{"id":"https://openalex.org/W2887020167","doi":"https://doi.org/10.1158/1538-7445.am2018-5481","title":"Abstract 5481: Targeting the kynurenine pathway as a novel metabolic treatment for head and neck cancer","display_name":"Abstract 5481: Targeting the kynurenine pathway as a novel metabolic treatment for head and neck cancer","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2887020167","doi":"https://doi.org/10.1158/1538-7445.am2018-5481","mag":"2887020167"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-5481","doi":"https://doi.org/10.1158/1538-7445.am2018-5481","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-5481","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075065118","display_name":"Chitra Subramanian","orcid":"https://orcid.org/0000-0003-1871-2834","observed_orcids":["https://orcid.org/0000-0003-1871-2834"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chitra Subramanian","raw_affiliation_strings":["Univ. of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064721563","display_name":"Thekkelnaycke M. Rajendiran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thekkelnaycke M. Rajendiran","raw_affiliation_strings":["Univ. of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112308010","display_name":"Tanu Soni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanu Soni","raw_affiliation_strings":["Univ. of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057675169","display_name":"Mark Steven Cohen","orcid":"https://orcid.org/0000-0002-2517-0757","observed_orcids":["https://orcid.org/0000-0002-2517-0757"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark S. Cohen","raw_affiliation_strings":["Univ. of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"5481","last_page":"5481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.426800012588501,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.426800012588501,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.3449999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kynurenine-pathway","display_name":"kynurenine pathway","score":0.9810000061988831},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ido1","display_name":"IDO1","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tryptophan-metabolism","display_name":"tryptophan metabolism","score":0.8349999785423279},{"id":"https://openalex.org/keywords/kynurenine","display_name":"kynurenine","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ido2","display_name":"IDO2","score":0.7630000114440918},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.7649999856948853},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7429999709129333},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.5730000138282776},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9409999847412109},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.9419999718666077},{"id":"https://openalex.org/keywords/metabolic-therapy","display_name":"metabolic therapy","score":0.5049999952316284},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.3140000104904175},{"id":"https://openalex.org/keywords/immunotherapy-sensitization","display_name":"immunotherapy sensitization","score":0.4950000047683716},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.3659999966621399},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.38199999928474426},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.8509904146194458},{"id":"https://openalex.org/C2777503454","wikidata":"https://www.wikidata.org/wiki/Q415768","display_name":"Kynurenine","level":4,"score":0.8326585292816162},{"id":"https://openalex.org/C2776710720","wikidata":"https://www.wikidata.org/wiki/Q80417","display_name":"Kynurenine pathway","level":5,"score":0.7676071524620056},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.7065324187278748},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6624869108200073},{"id":"https://openalex.org/C83478079","wikidata":"https://www.wikidata.org/wiki/Q908221","display_name":"Indoleamine 2,3-dioxygenase","level":4,"score":0.65306556224823},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5086499452590942},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4907337427139282},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.4834628701210022},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4830935001373291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44679051637649536},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4373228847980499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37004154920578003},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.31245237588882446},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.27691465616226196},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.26661545038223267},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2427854835987091},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21789821982383728},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11646375060081482},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.07314038276672363},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.048256486654281616},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.04350787401199341},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-5481","doi":"https://doi.org/10.1158/1538-7