{"id":"https://openalex.org/W2887729068","doi":"https://doi.org/10.15252/emmm.201708552","title":"Comprehensive evaluation of coding region point mutations in microsatellite\u2010unstable colorectal cancer","display_name":"Comprehensive evaluation of coding region point mutations in microsatellite\u2010unstable colorectal cancer","publication_year":2018,"publication_date":"2018-08-14","ids":{"openalex":"https://openalex.org/W2887729068","doi":"https://doi.org/10.15252/emmm.201708552","mag":"2887729068","pmid":"https://pubmed.ncbi.nlm.nih.gov/30108113"},"language":"en","primary_location":{"id":"doi:10.15252/emmm.201708552","doi":"https://doi.org/10.15252/emmm.201708552","is_oa":true,"landing_page_url":"https://doi.org/10.15252/emmm.201708552","pdf_url":"https://link.springer.com/content/pdf/10.15252/emmm.201708552.pdf","source":{"id":"https://openalex.org/S163075119","display_name":"EMBO Molecular Medicine","issn_l":"1757-4676","issn":["1757-4676","1757-4684"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.15252/emmm.201708552.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086751949","display_name":"Johanna Kondelin","orcid":"https://orcid.org/0000-0001-9160-0703","observed_orcids":["https://orcid.org/0000-0001-9160-0703"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Johanna Kondelin","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088991911","display_name":"Kari Salokas","orcid":"https://orcid.org/0000-0002-4471-6698","observed_orcids":["https://orcid.org/0000-0002-4471-6698"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":null,"type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kari Salokas","raw_affiliation_strings":["Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","Institute of Biotechnology, University of Helsinki, Helsinki, Finland","Helsinki Institute of Life Science University of Helsinki Helsinki Finland","Institute of Biotechnology University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"Institute of Biotechnology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Helsinki Institute of Life Science University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"Institute of Biotechnology University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112045631","display_name":"Lilli Saarinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Lilli Saarinen","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085480634","display_name":"Kristian Ovaska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kristian Ovaska","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089183453","display_name":"Heli Rauanheimo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Heli Rauanheimo","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073579492","display_name":"Roosa\u2010Maria Plaketti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Roosa\u2010Maria Plaketti","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083013099","display_name":"Jiri Hamberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jiri Hamberg","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010734018","display_name":"Xiaonan Liu","orcid":"https://orcid.org/0000-0002-9600-0536","observed_orcids":["https://orcid.org/0000-0002-9600-0536"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":null,"type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Xiaonan Liu","raw_affiliation_strings":["Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","Institute of Biotechnology, University of Helsinki, Helsinki, Finland","Helsinki Institute of Life Science University of Helsinki Helsinki Finland","Institute of Biotechnology University of Helsinki Helsinki Finland"],"raw_orcid":"https://orcid.org/0000-0002-9600-0536","affiliations":[{"raw_affiliation_string":"Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"Institute of Biotechnology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Helsinki Institute of Life Science University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"Institute of Biotechnology University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046429866","display_name":"Leena Yadav","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":null,"type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Leena Yadav","raw_affiliation_strings":["Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","Institute of Biotechnology, University of Helsinki, Helsinki, Finland","Helsinki Institute of Life Science University of Helsinki Helsinki Finland","Institute of Biotechnology University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"Institute of Biotechnology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Helsinki Institute of Life Science University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"Institute of Biotechnology University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079343886","display_name":"Alexandra E. Gylfe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Alexandra E Gylfe","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018822795","display_name":"Tatiana