{"id":"https://openalex.org/W2887328815","doi":"https://doi.org/10.1158/1538-7445.am2018-2231","title":"Abstract 2231: Insulin and multi-system alterations in non-diabetic American adults: NHANES 1999-2016","display_name":"Abstract 2231: Insulin and multi-system alterations in non-diabetic American adults: NHANES 1999-2016","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2887328815","doi":"https://doi.org/10.1158/1538-7445.am2018-2231","mag":"2887328815"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-2231","doi":"https://doi.org/10.1158/1538-7445.am2018-2231","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-2231","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019329822","display_name":"Neil E. Caporaso","orcid":"https://orcid.org/0000-0001-7562-4609","observed_orcids":["https://orcid.org/0000-0001-7562-4609"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil E. Caporaso","raw_affiliation_strings":["1NCI, Rockville, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NCI, Rockville, MD;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081592114","display_name":"Rena R. Jones","orcid":"https://orcid.org/0000-0003-1294-1679","observed_orcids":["https://orcid.org/0000-0003-1294-1679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rena R. Jones","raw_affiliation_strings":["2NCI, Silver Spring, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2NCI, Silver Spring, MD;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010107362","display_name":"Lisa Kahle","orcid":"https://orcid.org/0000-0002-1783-7240","observed_orcids":["https://orcid.org/0000-0002-1783-7240"]},"institutions":[{"id":"https://openalex.org/I4210110061","display_name":"Information Management Services","ror":"https://ror.org/020k7fn51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110061"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa L. Kahle","raw_affiliation_strings":["3Information Management Services Corp, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Information Management Services Corp, Rockville, MD","institution_ids":["https://openalex.org/I4210110061"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062588511","display_name":"Barry I. Graubard","orcid":"https://orcid.org/0000-0002-6787-1105","observed_orcids":["https://orcid.org/0000-0002-6787-1105"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry I. Graubard","raw_affiliation_strings":["1NCI, Rockville, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NCI, Rockville, MD;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"2231","last_page":"2231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9670000076293945},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nondiabetic-adults","display_name":"non-diabetic adults","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.6819999814033508},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.8450000286102295},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.7170000076293945},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5109999775886536},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8539999723434448},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9100000262260437},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.5080000162124634},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.7730000019073486},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.7350000143051147},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.5360000133514404},{"id":"https://openalex.org/keywords/respiratory-function","display_name":"respiratory function","score":0.6570000052452087},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.5180000066757202},{"id":"https://openalex.org/keywords/nhanes","display_name":"NHANES","score":0.5830000042915344},{"id":"https://openalex.org/keywords/c-peptide","display_name":"C-peptide","score":0.6209999918937683},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.828000009059906},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7835252285003662},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7790284156799316},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7190253734588623},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6158631443977356},{"id":"https://openalex.org/C2779874844","wikidata":"https://www.wikidata.org/wiki/Q1967281","display_name":"National Health and Nutrition Examination Survey","level":3,"score":0.48865869641304016},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.486782044172287},{"id":"https://openalex.org/C2778535154","wikidata":"https://www.wikidata.org/wiki/Q5889863","display_name":"Homeostatic model