{"id":"https://openalex.org/W2887560233","doi":"https://doi.org/10.1523/jneurosci.0102-18.2018","title":"Functional Connectivity within the Primate Extended Amygdala Is Heritable and Associated with Early-Life Anxious Temperament","display_name":"Functional Connectivity within the Primate Extended Amygdala Is Heritable and Associated with Early-Life Anxious Temperament","publication_year":2018,"publication_date":"2018-07-30","ids":{"openalex":"https://openalex.org/W2887560233","doi":"https://doi.org/10.1523/jneurosci.0102-18.2018","mag":"2887560233","pmid":"https://pubmed.ncbi.nlm.nih.gov/30061190","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6113902"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.0102-18.2018","doi":"https://doi.org/10.1523/jneurosci.0102-18.2018","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0102-18.2018","pdf_url":"https://www.jneurosci.org/content/jneuro/38/35/7611.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jneurosci.org/content/jneuro/38/35/7611.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101580701","display_name":"Andrew S. Fox","orcid":"https://orcid.org/0000-0003-0695-3323","observed_orcids":["https://orcid.org/0000-0003-0695-3323"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew S. Fox","raw_affiliation_strings":["Department of Psychology and California National Primate Research Center, University of California, Davis, California 95616","2Department of Psychology and California National Primate Research Center, University of California, Davis, California 95616,"],"raw_orcid":"https://orcid.org/0000-0003-0695-3323","affiliations":[{"raw_affiliation_string":"Department of Psychology and California National Primate Research Center, University of California, Davis, California 95616","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"2Department of Psychology and California National Primate Research Center, University of California, Davis, California 95616,","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065245179","display_name":"Jonathan A. Oler","orcid":"https://orcid.org/0000-0002-1333-6924","observed_orcids":["https://orcid.org/0000-0002-1333-6924"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan A. Oler","raw_affiliation_strings":["Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719","1Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719,"],"raw_orcid":"https://orcid.org/0000-0002-1333-6924","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"1Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719,","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021076382","display_name":"Rasmus M. Birn","orcid":"https://orcid.org/0000-0003-3938-1077","observed_orcids":["https://orcid.org/0000-0003-3938-1077"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rasmus M. Birn","raw_affiliation_strings":["Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53705","Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719","1Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719,","3Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53705,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53705","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"1Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719,","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"3Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53705,","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049400083","display_name":"Alexander J. Shackman","orcid":"https://orcid.org/0000-0002-3629-4704","observed_orcids":["https://orcid.org/0000-0002-3629-4704"]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander J. Shackman","raw_affiliation_strings":["Department of Psychology, Maryland Neuroimaging Center, and Neuroscience and Cognitive Science Program, University of Maryland, College Park, Maryland 20742, and","4Department of Psychology, Maryland Neuroimaging Center, and Neuroscience and Cognitive Science Program, University of Maryland, College Park, Maryland 20742, and"],"raw_orcid":"https://orcid.org/0000-0002-3629-4704","affiliations":[{"raw_affiliation_string":"Department of Psychology, Maryland Neuroimaging Center, and Neuroscience and Cognitive Science Program, University of Maryland, College Park, Maryland 20742, and","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"4Department of Psychology, Maryland Neuroimaging Center, and Neuroscience and Cognitive Science Program, University of Maryland, College Park, Maryland 20742, and","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052801688","display_name":"Andrew L. Alexander","orcid":"https://orcid.org/0000-0003-2695-768X","observed_orcids":["https://orcid.org/0000-0003-2695-768X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew L. Alexander","raw_affiliation_strings":["Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53705","Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719","1Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719,","3Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53705,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53705","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"1Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719,","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"3Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53705,","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062318456","display_name":"Ned