{"id":"https://openalex.org/W2887786916","doi":"https://doi.org/10.3389/fnmol.2018.00278","title":"The Alternative Complement System Mediates Cell Death in Retinal Ischemia Reperfusion Injury","display_name":"The Alternative Complement System Mediates Cell Death in Retinal Ischemia Reperfusion Injury","publication_year":2018,"publication_date":"2018-08-17","ids":{"openalex":"https://openalex.org/W2887786916","doi":"https://doi.org/10.3389/fnmol.2018.00278","mag":"2887786916","pmid":"https://pubmed.ncbi.nlm.nih.gov/30174588","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6107794"},"language":"en","primary_location":{"id":"doi:10.3389/fnmol.2018.00278","doi":"https://doi.org/10.3389/fnmol.2018.00278","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnmol.2018.00278","pdf_url":null,"source":{"id":"https://openalex.org/S39538987","display_name":"Frontiers in Molecular Neuroscience","issn_l":"1662-5099","issn":["1662-5099"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fnmol.2018.00278","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112313658","display_name":"Saori Inafuku","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saori Inafuku","raw_affiliation_strings":["Angiogenesis Laboratory, Massachusetts Eye & Ear Infirmary, Harvard Medical School, Harvard University, Boston, MA, United States","Department of Ophthalmology, Harvard Medical School, Harvard University, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Angiogenesis Laboratory, Massachusetts Eye & Ear Infirmary, Harvard Medical School, Harvard University, Boston, MA, United States","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Harvard University, Boston, MA, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017190724","display_name":"Garrett Klokman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garrett Klokman","raw_affiliation_strings":["Angiogenesis Laboratory, Massachusetts Eye & Ear Infirmary, Harvard Medical School, Harvard University, Boston, MA, United States","Department of Ophthalmology, Harvard Medical School, Harvard University, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Angiogenesis Laboratory, Massachusetts Eye & Ear Infirmary, Harvard Medical School, Harvard University, Boston, MA, United States","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Harvard University, Boston, MA, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025598941","display_name":"Kip M. Connor","orcid":"https://orcid.org/0000-0002-2048-9080","observed_orcids":["https://orcid.org/0000-0002-2048-9080"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kip M. Connor","raw_affiliation_strings":["Angiogenesis Laboratory, Massachusetts Eye & Ear Infirmary, Harvard Medical School, Harvard University, Boston, MA, United States","Department of Ophthalmology, Harvard Medical School, Harvard University, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Angiogenesis Laboratory, Massachusetts Eye & Ear Infirmary, Harvard Medical School, Harvard University, Boston, MA, United States","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Harvard University, Boston, MA, United States","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025598941"],"corresponding_institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.8598,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.69980295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"11","issue":null,"first_page":"278","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-ischemia-reperfusion-injury","display_name":"retinal ischemia-reperfusion injury","score":0.9200000166893005},{"id":"https://openalex.org/keywords/retinal-cell-death","display_name":"retinal cell death","score":0.8289999961853027},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7329999804496765},{"id":"https://openalex.org/keywords/complement-inhibitors","display_name":"complement inhibitors","score":0.9120000004768372},{"id":"https://openalex.org/keywords/crry","display_name":"Crry","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cd55","display_name":"CD55","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cd59","display_name":"CD59","score":0.8820000290870667},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.8399999737739563},{"id":"https://openalex.org/keywords/factor-b","display_name":"factor B","score":0.7649999856948853},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.8849999904632568},{"id":"https://openalex.org/keywords/retinal-endothelial-cells","display_name":"retinal endothelial cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.8669999837875366},{"id":"https://openalex.org/keywords/elevated-intraocular-pressure","display_name":"intraocular pressure elevation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.6316768527030945},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5695679187774658},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.5264618992805481},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.5258429646492004},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5076519250869751},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45587295293807983},{"id":"https://openalex.org/C189446657","wikidata":"https://www.wikidata.org/wiki/Q4736500","display_name":"Alternative complement pathway","level":4,"score":0.4511425495147705},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.43523871898651123},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4075056314468384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2737545073032379},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2500666081905365},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24398848414421082},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2221943736076355},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1618066132068634},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.12559393048286438},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09715282917022705},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08991566300392151},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fnmol.2018.00278","doi":"https://doi.org/10.3389/fnmol.2018.00278","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnmol.2018.00278","pdf_url":null,"source":{"id":"https://openalex.org/S39538987","display_name":"Frontiers in Molecular Neuroscience","issn_l":"1662-5099","issn":["1662-5099"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5071135","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6107794","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6107794","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6107794","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Mol