{"id":"https://openalex.org/W2887051679","doi":"https://doi.org/10.1158/1538-7445.am2018-3899","title":"Abstract 3899: Discovery and clinical implementation of individualized therapies in acute myeloid leukemia based on ex vivo drug sensitivity testing and multi-omics profiling","display_name":"Abstract 3899: Discovery and clinical implementation of individualized therapies in acute myeloid leukemia based on ex vivo drug sensitivity testing and multi-omics profiling","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2887051679","doi":"https://doi.org/10.1158/1538-7445.am2018-3899","mag":"2887051679"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-3899","doi":"https://doi.org/10.1158/1538-7445.am2018-3899","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-3899","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032196301","display_name":"Disha Malani","orcid":"https://orcid.org/0000-0001-9614-3281","observed_orcids":["https://orcid.org/0000-0001-9614-3281"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Disha Malani","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103277288","display_name":"Ashwini Kumar","orcid":"https://orcid.org/0000-0002-8168-5595","observed_orcids":["https://orcid.org/0000-0002-8168-5595"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ashwini Kumar","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079229880","display_name":"Bhagwan Yadav","orcid":"https://orcid.org/0000-0002-3502-9335","observed_orcids":["https://orcid.org/0000-0002-3502-9335"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bhagwan Yadav","raw_affiliation_strings":["2Hematology Research Unit Helsinki, Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Hematology Research Unit Helsinki, Helsinki, Finland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064764393","display_name":"Mika Kontro","orcid":"https://orcid.org/0000-0001-6353-0664","observed_orcids":["https://orcid.org/0000-0001-6353-0664"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mika Kontro","raw_affiliation_strings":["2Hematology Research Unit Helsinki, Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Hematology Research Unit Helsinki, Helsinki, Finland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053034632","display_name":"Swapnil Potdar","orcid":"https://orcid.org/0000-0002-2778-6918","observed_orcids":["https://orcid.org/0000-0002-2778-6918"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Swapnil Potdar","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023554856","display_name":"Oscar E. Br\u00fcck","orcid":"https://orcid.org/0000-0002-7842-9419","observed_orcids":["https://orcid.org/0000-0002-7842-9419"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oscar Br\u00fcck","raw_affiliation_strings":["2Hematology Research Unit Helsinki, Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Hematology Research Unit Helsinki, Helsinki, Finland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070175326","display_name":"Sari Kyt\u00f6l\u00e4","orcid":"https://orcid.org/0000-0003-1649-8993","observed_orcids":["https://orcid.org/0000-0003-1649-8993"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sari Kyt\u00f6l\u00e4","raw_affiliation_strings":["2Hematology Research Unit Helsinki, Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Hematology Research Unit Helsinki, Helsinki, Finland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062171296","display_name":"Jani Saarela","orcid":"https://orcid.org/0000-0001-7306-7175","observed_orcids":["https://orcid.org/0000-0001-7306-7175"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jani Saarela","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089248994","display_name":"Samuli Eldfors","orcid":"https://orcid.org/0000-0001-5056-4750","observed_orcids":["https://orcid.org/0000-0001-5056-4750"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Samuli Eldfors","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022872061","display_name":"Poojitha Ojamies","orcid":"https://orcid.org/0000-0002-4921-7134","observed_orcids":["https://orcid.org/0000-0002-4921-7134"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Poojitha Ojamies","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112381745","display_name":"Riikka Karjalainen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Karjalainen Riikka","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075634967","display_name":"Muntasir Mamun Majumder","orcid":"https://orcid.org/0000-0002-5550-2951","observed_orcids":["https://orcid.org/0000-0002-5550-2951"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Muntasir Mamun Majumder","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014441735","display_name":"Imre V\u00e4strik","orcid":"https://orcid.org/0000-0001-6658-9311","observed_orcids":["https://orcid.org/0000-0001-6658-9311"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Imre V\u00e4strik","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085276790","display_name":"Pekka