{"id":"https://openalex.org/W2887580969","doi":null,"title":"Current development and challenges in biomarkers for early identification of mild cognitive impairment and alzheimer\u2019s disease","display_name":"Current development and challenges in biomarkers for early identification of mild cognitive impairment and alzheimer\u2019s disease","publication_year":2018,"publication_date":"2018-03-01","ids":{"openalex":"https://openalex.org/W2887580969","mag":"2887580969"},"language":"en","primary_location":{"id":"mag:2887580969","doi":null,"is_oa":false,"landing_page_url":"https://www.biomedscidirect.com/2353/current_development_and_challenges_in_biomarkers_for_early_identification_of_mild_cognitive_impairment_and_alzheimer_s_disease/articlescategories","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016889163","display_name":"Abhai Kumar","orcid":"https://orcid.org/0000-0002-4379-6403","observed_orcids":["https://orcid.org/0000-0002-4379-6403"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abhai Kumar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4379-6403","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101973084","display_name":"Sm\u0131ta S\u0131ngh","orcid":"https://orcid.org/0000-0002-6219-4985","observed_orcids":["https://orcid.org/0000-0002-6219-4985","https://orcid.org/0009-0003-6887-2390"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Smita Singh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6219-4985","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080372412","display_name":"Vijaya Nath Mishra","orcid":"https://orcid.org/0000-0002-6627-7956","observed_orcids":["https://orcid.org/0000-0002-6627-7956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vijaya Nath Mishra","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6627-7956","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10603528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9309999942779541},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9160000085830688},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/prodromal-alzheimer-s-disease","display_name":"prodromal Alzheimer's disease","score":0.9390000104904175},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.9959999918937683},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.9440000057220459},{"id":"https://openalex.org/keywords/neuroimaging-biomarkers","display_name":"neuroimaging biomarkers","score":0.9929999709129333},{"id":"https://openalex.org/keywords/radioactive-tracers","display_name":"radioactive tracers","score":0.800000011920929},{"id":"https://openalex.org/keywords/nia-aa-criteria","display_name":"NIA-AA criteria","score":0.7760000228881836},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8410000205039978},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.8148313760757446},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7166508436203003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5969228744506836},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5725752711296082},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4751805365085602},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.47018492221832275},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.44753575325012207},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.4122944474220276},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3594627380371094},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33028721809387207},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3182380795478821},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.26761895418167114},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16917195916175842},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.15107190608978271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09819108247756958},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2887580969","doi":null,"is_oa":false,"landing_page_url":"https://www.biomedscidirect.com/2353/current_development_and_challenges_in_biomarkers_for_early_identification_of_mild_cognitive_impairment_and_alzheimer_s_disease/articlescategories","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2142486029","https://openalex.org/W2399495985","https://openalex.org/W292114726","https://openalex.org/W2969766245","https://openalex.org/W2137183174","https://openalex.org/W3028692979","https://openalex.org/W4389145210","https://openalex.org/W7095697328","https://openalex.org/W4205873753","https://openalex.org/W3100080537"],"abstract_inverted_index":{"Mild":[0],"cognitive":[1],"impairment":[2],"(MCI)":[3],"has":[4],"attracted":[5],"central":[6],"attraction":[7],"by":[8,19],"various":[9,173],"researchers":[10],"to":[11,33,48,109],"diagnose":[12],"prodromal":[13],"stage":[14],"of":[15,44,60,65,76,81,94,125,131,139,158,181,190],"Alzheimer\u2019s":[16],"disease":[17,28,95,191],"(AD)":[18],"using":[20,69],"different":[21,70],"biological":[22],"and":[23,40,67,86,107,117,135,146,163,175],"imaging":[24,165],"biomarkers.":[25],"In":[26],"evaluating":[27],"changes,":[29],"it":[30],"is":[31,47],"critical":[32],"have":[34,168],"measurements":[35],"that":[36],"are":[37],"sensitive,":[38],"specific,":[39],"reliable.":[41],"The":[42,73,119,149],"purpose":[43],"this":[45],"review":[46],"bring":[49],"a":[50],"comprehensive":[51],"overview":[52],"about":[53],"the":[54,79,153,176],"recent":[55],"studies":[56,100,174],"done":[57,101],"in":[58,92,129,156,172,179,187],"development":[59,104,155],"biomarker":[61,103,140],"for":[62,115],"clinical":[63,113,185],"diagnosis":[64,130],"MCI":[66,116],"pre-AD":[68],"technological":[71],"interventions.":[72],"current":[74],"state":[75],"knowledge":[77],"highlights":[78,152],"implication":[80],"certain":[82],"proteins,":[83],"transporter,":[84],"enzymes":[85],"metabolic":[87],"pathway":[88],"related":[89],"factors,":[90],"radiotracer":[91],"identification":[93],"progression.":[96],"However,":[97],"all":[98],"these":[99,182],"on":[102],"lack":[105],"sensitivity":[106],"specificity":[108],"be":[110],"classified":[111],"as":[112],"marker":[114],"AD.":[118],"revised":[120],"criteria":[121],"of,":[122],"National":[123],"Institute":[124],"Aging":[126],"(NIA)-Alzheimer\u2019s":[127],"association":[128],"MCI,":[132],"pre-clinical":[133],"AD":[134,136],"encompass":[137],"use":[138],"which":[141,167],"can":[142],"detect":[143],"pathological":[144],"process":[145],"subsequent":[147],"neurodegeneration.":[148],"present":[150],"article":[151],"significant":[154],"field":[157],"plasma,":[159],"cerebrospinal":[160],"fluid,":[161],"serum":[162],"neuro":[164],"biomarkers":[166,183],"shown":[169],"positive":[170],"result":[171],"future":[177],"challenges":[178],"application":[180],"at":[184],"setting":[186],"early":[188],"intervention":[189]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-22T00:00:00"}