{"id":"https://openalex.org/W2887219016","doi":"https://doi.org/10.1158/1538-7445.am2018-232","title":"Abstract 232: Genome-wide association study (GWAS) of total nicotine equivalents: A composite biomarker of nicotine uptake","display_name":"Abstract 232: Genome-wide association study (GWAS) of total nicotine equivalents: A composite biomarker of nicotine uptake","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2887219016","doi":"https://doi.org/10.1158/1538-7445.am2018-232","mag":"2887219016"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-232","doi":"https://doi.org/10.1158/1538-7445.am2018-232","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-232","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000929473","display_name":"Linda M. Polfus","orcid":"https://orcid.org/0000-0003-1123-2117","observed_orcids":["https://orcid.org/0000-0003-1123-2117"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda M. Polfus","raw_affiliation_strings":["1University of California, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, Los Angeles, CA;","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100769421","display_name":"So\u2010Hyun Park","orcid":"https://orcid.org/0000-0003-1929-9041","observed_orcids":["https://orcid.org/0000-0003-1929-9041"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Lani Park","raw_affiliation_strings":["1University of California, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, Los Angeles, CA;","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013179873","display_name":"Yesha M. Patel","orcid":"https://orcid.org/0000-0002-4983-1222","observed_orcids":["https://orcid.org/0000-0002-4983-1222"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yesha M. Patel","raw_affiliation_strings":["1University of California, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, Los Angeles, CA;","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022126431","display_name":"Sharon E. Murphy","orcid":"https://orcid.org/0000-0001-5391-8104","observed_orcids":["https://orcid.org/0000-0001-5391-8104"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon E. Murphy","raw_affiliation_strings":["2University of Minnesota, Minneapolis, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Minnesota, Minneapolis, MN;","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007768066","display_name":"David V. Conti","orcid":"https://orcid.org/0000-0002-2941-7833","observed_orcids":["https://orcid.org/0000-0002-2941-7833"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Conti","raw_affiliation_strings":["1University of California, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, Los Angeles, CA;","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046353086","display_name":"Christopher A Haiman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Haiman","raw_affiliation_strings":["1University of California, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, Los Angeles, CA;","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046710077","display_name":"Daniel O. Stram","orcid":"https://orcid.org/0000-0001-7099-9022","observed_orcids":["https://orcid.org/0000-0001-7099-9022"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel O. Stram","raw_affiliation_strings":["1University of California, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, Los Angeles, CA;","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053074659","display_name":"Lo\u0131\u0308c Le Marchand","orcid":"https://orcid.org/0000-0001-5013-980X","observed_orcids":["https://orcid.org/0000-0001-5013-980X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lo\u00efc Le Marchand","raw_affiliation_strings":["3University of California, Honolulu, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of California, Honolulu, HI","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"232","last_page":"232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.3174000084400177,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smoking-intensity","display_name":"smoking