{"id":"https://openalex.org/W2887613245","doi":"https://doi.org/10.1038/s41598-018-31309-5","title":"One-step process for production of N-methylated amino acids from sugars and methylamine using recombinant Corynebacterium glutamicum as biocatalyst","display_name":"One-step process for production of N-methylated amino acids from sugars and methylamine using recombinant Corynebacterium glutamicum as biocatalyst","publication_year":2018,"publication_date":"2018-08-21","ids":{"openalex":"https://openalex.org/W2887613245","doi":"https://doi.org/10.1038/s41598-018-31309-5","mag":"2887613245","pmid":"https://pubmed.ncbi.nlm.nih.gov/30150644","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6110843"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-31309-5","doi":"https://doi.org/10.1038/s41598-018-31309-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-31309-5","pdf_url":"https://www.nature.com/articles/s41598-018-31309-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-31309-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009932864","display_name":"Melanie Mindt","orcid":"https://orcid.org/0000-0003-1530-5555","observed_orcids":["https://orcid.org/0000-0003-1530-5555"]},"institutions":[{"id":"https://openalex.org/I20121455","display_name":"Bielefeld University","ror":"https://ror.org/02hpadn98","country_code":"DE","type":"education","lineage":["https://openalex.org/I20121455"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Melanie Mindt","raw_affiliation_strings":["Genetics of Prokaryotes, Faculty of Biology & CeBiTec, Bielefeld University, Universit\u00e4tsstr. 25, 33615, Bielefeld, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics of Prokaryotes, Faculty of Biology & CeBiTec, Bielefeld University, Universit\u00e4tsstr. 25, 33615, Bielefeld, Germany","institution_ids":["https://openalex.org/I20121455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073461102","display_name":"Joe Max Risse","orcid":"https://orcid.org/0000-0002-0047-7496","observed_orcids":["https://orcid.org/0000-0002-0047-7496"]},"institutions":[{"id":"https://openalex.org/I20121455","display_name":"Bielefeld University","ror":"https://ror.org/02hpadn98","country_code":"DE","type":"education","lineage":["https://openalex.org/I20121455"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joe Max Risse","raw_affiliation_strings":["Fermentation Technology, Technical Faculty & CeBiTec, Bielefeld University, Universit\u00e4tsstr. 25, 33615, Bielefeld, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fermentation Technology, Technical Faculty & CeBiTec, Bielefeld University, Universit\u00e4tsstr. 25, 33615, Bielefeld, Germany","institution_ids":["https://openalex.org/I20121455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037822905","display_name":"Hendrik Gru\u00df","orcid":"https://orcid.org/0000-0001-7267-9663","observed_orcids":["https://orcid.org/0000-0001-7267-9663"]},"institutions":[{"id":"https://openalex.org/I20121455","display_name":"Bielefeld University","ror":"https://ror.org/02hpadn98","country_code":"DE","type":"education","lineage":["https://openalex.org/I20121455"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hendrik Gru\u00df","raw_affiliation_strings":["Organic Chemistry III, Faculty of Chemistry & CeBiTec, Bielefeld University, Universit\u00e4tsstr. 25, 33615, Bielefeld, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organic Chemistry III, Faculty of Chemistry & CeBiTec, Bielefeld University, Universit\u00e4tsstr. 25, 33615, Bielefeld, Germany","institution_ids":["https://openalex.org/I20121455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077845134","display_name":"Norbert Sewald","orcid":"https://orcid.org/0000-0002-0309-2655","observed_orcids":["https://orcid.org/0000-0002-0309-2655"]},"institutions":[{"id":"https://openalex.org/I20121455","display_name":"Bielefeld University","ror":"https://ror.org/02hpadn98","country_code":"DE","type":"education","lineage":["https://openalex.org/I20121455"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Norbert Sewald","raw_affiliation_strings":["Organic Chemistry III, Faculty of Chemistry & CeBiTec, Bielefeld University, Universit\u00e4tsstr. 