{"id":"https://openalex.org/W2886764191","doi":"https://doi.org/10.1158/1538-7445.am2018-3842","title":"Abstract 3842: Potent antitumor activity of the HSP90 inhibitor SNX-2112 in type 1 papillary renal cell carcinoma","display_name":"Abstract 3842: Potent antitumor activity of the HSP90 inhibitor SNX-2112 in type 1 papillary renal cell carcinoma","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2886764191","doi":"https://doi.org/10.1158/1538-7445.am2018-3842","mag":"2886764191"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-3842","doi":"https://doi.org/10.1158/1538-7445.am2018-3842","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-3842","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043469487","display_name":"Roma Pahwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roma Pahwa","raw_affiliation_strings":["1Urologic Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Urologic Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089713864","display_name":"Abhigya Giri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhigya Giri","raw_affiliation_strings":["1Urologic Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Urologic Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073829273","display_name":"Carole Sourbier","orcid":"https://orcid.org/0000-0002-4853-7662","observed_orcids":["https://orcid.org/0000-0002-4853-7662"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carole Sourbier","raw_affiliation_strings":["1Urologic Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Urologic Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014278257","display_name":"Craig J. Thomas","orcid":"https://orcid.org/0000-0001-9386-9001","observed_orcids":["https://orcid.org/0000-0001-9386-9001"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig Thomas","raw_affiliation_strings":["2National Center for Advancing Translational Sciences (NCATS),NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2National Center for Advancing Translational Sciences (NCATS),NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107963543","display_name":"William Marston Linehan","orcid":"https://orcid.org/0000-0001-7983-3109","observed_orcids":["https://orcid.org/0000-0001-7983-3109"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W Marston Linehan","raw_affiliation_strings":["1Urologic Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Urologic Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079993679","display_name":"Len Neckers","orcid":"https://orcid.org/0000-0001-9639-7249","observed_orcids":["https://orcid.org/0000-0001-9639-7249"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Len Neckers","raw_affiliation_strings":["1Urologic Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Urologic Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031748968","display_name":"Ramaprasad Srinivasan","orcid":"https://orcid.org/0000-0001-6392-3169","observed_orcids":["https://orcid.org/0000-0001-6392-3169"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramaprasad Srinivasan","raw_affiliation_strings":["1Urologic Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Urologic Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"3842","last_page":"3842"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.548799991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.548799991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.44020000100135803,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/met-mutations","display_name":"MET mutations","score":0.609000027179718},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8790000081062317},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.996999979019165},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8709999918937683},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9860000014305115},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.41999998688697815},{"id":"https://openalex.org/keywords/chromosome-7-gain","display_name":"chromosome 7 gain","score":0.6859999895095825},{"id":"https://openalex.org/keywords/patient-derived-cell-lines","display_name":"patient-derived cell lines","score":0.6710000038146973},{"id":"https://openalex.org/keywords/anchorage-independent-colony-formation","display_name":"anchorage-independent colony formation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/clonogenicity","display_name":"clonogenicity","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7134054899215698},{"id":"https://openalex.org/C2777560012","wikidata":"https://www.wikidata.org/wiki/Q5924361","display_name":"Hsp90 inhibitor","level":5,"score":0.6672097444534302},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6655697822570801},{"id":"https://openalex.org/C2776531350","wikidata":"https://www.wikidata.org/wiki/Q16877679","display_name":"Papillary renal cell