intensity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/chrnb4","display_name":"CHRNB4","score":0.7039999961853027},{"id":"https://openalex.org/keywords/chrna3","display_name":"CHRNA3","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.8399999737739563},{"id":"https://openalex.org/keywords/genetic-susceptibility-to-smoking","display_name":"genetic susceptibility to smoking","score":0.7049999833106995},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.4189999997615814},{"id":"https://openalex.org/keywords/lung-cancer-risk","display_name":"lung cancer risk","score":0.8019999861717224},{"id":"https://openalex.org/keywords/multiethnic-cohort","display_name":"multi-ethnic cohort","score":0.8309999704360962},{"id":"https://openalex.org/keywords/ethnic-differences","display_name":"ethnic differences","score":0.460999995470047},{"id":"https://openalex.org/keywords/cotinine","display_name":"cotinine","score":0.46000000834465027},{"id":"https://openalex.org/keywords/trans-3-hydroxycotinine","display_name":"trans-3'-hydroxycotinine","score":0.8709999918937683},{"id":"https://openalex.org/keywords/nicotine-n-oxide","display_name":"nicotine N-oxide","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2776319443","wikidata":"https://www.wikidata.org/wiki/Q421177","display_name":"Cotinine","level":3,"score":0.8140025734901428},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.7603704929351807},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6390799283981323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5360598564147949},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4930281341075897},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.4888593554496765},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4409666657447815},{"id":"https://openalex.org/C2777843972","wikidata":"https://www.wikidata.org/wiki/Q2462253","display_name":"Smoking cessation","level":2,"score":0.4139117896556854},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.38426071405410767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3674573600292206},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26678037643432617},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.24159422516822815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1858079433441162},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10017123818397522},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09918427467346191}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-232","doi":"https://doi.org/10.1158/1538-7445.am2018-232","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-232","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390994310","https://openalex.org/W4391887938","https://openalex.org/W2101876919","https://openalex.org/W2127850370","https://openalex.org/W2144947515","https://openalex.org/W2124163128","https://openalex.org/W2330373060","https://openalex.org/W2108344795","https://openalex.org/W2112913914","https://openalex.org/W2030749524"],"abstract_inverted_index":{"Abstract":[0],"The":[1,353],"primary":[2,296],"risk":[3,397,411],"factor":[4],"for":[5,71,175,204,221,234,298,341,463],"lung":[6,409],"cancer":[7,11,410],"(second":[8],"most":[9],"common":[10,244],"in":[12,16,27,149,189,246,326,343,380,386,406],"men":[13],"and":[14,51,53,61,112,164,182,193,208,249,259,276,293,300,383,402],"women":[15],"the":[17,28,46,132,160,165,170,198,209,238,282,295,302,344,360,381,387,404,460],"U.S.)":[18],"is":[19,62,89,377,384],"tobacco":[20,113],"smoking.":[21,37,306,417],"Prior":[22],"GWAS":[23],"have":[24],"identified":[25],"variants":[26],"CHRNA5-CHRNA3-CHRNB4":[29],"cluster":[30],"(chr":[31],"15q25)":[32],"to":[33,84,91,110,169,271,281,305],"be":[34],"associated":[35],"with":[36,232,252,309,365,408],"Total":[38],"nicotine":[39,59,66,111,299,310,448,454],"equivalents":[40],"(TNE)":[41],"measured":[42,142],"from":[43,131],"urine":[44,154],"represents":[45],"sum":[47],"of":[48,65,79,97,100,103,121,136,178,290,389,400,413,416,446,453,459],"nicotine,":[49],"cotinine,":[50],"trans-3\u2032-hydroxycotinine":[52],"its":[54],"glucuronides,":[55],"as":[56,58,286],"well":[57],"N-oxide,":[60],"a":[63,77,117,176,395],"biomarker":[64,78,452],"uptake":[67,311,455],"and,":[68,105],"when":[69],"adjusted":[70,203,220],"cigarettes":[72,224],"smoked":[73],"per":[74,225],"day":[75,226],"(CPD),":[76],"smoking":[80,85,93,