{"id":"https://openalex.org/W2886978069","doi":"https://doi.org/10.1093/cvr/cvy199","title":"ADAM-15 and glycocalyx shedding: a new perspective on sepsis-related vasomotor dysfunction","display_name":"ADAM-15 and glycocalyx shedding: a new perspective on sepsis-related vasomotor dysfunction","publication_year":2018,"publication_date":"2018-08-01","ids":{"openalex":"https://openalex.org/W2886978069","doi":"https://doi.org/10.1093/cvr/cvy199","mag":"2886978069","pmid":"https://pubmed.ncbi.nlm.nih.gov/30085027"},"language":"en","primary_location":{"id":"doi:10.1093/cvr/cvy199","doi":"https://doi.org/10.1093/cvr/cvy199","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cvr/cvy199","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028734833","display_name":"John David Horowitz","orcid":"https://orcid.org/0000-0001-6883-0703","observed_orcids":["https://orcid.org/0000-0001-6883-0703"]},"institutions":[{"id":"https://openalex.org/I4210089491","display_name":"Basil Hetzel Institute","ror":"https://ror.org/008b3br98","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210089491"]},{"id":"https://openalex.org/I4210099777","display_name":"Queen Elizabeth Hospital","ror":"https://ror.org/00x362k69","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210099777","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"John D Horowitz","raw_affiliation_strings":["Cardiology Unit, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, 25 Woodville Road, Woodville South, SA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Unit, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, 25 Woodville Road, Woodville South, SA, Australia","institution_ids":["https://openalex.org/I4210089491","https://openalex.org/I4210099777","https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101684547","display_name":"Saifei Liu","orcid":"https://orcid.org/0000-0003-4200-431X","observed_orcids":["https://orcid.org/0000-0003-4200-431X"]},"institutions":[{"id":"https://openalex.org/I4210089491","display_name":"Basil Hetzel Institute","ror":"https://ror.org/008b3br98","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210089491"]},{"id":"https://openalex.org/I4210099777","display_name":"Queen Elizabeth Hospital","ror":"https://ror.org/00x362k69","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210099777","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Saifei Liu","raw_affiliation_strings":["Cardiology Unit, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, 25 Woodville Road, Woodville South, SA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Unit, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, 25 Woodville Road, Woodville South, SA, Australia","institution_ids":["https://openalex.org/I4210089491","https://openalex.org/I4210099777","https://openalex.org/I5681781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028734833"],"corresponding_institution_ids":["https://openalex.org/I4210089491","https://openalex.org/I4210099777","https://openalex.org/I5681781"],"apc_list":{"value":4715,"currency":"EUR","value_usd":5329},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"114","issue":"13","first_page":"1694","last_page":"1695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.12200000137090683,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.04839999973773956,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycocalyx-shedding","display_name":"glycocalyx shedding","score":0.9120000004768372},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.8949999809265137},{"id":"https://openalex.org/keywords/vasomotor-dysfunction","display_name":"vasomotor dysfunction","score":0.9629999995231628},{"id":"https://openalex.org/keywords/endothelial-glycocalyx","display_name":"endothelial glycocalyx","score":0.9369999766349792},{"id":"https://openalex.org/keywords/vascular-leakage","display_name":"vascular leakage","score":0.7870000004768372},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8500000238418579},{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.7099999785423279},{"id":"https://openalex.org/keywords/pulmonary-edema","display_name":"pulmonary