{"id":"https://openalex.org/W2887439360","doi":"https://doi.org/10.1242/dev.163303","title":"Glypican 4 and Mmp14 interact in regulating the migration of anterior endodermal cells by limiting extracellular matrix deposition","display_name":"Glypican 4 and Mmp14 interact in regulating the migration of anterior endodermal cells by limiting extracellular matrix deposition","publication_year":2018,"publication_date":"2018-08-06","ids":{"openalex":"https://openalex.org/W2887439360","doi":"https://doi.org/10.1242/dev.163303","mag":"2887439360","pmid":"https://pubmed.ncbi.nlm.nih.gov/30082271"},"language":"en","primary_location":{"id":"doi:10.1242/dev.163303","doi":"https://doi.org/10.1242/dev.163303","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.163303","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003172338","display_name":"Bo Hu","orcid":"https://orcid.org/0000-0001-5656-9632","observed_orcids":["https://orcid.org/0000-0001-5656-9632"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Hu","raw_affiliation_strings":["Carver College of Medicine, University of Iowa 1 Department of Anatomy and Cell Biology , , Iowa City, IA 52242 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carver College of Medicine, University of Iowa 1 Department of Anatomy and Cell Biology , , Iowa City, IA 52242 , USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102311269","display_name":"Yuanyuan Gao","orcid":"https://orcid.org/0000-0001-8122-2999","observed_orcids":["https://orcid.org/0000-0001-8122-2999"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanyuan Gao","raw_affiliation_strings":["Carver College of Medicine, University of Iowa 1 Department of Anatomy and Cell Biology , , Iowa City, IA 52242 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carver College of Medicine, University of Iowa 1 Department of Anatomy and Cell Biology , , Iowa City, IA 52242 , USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lauren Davies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Davies","raw_affiliation_strings":["Carver College of Medicine, University of Iowa 1 Department of Anatomy and Cell Biology , , Iowa City, IA 52242 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carver College of Medicine, University of Iowa 1 Department of Anatomy and Cell Biology , , Iowa City, IA 52242 , USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083198581","display_name":"Stephanie Woo","orcid":"https://orcid.org/0000-0002-1238-8167","observed_orcids":["https://orcid.org/0000-0002-1238-8167"]},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Woo","raw_affiliation_strings":["School of Natural Sciences, Merced, University of California Merced 2 , Merced, CA 95340 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Natural Sciences, Merced, University of California Merced 2 , Merced, CA 95340 , USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032982316","display_name":"Jacek Topczewski","orcid":"https://orcid.org/0000-0001-6023-9556","observed_orcids":["https://orcid.org/0000-0001-6023-9556"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL","US"],"is_corresponding":false,"raw_author_name":"Jacek Topczewski","raw_affiliation_strings":["Medical University of Lublin 4 Department of Biochemistry and Molecular Biology , , Lublin 20-093, \u2008 Poland","Northwestern University, Feinberg School of Medicine, Stanley Manne Children's Research Institute 3 , Chicago, IL 60611 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Lublin 4 Department of Biochemistry and Molecular Biology , , Lublin 20-093, \u2008 Poland","institution_ids":["https://openalex.org/I121032520"]},{"raw_affiliation_string":"Northwestern University, Feinberg School of Medicine, Stanley Manne Children's Research Institute 3 , Chicago, IL 60611 , USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035194031","display_name":"Jason R. Jessen","orcid":"https://orcid.org/0000-0002-8209-3620","observed_orcids":["https://orcid.org/0000-0002-8209-3620"]},"institutions":[{"id":"https://openalex.org/I169615421","display_name":"Middle Tennessee State University","ror":"https://ror.org/02n1hzn07","country_code":"US","type":"education","lineage":["https://openalex.org/I169615421"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason R. Jessen","raw_affiliation_strings":["Middle Tennessee State University 5 Department of Biology , , Murfreesboro, TN 37132 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Middle Tennessee State University 5 Department of Biology , , Murfreesboro, TN 37132 , USA","institution_ids":["https://openalex.org/I169615421"]}]},{"author_position":"last","author":{"id":null,"display_name":"Fang Lin","orcid":"https://orcid.org/0000-0002-1972-9294","observed_orcids":["https://orcid.org/0000-0002-1972-9294"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fang