Cajuso","orcid":"https://orcid.org/0000-0002-6354-5572","observed_orcids":["https://orcid.org/0000-0002-6354-5572"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tatiana Cajuso","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077508282","display_name":"Ulrika A. H\u00e4nninen","orcid":"https://orcid.org/0000-0003-1558-0450","observed_orcids":["https://orcid.org/0000-0003-1558-0450"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ulrika A H\u00e4nninen","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011030520","display_name":"Kimmo Palin","orcid":"https://orcid.org/0000-0002-4621-6128","observed_orcids":["https://orcid.org/0000-0002-4621-6128"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kimmo Palin","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020372678","display_name":"Heikki Ristolainen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Heikki Ristolainen","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062137975","display_name":"Riku Katainen","orcid":"https://orcid.org/0000-0003-4575-4239","observed_orcids":["https://orcid.org/0000-0003-4575-4239"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Riku Katainen","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079139506","display_name":"Eevi Kaasinen","orcid":"https://orcid.org/0000-0002-1333-8049","observed_orcids":["https://orcid.org/0000-0002-1333-8049"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Eevi Kaasinen","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040662921","display_name":"Tomas J. Tanskanen","orcid":"https://orcid.org/0000-0002-4541-1810","observed_orcids":["https://orcid.org/0000-0002-4541-1810"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tomas Tanskanen","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063496761","display_name":"Mervi Aavikko","orcid":"https://orcid.org/0000-0003-2583-0150","observed_orcids":["https://orcid.org/0000-0003-2583-0150"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mervi Aavikko","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018858408","display_name":"Minna Taipale","orcid":"https://orcid.org/0000-0002-1905-2551","observed_orcids":["https://orcid.org/0000-0002-1905-2551"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Minna Taipale","raw_affiliation_strings":["Division of Functional Genomics, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, Stockholm, Sweden","Division of Functional Genomics Department of Medical Biochemistry and Biophysics (MBB) Karolinska Institutet Stockholm Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Functional Genomics, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Division of Functional Genomics Department of Medical Biochemistry and Biophysics (MBB) Karolinska Institutet Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031611528","display_name":"Jussi Taipale","orcid":"https://orcid.org/0000-0003-4204-0951","observed_orcids":["https://orcid.org/0000-0003-4204-0951"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Jussi Taipale","raw_affiliation_strings":["Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden","Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Science for Life Center, Huddinge, Sweden","Department of Biosciences and Nutrition Karolinska Institutet Huddinge Sweden","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","Science for Life Center Huddinge Sweden"],"raw_orcid":"https://orcid.org/0000-0003-4204-0951","affiliations":[{"raw_affiliation_string":"Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Science for Life Center, Huddinge, Sweden","institution_ids":[]},{"raw_affiliation_string":"Department of Biosciences and Nutrition Karolinska Institutet Huddinge Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Science for Life Center Huddinge Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029377505","display_name":"Laura Renkonen\u2010Sinisalo","orcid":"https://orcid.org/0000-0002-3122-5312","observed_orcids":["https://orcid.org/0000-0002-3122-5312"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210166427","display_name":"Hospital District of Helsinki and Uusimaa","ror":"https://ror.org/020cpqb94","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Laura Renkonen\u2010Sinisalo","raw_affiliation_strings":["Department of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Helsinki, Finland","Department of Surgery Helsinki University Central Hospital Hospital District of Helsinki and Uusimaa Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"raw_affiliation_string":"Department of Surgery Helsinki University Central Hospital Hospital District of Helsinki and Uusimaa Helsinki Finland","institution_ids":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043808545","display_name":"Anna Lepist\u00f6","orcid":"https://orcid.org/0000-0002-5866-4059","observed_orcids":["https://orcid.org/0000-0002-5866-4059"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210166427","display_name":"Hospital District of Helsinki and Uusimaa","ror":"https://ror.org/020cpqb94","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Anna