25, 33615, Bielefeld, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0309-2655","affiliations":[{"raw_affiliation_string":"Organic Chemistry III, Faculty of Chemistry & CeBiTec, Bielefeld University, Universit\u00e4tsstr. 25, 33615, Bielefeld, Germany","institution_ids":["https://openalex.org/I20121455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025242621","display_name":"Bernhard J. Eikmanns","orcid":"https://orcid.org/0000-0002-3069-431X","observed_orcids":["https://orcid.org/0000-0002-3069-431X"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernhard J. Eikmanns","raw_affiliation_strings":["Institute of Microbiology and Biotechnology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Biotechnology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091393671","display_name":"Volker F. Wendisch","orcid":"https://orcid.org/0000-0003-3473-0012","observed_orcids":["https://orcid.org/0000-0003-3473-0012"]},"institutions":[{"id":"https://openalex.org/I20121455","display_name":"Bielefeld University","ror":"https://ror.org/02hpadn98","country_code":"DE","type":"education","lineage":["https://openalex.org/I20121455"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Volker F. Wendisch","raw_affiliation_strings":["Genetics of Prokaryotes, Faculty of Biology & CeBiTec, Bielefeld University, Universit\u00e4tsstr. 25, 33615, Bielefeld, Germany. volker.wendisch@uni-bielefeld.de","Genetics of Prokaryotes, Faculty of Biology & CeBiTec, Bielefeld University, Universit\u00e4tsstr. 25, 33615, Bielefeld, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3473-0012","affiliations":[{"raw_affiliation_string":"Genetics of Prokaryotes, Faculty of Biology & CeBiTec, Bielefeld University, Universit\u00e4tsstr. 25, 33615, Bielefeld, Germany. volker.wendisch@uni-bielefeld.de","institution_ids":["https://openalex.org/I20121455"]},{"raw_affiliation_string":"Genetics of Prokaryotes, Faculty of Biology & CeBiTec, Bielefeld University, Universit\u00e4tsstr. 25, 33615, Bielefeld, Germany","institution_ids":["https://openalex.org/I20121455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091393671"],"corresponding_institution_ids":["https://openalex.org/I20121455"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":1630,"currency":"EUR","value_usd":1757},"fwci":1.873,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.86294222,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"12895","last_page":"12895"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12688","display_name":"Microbial metabolism and enzyme function","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-methylated-amino-acids","display_name":"N-methylated amino acids","score":0.9940000176429749},{"id":"https://openalex.org/keywords/corynebacterium-glutamicum","display_name":"Corynebacterium glutamicum","score":0.9269999861717224},{"id":"https://openalex.org/keywords/whole-cell-biocatalysis","display_name":"whole-cell biocatalysis","score":0.859000027179718},{"id":"https://openalex.org/keywords/pseudomonas-putida","display_name":"Pseudomonas putida","score":0.9819999933242798},{"id":"https://openalex.org/keywords/methylamine","display_name":"methylamine","score":0.7450000047683716},{"id":"https://openalex.org/keywords/sugar-fermentation","display_name":"sugar fermentation","score":0.5989999771118164},{"id":"https://openalex.org/keywords/heterologous-expression","display_name":"heterologous expression","score":0.7390000224113464},{"id":"https://openalex.org/keywords/imine-reductase","display_name":"imine reductase","score":0.8479999899864197},{"id":"https://openalex.org/keywords/lignocellulosic-sugars","display_name":"lignocellulosic sugars","score":0.859000027179718},{"id":"https://openalex.org/keywords/xylose","display_name":"xylose","score":0.902999997138977},{"id":"https://openalex.org/keywords/arabinose","display_name":"arabinose","score":0.9940000176429749},{"id":"https://openalex.org/keywords/starch","display_name":"starch","score":0.41999998688697815},{"id":"https://openalex.org/keywords/fed-batch-fermentation","display_name":"fed-batch fermentation","score":0.6650000214576721},{"id":"https://openalex.org/keywords/stereoselectivity","display_name":"stereoselectivity","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2776260651","wikidata":"https://www.wikidata.org/wiki/Q292314","display_name":"Corynebacterium