{"id":"https://openalex.org/W2886836166","doi":"https://doi.org/10.1111/his.13728","title":"Expression of T\u2010cell receptor signalling pathway components in extranodal NK /T\u2010cell lymphoma","display_name":"Expression of T\u2010cell receptor signalling pathway components in extranodal NK /T\u2010cell lymphoma","publication_year":2018,"publication_date":"2018-08-13","ids":{"openalex":"https://openalex.org/W2886836166","doi":"https://doi.org/10.1111/his.13728","mag":"2886836166","pmid":"https://pubmed.ncbi.nlm.nih.gov/30102799"},"language":"en","primary_location":{"id":"doi:10.1111/his.13728","doi":"https://doi.org/10.1111/his.13728","is_oa":false,"landing_page_url":"https://doi.org/10.1111/his.13728","pdf_url":null,"source":{"id":"https://openalex.org/S14376486","display_name":"Histopathology","issn_l":"0309-0167","issn":["0309-0167","1365-2559"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histopathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066275550","display_name":"Tomoko Miyata\u2010Takata","orcid":"https://orcid.org/0009-0008-6360-4959","observed_orcids":["https://orcid.org/0009-0008-6360-4959"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Miyata\u2010Takata","raw_affiliation_strings":["Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072940959","display_name":"Shih\u2010Sung Chuang","orcid":"https://orcid.org/0000-0003-3971-525X","observed_orcids":["https://orcid.org/0000-0003-3971-525X"]},"institutions":[{"id":"https://openalex.org/I4210136334","display_name":"Chi Mei Medical Center","ror":"https://ror.org/02y2htg06","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210136334"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shih\u2010Sung Chuang","raw_affiliation_strings":["Department of Pathology, Chi-Mei Medical Centre, Tainan, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-3971-525X","affiliations":[{"raw_affiliation_string":"Department of Pathology, Chi-Mei Medical Centre, Tainan, Taiwan","institution_ids":["https://openalex.org/I4210136334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011042700","display_name":"Katsuyoshi Takata","orcid":"https://orcid.org/0000-0001-6890-1276","observed_orcids":["https://orcid.org/0000-0001-6890-1276","https://orcid.org/0009-0004-8468-1911"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["CA","JP"],"is_corresponding":true,"raw_author_name":"Katsuyoshi Takata","raw_affiliation_strings":["Department of Lymphoid Cancer Research, British Columbia Cancer, Vancouver, Canada","Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6890-1276","affiliations":[{"raw_affiliation_string":"Department of Lymphoid Cancer Research, British Columbia Cancer, Vancouver, Canada","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023545478","display_name":"Tomohiro Toji","orcid":"https://orcid.org/0000-0001-6542-2376","observed_orcids":["https://orcid.org/0000-0001-6542-2376"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro Toji","raw_affiliation_strings":["Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025889209","display_name":"Yoshinobu Maeda","orcid":"https://orcid.org/0000-0003-1634-5487","observed_orcids":["https://orcid.org/0000-0003-1634-5487"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinobu Maeda","raw_affiliation_strings":["Department of Haematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063147479","display_name":"Yasuharu Sato","orcid":"https://orcid.org/0000-0001-5234-6861","observed_orcids":["https://orcid.org/0000-0001-5234-6861"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuharu Sato","raw_affiliation_strings":["Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108362129","display_name":"Tadashi Yoshino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Yoshino","raw_affiliation_strings":["Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011042700"],"corresponding_institution_ids":["https://openalex.org/I1289530486","https://openalex.org/I163770644"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":1.6362,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.84096067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"73","issue":"6","first_page":"1030","last_page":"1038"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extranodal-nk-t-cell-lymphoma-nasal-type","display_name":"extranodal NK/T-cell lymphoma, nasal type","score":0.9900000095367432},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.8840000033378601},{"id":"https://openalex.org/keywords/zap-70","display_name":"ZAP-70","score":0.9229999780654907},{"id":"https://openalex.org/keywords/dok2","display_name":"DOK2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lck","display_name":"Lck","score":0.9950000047683716},{"id":"https://openalex.org/keywords/itk","display_name":"ITK","score":0.9950000047683716},{"id":"https://openalex.org/keywords/t-cell-lineage","display_name":"T cell lineage","score":0.4390000104904175},{"id":"https://openalex.org/keywords/nk-cell-lineage","display_name":"NK cell lineage","score":0.9340000152587891},{"id":"https://openalex.org/keywords/t-cell-receptor-gene-rearrangement","display_name":"T-cell receptor gene rearrangement","score":0.6759999990463257},{"id":"https://openalex.org/keywords/nasal-lymphoma","display_name":"nasal cavity lymphoma","score":0.6299999952316284},{"id":"https://openalex.org/keywords/immunophenotype","display_name":"immunophenotype","score":0.6830000281333923},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.7087329626083374},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.698874831199646},{"id":"https://openalex.org/C2777589544","wikidata":"https://www.wikidata.org/wiki/Q7667896","display_name":"T-cell