Ellonen","orcid":"https://orcid.org/0000-0001-6072-0489","observed_orcids":["https://orcid.org/0000-0001-6072-0489"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pekka Ellonen","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000875080","display_name":"Matti Kankainen","orcid":"https://orcid.org/0000-0002-4714-9481","observed_orcids":["https://orcid.org/0000-0002-4714-9481"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Matti Kankainen","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021708697","display_name":"Minna H. Suvela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Minna Suvela","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083500221","display_name":"Siv Knappila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Siv Knappila","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081143275","display_name":"Alun Parson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Alun Parson","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006604923","display_name":"Aino Palva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Aino Palva","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001822701","display_name":"Pirkko Mattila","orcid":"https://orcid.org/0000-0002-5741-607X","observed_orcids":["https://orcid.org/0000-0002-5741-607X"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pirkko Mattila","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016772828","display_name":"Evgeny Kulesskiy","orcid":"https://orcid.org/0000-0001-5965-2917","observed_orcids":["https://orcid.org/0000-0001-5965-2917"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Evgeny Kulesskiy1","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060810486","display_name":"Laura Turunen","orcid":"https://orcid.org/0000-0003-0274-4794","observed_orcids":["https://orcid.org/0000-0003-0274-4794"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Laura Turunen","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087624521","display_name":"Karoliina Laamanen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Karoliina Laamanen","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037910483","display_name":"Elina Lehtinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Elina Lehtinen","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089980412","display_name":"Piia Mikkonen","orcid":"https://orcid.org/0000-0003-4202-6412","observed_orcids":["https://orcid.org/0000-0003-4202-6412"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Piia Mikkonen","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria Nurmi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Maria Nurmi","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026664404","display_name":"Sanna H. Timonen","orcid":"https://orcid.org/0000-0002-8139-5950","observed_orcids":["https://orcid.org/0000-0002-8139-5950"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sanna Timonen","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033369123","display_name":"Astrid Murum\u00e4gi","orcid":"https://orcid.org/0000-0002-7797-188X","observed_orcids":["https://orcid.org/0000-0002-7797-188X"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Astrid Murum\u00e4gi","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057088387","display_name":"Bj\u00f8rn Tore Gjertsen","orcid":"https://orcid.org/0000-0001-9358-9704","observed_orcids":["https://orcid.org/0000-0001-9358-9704"]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Bjorn Tore Gjersten","raw_affiliation_strings":["3Department of Clinical Science, Bergen, Norway;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Clinical Science, Bergen, Norway;","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008868111","display_name":"Satu M. Mustjoki","orcid":"https://orcid.org/0000-0002-0816-8241","observed_orcids":["https://orcid.org/0000-0002-0816-8241"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satu Mustjoki","raw_affiliation_strings":["2Hematology Research Unit Helsinki, Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Hematology Research Unit Helsinki, Helsinki, Finland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016681267","display_name":"Tero A. Aittokallio","orcid":"https://orcid.org/0000-0002-0886-9769","observed_orcids":["https://orcid.org/0000-0002-0886-9769"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tero Aittokallio","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067760174","display_name":"Krister Wennerberg","orcid":"https://orcid.org/0000-0002-1352-4220","observed_orcids":["https://orcid.org/0000-0002-1352-4220"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Krister Wennerberg","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022280742","display_name":"Simon Anders","orcid":"https://orcid.org/0000-0003-4868-1805","observed_orcids":["https://orcid.org/0000-0003-4868-1805"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Simon Anders","raw_affiliation_strings":["4Center for Molecular Biology of University of Heidelberg (ZMBH), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Center for Molecular Biology of University of