edema","score":0.7020000219345093},{"id":"https://openalex.org/keywords/syndecan-1","display_name":"syndecan-1","score":0.4970000088214874},{"id":"https://openalex.org/keywords/syndecan-2","display_name":"syndecan-2","score":0.6050000190734863},{"id":"https://openalex.org/keywords/syndecan-3","display_name":"syndecan-3","score":0.7170000076293945},{"id":"https://openalex.org/keywords/syndecan-4","display_name":"syndecan-4","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2776214587","wikidata":"https://www.wikidata.org/wiki/Q3430227","display_name":"Vasomotor","level":2,"score":0.749254047870636},{"id":"https://openalex.org/C2780098789","wikidata":"https://www.wikidata.org/wiki/Q898356","display_name":"Glycocalyx","level":2,"score":0.5967154502868652},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5734703540802002},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5564197897911072},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.5081162452697754},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.42456740140914917},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41713351011276245},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17031478881835938},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.100119948387146},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019276","descriptor_name":"Glycocalyx","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019483","descriptor_name":"Disintegrins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/cvr/cvy199","doi":"https://doi.org/10.1093/cvr/cvy199","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cvr/cvy199","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},{"id":"pmid:30085027","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30085027","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular research","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1578062386","https://openalex.org/W1977556482","https://openalex.org/W1987748412","https://openalex.org/W1990360580","https://openalex.org/W1996531679","https://openalex.org/W2097785181","https://openalex.org/W2104849624","https://openalex.org/W2125326130","https://openalex.org/W2128939263","https://openalex.org/W2142268036","https://openalex.org/W2303241606","https://openalex.org/W2396212074","https://openalex.org/W2518750404","https://openalex.org/W2608654770","https://openalex.org/W2809857463","https://openalex.org/W4206055353","https://openalex.org/W6675873478","https://openalex.org/W6679308228","https://openalex.org/W6680780577","https://openalex.org/W6752171515"],"related_works":["https://openalex.org/W2809857463","https://openalex.org/W3175940485","https://openalex.org/W3217621883","https://openalex.org/W2947413603","https://openalex.org/W2915852744","https://openalex.org/W2123095004","https://openalex.org/W3004981896","https://openalex.org/W4224440146","https://openalex.org/W3010554503","https://openalex.org/W2036407838"],"abstract_inverted_index":{"This":[0,532,797],"editorial":[1],"refers":[2],"to":[3,12,66,72,105,129,137,401,413,498,513,522,687,704,743,770,812,829,841],"\u2018A":[4],"disintegrin":[5,235,286,367,736],"and":[6,43,77,88,140,147,152,178,196,204,221,236,272,287,349,368,391,398,446,467,483,520,541,640,670,746,789,823],"metalloproteinase":[7],"15-mediated":[8],"glycocalyx":[9,126,215,266,554,588,627,827],"shedding":[10],"contributes":[11,508],"vascular":[13,496,831],"leakage":[14],"during":[15],"inflammation\u2019":[16],"by":[17,378,427,444,448,480,633],"X.":[18],"Yang":[19,359,663],"et":[20,360,664],"al.,":[21],"pp.":[22],"1752\u20131763.":[23],"Septic":[24],"shock":[25],"represents":[26,336,547,672],"an":[27],"ongoing":[28],"clinical":[29,51,342,720],"conundrum,":[30],"with":[31,167],"high":[32],"mortality":[33],"rates":[34],"despite":[35],"the":[36,57,112,119,125,373,403,454,463,485,493,514,523,542,580,602,611,634,636,643,659,694,699,730,772,783,787],"usual":[37],"background":[38],"of":[39,46,59,75,78,83,89,111,116,118,124,134,149,155,171,183,188,214,229,265,280,327,344,375,405,441,456,516,525,534,545,559,601,614,617,622,626,642,646,718,732,738,780,786,847],"extensive":[40,60,682],"haemodynamic":[41