{"id":"https://openalex.org/W2887528069","doi":"https://doi.org/10.1080/17474124.2018.1511426","title":"Impact of Time to Start Systemic Therapy on the Outcomes of Patients with Metastatic Colorectal Cancer Treated with First Line FOLFOX Chemotherapy; a Patient-Level Pooled Analysis of Two Clinical Trials","display_name":"Impact of Time to Start Systemic Therapy on the Outcomes of Patients with Metastatic Colorectal Cancer Treated with First Line FOLFOX Chemotherapy; a Patient-Level Pooled Analysis of Two Clinical Trials","publication_year":2018,"publication_date":"2018-08-11","ids":{"openalex":"https://openalex.org/W2887528069","doi":"https://doi.org/10.1080/17474124.2018.1511426","mag":"2887528069","pmid":"https://pubmed.ncbi.nlm.nih.gov/30099922"},"language":"en","primary_location":{"id":"doi:10.1080/17474124.2018.1511426","doi":"https://doi.org/10.1080/17474124.2018.1511426","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17474124.2018.1511426","pdf_url":null,"source":{"id":"https://openalex.org/S175204640","display_name":"Expert Review of Gastroenterology & Hepatology","issn_l":"1747-4124","issn":["1747-4124","1747-4132"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Gastroenterology &amp; Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104038167","display_name":"Hani Oweira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hani Oweira","raw_affiliation_strings":["Department of surgery, Gastrointestinal Tumor Zentrum, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of surgery, Gastrointestinal Tumor Zentrum, Z\u00fcrich, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008998229","display_name":"Anwar Giryes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anwar Giryes","raw_affiliation_strings":["Department of surgery, Gastrointestinal Tumor Zentrum, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of surgery, Gastrointestinal Tumor Zentrum, Z\u00fcrich, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065607398","display_name":"Meinrad Mannhart","orcid":"https://orcid.org/0000-0002-7875-3171","observed_orcids":["https://orcid.org/0000-0002-7875-3171"]},"institutions":[{"id":"https://openalex.org/I4210096011","display_name":"Zug Cantonal Hospital","ror":"https://ror.org/00rm7zs53","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210096011"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Meinrad Mannhart","raw_affiliation_strings":["Department of Oncology, Center of Zug, Zug, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Center of Zug, Zug, Switzerland","institution_ids":["https://openalex.org/I4210096011"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Decker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Decker","raw_affiliation_strings":["Zentrum f\u00fcr Integrative Onkologie, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum f\u00fcr Integrative Onkologie, Zurich, Switzerland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108043749","display_name":"Omar Mohammed Abdel-Rahman","orcid":"https://orcid.org/0000-0002-5117-2502","observed_orcids":["https://orcid.org/0000-0002-5117-2502"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]},{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA","EG"],"is_corresponding":true,"raw_author_name":"Omar Abdel-Rahman","raw_affiliation_strings":["Clinical Oncology department, faculty of medicine, Ain shams university, Cairo, Egypt","Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, Canada"],"raw_orcid":"https://orcid.org/0000-0002-5117-2502","affiliations":[{"raw_affiliation_string":"Clinical Oncology department, faculty of medicine, Ain shams university, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, Canada","institution_ids":["https://openalex.org/I168635309"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108043749"],"corresponding_institution_ids":["https://openalex.org/I107720978","https://openalex.org/I168635309"],"apc_list":null,"apc_paid":null,"fwci":0.313,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58622734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"12","issue":"10","first_page":"1069","last_page":"1074"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/folfox-chemotherapy","display_name":"FOLFOX chemotherapy","score":0.7990000247955322},{"id":"https://openalex.org/keywords/first-line-chemotherapy","display_name":"first-line chemotherapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9190000295639038},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":1.0},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9169999957084656},{"id":"https://openalex.org/keywords/ecog-performance-status","display_name":"ECOG performance status","score":0.7609999775886536},{"id":"https://openalex.org/keywords/primary-tumor-resection","display_name":"primary tumor resection","score":0.546999990940094},{"id":"https://openalex.org/keywords/number-of-metastatic-sites","display_name":"number of metastatic