{"id":"https://openalex.org/W2886918600","doi":"https://doi.org/10.1158/1538-7445.am2018-lb-056","title":"Abstract LB-056: Novel molecular mechanism underlying cancer drug resistance: Involvement of p58IPKchaperone pathway","display_name":"Abstract LB-056: Novel molecular mechanism underlying cancer drug resistance: Involvement of p58IPKchaperone pathway","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2886918600","doi":"https://doi.org/10.1158/1538-7445.am2018-lb-056","mag":"2886918600"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-lb-056","doi":"https://doi.org/10.1158/1538-7445.am2018-lb-056","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-lb-056","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079917691","display_name":"Mohammad Athar","orcid":"https://orcid.org/0000-0001-5829-7992","observed_orcids":["https://orcid.org/0000-0001-5829-7992"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Athar","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071410072","display_name":"Ritesh K. Srivastava","orcid":"https://orcid.org/0000-0002-5344-0654","observed_orcids":["https://orcid.org/0000-0002-5344-0654"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ritesh Srivastava","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"LB","last_page":"056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.7275000214576721,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.7275000214576721,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.2476000040769577,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.796999990940094},{"id":"https://openalex.org/keywords/p58ipk","display_name":"p58IPK","score":0.8849999904632568},{"id":"https://openalex.org/keywords/rhabdomyosarcoma","display_name":"rhabdomyosarcoma","score":0.9010000228881836},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9160000085830688},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":1.0},{"id":"https://openalex.org/keywords/pkr","display_name":"PKR","score":0.7300000190734863},{"id":"https://openalex.org/keywords/eif2alpha-phosphorylation","display_name":"eIF2\u03b1 phosphorylation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mrp1","display_name":"MRP1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.6190000176429749},{"id":"https://openalex.org/keywords/drug-efflux","display_name":"drug efflux","score":0.6200000047683716},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.45899999141693115},{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":0.9120000004768372},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.6365137696266174},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.6143835783004761},{"id":"https://openalex.org/C2779638656","wikidata":"https://www.wikidata.org/wiki/Q6043166","display_name":"Integrated stress response","level":5,"score":0.5642994046211243},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5148690938949585},{"id":"https://openalex.org/C2780386689","wikidata":"https://www.wikidata.org/wiki/Q7739","display_name":"Arsenic trioxide","level":3,"score":0.4943857192993164},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.47939562797546387},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.46994927525520325},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4565839171409607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4025290608406067},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3776545524597168},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3669286370277405},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34871944785118103},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.33604395389556885},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31588250398635864},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.11926811933517456},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11918047070503235},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.10224628448486328},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08336108922958374},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-lb-056","doi":"https://doi.org/10.1158/1538-7445.am2018-lb-056","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-lb-056","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402266831","https://openalex.org/W4393071700","https://openalex.org/W4402267041","https://openalex.org/W7214015408","https://openalex.org/W3043532154","https://openalex.org/W4282943714","https://openalex.org/W4414501464","https://openalex.org/W4409634518","https://openalex.org/W4417196853","https://openalex.org/W7018919057"],"abstract_inverted_index":{"Abstract":[0],"Rhabdomyosarcoma":[1],