{"id":"https://openalex.org/W2887080950","doi":"https://doi.org/10.1186/s12964-018-0259-5","title":"Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence","display_name":"Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence","publication_year":2018,"publication_date":"2018-08-17","ids":{"openalex":"https://openalex.org/W2887080950","doi":"https://doi.org/10.1186/s12964-018-0259-5","mag":"2887080950","pmid":"https://pubmed.ncbi.nlm.nih.gov/30119678","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6098600"},"language":"en","primary_location":{"id":"doi:10.1186/s12964-018-0259-5","doi":"https://doi.org/10.1186/s12964-018-0259-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-018-0259-5","pdf_url":"https://biosignaling.biomedcentral.com/counter/pdf/10.1186/s12964-018-0259-5","source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biosignaling.biomedcentral.com/counter/pdf/10.1186/s12964-018-0259-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023474925","display_name":"Samir Tivari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samir Tivari","raw_affiliation_strings":["Department of Medicine, Rutgers New Jersey Medical School and Rutgers Cancer Institute of New Jersey, 205 South Orange Avenue, Cancer Center H1216, Newark, NJ, 07103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Rutgers New Jersey Medical School and Rutgers Cancer Institute of New Jersey, 205 South Orange Avenue, Cancer Center H1216, Newark, NJ, 07103, USA","institution_ids":["https://openalex.org/I4390039325","https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003050130","display_name":"Haiyan L\u00fc","orcid":"https://orcid.org/0000-0002-6711-0314","observed_orcids":["https://orcid.org/0000-0002-6711-0314","https://orcid.org/0000-0001-6291-2193"]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiyan Lu","raw_affiliation_strings":["Department of Medicine, Rutgers New Jersey Medical School and Rutgers Cancer Institute of New Jersey, 205 South Orange Avenue, Cancer Center H1216, Newark, NJ, 07103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Rutgers New Jersey Medical School and Rutgers Cancer Institute of New Jersey, 205 South Orange Avenue, Cancer Center H1216, Newark, NJ, 07103, USA","institution_ids":["https://openalex.org/I4390039325","https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112381785","display_name":"Tanya Dasgupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanya Dasgupta","raw_affiliation_strings":["Department of Medicine, Rutgers New Jersey Medical School and Rutgers Cancer Institute of New Jersey, 205 South Orange Avenue, Cancer Center H1216, Newark, NJ, 07103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Rutgers New Jersey Medical School and Rutgers Cancer Institute of New Jersey, 205 South Orange Avenue, Cancer Center H1216, Newark, NJ, 07103, USA","institution_ids":["https://openalex.org/I4390039325","https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033432620","display_name":"Mariana S. De Lorenzo","orcid":"https://orcid.org/0000-0002-7753-8138","observed_orcids":["https://orcid.org/0000-0002-7753-8138"]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariana S. De Lorenzo","raw_affiliation_strings":["Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School and Rutgers Cancer Institute of New Jersey, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School and Rutgers Cancer Institute of New Jersey, Newark, NJ, USA","institution_ids":["https://openalex.org/I4390039325","https://openalex.org/I4402554120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053615282","display_name":"Robert Wieder","orcid":"https://orcid.org/0000-0002-1005-493X","observed_orcids":["https://orcid.org/0000-0002-1005-493X"]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert Wieder","raw_affiliation_strings":["Department of Medicine, Rutgers New Jersey Medical School and Rutgers Cancer Institute of New Jersey, 205 South Orange Avenue, Cancer Center H1216, Newark, NJ, 07103, USA. wiederro@njms.rutgers.edu","Department of Medicine, Rutgers New Jersey Medical School and Rutgers Cancer Institute of New Jersey, 205 South Orange Avenue, Cancer Center H1216, Newark, NJ, 07103, USA"],"raw_orcid":"https://orcid.org/0000-0002-1005-493X","affiliations":[{"raw_affiliation_string":"Department of Medicine, Rutgers New Jersey Medical School and Rutgers Cancer Institute of New Jersey, 205 South Orange Avenue, Cancer Center H1216, Newark, NJ, 07103, USA. wiederro@njms.rutgers.edu","institution_ids":["https://openalex.org/I4390039325","https://openalex.org/I4402554120"]},{"raw_affiliation_string":"Department of Medicine, Rutgers New Jersey Medical School and Rutgers Cancer Institute of New Jersey, 205 South Orange Avenue, Cancer Center H1216, Newark, NJ, 07103, USA","institution_ids":["https://openalex.org/I4390039325","https://openalex.org/I4402554120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053615282"],"corresponding_institution_ids":["https://openalex.org/I4390039325","https://openalex.org/I4402554120"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":2.8182,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.93669846,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"1","first_page":"48","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-dormancy","display_name":"breast cancer