Neurosci","raw_type":"Text"},{"id":"pmid:30174588","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30174588","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in molecular neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6762d3a5deff454aa4e7f6c27aa4ce39","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6762d3a5deff454aa4e7f6c27aa4ce39","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Molecular Neuroscience, Vol 11 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnmol.2018.00278","doi":"https://doi.org/10.3389/fnmol.2018.00278","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnmol.2018.00278","pdf_url":null,"source":{"id":"https://openalex.org/S39538987","display_name":"Frontiers in Molecular Neuroscience","issn_l":"1662-5099","issn":["1662-5099"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G181896260","display_name":"The Alternative Complement System Facilitates Photoreceptor Degeneration in Retinal Detachment.","funder_award_id":"R01EY027303","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320308990","display_name":"BrightFocus Foundation","ror":"https://ror.org/03cvfxv40"},{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320309699","display_name":"Massachusetts Eye and Ear","ror":"https://ror.org/04g3dn724"},{"id":"https://openalex.org/F4320310048","display_name":"Massachusetts Lions Eye Research Fund","ror":"https://ror.org/05hffq650"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W121687570","https://openalex.org/W165896879","https://openalex.org/W186909258","https://openalex.org/W315197452","https://openalex.org/W1548566724","https://openalex.org/W1567784487","https://openalex.org/W1575309759","https://openalex.org/W1872828694","https://openalex.org/W1962125373","https://openalex.org/W1970232820","https://openalex.org/W1970713994","https://openalex.org/W1982422365","https://openalex.org/W1987985147","https://openalex.org/W2000499695","https://openalex.org/W2002552106","https://openalex.org/W2003870922","https://openalex.org/W2017921168","https://openalex.org/W2018789868","https://openalex.org/W2025898860","https://openalex.org/W2033740198","https://openalex.org/W2036080352","https://openalex.org/W2037190876","https://openalex.org/W2038348237","https://openalex.org/W2044143665","https://openalex.org/W2044753638","https://openalex.org/W2046265102","https://openalex.org/W2053189438","https://openalex.org/W2065577350","https://openalex.org/W2065933951","https://openalex.org/W2067215757","https://openalex.org/W2073130618","https://openalex.org/W2083682299","https://openalex.org/W2088438479","https://openalex.org/W2097222143","https://openalex.org/W2115038361","https://openalex.org/W2122918206","https://openalex.org/W2123676709","https://openalex.org/W2124032393","https://openalex.org/W2133771754","https://openalex.org/W2135324460","https://openalex.org/W2136648677","https://openalex.org/W2139731074","https://openalex.org/W2144071044","https://openalex.org/W2147540865","https://openalex.org/W2147633142","https://openalex.org/W2152506674","https://openalex.org/W2157360196","https://openalex.org/W2166194629","https://openalex.org/W2167918140","https://openalex.org/W2168194514","https://openalex.org/W2200661509","https://openalex.org/W2247449597","https://openalex.org/W2269776196","https://openalex.org/W2510286362","https://openalex.org/W2560254576","https://openalex.org/W2594833125","https://openalex.org/W2728801906","https://openalex.org/W2740094142","https://openalex.org/W2751932016","https://openalex.org/W2764163227"],"related_works":["https://openalex.org/W2144071044","https://openalex.org/W2147540865","https://openalex.org/W2101802469","https://openalex.org/W4382751856","https://openalex.org/W2269776196","https://openalex.org/W1647697134","https://openalex.org/W1982713501","https://openalex.org/W72193801","https://openalex.org/W1996375241","https://openalex.org/W2889681846"],"abstract_inverted_index":{"Ischemia":[0],"reperfusion":[1],"(IR)":[2],"injury":[3,26],"induces":[4],"retinal":[5,63,74,90,105,110,154,179,216,223],"cell":[6,195,243],"death":[7],"and":[8,66,108,116,133,147,190,192,241],"contributes":[9],"to":[10,52,78,161,238],"visual":[11],"impairment.":[12],"Previous":[13],"studies":[14],"suggest":[15],"that":[16,121,198,221],"the":[17,32,35,39,55,71,86,94,104,167,215,226],"complement":[18,36,57,125,127,143,148,170,186,211,228,235],"cascade":[19,58],"plays":[20,59],"a":[21,60,172,199],"key":[22],"role":[23,33,61,168],"in":[24,27,38,62,76,171,206,222],"IR":[25,64,79,91,162,207,224],"several":[28],"systemic":[29],"diseases.":[30],"However,":[31],"of":[34,48,70,89,124,142,169,174,201,214,234],"pathway":[37,72],"ischemic":[40],"retina":[41],"has":[42],"not":[43],"been":[44],"investigated.":[45],"The":[46],"aim":[47],"this":[49],"study":[50],"is":[51,98,159,230],"determine":[53],"if":[54],"alternative":[56,227],"injury,":[65,92,163,208,225],"identify":[67],"which":[68],"components":[69],"mediate":[73],"degeneration":[75],"response":[77],"injury.":[80],"To":[81],"accomplish":[82],"this,":[83],"we":[84,164],"utilized":[85],"mouse":[87],"model":[88,173],"wherein":[93],"intraocular":[95],"pressure":[96],"(IOP)":[97],"elevated":[99],"for":[100,210],"45":[101],"minutes,":[102],"collapsing":[103],"blood":[106],"vessels":[107],"inducing":[109],"ischemia,":[111],"followed":[112],"by":[113,232],"IOP":[114],"normalization":[115],"subsequent":[117],"reperfusion.":[118],"We":[119],"found":[120],"mRNA":[122],"expression":[123],"inhibitors":[126,187],"receptor":[128],"1-related":[129],"gene/protein-y":[130],"(Crry),":[131],"Cd55":[132,189],"Cd59a":[134],"was":[135],"down-regulated":[136],"after":[137],"IR.":[138],"Moreover,":[139],"genetic":[140],"deletion":[141],"component":[144],"3":[145],"(C3-/-)":[146],"factor":[149],"b":[150],"(Fb-/-)":[151],"decreased":[152],"IR-induced":[153],"apoptosis.":[155],"Because":[156],"vascular":[157,202,239],"dysfunction":[158,240],"central":[160],"also":[165],"assessed":[166],"shear":[175,183],"stress.":[176],"In":[177],"human":[178],"endothelial":[180],"cells":[181],"(HRECs),":[182],"stress":[184],"up-regulated":[185],"Cd46,":[188],"Cd59,":[191],"suppressed":[193],"complement-mediated":[194],"death,":[196],"indicating":[197],"lack":[200],"flow,":[203],"commonly":[204],"observed":[205],"allows":[209],"mediated":[212],"attack":[213],"vasculature.":[217],"These":[218],"results":[219],"suggested":[220],"system":[229],"activated":[231],"suppression":[233],"inhibitors,":[236],"leading":[237],"neuronal":[242],"death.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2018-08-22T00:00:00"}