{"id":"https://openalex.org/W2887778708","doi":null,"title":"Neuronal circuits of experience-dependent plasticity in the primary visual cortex","display_name":"Neuronal circuits of experience-dependent plasticity in the primary visual cortex","publication_year":2018,"publication_date":"2018-07-10","ids":{"openalex":"https://openalex.org/W2887778708","mag":"2887778708"},"language":"en","primary_location":{"id":"pmh:oai:era.ed.ac.uk:1842/31234","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1842/31234","pdf_url":"https://era.ed.ac.uk/bitstream/1842/31234/1/Dylda2018.pdf","source":{"id":"https://openalex.org/S7407055182","display_name":"ERA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://era.ed.ac.uk/bitstream/1842/31234/1/Dylda2018.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060100640","display_name":"Evelyn Dylda","orcid":"https://orcid.org/0000-0002-1883-4498","observed_orcids":["https://orcid.org/0000-0002-1883-4498"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Evelyn Dylda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5060100640"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.05530000105500221,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/experience-dependent-plasticity","display_name":"experience-dependent plasticity","score":0.984000027179718},{"id":"https://openalex.org/keywords/primary-visual-cortex","display_name":"primary visual cortex","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adult-neuroplasticity","display_name":"adult neuroplasticity","score":0.7319999933242798},{"id":"https://openalex.org/keywords/neural-circuits","display_name":"neural circuits","score":0.49399998784065247},{"id":"https://openalex.org/keywords/inhibitory-interneurons","display_name":"inhibitory interneurons","score":0.8460000157356262},{"id":"https://openalex.org/keywords/layer-2-3","display_name":"layer 2/3","score":0.8420000076293945},{"id":"https://openalex.org/keywords/monocular-deprivation","display_name":"monocular deprivation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/intellectual-disability","display_name":"intellectual disability","score":0.9660000205039978},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.8379999995231628},{"id":"https://openalex.org/keywords/gcamp6s","display_name":"GCaMP6s","score":0.9139999747276306},{"id":"https://openalex.org/keywords/neuronal-network-activity","display_name":"neuronal network activity","score":0.5609999895095825},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.375}],"concepts":[{"id":"https://openalex.org/C2779345533","wikidata":"https://www.wikidata.org/wiki/Q75785","display_name":"Visual cortex","level":2,"score":0.8173519372940063},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7213302850723267},{"id":"https://openalex.org/C3018998897","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Neuronal circuits","level":2,"score":0.5451329350471497},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4809802770614624},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.4628863036632538},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.45822107791900635},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.45063748955726624},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.3572089970111847},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.337727427482605},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15095874667167664},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:era.ed.ac.uk:1842/31234","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1842/31234","pdf_url":"https://era.ed.ac.uk/bitstream/1842/31234/1/Dylda2018.pdf","source":{"id":"https://openalex.org/S7407055182","display_name":"ERA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},{"id":"mag:2887778708","doi":null,"is_oa":false,"landing_page_url":"https://era.ed.ac.uk/handle/1842/31234","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:era.ed.ac.uk:1842/31234","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1842/31234","pdf_url":"https://era.ed.ac.uk/bitstream/1842/31234/1/Dylda2018.pdf","source":{"id":"https://openalex.org/S7407055182","display_name":"ERA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2887778708.pdf","grobid_xml":"https://content.openalex.org/works/W2887778708.grobid-xml"},"referenced_works_count":226,"referenced_works":["https://openalex.org/W924980902","https://openalex.org/W1023621276","https://openalex.org/W1120647606","https://openalex.org/W1500368251","https://openalex.org/W1521319725","https://openalex.org/W1538429890","https://openalex.org/W1570674668","https://openalex.org/W1570971182","https://openalex.org/W1572640432","https://openalex.org/W1592304224","https://openalex.org/W1601798363","https://openalex.org/W1675937554","https://openalex.org/W1735514526","https://openalex.org/W1963557285","https://openalex.org/W1963742335","https://openalex.org/W1963769676","https://openalex.org/W1966187182","https://openalex.org/W1966403223","https://openalex.org/W1966867248","https://openalex.org/W1967580786","https://openalex.org/W1967944899","https://openalex.org/W1969469807","https://openalex.org/W1969997932","https://openalex.org/W1970328692","https://openalex.org/W1970719523","https://openalex.org/W1970789949","https://openalex.org/W1971604198","https://openalex.org/W1971638449","https://openalex.org/W1972161349","https://openalex.org/W1972543620","https://openalex.org/W1972869628","https://openalex.org/W1976310317","https://openalex.org/W1981507482","https://openalex.org/W1982785464","https://openalex.org/W1983122063","https://openalex.org/W1988387613","https://openalex.org/W1988928031","https://openalex.org/W1991262228","https://openalex.org/W1991444801","https://openalex.org/W1992910467","https://openalex.org/W1993355218","https://openalex.org/W1993505652","https://openalex.org/W1993514627","https://openalex.org/W1994193742","https://openalex.org/W1994681591","https://openalex.org/W1996168091","https://openalex.org/W1996856166","https://openalex.org/W1996938738","https://openalex.org/W1997221105","https://openalex.org/W2000666080","https://openalex.org/W2001328691","https://openalex.org/W2003958121","https://openalex.org/W2008058093","https://openalex.org/W2008372697","https://openalex.org/W2009759904","https://openalex.org/W2009855862","https://openalex.org/W2011973215","https://openalex.org/W2012147706","https://openalex.org/W2012491533","https://openalex.org/W2013377646","https://openalex.org/W2013422844","https://openalex.org/W2018085295","https://openalex.org/W2022387796","https://openalex.org/W2025520018","https://openalex.org/W2025603247","https://openalex.org/W2025931153","https://openalex.org/W2027220714","https://openalex.org/W2031485856","https://openalex.org/W2032554925","https://openalex.org/W2036021747","https://openalex.org/W2036168567","https://openalex.org/W2037299451","https://openalex.org/W2037969635","https://openalex.org/W2038171794","https://openalex.org/W2039814229","https://openalex.org/W2039881289","https://openalex.org/W2040165511","https://openalex.org/W2040709031","https://openalex.org/W2041060053","https://openalex.org/W2041373424","https://openalex.org/W2042662796","https://openalex.org/W2043480380","https://openalex.org/W2045914027","https://openalex.org/W2046170065","https://openalex.org/W2046426203","https://openalex.org/W2048245455","https://openalex.org/W2049610475","https://openalex.org/W2051423370","https://openalex.org/W2051526952","https://openalex.org/W2053130385","https://openalex.org/W2053738369","https://openalex.org/W2054282296","https://openalex.org/W2055725584","https://openalex.org/W2056786415","https://openalex.org/W2059337036","https://openalex.org/W2060412896","https://openalex.org/W2061363020","https://openalex.org/W2061619540","https://openalex.org/W2061893190","https://openalex.org/W2062986942","https://openalex.org/W2063640158","https://openalex.org/W2065286706","https://openalex.org/W2065623491","https://openalex.org/W2067134379","https://openalex.org/W2067486032","https://openalex.org/W2068364567","https://openalex.org/W2071689705","https://openalex.org/W2071941483","https://openalex.org/W2073472689","https://openalex.org/W2074623278","https://openalex.org/W2074702824","https://openalex.org/W2074967846","https://openalex.org/W2075312701","https://openalex.org/W2075361934","https://openalex.org/W2075364461","https://openalex.org/W2076017177","https://openalex.org/W2076168055","https://openalex.org/W2076687395","https://openalex.org/W2077374589","https://openalex.org/W2080275784","https://openalex.org/W2080351494","https://openalex