{"id":"https://openalex.org/W2886952011","doi":"https://doi.org/10.1038/s41598-018-30159-5","title":"ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis","display_name":"ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis","publication_year":2018,"publication_date":"2018-08-14","ids":{"openalex":"https://openalex.org/W2886952011","doi":"https://doi.org/10.1038/s41598-018-30159-5","mag":"2886952011","pmid":"https://pubmed.ncbi.nlm.nih.gov/30127455","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6102283"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-30159-5","doi":"https://doi.org/10.1038/s41598-018-30159-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-30159-5","pdf_url":"https://www.nature.com/articles/s41598-018-30159-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-30159-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058559207","display_name":"Yuliya Pepelyayeva","orcid":"https://orcid.org/0000-0001-8205-3613","observed_orcids":["https://orcid.org/0000-0001-8205-3613"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuliya Pepelyayeva","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105768006","display_name":"David P. W. Rastall","orcid":"https://orcid.org/0000-0002-6374-9073","observed_orcids":["https://orcid.org/0000-0002-6374-9073"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David P. W. Rastall","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004667791","display_name":"Yasser Ali Aldhamen","orcid":"https://orcid.org/0000-0002-9560-8013","observed_orcids":["https://orcid.org/0000-0002-9560-8013"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasser A. Aldhamen","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069533218","display_name":"Patrick M. O\u2019Connell","orcid":"https://orcid.org/0000-0001-7534-4754","observed_orcids":["https://orcid.org/0000-0001-7534-4754"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick O\u2019Connell","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028557337","display_name":"Sandra Raehtz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Raehtz","raw_affiliation_strings":["Department of Physiology, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015748359","display_name":"Fadel S. Alyaqoub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fadel S. Alyaqoub","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022195358","display_name":"Maja K. Blake","orcid":"https://orcid.org/0000-0002-2916-846X","observed_orcids":["https://orcid.org/0000-0002-2916-846X"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maja K. Blake","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039942347","display_name":"Ashley M. Raedy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley M. Raedy","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034275585","display_name":"Ariana M. Angarita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariana M. Angarita","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019474976","display_name":"Abdulraouf M. Abbas","orcid":"https://orcid.org/0000-0002-0526-6524","observed_orcids":["https://orcid.org/0000-0002-0526-6524"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdulraouf M. Abbas","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006007580","display_name":"Cristiane Pereira\u2010Hicks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristiane N. Pereira-Hicks","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004452504","display_name":"Sarah G. Roosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah G. Roosa","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025670982","display_name":"Laura R. McCabe","orcid":"https://orcid.org/0000-0001-5407-162X","observed_orcids":["https://orcid.org/0000-0001-5407-162X"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura McCabe","raw_affiliation_strings":["Biomedical Imaging Research Center, Michigan State University, East Lansing, MI, 48824, USA","Department of Physiology, Michigan State University, East Lansing, MI, 48824, USA","Department of Radiology, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Imaging Research Center, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Physiology, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Radiology, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083266436","display_name":"Andrea Amalfitano","orcid":"https://orcid.org/0000-0001-9480-1420","observed_orcids":["https://orcid.org/0000-0001-9480-1420"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrea Amalfitano","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA. amalfit1@msu.edu","Department of Pediatrics, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, 48824, USA. amalfit1@msu.edu","Department of Pediatrics, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA. amalfit1@msu.edu","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Pediatrics, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, 48824, USA. amalfit1@msu.edu","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Pediatrics, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083266436"],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":2.4205,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.87655512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"12464","last_page":"12464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erap1","display_name":"ERAP1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ankylosing-spondylitis","display_name":"ankylosing spondylitis","score":0.984000027179718},{"id":"https://openalex.org/keywords/type-1-regulatory-t-cells","display_name":"type 1 regulatory T cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/tolerogenic-dendritic-cells","display_name":"tolerogenic dendritic cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/spinal-ankylosis","display_name":"spinal ankylosis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/spinal-cord-inflammation","display_name":"myelitis","score":0.5899999737739563},{"id":"https://openalex.org/keywords/foxp3-regulatory-t-cells","display_name":"Foxp3+ regulatory T cells","score":0.5730000138282776},{"id":"https://openalex.org/keywords/microbiota-transfer","display_name":"microbiota transfer","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C2777402515","wikidata":"https://www.wikidata.org/wiki/Q52849","display_name":"Ankylosing