{"id":"https://openalex.org/W28876791","doi":"https://doi.org/10.1023/a:1021420903355","title":"Modulation of Leukocyte Recruitment and IL-8 Expression by the Membrane Attack Complex of Complement (C5b-9) in a Rabbit Model of Antigen-Induced Arthritis","display_name":"Modulation of Leukocyte Recruitment and IL-8 Expression by the Membrane Attack Complex of Complement (C5b-9) in a Rabbit Model of Antigen-Induced Arthritis","publication_year":2002,"publication_date":"2002-12-01","ids":{"openalex":"https://openalex.org/W28876791","doi":"https://doi.org/10.1023/a:1021420903355","mag":"28876791","pmid":"https://pubmed.ncbi.nlm.nih.gov/12546141"},"language":"en","primary_location":{"id":"doi:10.1023/a:1021420903355","doi":"https://doi.org/10.1023/a:1021420903355","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1021420903355","pdf_url":null,"source":{"id":"https://openalex.org/S127393932","display_name":"Inflammation","issn_l":"0360-3997","issn":["0360-3997","1573-2576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110133244","display_name":"Nicole L. Tramontini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole L. Tramontini","raw_affiliation_strings":["Inflammation Pharmacology, Pfizer Global Research, Ann Arbor, MI 48105, USA","Inflammation Pharmacology, Pfizer Global Research, Ann Arbor,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammation Pharmacology, Pfizer Global Research, Ann Arbor, MI 48105, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Inflammation Pharmacology, Pfizer Global Research, Ann Arbor,","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044833561","display_name":"Paul J. Kuipers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J. Kuipers","raw_affiliation_strings":["Inflammation Pharmacology, Pfizer Global Research, Ann Arbor, MI, 48105","Inflammation Pharmacology, Pfizer Global Research, Ann Arbor,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammation Pharmacology, Pfizer Global Research, Ann Arbor, MI, 48105","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Inflammation Pharmacology, Pfizer Global Research, Ann Arbor,","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091130101","display_name":"Colleen M. Huber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen M. Huber","raw_affiliation_strings":["Inflammation Pharmacology, Pfizer Global Research, Ann Arbor, MI, 48105","Inflammation Pharmacology, Pfizer Global Research, Ann Arbor,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammation Pharmacology, Pfizer Global Research, Ann Arbor, MI, 48105","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Inflammation Pharmacology, Pfizer Global Research, Ann Arbor,","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012360986","display_name":"Kerri Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kerri Murphy","raw_affiliation_strings":["Inflammation Pharmacology, Pfizer Global Research, Ann Arbor, MI, 48105","Inflammation Pharmacology, Pfizer Global Research, Ann Arbor,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammation Pharmacology, Pfizer Global Research, Ann Arbor, MI, 48105","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Inflammation Pharmacology, Pfizer Global Research, Ann Arbor,","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042521771","display_name":"Keith B. Naylor","orcid":"https://orcid.org/0000-0001-9871-8317","observed_orcids":["https://orcid.org/0000-0001-9871-8317"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith B. Naylor","raw_affiliation_strings":["Inflammation Pharmacology, Pfizer Global Research, Ann Arbor, MI, 48105","Inflammation Pharmacology, Pfizer Global Research, Ann Arbor,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammation Pharmacology, Pfizer Global Research, Ann Arbor, MI, 48105","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Inflammation Pharmacology, Pfizer Global Research, Ann Arbor,","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057212655","display_name":"Autumn J. Broady","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Autumn J. Broady","raw_affiliation_strings":["Inflammation Pharmacology, Pfizer Global Research, Ann Arbor, MI, 48105","Inflammation Pharmacology, Pfizer Global Research, Ann Arbor,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammation Pharmacology, Pfizer Global Research, Ann Arbor, MI, 48105","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Inflammation Pharmacology, Pfizer Global Research, Ann Arbor,","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111562887","display_name":"Kenneth S. Kilgore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth S. Kilgore","raw_affiliation_strings":["Inflammation Pharmacology, Pfizer Global Research, Ann Arbor, MI, 48105","Inflammation Pharmacology, Pfizer Global Research, Ann Arbor,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammation Pharmacology, Pfizer Global Research, Ann Arbor, MI, 48105","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Inflammation Pharmacology, Pfizer Global Research, Ann Arbor,","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111562887"],"corresponding_institution_ids":["https://openalex.org/I180857899"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.4378,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.59374045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"26","issue":"6","first_page":"311","last_page":"319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.10700000077486038,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane-attack-complex","display_name":"membrane