Lepist\u00f6","raw_affiliation_strings":["Department of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Helsinki, Finland","Department of Surgery Helsinki University Central Hospital Hospital District of Helsinki and Uusimaa Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"raw_affiliation_string":"Department of Surgery Helsinki University Central Hospital Hospital District of Helsinki and Uusimaa Helsinki Finland","institution_ids":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070416118","display_name":"Selja Koskensalo","orcid":"https://orcid.org/0000-0001-6959-8715","observed_orcids":["https://orcid.org/0000-0001-6959-8715"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Selja Koskensalo","raw_affiliation_strings":["The HUCH Gastrointestinal Clinic, Helsinki University Central Hospital, Helsinki, Finland","The HUCH Gastrointestinal Clinic Helsinki University Central Hospital Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The HUCH Gastrointestinal Clinic, Helsinki University Central Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"The HUCH Gastrointestinal Clinic Helsinki University Central Hospital Helsinki Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019439765","display_name":"Jan B\u00f6hm","orcid":"https://orcid.org/0000-0001-9664-588X","observed_orcids":["https://orcid.org/0000-0001-9664-588X"]},"institutions":[{"id":"https://openalex.org/I4210140036","display_name":"Central Finland Health Care District","ror":"https://ror.org/054h11b04","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210140036"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jan B\u00f6hm","raw_affiliation_strings":["Department of Pathology, Jyv\u00e4skyl\u00e4 Central Hospital, Jyv\u00e4skyl\u00e4, Finland","Department of Pathology Jyv\u00e4skyl\u00e4 Central Hospital Jyv\u00e4skyl\u00e4 Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Jyv\u00e4skyl\u00e4 Central Hospital, Jyv\u00e4skyl\u00e4, Finland","institution_ids":["https://openalex.org/I4210140036"]},{"raw_affiliation_string":"Department of Pathology Jyv\u00e4skyl\u00e4 Central Hospital Jyv\u00e4skyl\u00e4 Finland","institution_ids":["https://openalex.org/I4210140036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063360662","display_name":"Jukka\u2010Pekka Mecklin","orcid":"https://orcid.org/0000-0003-4895-2249","observed_orcids":["https://orcid.org/0000-0003-4895-2249"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I94722563","display_name":"University of Jyv\u00e4skyl\u00e4","ror":"https://ror.org/05n3dz165","country_code":"FI","type":"education","lineage":["https://openalex.org/I94722563"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jukka\u2010Pekka Mecklin","raw_affiliation_strings":["Department Sport and Health Sciences, University of Jyv\u00e4skyl\u00e4, Jyv\u00e4skyl\u00e4, Finland","Department of Surgery, Jyv\u00e4skyl\u00e4 Central Hospital, University of Eastern Finland, Jyv\u00e4skyl\u00e4, Finland","Department Sport and Health Sciences University of Jyv\u00e4skyl\u00e4 Jyv\u00e4skyl\u00e4 Finland","Department of Surgery Jyv\u00e4skyl\u00e4 Central Hospital University of Eastern Finland Jyv\u00e4skyl\u00e4 Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Sport and Health Sciences, University of Jyv\u00e4skyl\u00e4, Jyv\u00e4skyl\u00e4, Finland","institution_ids":["https://openalex.org/I94722563"]},{"raw_affiliation_string":"Department of Surgery, Jyv\u00e4skyl\u00e4 Central Hospital, University of Eastern Finland, Jyv\u00e4skyl\u00e4, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department Sport and Health Sciences University of Jyv\u00e4skyl\u00e4 Jyv\u00e4skyl\u00e4 Finland","institution_ids":["https://openalex.org/I94722563"]},{"raw_affiliation_string":"Department of Surgery Jyv\u00e4skyl\u00e4 Central Hospital University of Eastern Finland Jyv\u00e4skyl\u00e4 Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063597148","display_name":"Halit Ongen","orcid":"https://orcid.org/0000-0002-4197-5790","observed_orcids":["https://orcid.org/0000-0002-4197-5790"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I4405280432","display_name":"Institute of Genetics and Genomics in Geneva","ror":"https://ror.org/02xybgt43","country_code":"CH","type":"facility","lineage":["https://openalex.org/I114457229","https://openalex.org/I4405280432"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Halit Ongen","raw_affiliation_strings":["Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland","Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland","Swiss Institute of Bioinformatics, Geneva, Switzerland","Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland","Institute for Genetics and Genomics in Geneva (iGE3) University of Geneva Geneva Switzerland","Swiss Institute of Bioinformatics Geneva Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4405280432"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Geneva, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Institute for Genetics and Genomics in Geneva (iGE3) University