{"id":"https://openalex.org/W288730141","doi":null,"title":"Regulation of CD95 ligand expression: a key element in immune regulation?","display_name":"Regulation of CD95 ligand expression: a key element in immune regulation?","publication_year":1996,"publication_date":"1996-10-01","ids":{"openalex":"https://openalex.org/W288730141","mag":"288730141","pmid":"https://pubmed.ncbi.nlm.nih.gov/8950474"},"language":"en","primary_location":{"id":"pmid:8950474","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8950474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behring Institute Mitteilungen","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076383050","display_name":"Tommy Brunner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Brunner","raw_affiliation_strings":["Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111845256","display_name":"Nam Jin Yoo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N J Yoo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076681768","display_name":"Thomas S. Griffith","orcid":"https://orcid.org/0000-0002-7205-9859","observed_orcids":["https://orcid.org/0000-0002-7205-9859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T S Griffith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108240901","display_name":"T A Ferguson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T A Ferguson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5075655484","display_name":"Douglas R. Green","orcid":"https://orcid.org/0000-0002-7332-1417","observed_orcids":["https://orcid.org/0000-0002-7332-1417"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D R Green","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6285,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.64442028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"97","first_page":"161","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.16670000553131104,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.9890000224113464},{"id":"https://openalex.org/keywords/fas-cd95","display_name":"Fas/CD95","score":0.6159999966621399},{"id":"https://openalex.org/keywords/activation-induced-cell-death","display_name":"activation-induced cell death","score":0.8970000147819519},{"id":"https://openalex.org/keywords/t-cell-apoptosis","display_name":"T cell apoptosis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.9869999885559082},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.5979999899864197},{"id":"https://openalex.org/keywords/immune-privilege","display_name":"immune privilege","score":0.8320000171661377},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7089999914169312},{"id":"https://openalex.org/keywords/non-lymphoid-tissues","display_name":"non-lymphoid tissues","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C3031857","wikidata":"https://www.wikidata.org/wiki/Q1649375","display_name":"Fas receptor","level":4,"score":0.8192338943481445},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6648285388946533},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6022941470146179},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5315511226654053},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5078397393226624},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4775839149951935},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4755506217479706},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.46605879068374634},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4457632601261139},{"id":"https://openalex.org/C2781185574","wikidata":"https://www.wikidata.org/wiki/Q3404271","display_name":"Immune privilege","level":3,"score":0.44575947523117065},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2947884202003479},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09700602293014526}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002148","descriptor_name":"Calmodulin-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002148","descriptor_name":"Calmodulin-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002148","descriptor_name":"Calmodulin-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019703","descriptor_name":"Calcineurin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019703","descriptor_name":"Calcineurin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019703","descriptor_name":"Calcineurin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053222","descriptor_name":"Fas Ligand Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053222","descriptor_name":"Fas Ligand Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053222","descriptor_name":"Fas Ligand Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8950474","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8950474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behring Institute Mitteilungen","raw_type":"Journal Article"},{"id":"mag:288730141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8950474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7200000286102295,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1991383991","https://openalex.org/W2377140302","https://openalex.org/W2120884463","https://openalex.org/W244168439","https://openalex.org/W2470508791","https://openalex.org/W2472033073","https://openalex.org/W2021693564","https://openalex.org/W2373252646","https://openalex.org/W2347673386","https://openalex.org/W2087041770"],"abstract_inverted_index":{"Peripheral":[0],"deletion":[1],"of":[2,13,16,56,97,168,173,184],"activated":[3],"T":[4,24,58,67,85,126,151],"cells":[5,29,68,127,191],"has":[6],"an":[7,17],"important":[8],"function":[9,163],"in":[10,125,136,149,165,187,198],"the":[11,14,23,57,110,166,171,182],"regulation":[12,183],"extent":[15],"immune":[18,179,199],"response.":[19],"Upon":[20],"restimulation":[21],"through":[22],"cell":[25,37,86,99,152],"receptor":[26],"previously":[27],"stimulated":[28],"have":[30,101,156],"been":[31,102],"shown":[32],"to":[33,104,115,122,193],"die":[34],"by":[35,47,84],"activation-induced":[36,98,150],"death.":[38],"Recent":[39],"data":[40],"indicate":[41],"that":[42,79,142],"this":[43],"process":[44],"is":[45,63,70,82,90,131,144,164],"mediated":[46],"a":[48,195],"CD95":[49,60,185],"(Fas/APO-1)/CD95":[50],"ligand":[51,61],"interaction":[52],"which":[53],"induces":[54],"apoptosis":[55],"cell.":[59],"(CD95-L)":[62],"absent":[64],"on":[65,109],"unactivated":[66],"but":[69,130,154],"readily":[71],"expressed":[72,135],"upon":[73],"stimulation.":[74],"Here":[75],"we":[76],"discuss":[77],"evidence":[78],"CD95-L":[80,116,118,143],"expression":[81,186],"induced":[83,124],"receptor-mediated":[87],"signals":[88],"and":[89,189],"regulated":[91],"at":[92],"different":[93],"levels.":[94],"Different":[95],"inhibitors":[96],"death":[100],"found":[103,133],"directly":[105],"or":[106],"indirectly":[107],"act":[108],"signal":[111],"transduction":[112],"pathway":[113],"leading":[114],"expression.":[117],"seems":[119],"not":[120,145],"only":[121,146],"be":[123],"after":[128],"activation":[129],"also":[132],"constitutively":[134],"many":[137],"non-lymphoid":[138,190],"tissues.":[139],"This":[140],"indicates":[141],"critically":[147],"involved":[148],"death,":[153],"may":[155],"other":[157],"functions":[158],"as":[159],"well.":[160],"One":[161],"such":[162],"maintenance":[167],"immunological":[169],"privilege,":[170],"protection":[172],"some":[174],"tissues":[175],"from":[176],"potentially":[177],"destructive":[178],"responses.":[180],"Thus,":[181],"lymphoid":[188],"appears":[192],"represent":[194],"key":[196],"element":[197],"regulation.":[200]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}