carcinomas","level":3,"score":0.6378645896911621},{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.5213881134986877},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4900123178958893},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.4841904938220978},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.44290637969970703},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.44039711356163025},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42898428440093994},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4187154769897461},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3758286237716675},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.37285280227661133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3378902077674866},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.2612271308898926},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2097204327583313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1974417269229889},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06880572438240051},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-3842","doi":"https://doi.org/10.1158/1538-7445.am2018-3842","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-3842","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4283577050","https://openalex.org/W2586275366","https://openalex.org/W2157371003","https://openalex.org/W3030232640","https://openalex.org/W2100147039","https://openalex.org/W2969782323","https://openalex.org/W3049459344","https://openalex.org/W2563481887","https://openalex.org/W2146810218","https://openalex.org/W2318231090"],"abstract_inverted_index":{"Abstract":[0],"Papillary":[1],"renal-cell":[2],"carcinoma":[3,332],"(pRCC)":[4],"is":[5,87,115,208,283,293],"the":[6,205,225,322,337],"second":[7],"most":[8],"common":[9],"form":[10],"of":[11,19,28,40,47,53,112,119,143,171,204,227,242,247,271,295,321,336],"kidney":[12],"cancer,":[13],"accounting":[14],"for":[15,31,133,179,196,340],"15":[16],"to":[17,58,91,210,224,240],"20%":[18],"all":[20],"cases.":[21],"There":[22],"are":[23,43,74],"currently":[24],"no":[25],"treatment":[26,220],"options":[27],"proven":[29],"benefit":[30],"patients":[32,78,180],"with":[33,45,79,163,181,184,214,221],"advanced":[34],"pRCC.":[35],"The":[36],"type":[37,80,152,327],"1":[38,81,153,290,328],"subset":[39],"pRCC":[41,154,182,211,274,291],"tumors":[42,183],"associated":[44],"gain":[46],"chromosome":[48],"7":[49],"and":[50,67,84,108,122,124,218,229,249,254,266,292,298],"activating":[51],"mutations":[52],"MET":[54,60,71,107,113,185,215,272],"that":[55,169,202,219,280],"could":[56],"lead":[57],"aberrant":[59],"pathway":[61,186,207,216],"activation":[62],"resulting":[63],"in":[64,76,261,288,326],"cell":[65,120,155,212,275,331],"proliferation":[66,121],"anti-apoptotic":[68],"signaling.":[69],"While":[70],"kinase":[72],"inhibitors":[73,137],"active":[75],"some":[77],"pRCC,":[82],"primary":[83],"acquired":[85],"resistance":[86],"common,":[88],"prompting":[89],"us":[90],"investigate":[92],"possible":[93],"therapeutic":[94,177,286],"alternatives.":[95],"Heat":[96],"shock":[97],"protein":[98],"90":[99],"(Hsp90),":[100],"which":[101],"stabilizes":[102],"numerous":[103],"oncogenic":[104],"proteins,":[105],"including":[106,251],"several":[109],"downstream":[110,231,244],"mediators":[111],"activity,":[114],"an":[116],"important":[117],"regulator":[118],"survival,":[123],"has":[125,257],"attracted":[126],"wide":[127],"interest":[128,144],"as":[129,141,191],"a":[130,175,192,284],"novel":[131,176],"target":[132],"cancer":[134],"therapy.":[135],"Hsp90":[136,172,194,206,281],"were":[138],"also":[139],"identified":[140],"molecules":[142],"based":[145],"on":[146],"antitumor":[147,319],"activity":[148,260,320],"against":[149],"patient":[150],"derived":[151],"lines":[156,213],"following":[157],"quantitative":[158],"high":[159],"throughput":[160],"screening":[161],"(qHTS)":[162],"small":[164],"molecule":[165],"libraries.":[166],"We":[167],"hypothesized":[168],"inhibition":[170,203,241,282],"might":[173],"provide":[174],"approach":[178],"activation.":[187],"SNX-2112":[188,222,238,256,325],"was":[189],"chosen":[190],"candidate":[193],"inhibitor":[195,324],"further":[197,296],"evaluation.":[198,300],"Our":[199],"data":[200,278],"demonstrate":[201,279],"lethal":[209],"activation,":[217],"leads":[223,239],"degradation":[226],"MET/pMET":[228],"its":[230],"signaling":[232],"intermediates":[233],"p-AKT,":[234],"AKT,":[235],"p-ERK.":[236],"Furthermore,":[237],"critical":[243],"transcriptional":[245],"targets":[246],"AKT":[248],"ERK,":[250],"VEGF,":[252],"c-Myc":[253],"BIRC5.":[255],"potent":[258],"anti-tumor":[259],"vitro,":[262],"inhibiting":[263],"proliferation,":[264],"clonogenicity":[265],"3D-anchorage":[267],"independent":[268],"colony":[269],"formation":[270],"activated":[273],"lines.":[276],"These":[277],"promising":[285],"strategy":[287],"Type":[289],"worthy":[294],"preclinical":[297],"clinical":[299],"Citation":[301],"Format:":[302],"Roma":[303],"Pahwa,":[304],"Abhigya":[305],"Giri,":[306],"Carole":[307],"Sourbier,":[308],"Craig":[309],"Thomas,":[310],"W":[311],"Marston":[312],"Linehan,":[313],"Len":[314],"Neckers,":[315],"Ramaprasad":[316],"Srinivasan.":[317],"Potent":[318],"HSP90":[323],"papillary":[329],"renal":[330],"[abstract].":[333],"In:":[334],"Proceedings":[335],"American":[338],"Association":[339],"Cancer":[341,354],"Research":[342],"Annual":[343],"Meeting":[344],"2018;":[345],"2018":[346],"Apr":[347],"14-18;":[348],"Chicago,":[349],"IL.":[350],"Philadelphia":[351],"(PA):":[352],"AACR;":[353],"Res":[355],"2018;78(13":[356],"Suppl):Abstract":[357],"nr":[358],"3842.":[359]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2018-08-22T00:00:00"}