.org/W2082188137","https://openalex.org/W2082627290","https://openalex.org/W2082783931","https://openalex.org/W2082905404","https://openalex.org/W2083060092","https://openalex.org/W2084615691","https://openalex.org/W2085768069","https://openalex.org/W2086338669","https://openalex.org/W2086871516","https://openalex.org/W2088928947","https://openalex.org/W2089242029","https://openalex.org/W2089823661","https://openalex.org/W2090206974","https://openalex.org/W2091116794","https://openalex.org/W2091823477","https://openalex.org/W2094045132","https://openalex.org/W2095421300","https://openalex.org/W2095691290","https://openalex.org/W2097237250","https://openalex.org/W2097532290","https://openalex.org/W2099525751","https://openalex.org/W2100171700","https://openalex.org/W2101574677","https://openalex.org/W2101626807","https://openalex.org/W2102422690","https://openalex.org/W2103775384","https://openalex.org/W2104508398","https://openalex.org/W2105805026","https://openalex.org/W2108488213","https://openalex.org/W2110313696","https://openalex.org/W2111587484","https://openalex.org/W2112541959","https://openalex.org/W2114350859","https://openalex.org/W2116679324","https://openalex.org/W2117940227","https://openalex.org/W2117957894","https://openalex.org/W2119119716","https://openalex.org/W2120795742","https://openalex.org/W2122489540","https://openalex.org/W2125527423","https://openalex.org/W2128840781","https://openalex.org/W2134494361","https://openalex.org/W2135238780","https://openalex.org/W2136008443","https://openalex.org/W2136592997","https://openalex.org/W2141847684","https://openalex.org/W2142467832","https://openalex.org/W2143886954","https://openalex.org/W2145255740","https://openalex.org/W2146257965","https://openalex.org/W2147607085","https://openalex.org/W2149561999","https://openalex.org/W2150951291","https://openalex.org/W2151464048","https://openalex.org/W2156780983","https://openalex.org/W2156874940","https://openalex.org/W2159619720","https://openalex.org/W2160094115","https://openalex.org/W2162507760","https://openalex.org/W2162860740","https://openalex.org/W2163636352","https://openalex.org/W2165462647","https://openalex.org/W2165685007","https://openalex.org/W2167460696","https://openalex.org/W2170397258","https://openalex.org/W2171332611","https://openalex.org/W2177262298","https://openalex.org/W2209706276","https://openalex.org/W2231009150","https://openalex.org/W2279702079","https://openalex.org/W2291957660","https://openalex.org/W2293414805","https://openalex.org/W2322893097","https://openalex.org/W2394641095","https://openalex.org/W2411028560","https://openalex.org/W2413686208","https://openalex.org/W2461298255","https://openalex.org/W2469581795","https://openalex.org/W2472683490","https://openalex.org/W2502163955","https://openalex.org/W2503929286","https://openalex.org/W2514452543","https://openalex.org/W2514946553","https://openalex.org/W2515318112","https://openalex.org/W2517589701","https://openalex.org/W2520592730","https://openalex.org/W2522229132","https://openalex.org/W2533568726","https://openalex.org/W2542327379","https://openalex.org/W2553225945","https://openalex.org/W2576309903","https://openalex.org/W2595012769","https://openalex.org/W2609336947","https://openalex.org/W2610474559","https://openalex.org/W2616960090","https://openalex.org/W2622256805","https://openalex.org/W2737137727","https://openalex.org/W2766767707","https://openalex.org/W2770732581","https://openalex.org/W2794648976","https://openalex.org/W2912696234","https://openalex.org/W2950893325","https://openalex.org/W2951631742","https://openalex.org/W4210574564","https://openalex.org/W4294214781"],"related_works":["https://openalex.org/W7132943769","https://openalex.org/W2074702824","https://openalex.org/W2005488274","https://openalex.org/W2889498516","https://openalex.org/W7112206932","https://openalex.org/W6986455779","https://openalex.org/W3045861595","https://openalex.org/W2740162770","https://openalex.org/W4409380732","https://openalex.org/W3150935825"],"abstract_inverted_index":{"Our":[0,234],"ability":[1],"to":[2,11,143,155,162,168,218,224,284],"learn":[3],"relies":[4],"on":[5,203],"the":[6,56,68,74,113,123,132,145,165,181,209,281,328,339],"potential":[7],"of":[8,70,103,116,125,134,147,149,183,188,192,198,251,270,294,