{"id":"https://openalex.org/W2886862850","doi":null,"title":"The Role of Ghrelin and Leptin in Obesity: Is Exogenous Administration of These Hormones a Possible Drug Therapy?","display_name":"The Role of Ghrelin and Leptin in Obesity: Is Exogenous Administration of These Hormones a Possible Drug Therapy?","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2886862850","mag":"2886862850"},"language":"en","primary_location":{"id":"pmh:oai:touroscholar.touro.edu:sjlcas-1167","doi":null,"is_oa":true,"landing_page_url":"https://touroscholar.touro.edu/sjlcas/vol4/iss2/7","pdf_url":"https://touroscholar.touro.edu/cgi/viewcontent.cgi?article=1167&context=sjlcas","source":{"id":"https://openalex.org/S4377196437","display_name":"Touro Scholar (Touro College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200437953","host_organization_name":"Touro College","host_organization_lineage":["https://openalex.org/I200437953"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Science Journal of the Lander College of Arts and Sciences","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://touroscholar.touro.edu/cgi/viewcontent.cgi?article=1167&context=sjlcas","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016346077","display_name":"Peri Eckstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Peri Eckstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016346077"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.31328924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"4","issue":"2","first_page":"7","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":1.0},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":1.0},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":1.0},{"id":"https://openalex.org/keywords/energy-balance","display_name":"energy balance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/food-intake-regulation","display_name":"food intake regulation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/appetite","display_name":"appetite","score":0.5450000166893005},{"id":"https://openalex.org/keywords/satiety","display_name":"satiety","score":0.8840000033378601},{"id":"https://openalex.org/keywords/gastrointestinal-hormones","display_name":"gastrointestinal hormones","score":0.9589999914169312},{"id":"https://openalex.org/keywords/sleep-deprivation","display_name":"sleep deprivation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/leptin-resistance","display_name":"leptin resistance","score":0.7900000214576721},{"id":"https://openalex.org/keywords/ghrelin-resistance","display_name":"ghrelin resistance","score":0.671999990940094},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5370000004768372},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.8849912881851196},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8252197504043579},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6272720694541931},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5882251858711243},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5651571750640869},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5650957822799683},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5396852493286133},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5082628130912781},{"id":"https://openalex.org/C2987276129","wikidata":"https://www.wikidata.org/wiki/Q12140","display_name":"Drug administration","level":2,"score":0.4114290773868561},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3700079619884491}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:touroscholar.touro.edu:sjlcas-1167","doi":null,"is_oa":true,"landing_page_url":"https://touroscholar.touro.edu/sjlcas/vol4/iss2/7","pdf_url":"https://touroscholar.touro.edu/cgi/viewcontent.cgi?article=1167&context=sjlcas","source":{"id":"https://openalex.org/S4377196437","display_name":"Touro Scholar (Touro College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200437953","host_organization_name":"Touro College","host_organization_lineage":["https://openalex.org/I200437953"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Science Journal of the Lander College of Arts and Sciences","raw_type":"article"},{"id":"mag:2886862850","doi":null,"is_oa":false,"landing_page_url":"https://touroscholar.touro.edu/cgi/viewcontent.cgi?article=1167&context=sjlcas","pdf_url":null,"source":{"id":"https://openalex.org/S4306532697","display_name":"The Science Journal of the Lander College of Arts and Sciences","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Science Journal of the Lander College of Arts and Sciences","raw_type":null}],"best_oa_location":{"id":"pmh:oai:touroscholar.touro.edu:sjlcas-1167","doi":null,"is_oa":true,"landing_page_url":"https://touroscholar.touro.edu/sjlcas/vol4/iss2/7","pdf_url":"https://touroscholar.touro.edu/cgi/viewcontent.cgi?article=1167&context=sjlcas","source":{"id":"https://openalex.org/S4377196437","display_name":"Touro Scholar (Touro College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200437953","host_organization_name":"Touro College","host_organization_lineage":["https://openalex.org/I200437953"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Science Journal of the Lander College of Arts and Sciences","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2886862850.pdf","grobid_xml":"https://content.openalex.org/works/W2886862850.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1833124830","https://openalex.org/W1963558494","https://openalex.org/W1989136084","https://openalex.org/W2000377148","https://openalex.org/W2025829758","https://openalex.org/W2027664697","https://openalex.org/W2035900275","https://openalex.org/W2041488037","https://openalex.org/W2052288867","https://openalex.org/W2060730575","https://openalex.org/W2065738278","https://openalex.org/W2112085129","https://openalex.org/W2156114719","https://openalex.org/W2157118250"],"related_works":["https://openalex.org/W2157118250","https://openalex.org/W7169203194","https://openalex.org/W4407755593","https://openalex.org/W2400190819","https://openalex.org/W2171314165","https://openalex.org/W4226506331","https://openalex.org/W1859253078","https://openalex.org/W2280533769","https://openalex.org/W7005694712","https://openalex.org/W2555361426"],"abstract_inverted_index":{"Ghrelin":[0],"and":[1,32,69,87,95,100,110,131,153],"leptin":[2,86,109,152],"are":[3],"two":[4],"hormones":[5,68,128,143],"that":[6,113],"have":[7,11],"been":[8,75],"recognized":[9],"to":[10,116],"a":[12,20,43,48,54,76],"major":[13],"influence":[14,71],"on":[15,38,85,129,141],"energy":[16,27,72],"balance.":[17],"Leptin":[18],"is":[19,42],"mediator":[21],"of":[22,26,57,78,103,119,126,138,151],"long":[23],"term":[24],"regulation":[25],"balance,":[28],"suppressing":[29],"food":[30,93],"intake":[31,94],"thereby":[33],"inducing":[34],"weight":[35,97],"loss.":[36],"Ghrelin,":[37],"the":[39,63,108,117,136,149],"other":[40],"hand,":[41],"fast":[44],"acting":[45],"hormone,":[46],"playing":[47],"role":[49,91,125],"in":[50,92,98,107],"meal":[51],"initiation.":[52],"As":[53],"growing":[55],"number":[56],"people":[58],"suffer":[59],"from":[60],"obesity,":[61],"understanding":[62],"mechanisms":[64],"by":[65],"which":[66],"various":[67],"neurotransmitters":[70],"balance":[73],"has":[74],"subject":[77],"intense":[79],"research.":[80],"This":[81],"paper":[82],"provides":[83],"background":[84],"ghrelin":[88,111,154],"hormones,":[89],"their":[90,101],"body":[96],"humans,":[99],"mechanism":[102],"action.":[104],"Possible":[105],"abnormalities":[106],"systems":[112],"may":[114],"contribute":[115],"development":[118],"obesity":[120],"will":[121,144,158],"be":[122,145,159],"mentioned.":[123],"The":[124],"gut":[127],"hunger":[130],"satiety":[132],"as":[133,135,155],"well":[134],"effect":[137],"sleep":[139],"deprivation":[140],"these":[142],"briefly":[146],"described.":[147],"Finally,":[148],"potentials":[150],"drug":[156],"targets":[157],"described":[160],"(Klok,":[161],"et":[162],"al.,":[163],"2006).":[164]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2018-08-22T00:00:00"}