assessment","level":4,"score":0.4362488389015198},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.42785027623176575},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.42117607593536377},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.38017112016677856},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2546253800392151},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-2231","doi":"https://doi.org/10.1158/1538-7445.am2018-2231","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-2231","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6399999856948853,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2981994291","https://openalex.org/W2013484108","https://openalex.org/W2110327688","https://openalex.org/W7097069315","https://openalex.org/W1531206489","https://openalex.org/W46003694","https://openalex.org/W7135171165","https://openalex.org/W2376663333","https://openalex.org/W2054360558","https://openalex.org/W7220711235"],"abstract_inverted_index":{"Abstract":[0],"Epidemiological":[1],"evidence":[2],"for":[3,120,148,192,231,311],"a":[4,202],"relationship":[5,191],"between":[6],"insulin":[7,59,67,78,215,247],"resistance":[8,68,216,248],"and":[9,13,28,60,103,114,128,159,167,182,226,236,295],"cancer":[10],"is":[11,198,249],"emerging,":[12],"insulins'":[14],"complex":[15],"actions":[16],"suggest":[17,245],"that":[18,246],"its":[19],"dysregulation":[20],"results":[21,244],"in":[22,46,54,58,108,220,253,298],"multisystem":[23,43],"alterations.":[24],"Using":[25],"cross-sectional":[26],"demographic":[27,121],"laboratory":[29],"data":[30],"from":[31,36],"the":[32,40,73,308],"continuous":[33],"NHANES":[34,232,302],"conducted":[35],"1999-2016.":[37],"we":[38,213],"surveyed":[39],"range":[41],"of":[42,66,77,151,177,206,307],"alterations":[44,297],"observed":[45,154],"normal":[47,254],"(not":[48],"diabetic":[49],"or":[50],"prediabetic)":[51],"adult":[52],"subjects":[53],"relation":[55,109],"to":[56,110,195,208,217,251],"variation":[57],"glucose":[61,116],"levels.":[62],"The":[63,190],"homeostatic":[64],"model":[65],"(HOMA-IR)":[69],"was":[70],"used":[71],"as":[72],"key":[74],"outcome":[75],"measure":[76],"resistance.":[79],"We":[80],"examined":[81],"cardiovascular":[82],"(BP),":[83],"respiratory":[84],"(FEV1,":[85],"FVC),":[86],"renal":[87],"(BUN,":[88],"creatinine),":[89],"inflammatory":[90,168,225],"(C-reactive":[91],"protein,":[92,172],"fibrinogen),":[93],"lipid":[94],"(triglycerides,":[95],"LDL,":[96],"HLD),":[97],"hematologic":[98],"(WBC,":[99],"hemoglobin,":[100],"cell":[101],"counts),":[102],"nutritional":[104,227],"(vitamin":[105],"levels)":[106],"factors":[107],"HOMA-IR,":[111],"C-peptide,":[112],"Hgb1Ac":[113],"fasting":[115],"levels":[117,176],"after":[118],"adjustment":[119],"(age,":[122],"gender,":[123],"smoking,":[124],"alcohol,":[125],"race,":[126],"SES)":[127],"anthropometric":[129],"(BMI)":[130],"factors.":[131],"Every":[132],"system":[133],"exhibited":[134],"highly":[135],"significant":[136],"associations":[137],"with":[138,155,188],"insulin/glucose":[139],"measures.":[140],"Strong":[141],"correlations":[142],"(p":[143],"<":[144],"0.0001,":[145],"Pearson,":[146],"accounting":[147,230],"sample":[149,205,233],"weights)":[150],"HOMA-IR":[152,196,259],"were":[153,185],"waist":[156],"size,":[157],"systolic":[158],"diastolic":[160],"blood":[161],"pressure,":[162],"triglycerides,":[163],"HDL":[164],"(inverse),":[165],"LDL":[166],"markers:":[169],"fibrinogen,":[170],"C-reactive":[171],"ferritin.":[173],"Measured":[174],"serum":[175],"vitamin":[178,180],"C,":[179],"D,":[181],"folate":[183],"(RBC),":[184],"inversely":[186],"associated":[187],"HOMA-IR.":[189],"selected":[193],"variables,":[194],"quartiles":[197],"shown":[199],"below.":[200],"In":[201],"broad,":[203],"representative":[204],"up":[207],"9000":[209],"non-diabetic":[210,299],"US":[211],"subjects,":[212],"relate":[214],"adverse":[218],"changes":[219],"anthropometric,":[221],"cardiovascular,":[222],"renal,":[223],"metabolic,":[224],"markers.":[228],"Analyses":[229],"design,":[234],"confounding":[235],"potential":[237],"interactions":[238],"will":[239],"be":[240],"reported.":[241],"Our":[242],"preliminary":[243],"linked":[250],"perturbations":[252],"function":[255],"across":[256],"numerous":[257],"systems.":[258],"Quartiles,":[260],"adjusted":[261],"(95%":[262],"CI)1st2nd3rd4thFerritin79.1(71-87)75.9":[263],"(70-82)82.3":[264],"(76-89)96.2":[265],"(82-110)BP":[266],"(d)69.7":[267],"(69-71)71.8":[268],"(70-73)71.4":[269],"(70-73)73.2":[270],"(72-75)HDL60.8":[271],"(60-62)56.3":[272],"(56-57)54.1":[273],"(53-55)51.3":[274],"(50-52)WBC6.37":[275],"(6.3-6.5)6.44":[276],"(6.3-6.6)6.68":[277],"(6.5-6.8)6.96":[278],"(6.8-7.1)":[279],"Citation":[280],"Format:":[281],"Neil":[282],"E.":[283],"Caporaso,":[284],"Rena":[285],"R.":[286],"Jones,":[287],"Lisa":[288],"L.":[289],"Kahle,":[290],"Barry":[291],"I.":[292],"Graubard.":[293],"Insulin":[294],"multi-system":[296],"American":[300,309],"adults:":[301],"1999-2016":[303],"[abstract].":[304],"In:":[305],"Proceedings":[306],"Association":[310],"Cancer":[312,325],"Research":[313],"Annual":[314],"Meeting":[315],"2018;":[316],"2018":[317],"Apr":[318],"14-18;":[319],"Chicago,":[320],"IL.":[321],"Philadelphia":[322],"(PA):":[323],"AACR;":[324],"Res":[326],"2018;78(13":[327],"Suppl):Abstract":[328],"nr":[329],"2231.":[330]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2018-08-22T00:00:00"}