H. Kalin","orcid":"https://orcid.org/0000-0003-1184-0868","observed_orcids":["https://orcid.org/0000-0003-1184-0868"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ned H. Kalin","raw_affiliation_strings":["Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719, nkalin@wisc.edu","Wisconsin National Primate Research Center, Madison, Wisconsin 53715","1Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719,","5Wisconsin National Primate Research Center, Madison, Wisconsin 53715"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719, nkalin@wisc.edu","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Wisconsin National Primate Research Center, Madison, Wisconsin 53715","institution_ids":[]},{"raw_affiliation_string":"1Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53719,","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"5Wisconsin National Primate Research Center, Madison, Wisconsin 53715","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.5982,"has_fulltext":true,"cited_by_count":127,"citation_normalized_percentile":{"value":0.99227238,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"38","issue":"35","first_page":"7611","last_page":"7621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.33739998936653137,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.33739998936653137,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.19300000369548798,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.13729999959468842,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extended-amygdala","display_name":"extended amygdala","score":0.8960000276565552},{"id":"https://openalex.org/keywords/central-nucleus-of-the-amygdala","display_name":"central amygdala","score":0.9380000233650208},{"id":"https://openalex.org/keywords/bed-nucleus-of-the-stria-terminalis","display_name":"bed nucleus of the stria terminalis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anxious-temperament","display_name":"anxious temperament","score":0.7429999709129333},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.9480000138282776},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"functional connectivity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.7749999761581421},{"id":"https://openalex.org/keywords/family-pedigree","display_name":"family pedigree","score":0.7300000190734863},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.6489999890327454},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.6980000138282776},{"id":"https://openalex.org/keywords/periaqueductal-gray","display_name":"periaqueductal gray","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cerebral-metabolism","display_name":"brain metabolism","score":0.6740000247955322},{"id":"https://openalex.org/keywords/neuroendocrine-regulation","display_name":"neuroendocrine regulation","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.8625136017799377},{"id":"https://openalex.org/C61644593","wikidata":"https://www.wikidata.org/wiki/Q80157","display_name":"Temperament","level":3,"score":0.747881293296814},{"id":"https://openalex.org/C2778652331","wikidata":"https://www.wikidata.org/wiki/Q3122152","display_name":"Stria terminalis","level":3,"score":0.7259112596511841},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6199832558631897},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5942226648330688},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.584241509437561},{"id":"https://openalex.org/C2780509455","wikidata":"https://www.wikidata.org/wiki/Q7380","display_name":"Primate","level":2,"score":0.5004620552062988},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.45792824029922485},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.4373050332069397},{"id":"https://openalex.org/C52338299","wikidata":"https://www.wikidata.org/wiki/Q1004354","display_name":"Functional neuroimaging","level":3,"score":0.417710542678833},{"id":"https://openalex.org/C187288502","wikidata":"https://www.wikidata.org/wiki/Q641118","display_name":"Personality","level":2,"score":0.24109047651290894},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.181439608335495},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.07362973690032959}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010487","descriptor_name":"Periaqueductal Gray","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012686","descriptor_name":"Septal Nuclei","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012686","descriptor_name":"Septal Nuclei","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013694","descriptor_name":"Temperament","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046353","descriptor_name":"Immobility Response, Tonic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063132","descriptor_name":"Connectome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066274","descriptor_name":"Central Amygdaloid Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066274","descriptor_name":"Central Amygdaloid Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1523/jneurosci.0102-18.2018","doi":"https://doi.org/10.1523/jneurosci.0102-18.2018","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0102-18.2018","pdf_url":"https://www.jneurosci.org/content/jneuro/38/35/7611.