445.am2018-5481","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-5481","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7125906446","https://openalex.org/W2953662191","https://openalex.org/W3164178299","https://openalex.org/W2912372112","https://openalex.org/W4396846272","https://openalex.org/W2475502170","https://openalex.org/W2887352318","https://openalex.org/W4409459494","https://openalex.org/W2989668645","https://openalex.org/W2885978192"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Head":[2],"and":[3,48,121,138,166,206,211,243,280,286,288,294,303,310,353,394],"neck":[4,395],"squamous":[5],"cell":[6,106],"carcinoma":[7],"(HNSCC)":[8],"still":[9],"claims":[10],"330,000":[11],"lives":[12],"globally":[13],"each":[14],"year,":[15],"indicating":[16],"a":[17,192,388],"critical":[18,193],"need":[19],"for":[20,99,135,363,369,392,404],"novel":[21,366,389],"therapies.":[22],"Recently,":[23],"we":[24],"identified":[25],"high":[26],"levels":[27,76,114,123,187,231,248],"of":[28,38,159,184,188,203,217,232,241,254,266,327,346,357,365,400],"kynurenine":[29,196,233,247,385],"(K)":[30],"in":[31,110,124,195,208,270,299,322,333,339],"HNSCC":[32,39,105,323],"patients":[33],"through":[34],"global":[35],"metabolic":[36,367,390],"profiling":[37],"tumor":[40,62,213],"tissues":[41],"via":[42],"mass":[43],"spectrometry":[44],"(MS).":[45],"Indoleamine-2,3-dioxygenase":[46],"(IDO)":[47],"tryptophan-2,3-":[49],"dioxygenase":[50],"(TDO)":[51],"are":[52,77],"enzymes":[53,147,189,219],"that":[54,84,190,221],"degrade":[55],"tryptophan":[56,145,351],"to":[57,64,88,142,227,330],"K.":[58],"Elevated":[59],"K":[60],"allows":[61],"cells":[63],"evade":[65],"immune":[66,86,354],"response":[67,87],"more":[68,235],"easily,":[69],"promoting":[70],"cancer":[71,167,174,261,396],"progression,":[72],"while":[73],"increased":[74,331],"IDO":[75],"associated":[78,168],"with":[79,324],"poorer":[80],"prognosis.":[81],"We":[82],"hypothesize":[83],"restoring":[85],"tumors":[89],"by":[90,117,129,155,198,234,250,258],"blocking":[91],"IDO1":[92,223,255,328,358],"will":[93,359],"be":[94],"an":[95],"effective":[96],"therapeutic":[97],"strategy":[98],"sensitizing":[100],"HNSCC.":[101,370],"Methods:":[102],"Validated":[103],"human":[104],"lines":[107],"were":[108,115,127,140,170,315],"grown":[109],"2D":[111],"culture.":[112],"Kynurenine":[113,318],"measured":[116,128],"MS.":[118],"IDO1,":[119,136,160,204],"IDO2":[120,205,242],"TDO":[122,139,244],"tissue":[125],"samples":[126],"Western":[130],"blot":[131],"(WB)":[132],"analysis.":[133],"siRNAs":[134],"IDO2,":[137],"used":[141],"knock":[143],"down":[144],"pathway":[146,175,197,262,352,386],"(non-targeting":[148],"siRNA":[149],"controls).":[150],"Knockdown":[151],"efficiency":[152],"was":[153,162,225],"evaluated":[154,257],"immunocytochemistry.":[156],"After":[157],"knockdown":[158,216,224,240],"RNA":[161],"isolated,":[163],"reverse":[164],"transcribed":[165],"pathways":[169],"analyzed":[171,178],"using":[172,179],"RT2":[173,260],"profiler":[176],"(data":[177],"GeneGlobe;":[180],"Qiagen).":[181],"Results:":[182],"Evaluation":[183],"the":[185,230,246,259,350,384,401],"expression":[186],"play":[191],"role":[194],"WB":[199],"analysis":[200,345],"indicated":[201,220,264],"upregulation":[202],"TOD":[207],"both":[209],"primary":[210],"metastatic":[212],"samples.":[214],"siRNA-mediated":[215],"these":[218],"only":[222,249],"able":[226],"significantly":[228],"reduce":[229],"than":[236],"80%":[237],"(p<0.001),":[238],"whereas":[239,296],"reduced":[245],"10-25%":[251],"(p>0.05%).":[252],"Regulation":[253],"function":[256],"finder":[263],"downregulation":[265],"several":[267,340],"genes":[268,297],"involved":[269,298],"angiogenesis":[271],"(ANGPT1,":[272],"MCP-1,":[273],"FGF2,":[274],"TEK,":[275],"VEGF,":[276],"SERPINF1),":[277],"pro-survival":[278],"(c-IAP2":[279],"XIAP),":[281],"EMT":[282],"transition":[283],"(CDH2,":[284],"OCLN":[285],"SNAI1),":[287],"DNA":[289,305],"repair":[290],"(LIG4,":[291],"POLB,":[292],"ERCC3":[293],"DDB2),":[295],"glycolysis":[300],"(ACLY,":[301],"G6PD,COX5A,LPL":[302],"PFKL),":[304],"damage":[306],"(GADD34,":[307],"GADD45G":[308],"etc)":[309],"apoptosis":[311,332],"(CASP7,":[312],"CASP9,":[313],"BCL2L11)":[314],"upregulated.":[316],"Conclusion:":[317],"is":[319],"highly":[320],"upregulated":[321],"checkpoint":[325,355],"inhibition":[326,356],"leading":[329],"vitro":[334],"as":[335,337,387],"well":[336],"increases":[338],"glycolytic":[341,347],"enzymes.":[342],"Further":[343],"translational":[344],"influences":[348],"on":[349],"provide":[360],"mechanistic":[361],"support":[362],"development":[364],"therapies":[368],"Citation":[371],"Format:":[372],"Chitra":[373],"Subramanian,":[374],"Thekkelnaycke":[375],"M.":[376],"Rajendiran,":[377],"Tanu":[378],"Soni,":[379],"Mark":[380],"S.":[381],"Cohen.":[382],"Targeting":[383],"treatment":[391],"head":[393],"[abstract].":[397],"In:":[398],"Proceedings":[399],"American":[402],"Association":[403],"Cancer":[405,418],"Research":[406],"Annual":[407],"Meeting":[408],"2018;":[409],"2018":[410],"Apr":[411],"14-18;":[412],"Chicago,":[413],"IL.":[414],"Philadelphia":[415],"(PA):":[416],"AACR;":[417],"Res":[419],"2018;78(13":[420],"Suppl):Abstract":[421],"nr":[422],"5481.":[423]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-22T00:00:00"}