Lin","raw_affiliation_strings":["Carver College of Medicine, University of Iowa 1 Department of Anatomy and Cell Biology , , Iowa City, IA 52242 , USA"],"raw_orcid":"https://orcid.org/0000-0002-1972-9294","affiliations":[{"raw_affiliation_string":"Carver College of Medicine, University of Iowa 1 Department of Anatomy and Cell Biology , , Iowa City, IA 52242 , USA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":null,"apc_paid":null,"fwci":1.0145,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.73068113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"145","issue":"17","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.6557999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.6557999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.3052000105381012,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glypican-4","display_name":"GPC4","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mmp-14","display_name":"MMP-14","score":0.9229999780654907},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.8830000162124634},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.8769999742507935},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":1.0},{"id":"https://openalex.org/keywords/heparan-sulfate-proteoglycans","display_name":"heparan sulfate proteoglycans","score":0.8169999718666077},{"id":"https://openalex.org/keywords/rac-activation","display_name":"Rac activation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/lamellipodia","display_name":"lamellipodia","score":0.8370000123977661},{"id":"https://openalex.org/keywords/non-cell-autonomous-signaling","display_name":"non-cell-autonomous signaling","score":0.7699999809265137},{"id":"https://openalex.org/keywords/gastrulation","display_name":"gastrulation","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2777164004","wikidata":"https://www.wikidata.org/wiki/Q331858","display_name":"Endoderm","level":4,"score":0.8755149245262146},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7481065392494202},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6264413595199585},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.5375117659568787},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.5262407660484314},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.5096545219421387},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.5062300562858582},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48948800563812256},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.27073150873184204},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.22560033202171326},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.21811038255691528},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.16031226515769958},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14848458766937256},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05568709969520569}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004707","descriptor_name":"Endoderm","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020744","descriptor_name":"rac GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053511","descriptor_name":"Matrix Metalloproteinase 14","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053511","descriptor_name":"Matrix Metalloproteinase 14","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053673","descriptor_name":"Glypicans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053673","descriptor_name":"Glypicans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054262","descriptor_name":"Gastrulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1242/dev.163303","doi":"https://doi.org/10.1242/dev.163303","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.163303","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:30082271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30082271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt7j33z5bx","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7j33z5bx","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Development (Cambridge, England), vol 145, iss 17","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7j33z5bx","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7j33z5bx","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Development, vol 145, iss 17","raw_type":"article"},{"id":"pmh:oai:open-archive.highwire.org:develop:145/17/dev163303","doi":null,"is_oa":false,"landing_page_url":"http://dev.biologists.org/cgi/content/short/145/17/dev163303","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1857588083","display_name":"The role of endoderm in cardiac