Heidelberg (ZMBH), Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042781409","display_name":"Maija Wolf","orcid":"https://orcid.org/0009-0004-9046-8930","observed_orcids":["https://orcid.org/0009-0004-9046-8930"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Maija Wolf","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061939140","display_name":"Caroline Akemi Heckman","orcid":"https://orcid.org/0000-0002-4324-8706","observed_orcids":["https://orcid.org/0000-0002-4324-8706"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Caroline Heckman","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050873337","display_name":"Kimmo Porkka","orcid":"https://orcid.org/0000-0003-4112-5902","observed_orcids":["https://orcid.org/0000-0003-4112-5902"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimmo Porkka","raw_affiliation_strings":["2Hematology Research Unit Helsinki, Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Hematology Research Unit Helsinki, Helsinki, Finland;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050670008","display_name":"Olli Kallioniemi","orcid":"https://orcid.org/0000-0002-3231-0332","observed_orcids":["https://orcid.org/0000-0002-3231-0332"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Olli Kallioniemi","raw_affiliation_strings":["1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Inst. for Molec. Medicine Finland (FIMM), Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"3899","last_page":"3899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ex-vivo-drug-sensitivity-testing","display_name":"ex vivo drug sensitivity testing","score":0.9509999752044678},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.7459999918937683},{"id":"https://openalex.org/keywords/multi-omics-profiling","display_name":"multi-omics profiling","score":0.7559999823570251},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.6859999895095825},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.5529999732971191},{"id":"https://openalex.org/keywords/bcl2-inhibitors","display_name":"BCL-2 inhibitor","score":0.7559999823570251},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.7730000019073486},{"id":"https://openalex.org/keywords/npm1-mutation","display_name":"NPM1 mutation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/jak-inhibitors","display_name":"JAK inhibitors","score":0.9879999756813049},{"id":"https://openalex.org/keywords/bet-inhibitors","display_name":"BET inhibitors","score":0.7940000295639038},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.9929999709129333},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5070000290870667},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.8234149217605591},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7646874189376831},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5855407118797302},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5517834424972534},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5273376703262329},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4989500045776367},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4775044322013855},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4570070207118988},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33913201093673706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1486893594264984},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-3899","doi":"https://doi.org/10.1158/1538-7445.am2018-3899","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-3899","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2984908043","https://openalex.org/W3146553835","https://openalex.org/W2324713340","https://openalex.org/W4240078795","https://openalex.org/W2903100949","https://openalex.org/W3167961099","https://openalex.org/W178117945","https://openalex.org/W2886974404","https://openalex.org/W4417009146","https://openalex.org/W4389433411"],"abstract_inverted_index":{"Abstract":[0],"Acute":[1],"myeloid":[2,488],"leukemia":[3,348,489],"(AML)":[4],"is":[5],"a":[6,205,291,373,378],"heterogeneous":[7],"disease":[8],"characterized":[9],"by":[10,136],"multiple":[11],"molecular":[12,24,66,167,399],"subtypes":[13,67],"and":[14,26,34,70,77,90,101,122,127,134,138,166,168,175,214,269,310,319,361,389,480,497],"lack":[15],"of":[16,68,154,161,181,201,207,234,244,277,299,354,483,503],"effective":[17],"targeted":[18,216,325],"therapies.":[19],"Here,":[20],"we":[21,303,359],"performed":[22],"extensive":[23],"profiling":[25,499],"ex":[27,187,238,285,492],"vivo":[28,188,239,286,493],"drug":[29,61,125,164,189,224,240,250,293,387,394,494],"testing":[30,496],"with":[31],"515":[32],"approved":[33],"emerging":[35,78],"cancer":[36,79],"drugs":[37,217,246,309],"on":[38,186,491],"164":[39],"AML":[40,54,69,88,281,300,336,368],"patient":[41,183],"samples.":[42],"The":[43,141,221,338,382],"aim":[44],"was":[45,209,252],"to":[46,52,74,146,149,212,288,321,343],"i)":[47],"assign":[48],"individualized":[49,364,484],"treatment":[50,156,326],"options":[51,366],"advanced":[53],"patients":[55,89,282],"in":[56,112,192,223,226