124,321],"intensity.":[81],"In":[82],"addition":[83],"status,":[86],"genetic":[87,396],"variation":[88],"likely":[90],"influence":[92,320],"behavior":[94],"(e.g.,":[95],"number":[96,99],"cigarettes,":[98],"puffs,":[101],"depth":[102],"inhalation)":[104],"thus,":[106],"one's":[107],"internal":[108],"exposure":[109],"carcinogens.":[114],"We":[115],"conducted":[116,158,188],"genome-wide":[118,336],"association":[119,407,443],"study":[120,444],"TNE":[122,140,201,233],"(i.e.":[123],"dose)":[125],"among":[126],"2,239":[127],"cancer-free,":[128],"current":[129],"smokers":[130],"Multiethnic":[133],"Cohort,":[134],"comprised":[135],"5":[137],"ethnic":[138,195,366],"groups.":[139],"was":[141,157,356],"using":[143,197],"liquid":[144],"chromatography-tandem":[145],"mass":[146],"spectrometry":[147],"analysis":[148],"overnight":[150],"or":[151],"first":[152,210],"morning":[153],"samples.":[155],"Genotyping":[156],"utilizing":[159],"Illumina":[161],"1M":[162],"array":[163],"data":[166,363],"were":[167,187,334],"imputed":[168],"1000":[171],"Genomes":[172],"reference":[173],"panel,":[174],"total":[177,447],"11.9":[179],"million":[180],"SNPs":[181,245,333],"indels.":[183],"Linear":[184],"regression":[185],"models":[186],"all":[190,327],"subjects":[191],"combined":[192],"each":[194],"group":[196],"log":[199,222],"transformed":[200,223],"measurement,":[202],"age,":[205],"BMI,":[206],"sex,":[207],"ten":[211],"principle":[212],"components":[213],"(Model":[214,227],"1).":[215],"A":[216,450],"separate":[217],"model":[218],"additionally":[219],"2).":[228],"Genome-wide":[229,442],"significant":[230],"associations":[231],"Model":[235,324],"1":[236],"included":[237],"chr":[239],"15q25":[240],"region,":[241],"specifically,":[242],"intronic":[243,332],"CHRNB4":[247],"(rs17487223)":[248],"CHRNA3":[250],"(rs55676755)":[251],"P=7.37x10-9":[253],"(Beta":[254,261],"(SE)":[255,262,349,372],"=":[256,263,350,373],"0.21":[257],"(0.04))":[258],"P=2.22x10-8":[260],"0.19":[264],"(0.03)),":[265],"respectively.":[266],"Ethnic":[267],"specific":[268,367],"analyses":[269],"pointed":[270],"European":[272],"American,":[273,275],"African":[274,361],"Hispanic":[277],"individuals":[278],"mainly":[279],"contributing":[280],"signal.":[283],"Nicotinic":[284],"receptors,":[285],"ligand-gated":[287],"channels":[288],"consist":[289],"five":[291],"subunits":[292],"are":[294],"targets":[297],"initiate":[301],"brain":[303,382],"responses":[304],"Our":[307],"findings":[308],"confirm":[312],"previous":[313],"reports":[314],"that":[315],"these":[316],"biologically":[317],"plausible":[318],"genes":[319],"behavior.":[322],"For":[323],"2":[325],"pooled":[328],"ethnicities":[329],"combined,":[330],"three":[331],"near":[335],"significance":[337],"(with":[338],"lowest":[339],"P=7.13x10-8":[340],"rs55934265)":[342],"beta-1,3-galactosyltransferase":[345],"(B3GALT1)":[346],"gene,":[347],"Beta":[348,371],"-0.57":[351],"(0.10).":[352],"B3GALT1":[354,376],"signal":[355],"primarily":[357],"driven":[358],"by":[359],"American":[362,461],"(N=364)":[364],"results":[368],"at":[369],"P=5.3x10-4,":[370],"-0.47":[374],"(0.13).":[375],"expressed":[378],"exclusively":[379],"involved":[385],"biosynthesis":[388],"glycolipids.":[390],"Next":[391],"steps":[392],"include":[393],"constructing":[394],"score":[398],"(GRS)":[399],"TNE,":[401],"evaluating":[403],"GRS":[405],"independent":[412],"self-reported":[414],"levels":[415],"Citation":[418],"Format:":[419],"Linda":[420],"M.":[421,427],"Polfus,":[422],"S.":[423],"Lani":[424],"Park,":[425],"Yesha":[426],"Patel,":[428],"Sharon":[429],"E.":[430],"Murphy,":[431],"David":[432],"Conti,":[433],"Christopher":[434],"Haiman,":[435],"Daniel":[436],"O.":[437],"Stram,":[438],"Lo\u00efc":[439],"Le":[440],"Marchand.":[441],"(GWAS)":[445],"equivalents:":[449],"composite":[451],"[abstract].":[456],"In:":[457],"Proceedings":[458],"Association":[462],"Cancer":[464,477],"Research":[465],"Annual":[466],"Meeting":[467],"2018;":[468],"2018":[469],"Apr":[470],"14-18;":[471],"Chicago,":[472],"IL.":[473],"Philadelphia":[474],"(PA):":[475],"AACR;":[476],"Res":[478],"2018;78(13":[479],"Suppl):Abstract":[480],"nr":[481],"232.":[482]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-22T00:00:00"}