spondylitis","level":2,"score":0.7851017713546753},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6841193437576294},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5580814480781555},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.5092881917953491},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.487842321395874},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4866867661476135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43168574571609497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3902173638343811},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30257540941238403},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29413163661956787},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19421851634979248}],"mesh":[{"descriptor_ui":"D000626","descriptor_name":"Aminopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000626","descriptor_name":"Aminopeptidases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-018-30159-5","doi":"https://doi.org/10.1038/s41598-018-30159-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-30159-5","pdf_url":"https://www.nature.com/articles/s41598-018-30159-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5052328","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6102283","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6102283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6102283","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:30127455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30127455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c7acf6dbd31d4932b4bbd6e71ed2147c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c7acf6dbd31d4932b4bbd6e71ed2147c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-30159-5","doi":"https://doi.org/10.1038/s41598-018-30159-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-30159-5","pdf_url":"https://www.nature.com/articles/s41598-018-30159-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5809476773","display_name":"ER-Localized Aminopeptidases in Ankylosing Spondylitis","funder_award_id":"R01AR056981","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6267270801","display_name":null,"funder_award_id":"5R01AR056981","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G748379815","display_name":"Mechanistic basis of probiotic prevention of osteoporosis","funder_award_id":"R01AT007695","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G9000865330","display_name":"Michigan Diabetes Research Center (MDRC)","funder_award_id":"P30DK020572","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320311270","display_name":"Osteopathic Heritage Foundation","ror":"https://ror.org/00ps0j197"},{"id":"https://openalex.org/F4320316470","display_name":"Michigan State University Foundation","ror":"https://ror.org/04njz3m02"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2886952011.pdf","grobid_xml":"https://content.openalex.org/works/W2886952011.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W7012447","https://openalex.org/W1513304325","https://openalex.org/W1526621387","https://openalex.org/W1557481987","https://openalex.org/W1560818763","https://openalex.org/W1954263225","https://openalex.org/W1972243816","https://openalex.org/W1976696463","https://openalex.org/W1981924088","https://openalex.org/W2013110475","https://openalex.org/W2017689500","https://openalex.org/W2019528814","https://openalex.org/W2034546426","https://openalex.org/W2038400343","https://openalex.org/W2043796257","https://openalex.org/W2054947125","https://openalex.org/W2056652156","https://openalex.org/W2060076537","https://openalex.org/W2067696229","https://openalex.org/W2082966402","https://openalex.org/W2083784772","https://openalex.org/W2083964428","https://openalex.org/W2084331043","https://openalex.org/W2088695473","https://openalex.org/W2088921443","https://openalex.org/W2089612851","https://openalex.org/W2092249083","https://openalex.org/W2098267742","https://openalex.org/W2098623286","https://openalex.org/W2110389012","https://openalex.org/W2113772135","https://openalex.org/W2118751598","https://openalex.org/W2123821833","https://openalex.org/W2150968312","https://openalex.org/W2156459362","https://openalex.org/W2159431457","https://openalex.org/W2165923702","https://openalex.org/W2166444828","https://openalex.org/W2167418901","https://openalex.org/W2193331464","https://openalex.org/W2328466578","https://openalex.org/W2462435467","https://openalex.org/W2542957072","https://openalex.org/W2557953350","https://openalex.org/W2624861270","https://openalex.org/W2735393965","https://openalex.org/W2736839127","https://openalex.org/W2755782805","https://openalex.org/W2767067645","https://openalex.org/W4210974969"],"related_works":["https://openalex.org/W7095444989","https://openalex.org/W2735393965","https://openalex.org/W2777440870","https://openalex.org/W2042569235","https://openalex.org/W3199865985","https://openalex.org/W2055311201","https://openalex.org/W2187133577","https://openalex.org/W2759778862","https://openalex.org/W2142345903","https://openalex.org/W2143669749"],"abstract_inverted_index":{"Abstract":[0],"Ankylosing":[1,187],"spondylitis":[2],"(AS)":[3],"is":[4,46],"a":[5,173],"prototypical":[6],"sero-negative":[7],"autoimmune":[8],"disease":[9],"that":[10,131,167],"affects":[11],"millions":[12],"worldwide.":[13],"Single":[14],"nucleotide":[15],"polymorphisms":[16],"in":[17,75,103],"the":[18,34,61,69,88,107,122],"Endoplasmic":[19],"Reticulum":[20],"Aminopeptidase":[21],"1":[22],"(ERAP1)":[23],"gene":[24],"have":[25],"been":[26],"linked":[27],"to":[28,38,42,56,97],"AS":[29,45,74],"via":[30,116],"GWAS":[31],"studies,":[32],"however,":[33],"exact":[35],"mechanism":[36],"as":[37,172],"how":[39],"ERAP1":[40],"contributes":[41],"pathogenesis":[43,179],"of":[44,60,64,73,90,109,125,138,146,180,186],"not":[47,120],"understood.":[48],"We":[49,85],"undertook":[50],"\u00b5CT":[51],"imaging":[52],"and":[53,67,82,94,152,183],"histologic":[54],"analysis":[55,129],"evaluate":[57],"bone":[58],"morphology":[59],"axial":[62],"skeletons":[63],"ERAP1\u2212/\u2212":[65,104,126,133,168],"mice":[66,115,134,169],"discovered":[68],"hallmark":[70],"skeletal":[71,123],"features":[72],"these":[76],"mice,":[77,105],"including":[78],"spinal":[79,83],"ankylosis,":[80],"osteoporosis,":[81],"inflammation.":[84],"also":[86],"confirmed":[87],"presence":[89],"spontaneous":[91],"intestinal":[92],"dysbiosis":[93],"increased":[95],"susceptibility":[96],"Dextran":[98],"Sodium":[99],"Sulfate":[100],"(DSS)-induced":[101],"colitis":[102],"however":[106],"transfer":[108],"healthy":[110],"microbiota":[111],"from":[112],"wild":[113],"type":[114],"cross-fostering":[117],"experiments":[118],"did":[119],"resolve":[121],"phenotypes":[124],"mice.":[127],"Immunological":[128],"demonstrated":[130],"while":[132],"had":[135,143],"normal":[136],"numbers":[137,145],"peripheral":[139],"Foxp3+":[140],"Tregs,":[141],"they":[142],"reduced":[144],"both":[147],"\u201cTr1-like\u201d":[148],"regulatory":[149],"T":[150],"cells":[151],"tolerogenic":[153],"dendritic":[154],"cells,":[155],"which":[156],"are":[157],"important":[158],"for":[159,177],"Tr1":[160],"cell":[161],"differentiation.":[162],"Together,":[163],"our":[164],"data":[165],"suggests":[166],"may":[170],"serve":[171],"useful":[174],"animal":[175],"model":[176],"studying":[178],"intestinal,":[181],"skeletal,":[182],"immunological":[184],"manifestations":[185],"Spondylitis.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-22T00:00:00"}