,247,296,331,334,351,372,377,397,486],"real":[57],"time,":[58],"ii)":[59],"explore":[60],"response":[62,190,388],"patterns":[63,191],"across":[64,259],"the":[65,97,102,150,159,227,232,248,278,504],"iii)":[71],"identify":[72],"opportunities":[73,327,396],"repurpose":[75],"existing":[76],"drugs.":[80],"Bone":[81],"marrow":[82],"samples":[83,184,208],"(n=164)":[84],"from":[85,96],"129":[86],"consecutive":[87],"17":[91],"healthy":[92],"donors":[93],"were":[94,109,178,328],"studied":[95,135],"Helsinki":[98],"University":[99,104],"Hospital":[100],"Haukeland":[103],"Hospital,":[105],"Bergen.":[106],"Mononuclear":[107],"cells":[108],"resuspended":[110],"either":[111],"mononuclear":[113],"cell":[114],"medium":[115,120],"(MCM)":[116],"or":[117,347],"stroma":[118],"conditioned":[119],"(CM)":[121],"tested":[123,330],"for":[124,152,237,262,367,507],"sensitivity":[126,287,320,495],"resistance":[128],"as":[129,255,257],"previously":[130],"described":[131],"(PMID:":[132],"24056683)":[133],"exome":[137],"transcriptome":[139],"sequencing.":[140],"study":[142],"protocol":[143],"allowed":[144],"us":[145],"return":[147],"data":[148],"clinician":[151],"consideration":[153],"novel":[155,393],"options.":[157],"For":[158,203],"meta-analysis":[160],"associations":[162,307,383],"between":[163,264,308,316,385],"responses":[165,225,376],"clinical":[169,340,375,481],"parameters,":[170],"Wilcoxon":[171],"signed":[172],"ranked":[173],"test":[174],"logistic":[176],"regression":[177],"applied.":[179],"Clustering":[180],"all":[182,215],"based":[185,490],"both":[193],"media":[194,229],"types":[195,230],"identified":[196,304,384],"7":[197],"distinct":[198],"functional":[199],"groups":[200],"AML.":[202],"example,":[204],"subgroup":[206],"highly":[210],"resistant":[211],"chemotherapeutics":[213],"except":[218],"BCL-2":[219],"inhibitors.":[220,273,323],"differences":[222],"two":[228],"highlighted":[231],"importance":[233],"assay":[235],"conditions":[236],"testing.":[241],"Strong":[242],"clustering":[243,258],"several":[245],"same":[249],"classes":[251],"often":[253],"observed":[254],"well":[256],"different":[260],"classes,":[261],"example":[263],"BET":[265],"(JQ1,":[266],"I-BET151,":[267],"birabresib)":[268],"MEK":[270],"(trametinib,":[271],"cobimetinib)":[272],"About":[274],"24":[275],"percent":[276],"FLT3":[279],"negative":[280],"manifested":[283],"strong":[284],"glucocorticoids,":[289],"highlighting":[290],"potential":[292],"repositioning":[294,395],"opportunity":[295],"this":[297],"subset":[298],"patients.":[301,337],"Overall,":[302],"320":[305],"significant":[306],"mutated":[311],"driver":[312,390],"genes":[313],"including":[314],"association":[315],"NPM1":[317],"mutation":[318],"JAK":[322],"Altogether,":[324],"clinically":[329,362],"25":[332],"occasions":[333],"chemorefractory":[335],"tailored":[339],"therapy":[341],"led":[342],"transient":[344],"complete":[345],"remission":[346],"free":[349],"state":[350],"36%":[352,374],"(9/25)":[353],"these":[355],"cases.":[356],"In":[357],"conclusion,":[358],"discovered":[360],"implemented":[363],"therapeutic":[365],"patients,":[369],"which":[370],"resulted":[371],"non-randomized":[379],"proof-of-concept":[380],"study.":[381],"ex-vivo":[386],"mutations":[391],"provided":[392],"specific":[398],"subtypes.":[400],"Citation":[401],"Format:":[402],"Disha":[403],"Malani,":[404],"Ashwini":[405],"Kumar,":[406],"Bhagwan":[407],"Yadav,":[408],"Mika":[409],"Kontro,":[410],"Swapnil":[411],"Potdar,":[412],"Oscar":[413],"Br\u00fcck,":[414],"Sari":[415],"Kyt\u00f6l\u00e4,":[416],"Jani":[417],"Saarela,":[418],"Samuli":[419],"Eldfors,":[420],"Poojitha":[421],"Ojamies,":[422],"Karjalainen":[423],"Riikka,":[424],"Muntasir":[425],"Mamun":[426],"Majumder,":[427],"Imre":[428],"V\u00e4strik,":[429],"Pekka":[430],"Ellonen,":[431],"Matti":[432],"Kankainen,":[433],"Minna":[434],"Suvela,":[435],"Siv":[436],"Knappila,":[437],"Alun":[438],"Parson,":[439],"Aino":[440],"Palva,":[441],"Pirkko":[442],"Mattila,":[443],"Evgeny":[444],"Kulesskiy1,":[445],"Laura":[446],"Turunen,":[447],"Karoliina":[448],"Laamanen,":[449],"Elina":[450],"Lehtinen,":[451],"Piia":[452],"Mikkonen,":[453],"Maria":[454],"Nurmi,":[455],"Sanna":[456],"Timonen,":[457],"Astrid":[458],"Murum\u00e4gi,":[459],"Bjorn":[460],"Tore":[461],"Gjersten,":[462],"Satu":[463],"Mustjoki,":[464],"Tero":[465],"Aittokallio,":[466],"Krister":[467],"Wennerberg,":[468],"Simon":[469],"Anders,":[470],"Maija":[471],"Wolf,":[472],"Caroline":[473],"Heckman,":[474],"Kimmo":[475],"Porkka,":[476],"Olli":[477],"Kallioniemi.":[478],"Discovery":[479],"implementation":[482],"therapies":[485],"acute":[487],"multi-omics":[498],"[abstract].":[500],"In:":[501],"Proceedings":[502],"American":[505],"Association":[506],"Cancer":[508,521],"Research":[509],"Annual":[510],"Meeting":[511],"2018;":[512],"2018":[513],"Apr":[514],"14-18;":[515],"Chicago,":[516],"IL.":[517],"Philadelphia":[518],"(PA):":[519],"AACR;":[520],"Res":[522],"2018;78(13":[523],"Suppl):Abstract":[524],"nr":[525],"3899.":[526]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2018-08-22T00:00:00"}