lymphoma","level":3,"score":0.6453772783279419},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5543649196624756},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5065428018569946},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46599259972572327},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2982025146484375},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0730808675289154}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D054391","descriptor_name":"Lymphoma, Extranodal NK-T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054391","descriptor_name":"Lymphoma, Extranodal NK-T-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055611","descriptor_name":"Natural Killer T-Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055611","descriptor_name":"Natural Killer T-Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/his.13728","doi":"https://doi.org/10.1111/his.13728","is_oa":false,"landing_page_url":"https://doi.org/10.1111/his.13728","pdf_url":null,"source":{"id":"https://openalex.org/S14376486","display_name":"Histopathology","issn_l":"0309-0167","issn":["0309-0167","1365-2559"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histopathology","raw_type":"journal-article"},{"id":"pmid:30102799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30102799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histopathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1517868493","https://openalex.org/W1576212058","https://openalex.org/W1965066391","https://openalex.org/W1965247614","https://openalex.org/W1996224617","https://openalex.org/W1996917223","https://openalex.org/W2005376366","https://openalex.org/W2019537425","https://openalex.org/W2020094108","https://openalex.org/W2020738705","https://openalex.org/W2030338309","https://openalex.org/W2033715157","https://openalex.org/W2038035645","https://openalex.org/W2044304932","https://openalex.org/W2050818562","https://openalex.org/W2052935616","https://openalex.org/W2063110971","https://openalex.org/W2080627154","https://openalex.org/W2084388859","https://openalex.org/W2094642095","https://openalex.org/W2133195899","https://openalex.org/W2134020845","https://openalex.org/W2142604595","https://openalex.org/W2148405212","https://openalex.org/W2149650496","https://openalex.org/W2311331069","https://openalex.org/W2497920204"],"related_works":["https://openalex.org/W2311331069","https://openalex.org/W2164982880","https://openalex.org/W2063110971","https://openalex.org/W4286809378","https://openalex.org/W263691236","https://openalex.org/W2339052946","https://openalex.org/W4388923786","https://openalex.org/W1996224617","https://openalex.org/W3193968116","https://openalex.org/W4416339611"],"abstract_inverted_index":{"AIMS:":[0],"Although":[1,202],"the":[2,18,35,38,63,109,146,168,219,239],"neoplastic":[3],"cells":[4],"of":[5,37,65,98,171,191,241],"extranodal":[6],"natural":[7],"killer":[8],"(NK)/T-cell":[9],"lymphoma":[10],"(ENKTL)":[11],"usually":[12],"do":[13],"not":[14],"express":[15],"T-cell":[16,19],"antigens,":[17],"receptor":[20],"(TCR)":[21],"gene":[22],"might":[23,222,234],"be":[24,223,235],"rearranged":[25],"and":[26,43,87,140,173,184,211],"TCR":[27,40,66,209,214,220],"protein":[28],"expressed.":[29],"The":[30,69],"aim":[31],"is":[32],"to":[33,60,145],"elucidate":[34],"expression":[36,64,111,169],"downstream":[39],"pathway":[41,67,221],"components":[42],"their":[44],"importance":[45],"in":[46,115,177,195,225],"ENKTL.":[47],"METHODS":[48],"AND":[49],"RESULTS:":[50],"We":[51],"used":[52],"formalin-fixed":[53],"paraffin-embedded":[54],"tissues":[55],"from":[56],"91":[57],"ENKTL":[58,242],"samples":[59],"immunohistochemically":[61],"characterise":[62],"components.":[68],"following":[70],"proteins":[71],"were":[72,94,141,156,175,206],"variably":[73],"expressed:":[74],"ZAP70":[75],"(94%;":[76],"83/88),":[77],"GRAP2/GADS":[78,110,172],"(68%;":[79],"60/88),":[80],"DOK2":[81,136],"(42%;":[82],"38/90),":[83],"LCK":[84,192],"(35%;":[85],"31/88),":[86],"ITK":[88,174,247],"(10%;":[89],"9/90).":[90],"When":[91],"these":[92,154],"tumours":[93,118,132,155,180,197],"classified":[95,158],"as":[96],"being":[97],"T":[99,116,161,178,228],"lineage":[100,103,107,117,131],"(16%),":[101],"NK":[102,130,165,232],"(45%),":[104],"or":[105,164],"indeterminate":[106],"(38%),":[108],"rate":[112],"was":[113,193],"higher":[114,176,194],"(versus":[119],"NK,":[120],"P":[121,126,185],"=":[122,127,138,150,182,186,199],"0.0073;":[123],"versus":[124,230],"indeterminate,":[125],"0.00082).":[128],"GRAP2/GADS-positive":[129],"more":[133,142],"frequently":[134],"expressed":[135],"(P":[137,149,181,198],"0.0073),":[139],"often":[143],"confined":[144],"nasal":[147],"areas":[148],"0.014).":[151],"Furthermore,":[152,246],"when":[153],"immunophenotypically":[157],"into":[159],"a":[160,231,250],"signature":[162,166,179,229,233],"(42%)":[163],"(58%),":[167],"rates":[170],"0.00074":[183],"0.067,":[187],"respectively),":[188],"whereas":[189],"that":[190,218],"NK-signature":[196],"0.10).":[200],"CONCLUSIONS:":[201],"some":[203],"ENTKL":[204],"cases":[205],"polyclonal":[207],"for":[208,237,254],"rearrangement":[210],"others":[212],"lacked":[213],"expression,":[215],"we":[216],"speculate":[217],"functioning":[224],"ENKTLs.":[226],"A":[227],"better":[236],"delineating":[238],"physiology":[240],"than":[243],"cellular":[244],"lineage.":[245],"may":[248],"represent":[249],"potential":[251],"therapeutic":[252],"target":[253],"patients":[255],"with":[256],"ITK-expressing":[257],"tumours.":[258]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-08-22T00:00:00"}