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5373428","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6113902","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6113902","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6113902","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:30061190","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30061190","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt983459xn","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/983459xn","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroscience, vol 38, iss 35","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.0102-18.2018","doi":"https://doi.org/10.1523/jneurosci.0102-18.2018","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0102-18.2018","pdf_url":"https://www.jneurosci.org/content/jneuro/38/35/7611.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1665135056","display_name":null,"funder_award_id":"R01-MH107444","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G175099621","display_name":"The Role of Anxiety-Related Brain Circuits in Tobacco Dependence and Withdrawal","funder_award_id":"R21DA040717","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2682194152","display_name":"Waisman Intellectual and Developmental Disabilities Research Center","funder_award_id":"U54HD090256","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4890306693","display_name":"Prospective Determination of Neurobehavioral Risk for the Development of Emotion Disorders","funder_award_id":"5r01mh107444-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6429418796","display_name":"Early neurodevelopment origins of anxiety","funder_award_id":"P50MH100031","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000858043","display_name":"Wisconsin National Primate Research Center Support","funder_award_id":"P51OD011106","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000875228","display_name":"Development and Regulation of Emotion in Primates","funder_award_id":"R01MH046729","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000913754","display_name":"Brain Mechanisms Mediating Genetic Risk for Anxiety and Depression","funder_award_id":"R01MH081884","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320310578","display_name":"University of Maryland","ror":"https://ror.org/01r0c1p88"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332564","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2887560233.pdf","grobid_xml":"https://content.openalex.org/works/W2887560233.grobid-xml"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W1494369493","https://openalex.org/W1585488465","https://openalex.org/W1604086900","https://openalex.org/W1670869140","https://openalex.org/W1850231759","https://openalex.org/W1857361093","https://openalex.org/W1908991493","https://openalex.org/W1922301328","https://openalex.org/W1964290461","https://openalex.org/W1967251218","https://openalex.org/W1970309247","https://openalex.org/W1971911881","https://openalex.org/W1971994650","https://openalex.org/W1972227186","https://openalex.org/W1978029233","https://openalex.org/W1983560277","https://openalex.org/W1992488134","https://openalex.org/W1992859026","https://openalex.org/W1992909158","https://openalex.org/W2004241099","https://openalex.org/W2005111389","https://openalex.org/W2005198702","https://openalex.org/W2007307305","https://openalex.org/W2009764368","https://openalex.org/W2010143351","https://openalex.org/W2010778222","https://openalex.org/W2011224808","https://openalex.org/W2012367545","https://openalex.org/W2015844309","https://openalex.org/W2018731294","https://openalex.org/W2030585557","https://openalex.org/W2034312988","https://openalex.org/W2035508647","https://openalex.org/W2037462540","https://openalex.org/W2044413038","https://openalex.org/W2044423747","https://openalex.org/W2046314814","https://openalex.org/W2052651088","https://openalex.org/W2053117653","https://openalex.org/W2062240034","https://openalex.org/W2064316672","https://openalex.org/W2065784037","https://openalex.org/W2067411830","https://openalex.org/W2072159950","https://openalex.org/W2072522618","https://openalex.org/W2073159866","https://openalex.org/W2078701201","https://openalex.org/W2081281959","https://openalex.org/W2087160026","https://openalex.org/W2089565962","https://openalex.org/W2094899584","https://openalex.org/W2101374770","https://openalex.org/W2111616302","https://openalex.org/W2115335486","https://openalex.org/W2117140276","https://openalex.org/W2121113124","https://openalex.org/W2121154900","https://openalex.org/W2122334403","https://openalex.org/W2132929960","https://openalex.org/W2133497932","https://openalex.org/W2136145485","https://openalex.org/W2138092999","https://openalex.org/W2143433106","https://openalex.org