of Geneva Geneva Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4405280432"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics Geneva Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084258150","display_name":"Emmanouil T. Dermitzakis","orcid":"https://orcid.org/0000-0002-9302-6490","observed_orcids":["https://orcid.org/0000-0002-9302-6490"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I4405280432","display_name":"Institute of Genetics and Genomics in Geneva","ror":"https://ror.org/02xybgt43","country_code":"CH","type":"facility","lineage":["https://openalex.org/I114457229","https://openalex.org/I4405280432"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Emmanouil T Dermitzakis","raw_affiliation_strings":["Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland","Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland","Swiss Institute of Bioinformatics, Geneva, Switzerland","Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland","Institute for Genetics and Genomics in Geneva (iGE3) University of Geneva Geneva Switzerland","Swiss Institute of Bioinformatics Geneva Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4405280432"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Geneva, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Institute for Genetics and Genomics in Geneva (iGE3) University of Geneva Geneva Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4405280432"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics Geneva Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064183750","display_name":"Outi Kilpivaara","orcid":"https://orcid.org/0000-0001-8467-2100","observed_orcids":["https://orcid.org/0000-0001-8467-2100"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Outi Kilpivaara","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035432984","display_name":"Pia Vahteristo","orcid":"https://orcid.org/0000-0002-4615-3825","observed_orcids":["https://orcid.org/0000-0002-4615-3825"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pia Vahteristo","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032755735","display_name":"Mikko M. Turunen","orcid":"https://orcid.org/0000-0001-5134-1559","observed_orcids":["https://orcid.org/0000-0001-5134-1559"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mikko Turunen","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033102814","display_name":"Sampsa Hautaniemi","orcid":"https://orcid.org/0000-0002-7749-2694","observed_orcids":["https://orcid.org/0000-0002-7749-2694"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sampsa Hautaniemi","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049996829","display_name":"Sari Tuupanen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sari Tuupanen","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011100591","display_name":"Auli Karhu","orcid":"https://orcid.org/0000-0002-7927-0796","observed_orcids":["https://orcid.org/0000-0002-7927-0796"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Auli Karhu","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070318939","display_name":"Niko V\u00e4lim\u00e4ki","orcid":"https://orcid.org/0000-0001-9200-9560","observed_orcids":["https://orcid.org/0000-0001-9200-9560"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Niko V\u00e4lim\u00e4ki","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088559880","display_name":"Markku T Varjosalo","orcid":"https://orcid.org/0000-0002-1340-9732","observed_orcids":["https://orcid.org/0000-0002-1340-9732"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":null,"type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Markku Varjosalo","raw_affiliation_strings":["Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","Institute of Biotechnology, University of Helsinki, Helsinki, Finland","Helsinki Institute of Life Science University of Helsinki Helsinki Finland","Institute of Biotechnology University of Helsinki Helsinki Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"Institute of Biotechnology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Helsinki Institute of Life Science University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"Institute of Biotechnology University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004439161","display_name":"Esa Pitk\u00e4nen","orcid":"https://orcid.org/0000-0002-9818-6370","observed_orcids":["https://orcid.org/0000-0002-9818-6370"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Esa Pitk\u00e4nen","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":"https://orcid.org/0000-0002-9818-6370","affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028725974","display_name":"Lauri A. Aaltonen","orcid":"https://orcid.org/0000-0001-6839-4286","observed_orcids":["https://orcid.org/0000-0001-6839-4286"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Lauri A Aaltonen","raw_affiliation_strings":["Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland lauri.aaltonen@helsinki.fi","Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland"],"raw_orcid":"https://orcid.org/0000-0001-6839-4286","affiliations":[{"raw_affiliation_string":"Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland lauri.aaltonen@helsinki.fi","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Genome-Scale Biology Research Program Research Programs Unit University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Medicum/Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5028725974"],"corresponding_institution_ids":["https://openalex.org/I133731052"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":{"value":7990,"currency":"USD","value_usd":7990},"fwci":0.9646,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.74771872,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"10","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.9589999914169312},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/somatic-point-mutations","display_name":"somatic point mutations","score":0.9470000267028809},{"id":"https://openalex.org/keywords/driver-genes","display_name":"driver genes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/mutsigcv","display_name":"MutSigCV","score":0.949999988079071},{"id":"https://openalex.org/keywords/smarcb1","display_name":"SMARCB1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7450000047683716},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.7037019729614258},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.701575517654419},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.639761745929718},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.628042995929718},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.5255737900733948},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5196493864059448},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47203174233436584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46868446469306946},{"id":"https://openalex.org/C179518139","wikidata":"https://www.wikidata.org/wiki/Q5140297","display_name":"Coding (social sciences)","level":2,"score":0.4162830412387848},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.37262603640556335},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3663730025291443},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3356599807739258},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28982728719711304},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13049089908599854},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.07394054532051086},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.07281726598739624}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053842","descriptor_name":"Microsatellite Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053842","descriptor_name":"Microsatellite Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053842","descriptor_name":"Microsatellite Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.15252/emmm.201708552","doi":"https://doi.org/10.15252/emmm.201708552","is_oa":true,"landing_page_url":"https://doi.org/10.15252/emmm.201708552","pdf_url":"https://link.springer.com/content/pdf/10.15252/emmm.201708552.pdf","source":{"id":"https://openalex.org/S163075119","display_name":"EMBO Molecular Medicine","issn_l":"1757-4676","issn":["1757-4676","1757-4684"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:30108113","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30108113","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:unige.ch:aou:unige:120174","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:120174","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 1757-4676","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:jyx.jyu.fi:123456789/59309","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:NBN:fi:jyu-201808213897","pdf_url":"http://urn.fi/URN:NBN:fi:jyu-201808213897","source":{"id":"https://openalex.org/S4306400563","display_name":"Jyv\u00e4skyl\u00e4 University Digital Archive (University of Jyv\u00e4skyl\u00e4)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I94722563","host_organization_name":"University of Jyv\u00e4skyl\u00e4","host_organization_lineage":["https://openalex.org/I94722563"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"research article"},{"id":"pmh:oai:erepo.uef.fi:123456789/6842","doi":null,"is_oa":true,"landing_page_url":"https://erepo.uef.fi/handle/123456789/6842","pdf_url":"https://erepo.uef.fi/bitstreams/de8fc56b-a08a-40b2-8096-940ed128b9a9/download","source":{"id":"https://openalex.org/S4306402418","display_name":"UEF eRepo (University of Eastern Finland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I175532246","host_organization_name":"University of Eastern Finland","host_organization_lineage":["https://openalex.org/I175532246"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:5405241","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6402450","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6402450","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6402450","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EMBO