],"support":[42],"multiple":[44],"foci":[45],"therapeutic":[47],"endeavour.1":[48],"A":[49,102,234,285],"prominent":[50],"feature":[52],"in":[53,131,347,372,394,417,432,462,471,492,518,529,693,698,710,729,755,775],"such":[54],"cases":[55],"is":[56,93,108,127,190,354,370,574,619,666,716,765,818],"appearance":[58],"fluid":[61,139],"extravasation,":[62],"contributing":[63],"not":[64,198,511,685],"only":[65,199,686],"\u2018non-haemodynamic\u2019":[67],"pulmonary":[68],"oedema,":[69],"but":[70,206,341,510,702],"also":[71,92,703,752],"further":[73],"impairment":[74],"haemodynamics":[76],"respiratory":[79],"gas":[80],"exchange.2":[81],"Impairment":[82],"left":[84],"ventricular":[85],"systolic":[86],"function":[87,91,527],"renal":[90],"observed":[94],"frequently,3,4":[95],"as":[96,142,144,186,323,584,631,759,761],"patients":[97],"enter":[98],"a":[99,168,324,337,366,395,418,438,535,548,557,673,819,825],"\u2018downhill":[100],"spiral\u2019.":[101],"major":[103],"contributor":[104],"this":[106,357,457,530],"deterioration":[107],"inflammatory":[109,156],"erosion":[110],"endothelial":[113,135,647,838],"glycocalyx.":[114],"Depletion":[115],"any":[117],"proteoglycan":[120],"or":[121],"glycoprotein":[122],"components":[123,600,645],"likely":[128],"result":[130],"increased":[132,383,488],"permeability":[133,497],"cells":[136],"both":[138,461,539],"leucocytes/monocytes,":[141],"well":[143,760],"platelet":[145],"aggregation":[146],"development":[148],"non-laminar":[150],"flow":[151],"resultant":[153],"accentuation":[154],"responses.5":[157],"Apart":[158],"from":[159,567,586,662],"sepsis,":[160,519],"\u2018glycocalyx":[161],"shedding\u2019":[162],"(GS)":[163],"has":[164,319,725,740,751],"been":[165,320,726,741,753],"associated":[166],"large":[169],"number":[170,558],"disease":[172,217,268],"states,":[173,218,269],"including":[174,650],"acute":[175,351],"myocardial":[176],"infarction6":[177],"diabetic":[179],"nephopathy.7":[180],"The":[181,380,713,833],"list":[182],"\u2018sheddases\u2019":[184,593],"implicated":[185,727],"precipitants":[187],"GS":[189,376,517,618,639,709],"increasingly":[191],"long":[192],"(see":[193],"Table":[194],"1)":[195],"includes":[197],"catecholamines,":[200],"B-type":[201,250,301],"natriuretic":[202,240,251,255,291,302,306],"peptide":[203],"peroxynitrite,":[205],"several":[207],"enzymes,":[208],"especially":[209],"matrix":[210],"metalloproteinases":[211,781],"(MMP).8":[212],"Perspectives":[213,264],"shedding:":[216,267],"candidate":[219,270],"\u2018sheddases\u2019,":[220,271],"potential":[222,273,719],"plasma":[223,274,384],"markers":[224,275],"\u2018Sheddases\u2019":[225,276],"are":[226,277],"listed":[227,278],"independent":[228,279],"suggested":[230,281],"disease-related":[231,282],"roles.":[232,283],"ADAM,":[233,284],"metalloproteinase;":[237,288],"ANP,":[238,289],"A-type":[239,290],"peptide;":[241,252,256,292,303,307],"BACE,":[242,293],"\u03b2-site":[243,294],"amyloid":[244,295],"precursor":[245,296],"protein":[246,297],"cleaving":[247,298],"enzyme;":[248,299],"BNP,":[249,300],"CNP,":[253,304],"C-type":[254,305],"CABG,":[257,308],"coronary":[258,309],"artery":[259,310],"bypass":[260,311],"grafting;":[261,312],"SD,":[262,313],"syndecan.":[263,314],"To":[315,722],"date,":[316,723],"no":[317,606,767],"treatment":[318],"validated":[321],"clinically":[322],"\u2018broad-spectrum\u2019":[325],"inhibitor":[326],"sheddase":[328],"activation.":[329],"Preliminary":[330],"data":[331],"suggest":[332,505],"that":[333,364,506,591,610,815,824],"low-dose":[334],"doxycycline":[335],"non-specific":[338],"MMP":[339],"inhibitor,9":[340],"evidence":[343,363],"its":[345,409,689],"efficacy":[346],"sepsis":[348,393],"other":[350,711],"GS-associated":[352],"disorders":[353],"minimal":[355],"at":[356,484],"stage.":[358],"al.10":[361,665],"revisit":[362],"ADAM-15,":[365,445],"metalloproteinase,":[369],"involved":[371],"pathogenesis":[374,515],"induced":[377],"sepsis.":[379],"investigators":[381],"detected":[382,491],"CD44":[385,406,429,449,489,546],"ectodomain":[386,410,544],"concentrations":[387],"after":[388],"caecal":[389],"ligation":[390],"puncture-induced":[392],"mouse":[396,695],"model