[34],"literature":[35,63],"emerging":[37],"methods":[38],"delivering":[40],"higher":[41,74],"conformal":[44],"using":[46],"stereotactic":[47,90],"body":[48,91],"radiation,":[49,52,56],"intensity":[50,97],"modulated":[51,98],"particle":[54],"beam":[55],"highlighting":[57],"clinical":[58],"outcomes":[59],"toxicities.":[61],"review":[64],"suggests":[65,107],"low":[66],"rates":[67],"acute":[69],"late":[71],"toxicities":[72],"when":[73],"radiation":[77,99],"are":[78,127],"given":[79],"with":[80,96],"careful":[81],"attention":[82],"to":[83],"normal":[84],"tissue":[85],"dose":[86],"constraints,":[87],"including":[88],"(SBRT),":[93],"escalated":[94],"therapy":[100],"(IMRT),":[101],"particle-based":[103],"therapy.":[104],"Retrospective":[105],"evidence":[106],"prolonged":[108],"survival":[109],"patients":[111],"who":[112],"receive":[113],"biological":[114],"equivalent":[115],"above":[117],"70":[118],"Gy.":[119],"Prospective":[120],"trials":[121],"evaluate":[123],"modern":[124],"warranted":[128],"LAPC.":[130]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-22T00:00:00"}