Mol Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ef342cd752574cf1b549cf1e60ecdf37","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ef342cd752574cf1b549cf1e60ecdf37","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EMBO Molecular Medicine, Vol 10, Iss 9, Pp 1-20 (2018)","raw_type":"article"},{"id":"pmh:oai:helda.helsinki.fi:10138/299729","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/299729","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:unige.ch:unige:120174","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:120174","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1757-4676","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/293417","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/293417","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.40569","doi":"https://doi.org/10.17863/cam.40569","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.40569","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.15252/emmm.201708552","doi":"https://doi.org/10.15252/emmm.201708552","is_oa":true,"landing_page_url":"https://doi.org/10.15252/emmm.201708552","pdf_url":"https://link.springer.com/content/pdf/10.15252/emmm.201708552.pdf","source":{"id":"https://openalex.org/S163075119","display_name":"EMBO Molecular Medicine","issn_l":"1757-4676","issn":["1757-4676","1757-4684"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1019374866","display_name":null,"funder_award_id":"HL 102923","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1076600624","display_name":null,"funder_award_id":"20122017","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G1337588488","display_name":null,"funder_award_id":"250345","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G140944187","display_name":null,"funder_award_id":"HL-102924","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2032172404","display_name":null,"funder_award_id":"HL-102925","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3187257985","display_name":null,"funder_award_id":"#250345","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G4321129689","display_name":null,"funder_award_id":"UK10K","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G475171617","display_name":null,"funder_award_id":"HL 103010","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5794705214","display_name":null,"funder_award_id":"312041","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G7652945577","display_name":null,"funder_award_id":"294173","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G843766559","display_name":null,"funder_award_id":"HL-102926","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8491121283","display_name":null,"funder_award_id":"WT091310","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320309952","display_name":"Ida Montinin S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0269hs475"},{"id":"https://openalex.org/F4320310086","display_name":"Helsingin Yliopisto","ror":"https://ror.org/040af2s02"},{"id":"https://openalex.org/F4320311810","display_name":"Maud Kuistilan Muistos\u00e4\u00e4ti\u00f6","ror":"https://ror.org/05xs6nw18"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320322135","display_name":"Biomedicum Helsinki-s\u00e4\u00e4ti\u00f6","ror":"https://ror.org/02e8hzf44"},{"id":"https://openalex.org/F4320322282","display_name":"Jane ja Aatos Erkon S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/03vxy9y38"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320322861","display_name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/005rt3g54"},{"id":"https://openalex.org/F4320322905","display_name":"Samfundet Folkh\u00e4lsan","ror":"https://ror.org/05xznzw56"},{"id":"https://openalex.org/F4320323423","display_name":"Oskar \u00d6flunds Stiftelse","ror":"https://ror.org/0446gjc92"},{"id":"https://openalex.org/F4320324148","display_name":"Orionin Tutkimuss\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0296s4x19"},{"id":"https://openalex.org/F4320327840","display_name":"Otto A. Malm Lahjoitusrahasto","ror":"https://ror.org/05srazs86"},{"id":"https://openalex.org/F4320333873","display_name":"Helsinki Institute of Life Science, Helsingin Yliopisto","ror":"https://ror.org/018bh0m68"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2887729068.pdf","grobid_xml":"https://content.openalex.org/works/W2887729068.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W1482498530","https://openalex.org/W1565385417","https://openalex.org/W1596380405","https://openalex.org/W1864290935","https://openalex.org/W1907599506","https://openalex.org/W1919257374","https://openalex.org/W1965948555","https://openalex.org/W1967559370","https://openalex.org/W1969453178","https://openalex.org/W1975635514","https://openalex.org/W1976760549","https://openalex.org/W1977688889","https://openalex.org/W1984068087","https://openalex.org/W1985035689","https://openalex.org/W1992876087","https://openalex.org/W1998593414","https://openalex.org/W2000647043","https://openalex.org/W2003132497","https://openalex.org/W2009720434","https://openalex.org/W2010053675","https://openalex.org/W2011115717