":[397,466],"were":[399],"able":[400],"attribute":[402],"cleavage":[404],"(thus":[407],"releasing":[408],"into":[411],"plasma)":[412],"ADAM-15.":[414,805],"In":[415,657],"turn,":[416],"cell":[419,465,648],"culture":[420],"model,":[421],"transendothelial":[422],"electric":[423],"resistance":[424],"was":[425,451,459,477,490,500],"reduced":[426],"exogenous":[428],"ectodomain,":[430,450],"resulting":[431],"cell\u2013cell":[433],"adherence":[434],"junction":[435],"disorganization.":[436],"Thus":[437],"\u2018two-step\u2019":[439],"process":[440],"GS,":[442],"initiated":[443],"exacerbated":[447],"delineated.":[452],"Furthermore,":[453],"presence":[455],"cascade":[458,537,774],"confirmed":[460],"isolated":[464,472],"ADAM-15\u2212/\u2212":[468],"mice.":[469],"Finally,":[470],"intact":[473],"human":[474,735],"lung,":[475],"ADAM-15":[476,507,540,724,739,750],"significantly":[478],"up-regulated":[479],"lipopolysaccharide":[481],"perfusion":[482],"same":[486],"time,":[487],"effluent,":[494],"while":[495],"albumin":[499],"increased.":[501],"These":[502,806],"results":[503],"therefore":[504],"substantially,":[509],"exclusively,":[512],"therefore,":[521],"loss":[524],"barrier":[526],"implicit":[528],"process.":[531],"delineation":[533],"deleterious":[536],"involving":[538],"shed":[543],"totally":[549],"new":[550,674,807],"mechanism":[551],"for":[552,835,837],"self-accelerating":[553],"damage.":[555],"However,":[556],"important":[560,569],"residual":[561],"issues":[562],"and,":[563],"indeed,":[564],"caveats,":[565],"arise":[566],"these":[568],"findings.":[570],"For":[571],"example,":[572],"there":[573],"little":[575],"current":[576,660,700],"information":[577],"about":[578],"either":[579],"mechanism(s)":[581],"underlying":[582],"physiological,":[583],"distinct":[585],"pathological,":[587],"turnover.":[589],"Given":[590],"differing":[592],"may":[594,790],"have":[595,744],"selective":[596],"impacts":[597],"on":[598,676,793],"various":[599,644],"glycocalyx,":[603],"it":[604,680,707],"can":[605],"longer":[607],"be":[608,791,801],"assumed":[609],"pathophysiological":[612],"impact":[613,692],"all":[615],"forms":[616],"similar,":[620],"irrespective":[621],"potentially":[623,667],"differential":[624],"targeting":[625],"components.":[628],"Most":[629],"importantly,":[630],"recognized":[632],"authors,":[635],"relationship":[637],"between":[638],"derangement":[641],"function,":[649],"nitric":[651],"oxide":[652],"signalling,":[653],"remains":[654],"essentially":[655],"unexplored.":[656],"conclusion,":[658],"report":[661],"very":[668,820],"important,":[669],"certainly":[671],"slant":[675],"GS.":[677],"As":[678],"such,":[679],"merits":[681],"follow-up":[683],"investigations,":[684],"ascertain":[688],"full":[690],"physiological":[691],"models":[696],"used":[697],"study":[701],"determine":[705],"whether":[706],"modulates":[708],"circumstances.":[712],"final":[714],"question":[715],"always":[717],"utility.":[721],"largely":[728],"setting":[731],"carcinogenesis.":[733],"Recombinant":[734],"domain":[737],"shown":[742],"anti-tumour":[745],"anti-angiogenic":[747],"activity.11":[748],"Increased":[749],"reported":[754],"lung":[756],"inflammation,12":[757],"atherogenesis,13":[758],"rheumatoid":[762],"arthritis.14":[763],"There":[764],"currently":[766],"convenient":[768],"method":[769],"suppress":[771],"ADAM-15/CD44":[773],"humans.":[776],"Endogenous":[777],"tissue":[778],"inhibitors":[779],"modulate":[782],"enzymatic":[784],"activity":[785],"ADAMs":[788],"effective":[792],"selectively":[794],"inhibiting":[795],"ADAMs.15":[796],"interaction":[798],"should":[799],"now":[800],"specifically":[802],"evaluated":[803],"regarding":[804],"insights":[808],"serve":[809],"once":[810],"more":[811],"remind":[813],"us":[814],"\u2018endothelial":[816],"dysfunction\u2019":[817],"imprecise":[821],"term,":[822],"sick":[826,830],"equates":[828],"endothelium.":[832],"search":[834],"cures":[836],"dysfunction":[839],"needs":[840],"embrace":[842],"specific":[843],"pathogenetic":[844],"pathways.":[845],"Conflict":[846],"interest:":[848],"none":[849],"declared.":[850]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-22T00:00:00"}