sites","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9380073547363281},{"id":"https://openalex.org/C2778260052","wikidata":"https://www.wikidata.org/wiki/Q117636","display_name":"FOLFOX","level":5,"score":0.8030312657356262},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.743698239326477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7383813858032227},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6837014555931091},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.6628855466842651},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.616389811038971},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.6149866580963135},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.5275642275810242},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5190963745117188},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4738781154155731},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.433799684047699},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4330647885799408},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.2477564811706543}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006304","descriptor_name":"Health Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061665","descriptor_name":"Time-to-Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/17474124.2018.1511426","doi":"https://doi.org/10.1080/17474124.2018.1511426","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17474124.2018.1511426","pdf_url":null,"source":{"id":"https://openalex.org/S175204640","display_name":"Expert Review of Gastroenterology & Hepatology","issn_l":"1747-4124","issn":["1747-4124","1747-4132"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Gastroenterology &amp; Hepatology","raw_type":"journal-article"},{"id":"pmid:30099922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30099922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of gastroenterology & hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1627088494","https://openalex.org/W1654900416","https://openalex.org/W1687191618","https://openalex.org/W1824621050","https://openalex.org/W1986195579","https://openalex.org/W2012210630","https://openalex.org/W2041385581","https://openalex.org/W2083774542","https://openalex.org/W2086859932","https://openalex.org/W2119938514","https://openalex.org/W2132477894","https://openalex.org/W2518246033","https://openalex.org/W2623600194","https://openalex.org/W2765088751","https://openalex.org/W2769294998","https://openalex.org/W2770262952"],"related_works":["https://openalex.org/W2967381801","https://openalex.org/W4316652474","https://openalex.org/W2086622904","https://openalex.org/W2520145764","https://openalex.org/W2921084948","https://openalex.org/W150229492","https://openalex.org/W2590336675","https://openalex.org/W4411716017","https://openalex.org/W4383186688","https://openalex.org/W2467100100"],"abstract_inverted_index":{"BACKGROUND:":[0],"Impact":[1],"of":[2,11,26,30,34,44,46,70,110,130,138,168,185],"time":[3,83],"to":[4,17,84,149,175,201,208],"start":[5,85,202],"first-line":[6],"systemic":[7,86,203],"chemotherapy":[8,204],"following":[9,106,164],"diagnosis":[10],"metastatic":[12,131,186],"colorectal":[13],"cancer":[14],"(mCRC)":[15],"needs":[16],"be":[18],"studied.":[19],"METHODS:":[20],"This":[21],"is":[22],"a":[23],"pooled":[24],"analysis":[25,72,101,159],"the":[27,31,67,71,76,105,139,150,163,176],"raw":[28],"data":[29],"comparator":[32],"arms":[33],"two":[35],"randomized":[36],"studies":[37],"(NCT00272051;":[38],"NCT00305188).":[39],"Univariate":[40],"and":[41,48,145,191],"multivariate":[42,77,100,158],"analyses":[43],"predictors":[45],"overall":[47,91,103,112,210],"progression-free":[49,93,161,170,212],"survival":[50,94,213],"were":[51,73,108,166],"conducted":[52],"through":[53],"Cox":[54],"regression":[55],"analysis.":[56,78],"Factors":[57],"with":[58],"statistically":[59],"significant":[60],"P":[61],"value":[62],"(P":[63,116,123,133,142,153,178,188,196],"<":[64,154,179,189],"0.05)":[65],"in":[66,75,157],"univariate":[68,81],"part":[69],"included":[74],"RESULTS:":[79],"In":[80,99],"analysis,":[82],"therapy":[87],"did":[88],"not":[89,206],"affect":[90],"or":[92,211],"(P=0.694;":[95],"P=":[96],"0.891":[97],"respectively).":[98],"for":[102,160],"survival,":[104,162],"factors":[107,165],"predictive":[109,167],"worse":[111,169],"survival:":[113,171],"younger":[114],"age":[115],"=":[117,124,134,143,197],"0.019),":[118],"higher":[119],"ECOG":[120],"performance":[121],"score":[122],"0.001),":[125,180,190],"more":[126,181],"than":[127,182],"one":[128,183],"site":[129,137],"disease":[132,187],"0.002),":[135],"colon":[136],"primary":[140,151,177],"tumor":[141,152],"0.004),":[144],"no":[146,172,192],"oncologic":[147,173],"surgery":[148,174],"0.001).":[155],"Likewise,":[156],"organ":[184],"concurrent":[193],"bevacizumab":[194],"administration":[195],"0.015).":[198],"CONCLUSION:":[199],"Time":[200],"does":[205],"appear":[207],"impact":[209],"among":[214],"mCRC":[215],"patients.":[216]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-08-22T00:00:00"}