"(RMS)":[2],"is":[3,137,155],"an":[4,138],"aggressive":[5],"and":[6,28,58,89,186,234,251,285],"highly":[7],"malignant":[8],"form":[9],"of":[10,21,70,127,140,153,216,221,243,317,325,381,387],"pediatric":[11],"cancer":[12,377],"that":[13,79,132,150,225],"develops":[14],"from":[15],"skeletal":[16],"muscle":[17],"cells.":[18,168,190],"A":[19],"third":[20],"these":[22,74,318],"cancers":[23],"become":[24],"drug":[25,56,61,71,112,158,165,174,183,187,207,260,269,282,309,333,342,378],"resistant,":[26],"metastatic":[27,46],"fatal.":[29],"Current":[30],"therapeutic":[31],"approaches":[32],"have":[33,338,350],"not":[34],"resulted":[35],"in":[36,39,73,80,107,157,173,182,218,228,245,256,271,289,328,345,353,356,362,364],"significant":[37],"improvement":[38],"outcome":[40],"for":[41,391],"patients":[42],"with":[43,292,304,313],"recurrent":[44],"and/or":[45],"disease.":[47],"Here,":[48],"employing":[49],"two":[50],"RMS-derived":[51],"cell":[52,109],"lines":[53],"(RH30,":[54],"a":[55,60,65,340],"sensitive":[57,166,188,197],"RD,":[59],"resistant),":[62],"we":[63,176,223,337],"demonstrate":[64,211],"novel":[66,341],"underlying":[67,122,263,376],"molecular":[68,129,374],"mechanism":[69,121,264,344,375],"resistance":[72,113,159,334,343],"tumor":[75],"subtypes.":[76],"We":[77,148],"show":[78],"response":[81,100,257],"to":[82,164,198,258,281,302],"chemotherapeutics":[83],"drugs":[84],"[actinomysin":[85],"D,":[86],"torisol,":[87],"etoposide":[88],"arsenic":[90],"trioxide":[91],"(ATO)],":[92],"endoplasmic":[93],"reticulum":[94],"(ER)":[95],"stress":[96],"associated":[97],"unfolded":[98],"protein":[99,135,145],"(UPR)":[101],"signaling":[102],"pathway":[103,383],"could":[104],"be":[105],"induced":[106],"RH30":[108,167,189,204,229,303],"only,":[110],"while":[111,201,241],"RD":[114,160,185,194,246,290],"cells":[115,161,195,205,230,247,273,291,330],"largely":[116],"lack":[117],"this":[118],"ability.":[119],"The":[120,191,262],"UPR":[123],"induction":[124],"involves":[125,274],"activation":[126],"multifunctional":[128],"chaperone":[130,276],"P58IPK":[131,226,267],"besides":[133],"regulating":[134],"homeostasis":[136],"inhibitor":[139],"the":[141,151,212,219,314,388],"interferon-induced":[142],"double-stranded":[143],"RNA-activated":[144],"kinase":[146],"(PKR).":[147],"observed":[149],"expression":[152,220],"p58IPK":[154,180,192,203,222,244,294,326],"high":[156,293],"as":[162,300],"compared":[163,301],"To":[169,209],"confirm":[170],"its":[171,275,279],"role":[172],"resistance,":[175],"ablated":[177],"or":[178,323],"overexpressed":[179],"respectively":[181],"resistant":[184],"depleted":[193],"became":[196],"chemotherapeutic":[199,259],"agents":[200],"overexpressing":[202],"manifested":[206],"resistance.":[208],"further":[210],"known":[213],"functional":[214],"consequences":[215],"manipulation":[217],"found":[224],"over-expression":[227],"inhibited":[231],"eIF2\u03b1":[232,249],"phosphorylation":[233,250],"diminished":[235],"apoptosis":[236,255],"by":[237,265,278],"downregulating":[238],"ATF4/CHOP/Cleaved":[239,253],"caspase-3,":[240],"silencing":[242],"enhanced":[248],"increased":[252],"caspase-3-dependent":[254],"treatment.":[261],"which":[266],"alters":[268],"sensitivity":[270],"RMS":[272],"function":[277],"binding":[280],"transporters":[283],"ABCB-1":[284],"ABCC-1.":[286],"At":[287],"baseline,":[288],"manifest":[295],"significantly":[296],"higher":[297],"dye":[298],"efflux":[299],"low":[305],"p58IPK.":[306],"This":[307],"baseline":[308],"exclusion":[310],"profile":[311],"correlated":[312],"ATPase":[315],"activity":[316],"ABC":[319],"transporters.":[320],"However,":[321],"ablation":[322],"overexpression":[324],"respectively,":[327],"RH30/RD":[329],"reversed":[331],"their":[332],"phenotype.":[335],"Thus,":[336],"identified":[339],"RMS.":[346],"These":[347,359],"results":[348],"may":[349],"translational":[351],"implications":[352],"overcoming":[354],"drug-resistance":[355],"deadly":[357],"neoplasm.":[358],"studies":[360],"are":[361],"progress":[363],"our":[365],"laboratory.":[366],"Citation":[367],"Format:":[368],"Mohammad":[369],"Athar,":[370],"Ritesh":[371],"Srivastava.":[372],"Novel":[373],"resistance:":[379],"Involvement":[380],"p58IPKchaperone":[382],"[abstract].":[384],"In:":[385],"Proceedings":[386],"American":[389],"Association":[390],"Cancer":[392,405],"Research":[393],"Annual":[394],"Meeting":[395],"2018;":[396],"2018":[397],"Apr":[398],"14-18;":[399],"Chicago,":[400],"IL.":[401],"Philadelphia":[402],"(PA):":[403],"AACR;":[404],"Res":[406],"2018;78(13":[407],"Suppl):Abstract":[408],"nr":[409],"LB-056.":[410]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2018-08-22T00:00:00"}