","https://openalex.org/W2012673284","https://openalex.org/W2016991737","https://openalex.org/W2023124677","https://openalex.org/W2025221656","https://openalex.org/W2032484783","https://openalex.org/W2036298102","https://openalex.org/W2042962536","https://openalex.org/W2044433401","https://openalex.org/W2047077861","https://openalex.org/W2047425230","https://openalex.org/W2054094290","https://openalex.org/W2064423959","https://openalex.org/W2068077839","https://openalex.org/W2075914357","https://openalex.org/W2076721268","https://openalex.org/W2077059059","https://openalex.org/W2081094927","https://openalex.org/W2081530009","https://openalex.org/W2083457841","https://openalex.org/W2085289502","https://openalex.org/W2094390470","https://openalex.org/W2095680943","https://openalex.org/W2099761160","https://openalex.org/W2101425604","https://openalex.org/W2105047045","https://openalex.org/W2105707485","https://openalex.org/W2106787323","https://openalex.org/W2111916909","https://openalex.org/W2114248087","https://openalex.org/W2117275311","https://openalex.org/W2118151336","https://openalex.org/W2120375519","https://openalex.org/W2122683600","https://openalex.org/W2128140173","https://openalex.org/W2132629607","https://openalex.org/W2134626691","https://openalex.org/W2135535735","https://openalex.org/W2138723913","https://openalex.org/W2147804812","https://openalex.org/W2148043260","https://openalex.org/W2150625137","https://openalex.org/W2152061559","https://openalex.org/W2152921920","https://openalex.org/W2154546296","https://openalex.org/W2155201844","https://openalex.org/W2156166905","https://openalex.org/W2158197251","https://openalex.org/W2158217645","https://openalex.org/W2159675211","https://openalex.org/W2160517146","https://openalex.org/W2163188200","https://openalex.org/W2166800162","https://openalex.org/W2167844024","https://openalex.org/W2170617996","https://openalex.org/W2223413920","https://openalex.org/W2223724347","https://openalex.org/W2224056471","https://openalex.org/W2256016639","https://openalex.org/W2262414037","https://openalex.org/W2267831227","https://openalex.org/W2311960695","https://openalex.org/W2364449803","https://openalex.org/W2436745791","https://openalex.org/W2460529418","https://openalex.org/W2508780522","https://openalex.org/W2557187647","https://openalex.org/W2597030906","https://openalex.org/W2620040328","https://openalex.org/W2625789005","https://openalex.org/W2756405493","https://openalex.org/W2783674686","https://openalex.org/W2789251983","https://openalex.org/W2789646648","https://openalex.org/W2953390364","https://openalex.org/W4300196896"],"related_works":["https://openalex.org/W2412807156","https://openalex.org/W2081783593","https://openalex.org/W2029130118","https://openalex.org/W1654308148","https://openalex.org/W2981371073","https://openalex.org/W2067665082","https://openalex.org/W2473005840","https://openalex.org/W2969016060","https://openalex.org/W1982747239","https://openalex.org/W4389733843"],"abstract_inverted_index":{"Abstract":[0],"Microsatellite":[1],"instability":[2],"(MSI)":[3],"leads":[4],"to":[5,141,147],"accumulation":[6],"of":[7,11,162],"an":[8,71],"excessive":[9],"number":[10],"mutations":[12,30,51,168],"in":[13,52,109,169],"the":[14,79],"genome,":[15],"mostly":[16],"small":[17],"insertions":[18],"and":[19,67,89,92,98,124,153],"deletions.":[20],"MSI":[21,53,87,96,112,120],"colorectal":[22],"cancers":[23],"(CRCs),":[24],"however,":[25],"also":[26,157],"contain":[27],"more":[28],"point":[29,50,75],"than":[31],"microsatellite\u2010stable":[32],"(MSS)":[33],"tumors,":[34],"yet":[35],"they":[36],"have":[37,140],"not":[38,144],"been":[39,145],"as":[40,134,136],"comprehensively":[41],"studied.":[42],"To":[43],"identify":[44],"candidate":[45,132],"driver":[46,122],"genes":[47,57,106,123,133,138],"affected":[48],"by":[49],"CRC,":[54],"we":[55],"ranked":[56],"based":[58],"on":[59],"mutation":[60,76],"significance":[61],"while":[62],"correcting":[63],"for":[64,128,166],"replication":[65],"timing":[66],"gene":[68],"expression":[69],"utilizing":[70],"algorithm,":[72],"MutSigCV.":[73],"Somatic":[74],"data":[77],"from":[78,83],"exome":[80],"kit\u2010targeted":[81],"area":[82],"24":[84],"exome\u2010sequenced":[85],"sporadic":[86,95],"CRCs":[88,97],"respective":[90,99],"normals,":[91],"12":[93],"whole\u2010genome\u2010sequenced":[94],"normals":[100],"were":[101,107,156],"utilized.":[102],"The":[103,114],"top":[104],"73":[105],"validated":[108],"93":[110],"additional":[111,126],"CRCs.":[113],"MutSigCV":[115],"ranking":[116],"identified":[117],"several":[118],"well\u2010established":[119],"CRC":[121,131,148],"provided":[125],"evidence":[127,161],"previously":[129],"proposed":[130],"well":[135],"shortlisted":[137],"that":[139],"our":[142],"knowledge":[143],"linked":[146],"before.":[149],"Two":[150],"genes,":[151],"SMARCB1":[152,167],"STK38L":[154],",":[155],"functionally":[158],"scrutinized,":[159],"providing":[160],"a":[163],"tumorigenic":[164],"role,":[165],"particular.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}