attack complex","score":0.796999990940094},{"id":"https://openalex.org/keywords/complement-c5b-9","display_name":"complement C5b-9","score":0.8769999742507935},{"id":"https://openalex.org/keywords/c6-deficiency","display_name":"C6 deficiency","score":0.6570000052452087},{"id":"https://openalex.org/keywords/antigen-induced-arthritis","display_name":"antigen-induced arthritis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/leukocyte-recruitment","display_name":"leukocyte recruitment","score":0.9739999771118164},{"id":"https://openalex.org/keywords/il-8-expression","display_name":"IL-8 expression","score":0.8820000290870667},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/proteoglycans","display_name":"proteoglycans","score":0.8050000071525574},{"id":"https://openalex.org/keywords/hydroxyproline","display_name":"hydroxyproline","score":0.8790000081062317},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7281174063682556},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.6128657460212708},{"id":"https://openalex.org/C79196540","wikidata":"https://www.wikidata.org/wiki/Q14905298","display_name":"Complement membrane attack complex","level":4,"score":0.60768723487854},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.5829747319221497},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5664509534835815},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.5460243225097656},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5243644714355469},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5041259527206421},{"id":"https://openalex.org/C2777652487","wikidata":"https://www.wikidata.org/wiki/Q575064","display_name":"Synovial membrane","level":3,"score":0.45838943123817444},{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.44583606719970703},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.4358797073364258},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4145326614379883},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3667244017124176},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3536610007286072},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3199748992919922},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23553553223609924},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.2023131251335144},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1785670518875122},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003183","descriptor_name":"Complement C6","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D003183","descriptor_name":"Complement C6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013582","descriptor_name":"Synovial Fluid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013582","descriptor_name":"Synovial Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015938","descriptor_name":"Complement Membrane Attack Complex","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D015938","descriptor_name":"Complement Membrane Attack Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1021420903355","doi":"https://doi.org/10.1023/a:1021420903355","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1021420903355","pdf_url":null,"source":{"id":"https://openalex.org/S127393932","display_name":"Inflammation","issn_l":"0360-3997","issn":["0360-3997","1573-2576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation","raw_type":"journal-article"},{"id":"pmid:12546141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12546141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W98575697","https://openalex.org/W131465187","https://openalex.org/W160726163","https://openalex.org/W175199685","https://openalex.org/W1422031307","https://openalex.org/W1464621722","https://openalex.org/W1499161051","https://openalex.org/W1504101711","https://openalex.org/W1534428859","https://openalex.org/W1557940991","https://openalex.org/W1582917949","https://openalex.org/W1598029558","https://openalex.org/W1664132864","https://openalex.org/W1828340002","https://openalex.org/W1961339089","https://openalex.org/W1972413390","https://openalex.org/W1979228328","https://openalex.org/W1986651673","https://openalex.org/W1994955127","https://openalex.org/W1998827078","https://openalex.org/W2000045462","https://openalex.org/W2000236013","https://openalex.org/W2003126200","https://openalex.org/W2009333747","https://openalex.org/W2013975695","https://openalex.org/W2038384507","https://openalex.org/W2044933014","https://openalex.org/W2046219128","https://openalex.org/W2057635936","https://openalex.org/W2064291141","https://openalex.org/W2093367807","https://openalex.org/W2104223335","https://openalex.org/W2104511958","https://openalex.org/W2111334371","https://openalex.org/W2112387394","https://openalex.org/W2152670955","https://openalex.org/W2168950748","https://openalex.org/W2210727926","https://openalex.org/W2397980352","https://openalex.org/W2410856001","https://openalex.org/W2411896452","https://openalex.org/W2471729188"],"related_works":["https://openalex.org/W2155546923","https://openalex.org/W2056824071","https://openalex.org/W2100706530","https://openalex.org/W7064575843","https://openalex.org/W2088183101","https://openalex.org/W1543853846","https://openalex.org/W2327417977","https://openalex.org/W2038773223","https://openalex.org/W2074477433","https://openalex.org/W2771861718"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