dormancy","score":0.8220000267028809},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.9110000133514404},{"id":"https://openalex.org/keywords/bone-marrow-micrometastasis","display_name":"bone marrow micrometastases","score":0.9319999814033508},{"id":"https://openalex.org/keywords/bone-marrow-stroma","display_name":"bone marrow stroma","score":0.9179999828338623},{"id":"https://openalex.org/keywords/stromal-inflammation","display_name":"stromal inflammation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7889999747276306},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8709999918937683},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8970000147819519},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mesenchymal-phenotype","display_name":"mesenchymal phenotype","score":0.7559999823570251},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.753000020980835},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6226850152015686},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.59134441614151},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5715242028236389},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5302345752716064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5127926468849182},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.42307624220848083},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38186925649642944},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3744160234928131},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3511650562286377},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2741495966911316},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25822749733924866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21083134412765503}],"mesh":[{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12964-018-0259-5","doi":"https://doi.org/10.1186/s12964-018-0259-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-018-0259-5","pdf_url":"https://biosignaling.biomedcentral.com/counter/pdf/10.1186/s12964-018-0259-5","source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5048505","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6098600","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30119678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30119678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell communication and signaling : CCS","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6098600","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6098600/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Commun Signal","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4e7ee437eeff4b6989b8fb6d3971caf0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4e7ee437eeff4b6989b8fb6d3971caf0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-18 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12964-018-0259-5","doi":"https://doi.org/10.1186/s12964-018-0259-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-018-0259-5","pdf_url":"https://biosignaling.biomedcentral.com/counter/pdf/10.1186/s12964-018-0259-5","source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2331908676","display_name":"Reactivation of breast cancer micrometastases by senescent bone marrow stroma","funder_award_id":"R21CA142537","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4168714370","display_name":"Reactivation of Breast Cancer Micrometastases by Senescent Bone Marrow Stroma","funder_award_id":"W81XWH-09-1-0119","funder_id":"https://openalex.org/F4320338273","funder_display_name":"Congressionally Directed Medical Research Programs"},{"id":"https://openalex.org/G5405843604","display_name":null,"funder_award_id":"CA142537","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338273","display_name":"Congressionally Directed Medical Research Programs","ror":"https://ror.org/03g2zjp07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2887080950.pdf","grobid_xml":"https://content.openalex.org/works/W2887080950.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W1516082547","https://openalex.org/W1559761050","https://openalex.org/W1574713623","https://openalex.org/W1575402832","https://openalex.org/W1589844632","https://openalex.org/W1678482413","https://openalex.org/W1964081206","https://openalex.org/W1964847767","https://openalex.org/W1966701340","https://openalex.org/W1968628080","https://openalex.org/W1970098795","https://openalex.org/W1975120553","https://openalex.org/W1979988883","https://openalex.org/W1988748783","https://openalex.org/W1990316038","https://openalex.org/W1990425294","https://openalex.org/W1993322072","https://openalex.org/W1993497779","https://openalex.org/W2001012450","https://openalex.org/W2003047764","https://openalex.org/W2004395531","https://openalex.org/W2006986876","https://openalex.org/W2007724985","https://openalex.org/W2012315119","https://openalex.org/W2014098577","https://openalex.org/W2016360721","https://openalex.org/W2018446432","https://openalex.org/W2023720445","https://openalex.org/W2027933117","https://openalex.org/W2028919524","https://openalex.org/W2030914607","https://openalex.org/W2040672475","https://openalex.org/W2042397841","https://openalex.org/W2043291678","https://openalex.org/W2054719244","https://openalex.org/W2054917860","https://openalex.org/W2063660731","https://openalex.org/W2068503417","https://openalex.org/W2069295237","https://openalex.org/W2069547975","https://openalex.org/W2077211484","https://openalex.org/W2097971577","https://openalex.org/W2099792017","https://openalex.org/W2101335366","https://openalex.org/W2101446068","https://openalex.org/W2101791298","https://openalex.org/W2103878518","https://openalex.org/W2106263242","https://openalex.org/W2106738771","https://openalex.org/W2107164894","https://openalex.org/W2108286621","https://openalex.org/W2108296770","https://openalex.org/W2111414495","https://openalex.org/W2112194601","https://openalex.org/W2115900736","https://openalex.org/W2117864836","https://openalex.org/W2124009013","https://openalex.org/W2126923814","https://openalex.org/W2127690474","https://openalex.org/W2128668256","https://openalex.org/W2129019171","https://openalex.org/W2130378759","https://openalex.org/W2133857939","https://openalex.org/W2134160865","https://openalex.org/W2136280424","https://openalex.org/W2138225432","https://openalex.org/W2144040453","https://openalex.org/W2145228970","https://openalex.org/W2147671525","https://openalex.org/W2148341801","https://openalex.org/W2149053153","https://openalex.org/W2150091603","https://openalex.org/W2154706646","https://openalex.org/W2155542819","https://openalex.org/W2159303972","https://openalex.org/W2163472474","https://openalex.org/W2168015079","https://openalex.org/W2171774285","https://openalex.org/W2194404144","https://openalex.org/W2271721498","https://openalex.org/W2282477053","https://openalex.org/W2343623791","https://openalex.org/W2464001628","https://openalex.org/W2506244296","https://openalex.org/W2507728208","https://openalex.org/W2510922180","https://openalex.org/W2522829580","https://openalex.org/W2523245974","https://openalex.org/W2552831679","https://openalex.org/W2580755748","https://openalex.org/W2781438702","https://openalex.org/W4247655731","https://openalex.org/W7097257540"],"related_works":["https://openalex.org/W1600172868","https://openalex.org/W2891429022","https://openalex.org/W2549259281","https://openalex.org/W2495831503","https://openalex.org/W7148822861","https://openalex.org/W6950302145","https://openalex.org/W2158957824","https://openalex.org/W4379145124","https://openalex.org/W4404451180","https://openalex.org/W4409634746"],"abstract_inverted_index":{"Dormant":[0,153,232],"estrogen":[1,102,161],"receptor":[2,162],"positive":[3,295],"(ER+)":[4],"breast":[5,35,51,73,128,234,278],"cancer":[6,36,52,74,129,235,279],"micrometastases":[7],"in":[8,42,94,230],"the":[9,63,85,122,214,291],"bone":[10],"marrow":[11],"survive":[12],"adjuvant":[13],"chemotherapy":[14],"and":[15,84,101,115,120,160,165,170,190,212,226,246,262,288],"recur":[16],"stochastically":[17],"for":[18],"more":[19],"than":[20],"20":[21],"years.":[22],"We":[23,38,76,90],"hypothesized":[24],"that":[25],"inflammatory":[26,66],"cytokines":[27,67],"produced":[28],"by":[29,98,228,290],"stromal":[30,96],"injury":[31,198],"can":[32],"re-awaken":[33],"dormant":[34,71,147,178,252],"cells.":[37,75,130,219],"used":[39],"an":[40,191,270],"established":[41],"vitro":[43],"dormancy":[44],"model":[45],"of":[46,65,70,79,126,146,158,168,177,182,201,216,224,286],"Michigan":[47],"Cancer":[48],"Foundation-7":[49],"(MCF-7)":[50],"cells":[53,149,154,221,236,268,280],"incubated":[54],"at":[55],"clonogenic":[56],"density":[57],"on":[58,68,124,150],"fibronectin-coated":[59,151],"plates":[60],"to":[61,87,194,273],"determine":[62],"effects":[64,123],"reactivation":[69],"ER+":[72,233],"measured":[77],"induction":[78],"a":[80,185,251,263,294],"mesenchymal":[81,186,240,264],"phenotype,":[82],"motility":[83,189],"capacity":[86,193],"re-enter":[88,195,274],"dormancy.":[89,196,275],"induced":[91,144,180,199,222],"secretory":[92],"senescence":[93],"murine":[95],"monolayers":[97],"oxidation,":[99],"hypoxia":[100],"deprivation":[103],"with":[104,282],"hydrogen":[105],"peroxide":[106],"(H":[107],"2":[108,110],"O":[109],"),":[111],"carbonyl-cyanide":[112],"m-chlorophenylhydrazzone":[113],"(CCCP)":[114],"Fulvestrant":[116],"(ICI":[117],"182780),":[118],"respectively,":[119],"determined":[121],"growth":[125,140,215,261],"co-cultivated":[127,217],"Exogenous":[131],"recombinant":[132],"human":[133],"(rh)":[134],"interleukin":[135],"(IL)-6,":[136],"IL-8":[137,227,289],"or":[138,174],"transforming":[139],"factor":[141,207],"\u03b21":[142],"(TGF\u03b21)":[143],"regrowth":[145],"MCF-7":[148,218,220],"plates.":[152],"had":[155],"decreased":[156],"expression":[157,167,244],"E-cadherin":[159],"\u03b1":[163],"(ER\u03b1)":[164],"increased":[166,188],"N-cadherin":[169],"SNAI2":[171],"(SLUG).":[172],"Cytokine":[173],"TGF\u03b21":[175],"treatment":[176],"clones":[179],"formation":[181],"growing":[183,267],"clones,":[184],"appearance,":[187],"impaired":[192,271],"Stromal":[197,255],"secretion":[200,223,285],"IL-6,":[202],"IL-8,":[203],"upregulated":[204],"tumor":[205],"necrosis":[206],"alpha":[208],"(TNF\u03b1),":[209],"activated":[210,238],"TGF\u03b2":[211],"stimulated":[213],"IL-6":[225,287],"stroma":[229,283],"co-culture.":[231],"have":[237,269],"epithelial":[239,253],"transition":[241],"(EMT)":[242],"gene":[243],"programs":[245],"downregulated":[247],"ER\u03b1":[248],"but":[249],"maintain":[250],"phenotype.":[254,265],"inflammation":[256],"reactivates":[257],"these":[258],"cells,":[259],"induces":[260],"Reactivated,":[266],"ability":[272],"In":[276],"turn,":[277],"co-cultured":[281],"induce":[284],"stroma,":[292],"creating":[293],"feedback":[296],"loop.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2018-08-22T00:00:00"}