314,330],"neuronal":[9,31,53,104,177,231,242,344,359,389],"networks":[10],"change":[12],"through":[13],"experience.":[14],"The":[15],"primary":[16],"visual":[17,71],"cortex":[18],"(V1)":[19],"has":[20,37,334],"become":[21],"a":[22,94,126,204,220,225,249,267,291,308,320],"popular":[23],"system":[24],"for":[25,100,112,122,131,323],"studying":[26],"how":[27,65],"experience":[28],"shapes":[29],"cortical":[30,388],"networks.":[32],"Experience-dependent":[33],"plasticity":[34,81,253,289],"in":[35,41,47,55,73,85,106,175,195,241,254,264,273,287,290,347,357,366,377,387,398],"V1":[36,176],"been":[38,335],"extensively":[39],"studied":[40,337],"young":[42],"animals,":[43],"revealing":[44],"that":[45,214],"experiences":[46,66],"early":[48],"postnatal":[49],"life":[50],"substantially":[51],"shape":[52],"activity":[54,105,146,182,271,360,380,391],"developing":[57],"cortex.":[58],"In":[59,77,352],"contrast,":[60],"less":[61],"is":[62,307,318],"known":[63],"about":[64],"modify":[67],"representation":[69],"stimuli":[72],"adult":[75,79,199,367],"brain.":[76],"addition,":[78],"experience-dependent":[80,173,288],"remains":[82],"largely":[83,350],"unexplored":[84],"neurodevelopmental":[86],"disorders.":[87,326],"To":[88],"address":[89],"this":[90,160,353],"issue,":[91],"we":[92,259,355],"established":[93],"two-photon":[95],"calcium":[96,119,136],"imaging":[97,102,137],"set-up,":[98],"suitable":[99],"chronic":[101,127,135],"awake-behaving":[107],"mice.":[108],"We":[109,158,179,207,278],"implemented":[110],"protocols":[111],"reliable":[114],"expression":[115],"genetically":[117],"encoded":[118],"indicators":[120],"(GCaMP6),":[121],"implantation":[124],"cranial":[128],"window":[129],"and":[130,153,187,228,262,317,341,362,370,395],"analysis":[133],"data.":[138],"This":[139],"approach":[140],"enables":[141],"us":[142],"monitor":[144],"hundreds":[148],"neurons":[150,186],"across":[151],"days,":[152],"up":[154],"4-5":[156],"weeks.":[157],"used":[159],"technique":[161],"determine":[163],"whether":[164],"daily":[166,217],"exposure":[167],"high-contrast":[169,221],"gratings":[170],"would":[171],"induce":[172],"changes":[174,272],"activity.":[178],"monitored":[180],"putative":[184],"excitatory":[185],"three":[189],"non-overlapping":[190],"populations":[191],"inhibitory":[193],"interneurons":[194],"layer":[196],"2/3":[197],"mice":[200,213,369],"freely":[201],"running":[202],"cylindrical":[205],"treadmill.":[206],"compared":[208,356],"results":[210,235,374],"obtained":[211],"from":[212],"were":[215],"exposed":[216],"either":[219],"grating":[222],"or":[223],"grey":[226],"screen":[227],"characterized":[229],"their":[230],"response":[232],"properties.":[233],"did":[236,260],"not":[237],"reveal":[238],"significant":[239],"differences":[240,376],"properties":[243],"between":[244,381],"these":[245],"two":[246],"groups,":[247,266],"suggesting":[248],"lack":[250],"stimulus-specific":[252],"our":[255],"experimental":[256,383],"conditions.":[257],"However,":[258],"observe":[261],"characterize,":[263],"both":[265,382],"wide":[268],"range":[269],"individual":[274],"cells":[275],"over":[276],"time.":[277],"finally":[279],"applied":[280],"same":[282],"method":[283],"investigate":[285],"impairments":[286,386],"mouse":[292],"model":[293],"intellectual":[295],"disability":[296],"(ID),":[297],"caused":[298],"by":[299],"synaptic":[300],"GTPase-activating":[301],"protein":[302],"(SynGAP)":[303],"haploinsufficiency.":[304],"SynGAP":[305],"haploinsufficiency":[306],"common":[309],"de":[310],"novo":[311],"genetic":[312],"cause":[313],"non-syndromic":[315],"ID":[316],"considered":[319],"Type1":[321],"risk":[322],"autism":[324],"spectrum":[325],"While":[327],"impact":[329],"Syngap":[331,401],"gene":[332,402],"mutations":[333],"thoroughly":[336],"at":[338],"molecular":[340],"cellular":[342],"levels,":[343],"network":[345,379,390],"deficits":[346,397],"vivo":[348,358],"remain":[349],"unexplored.":[351],"study,":[354],"before":[361],"after":[363],"monocular":[364],"deprivation":[365],"mutant":[368],"littermate":[371],"controls.":[372],"These":[373,385],"revealed":[375],"baseline":[378],"groups.":[384],"may":[392],"underlie":[393],"sensory":[394],"cognitive":[396],"patients":[399],"with":[400],"mutations.":[403]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-08-22T00:00:00"}