/W2147135827","https://openalex.org/W2147784213","https://openalex.org/W2153220740","https://openalex.org/W2154843838","https://openalex.org/W2158611196","https://openalex.org/W2160463229","https://openalex.org/W2163421192","https://openalex.org/W2167107038","https://openalex.org/W2219420351","https://openalex.org/W2238387778","https://openalex.org/W2269618402","https://openalex.org/W2278585186","https://openalex.org/W2316801295","https://openalex.org/W2346055880","https://openalex.org/W2400483370","https://openalex.org/W2415217866","https://openalex.org/W2415454732","https://openalex.org/W2475160222","https://openalex.org/W2480456513","https://openalex.org/W2491422019","https://openalex.org/W2513307195","https://openalex.org/W2515058491","https://openalex.org/W2522867222","https://openalex.org/W2529620065","https://openalex.org/W2530132460","https://openalex.org/W2571093196","https://openalex.org/W2590328111","https://openalex.org/W2596596521","https://openalex.org/W2605174309","https://openalex.org/W2605494532","https://openalex.org/W2612069075","https://openalex.org/W2613192640","https://openalex.org/W2737349650","https://openalex.org/W2744000261","https://openalex.org/W2747382464","https://openalex.org/W2767933848","https://openalex.org/W2771062571","https://openalex.org/W2787637221","https://openalex.org/W2788889533","https://openalex.org/W2790169674","https://openalex.org/W2949956332","https://openalex.org/W2991100069","https://openalex.org/W3098533534","https://openalex.org/W3168033202","https://openalex.org/W4210615564","https://openalex.org/W4238231280"],"related_works":["https://openalex.org/W7097154667","https://openalex.org/W2134613655","https://openalex.org/W2118507669","https://openalex.org/W4224986554","https://openalex.org/W2094899584","https://openalex.org/W2609553165","https://openalex.org/W2613192640","https://openalex.org/W4384665067","https://openalex.org/W4392857138","https://openalex.org/W2513307195"],"abstract_inverted_index":{"Children":[0],"with":[1,54,111,140,172,282],"an":[2],"extremely":[3],"inhibited,":[4],"anxious":[5,207],"temperament":[6,208],"(AT)":[7,209],"are":[8],"at":[9],"increased":[10],"risk":[11,217],"for":[12,97,126,160,193,279],"anxiety":[13,220,274],"disorders":[14,181],"and":[15,44,70,85,108,117,124,145,166,175,197,246,257],"depression.":[16],"Using":[17],"a":[18,73,98,202,276],"rhesus":[19,79],"monkey":[20],"model":[21,205],"of":[22,40,47,78,103,154,186,206,226,243,250,285],"early-life":[23,216,260,280],"AT,":[24,107],"we":[25,60,200,234],"previously":[26],"demonstrated":[27],"that":[28,90,134,236],"metabolism":[29,120,141,167],"in":[30,57,72,106,129,142,164,168,189,231,289],"the":[31,37,41,48,104,143,152,158,184,212,215,223,240,244,247,251,283],"central":[32,38,241,265],"extended":[33,266],"amygdala":[34,42,245,267],"(EAc),":[35],"including":[36],"nucleus":[39,46,242,249],"(Ce)":[43],"bed":[45,248],"stria":[49,252],"terminalis":[50,253],"(BST),":[51],"is":[52,94,109,138,254],"associated":[53,139,171],"trait-like":[55],"variation":[56],"AT.":[58,112,130,261],"Here,":[59,199],"use":[61,201],"fMRI":[62],"to":[63,210,218,271],"examine":[64],"relationships":[65],"between":[66,239],"Ce\u2013BST":[67,91,114,135],"functional":[68,92,115,136],"connectivity":[69,93,116,137],"AT":[71,165],"large":[74],"multigenerational":[75],"family":[76],"pedigree":[77],"monkeys":[80],"(n":[81],"=":[82],"170":[83],"females":[84],"208":[86],"males).":[87],"Results":[88],"demonstrate":[89,235],"heritable,":[95],"accounts":[96],"significant":[99],"but":[100],"modest":[101],"portion":[102],"variance":[105,128],"coheritable":[110],"Interestingly,":[113],"AT-related":[118],"BST":[119],"were":[121],"not":[122],"correlated":[123,255],"accounted":[125],"non-overlapping":[127],"Exploratory":[131],"analyses":[132],"suggest":[133,151],"hypothalamus":[144],"periaqueductal":[146],"gray.":[147],"Together,":[148],"these":[149,264],"results":[150],"importance":[153],"coordinated":[155,237],"function":[156],"within":[157],"EAc":[159],"determining":[161],"individual":[162],"differences":[163],"brain":[169],"regions":[170,268],"its":[173],"behavioral":[174],"neuroendocrine":[176],"components.":[177],"SIGNIFICANCE":[178],"STATEMENT":[179],"Anxiety":[180],"directly":[182],"impact":[183],"lives":[185],"nearly":[187],"one":[188],"five":[190],"people,":[191],"accounting":[192],"substantial":[194],"worldwide":[195],"suffering":[196],"disability.":[198],"nonhuman":[203],"primate":[204],"understand":[211],"neurobiology":[213],"underlying":[214],"develop":[219],"disorders.":[221],"Leveraging":[222],"same":[224],"kinds":[225],"neuroimaging":[227],"measures":[228],"routinely":[229],"used":[230],"human":[232],"studies,":[233],"activation":[238],"with,":[256,259],"coinherited":[258],"Understanding":[262],"how":[263],"work":[269],"together":[270],"produce":[272],"extreme":[273],"provides":[275],"neural":[277],"target":[278],"interventions":[281],"promise":[284],"preventing":[286],"lifelong":[287],"disability":[288],"at-risk":[290],"children.":[291]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":52},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-08-22T00:00:00"}