glutamicum","level":3,"score":0.8050780296325684},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6641976833343506},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6222363114356995},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5906652808189392},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000073893","descriptor_name":"Sugars","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008744","descriptor_name":"Methylamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048230","descriptor_name":"Corynebacterium glutamicum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048230","descriptor_name":"Corynebacterium glutamicum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-018-31309-5","doi":"https://doi.org/10.1038/s41598-018-31309-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-31309-5","pdf_url":"https://www.nature.com/articles/s41598-018-31309-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5064657","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6110843","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30150644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30150644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6110843","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6110843/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:832da21b22964f9ba5dbee326e8f0e9f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/832da21b22964f9ba5dbee326e8f0e9f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)","raw_type":"article"},{"id":"pmh:oai:pub.uni-bielefeld.de:2930292","doi":null,"is_oa":true,"landing_page_url":"https://pub.uni-bielefeld.de/record/2930292","pdf_url":null,"source":{"id":"https://openalex.org/S4306401671","display_name":"PUB \u2013 Publications at Bielefeld University (Bielefeld University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20121455","host_organization_name":"Bielefeld University","host_organization_lineage":["https://openalex.org/I20121455"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mindt M, Risse JM, Gru\u00df H, Sewald N, Eikmanns BJ, Wendisch VF. One-step process for production of N-methylated amino acids from sugars and methylamine using recombinant Corynebacterium glutamicum as biocatalyst. <em>Scientific Reports</em>. 2018;8(1):12895: 12895.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-31309-5","doi":"https://doi.org/10.1038/s41598-018-31309-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-31309-5","pdf_url":"https://www.nature.com/articles/s41598-018-31309-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320323389","display_name":"Universit\u00e4t Bielefeld","ror":"https://ror.org/02hpadn98"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2887613245.pdf","grobid_xml":"https://content.openalex.org/works/W2887613245.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W565446105","https://openalex.org/W629995711","https://openalex.org/W1484354876","https://openalex.org/W1485044783","https://openalex.org/W1505854362","https://openalex.org/W1516063641","https://openalex.org/W1603157834","https://openalex.org/W1761707887","https://openalex.org/W1869265908","https://openalex.org/W1902958628","https://openalex.org/W1965608659","https://openalex.org/W1971439989","https://openalex.org/W1977499611","https://openalex.org/W1979639397","https://openalex.org/W1979677214","https://openalex.org/W1981643986","https://openalex.org/W1990931150","https://openalex.org/W1994533881","https://openalex.org/W2003807244","https://openalex.org/W2004235627","https://openalex.org/W2005221052","https://openalex.org/W2005286603","https://openalex.org/W2006724140","https://openalex.org/W2006789930","https://openalex.org/W2010598280","https://openalex.org/W2014516639","https://openalex.org/W2019714368","https://openalex.org/W2019796789","https://openalex.org/W2020492826","https://openalex.org/W2020804046","https://openalex.org/W2025288057","https://openalex.org/W2026389167","https://openalex.org/W2030838274","https://openalex.org/W2031460737","https://openalex.org/W2031653598","https://openalex.org/W2034413905","https://openalex.org/W2037719248","https://openalex.org/W2038734729","https://openalex.org/W2041426527","https://openalex.org/W2044070697","https://openalex.org/W2051658488","https://openalex.org/W2057986258","https://openalex.org/W2059352446","https://openalex.org/W2059388536","https://openalex.org/W2059737879","https://openalex.org/W2064467376","https://openalex.org/W2064529557","https://openalex.org/W2065889205","https://openalex.org/W2069573895","https://openalex.org/W2069917850","https://openalex.org/W2070388868","https://openalex.org/W2070731342","https://openalex.org/W2074231563","https://openalex.org/W2079003753","https://openalex.org/W2083112939","https://openalex.org/W2083611079","https://openalex.org/W2091470498","https://openalex.org/W2108738397","https://openalex.org/W2112300345","https://openalex.org/W2119388149","https://openalex.org/W2128635872","https://openalex.org/W2129769626","https://openalex.org/W2132417094","https://openalex.org/W2133834597","https://openalex.org/W2140373206","https://openalex.org/W2141454736","https://openalex.org/W2156238351","https://openalex.org/W2159910931","https://openalex.org/W2166470414","https://openalex.org/W2169840290","https://openalex.org/W2170400465","https://openalex.org/W2209619530","https://openalex.org/W2268012897","https://openalex.org/W2323839409","https://openalex.org/W2346681321","https://openalex.org/W2409594991","https://openalex.org/W2520823969","https://openalex.org/W2547778572","https://openalex.org/W2556681194","https://openalex.org/W2560971454","https://openalex.org/W2587095210","https://openalex.org/W2610824734","https://openalex.org/W2619240226","https://openalex.org/W2745864002","https://openalex.org/W2900266212","https://openalex.org/W2971136151","https://openalex.org/W2976074715","https://openalex.org/W4251687119","https://openalex.org/W4285719527","https://openalex.org/W6611021942"],"related_works":["https://openalex.org/W3156679861","https://openalex.org/W2900266212","https://openalex.org/W3033522927","https://openalex.org/W4225130918","https://openalex.org/W2976074715","https://openalex.org/W6998238426","https://openalex.org/W1957369233","https://openalex.org/W1977499611","https://openalex.org/W1558471380","https://openalex.org/W2589053994"],"abstract_inverted_index":{"Abstract":[0],"N-methylated":[1,40,52,96],"amino":[2,14,41,53,97],"acids":[3,15,42,54],"are":[4,60],"found":[5],"in":[6,8,145],"Nature":[7],"various":[9],"biological":[10],"compounds.":[11],"N-methylation":[12],"of":[13,23,51,90,117,130,137,168],"has":[16,81],"been":[17,84],"shown":[18],"to":[19,27,37,94,160,166],"improve":[20],"pharmacokinetic":[21],"properties":[22],"peptide":[24],"drugs":[25],"due":[26],"conformational":[28],"changes,":[29],"improved":[30],"proteolytic":[31],"stability":[32],"and/or":[33],"higher":[34],"lipophilicity.":[35],"Due":[36],"these":[38],"characteristics":[39],"received":[43],"increasing":[44],"interest":[45],"by":[46,55,114],"the":[47,95,118,178],"pharmaceutical":[48],"industry.":[49],"Syntheses":[50],"chemical":[56],"and":[57,92,182],"biocatalytic":[58],"approaches":[59],"known,":[61],"but":[62],"often":[63],"show":[64],"incomplete":[65],"stereoselectivity,":[66],"low":[67],"yields":[68],"or":[69,177],"expensive":[70],"co-factor":[71],"regeneration.":[72],"So":[73],"far":[74],"a":[75,87,108,135],"one-step":[76,88],"fermentative":[77],"process":[78],"from":[79,107,123,170],"sugars":[80,91,180],"not":[82],"yet":[83],"described.":[85],"Here,":[86],"conversion":[89],"methylamine":[93],"acid":[98,120],"N-methyl-l-alanine":[99,128,169],"was":[100,105,157],"developed.":[101],"A":[102],"whole-cell":[103],"biocatalyst":[104],"derived":[106],"pyruvate":[109],"overproducing":[110],"C.":[111,149],"glutamicum":[112,150],"strain":[113,151],"heterologous":[115],"expression":[116],"N-methyl-l-amino":[119],"dehydrogenase":[121],"gene":[122],"Pseudomonas":[124],"putida.":[125],"As":[126],"proof-of-concept,":[127],"titers":[129],"31.7":[131],"g":[132,139,141],"L\u22121":[133],"with":[134],"yield":[136],"0.71":[138],"per":[140],"glucose":[142],"were":[143],"achieved":[144],"fed-batch":[146],"cultivation.":[147],"The":[148],"producing":[152],"this":[153,162],"imine":[154],"reductase":[155],"enzyme":[156],"engineered":[158],"further":[159],"extend":[161],"green":[163],"chemistry":[164],"route":[165],"production":[167],"alternative":[171],"feed":[172],"stocks":[173],"such":[174],"as":[175],"starch":[176],"lignocellulosic":[179],"xylose":[181],"arabinose.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-08-22T00:00:00"}