morphogenesis","funder_award_id":"1354457","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W48566380","https://openalex.org/W1844826852","https://openalex.org/W1962881891","https://openalex.org/W1965498876","https://openalex.org/W1969670014","https://openalex.org/W1974723367","https://openalex.org/W1980199345","https://openalex.org/W1981264477","https://openalex.org/W1986158200","https://openalex.org/W1986219096","https://openalex.org/W1988821294","https://openalex.org/W1993199560","https://openalex.org/W1996788021","https://openalex.org/W2004237413","https://openalex.org/W2007776004","https://openalex.org/W2009718333","https://openalex.org/W2014457703","https://openalex.org/W2026292446","https://openalex.org/W2029781891","https://openalex.org/W2039943198","https://openalex.org/W2040131518","https://openalex.org/W2045031690","https://openalex.org/W2047904724","https://openalex.org/W2050546910","https://openalex.org/W2053188090","https://openalex.org/W2053958751","https://openalex.org/W2055202626","https://openalex.org/W2059178311","https://openalex.org/W2059813768","https://openalex.org/W2062630837","https://openalex.org/W2074966513","https://openalex.org/W2083571731","https://openalex.org/W2088703231","https://openalex.org/W2090733040","https://openalex.org/W2091161326","https://openalex.org/W2092100012","https://openalex.org/W2096251733","https://openalex.org/W2097761421","https://openalex.org/W2099491263","https://openalex.org/W2106675234","https://openalex.org/W2108050451","https://openalex.org/W2111955181","https://openalex.org/W2112067413","https://openalex.org/W2118305000","https://openalex.org/W2120573222","https://openalex.org/W2124140082","https://openalex.org/W2125349610","https://openalex.org/W2129105171","https://openalex.org/W2130255071","https://openalex.org/W2132581785","https://openalex.org/W2138291240","https://openalex.org/W2141071307","https://openalex.org/W2159853266","https://openalex.org/W2160922979","https://openalex.org/W2161533644","https://openalex.org/W2340337877","https://openalex.org/W2342313938","https://openalex.org/W2428872795","https://openalex.org/W2519400635","https://openalex.org/W2571718349","https://openalex.org/W2599641104","https://openalex.org/W2604799076","https://openalex.org/W2605067960","https://openalex.org/W2767529657","https://openalex.org/W4241399562"],"related_works":["https://openalex.org/W3167387178","https://openalex.org/W3204507417","https://openalex.org/W2519400635","https://openalex.org/W1988821294","https://openalex.org/W4236479556","https://openalex.org/W2054389684","https://openalex.org/W3211984657","https://openalex.org/W2026292446","https://openalex.org/W1969670014","https://openalex.org/W1978881331"],"abstract_inverted_index":{"ABSTRACT":[0],"During":[1],"embryogenesis,":[2],"the":[3,7,18,23,56,99,110,121,136,162],"germ":[4],"layers,":[5],"including":[6],"endoderm,":[8],"undergo":[9],"convergence":[10],"and":[11,16,112,116],"extension":[12],"movements":[13],"to":[14,76,149],"narrow":[15],"elongate":[17],"body":[19],"plan.":[20],"In":[21],"zebrafish,":[22],"dorsal":[24],"migration":[25,65,90,102,167],"of":[26,55,66,114,120,138,168,175],"endodermal":[27,68,169],"cells":[28,69],"during":[29,44,70,141,177],"gastrulation":[30],"is":[31,38,61,133,158],"controlled":[32],"by":[33],"chemokine":[34],"signaling,":[35],"but":[36],"little":[37],"known":[39],"about":[40],"how":[41],"they":[42],"migrate":[43],"segmentation.":[45],"Here,":[46],"we":[47,126],"show":[48],"that":[49,86,98,128,156],"glypican":[50],"4":[51],"(Gpc4),":[52],"a":[53,92,172],"member":[54],"heparin":[57],"sulfate":[58],"proteoglycan":[59],"family,":[60],"required":[62,134,164],"for":[63,135,160,165],"efficient":[64,166],"anterior":[67],"early":[71],"segmentation,":[72],"regulating":[73],"Rac":[74],"activation":[75],"maintain":[77],"polarized":[78],"actin-rich":[79],"lamellipodia.":[80],"An":[81],"endoderm":[82,89,101,142],"transplantation":[83],"assay":[84],"showed":[85],"Gpc4":[87,145,157,176],"regulates":[88],"in":[91,103,109],"non-cell-autonomous":[93],"fashion.":[94],"Further":[95],"analyses":[96],"revealed":[97],"impaired":[100],"gpc4":[104],"mutants":[105],"results":[106,154],"from":[107],"increases":[108],"expression":[111,140],"assembly":[113],"fibronectin":[115],"laminin,":[117],"major":[118],"components":[119],"extracellular":[122],"matrix":[123,129],"(ECM).":[124],"Notably,":[125],"found":[127],"metalloproteinase":[130],"14":[131],"(Mmp14a/b)":[132],"control":[137],"ECM":[139,151],"migration,":[143],"with":[144],"acting":[146],"through":[147],"Mmp14a/b":[148],"limit":[150],"expression.":[152],"Our":[153],"suggest":[155],"crucial":[159],"generating":[161],"environment":[163],"cells,":[170],"uncovering":[171],"novel":[173],"function":[174],"development.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-22T00:00:00"}