{"id":"https://openalex.org/W2886730459","doi":"https://doi.org/10.1158/1538-7445.am2018-5072","title":"Abstract 5072: Immunohistochemical expression of CC-chemokine receptor-like 2/CCRL2 in a prostate cancer tissue microarray","display_name":"Abstract 5072: Immunohistochemical expression of CC-chemokine receptor-like 2/CCRL2 in a prostate cancer tissue microarray","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2886730459","doi":"https://doi.org/10.1158/1538-7445.am2018-5072","mag":"2886730459"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-5072","doi":"https://doi.org/10.1158/1538-7445.am2018-5072","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-5072","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047682099","display_name":"Niradiz Reyes","orcid":"https://orcid.org/0000-0002-0368-9072","observed_orcids":["https://orcid.org/0000-0002-0368-9072"]},"institutions":[{"id":"https://openalex.org/I153390918","display_name":"Universidad de Cartagena","ror":"https://ror.org/0409zd934","country_code":"CO","type":"education","lineage":["https://openalex.org/I153390918"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Niradiz Reyes","raw_affiliation_strings":["1School of Medicine, University of Cartagena, Cartagena, Colombia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Medicine, University of Cartagena, Cartagena, Colombia;","institution_ids":["https://openalex.org/I153390918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008823701","display_name":"In\u00e9s Benedetti P","orcid":"https://orcid.org/0000-0002-6287-4470","observed_orcids":["https://orcid.org/0000-0002-6287-4470"]},"institutions":[{"id":"https://openalex.org/I153390918","display_name":"Universidad de Cartagena","ror":"https://ror.org/0409zd934","country_code":"CO","type":"education","lineage":["https://openalex.org/I153390918"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Ines Benedetti","raw_affiliation_strings":["1School of Medicine, University of Cartagena, Cartagena, Colombia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Medicine, University of Cartagena, Cartagena, Colombia;","institution_ids":["https://openalex.org/I153390918"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037029599","display_name":"Jan Geliebter","orcid":"https://orcid.org/0000-0002-2944-7960","observed_orcids":["https://orcid.org/0000-0002-2944-7960"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Geliebter","raw_affiliation_strings":["2New York Medical College, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2New York Medical College, Valhalla, NY","institution_ids":["https://openalex.org/I181190671"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"5072","last_page":"5072"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ccrl2","display_name":"CCRL2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7200000286102295},{"id":"https://openalex.org/keywords/atypical-chemokine-receptors","display_name":"atypical chemokine receptors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/protein-expression","display_name":"protein expression","score":0.699999988079071},{"id":"https://openalex.org/keywords/benign-prostatic-tissue","display_name":"benign prostatic tissue","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tumor-microarray","display_name":"tumor microarray","score":0.5389999747276306},{"id":"https://openalex.org/keywords/h-score","display_name":"H-score","score":0.4339999854564667},{"id":"https://openalex.org/keywords/localized-prostate-cancer","display_name":"localized prostate cancer","score":0.6389999985694885},{"id":"https://openalex.org/keywords/tumor-epithelial-cells","display_name":"tumor epithelial cells","score":0.48500001430511475},{"id":"https://openalex.org/keywords/inflammation-in-cancer","display_name":"inflammation in cancer","score":0.6320000290870667},{"id":"https://openalex.org/keywords/immunotherapy-targets","display_name":"immunotherapy targets","score":0.7820000052452087},{"id":"https://openalex.org/keywords/anti-inflammatory-strategies","display_name":"anti-inflammatory strategies","score":0.5989999771118164},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.5080000162124634},{"id":"https://openalex.org/keywords/cancer-immunotherapy-biomarkers","display_name":"cancer immunotherapy biomarkers","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cancer-immunotherapy-targets","display_name":"cancer immunotherapy targets","score":0.4819999933242798},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.7341901063919067},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7273608446121216},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6642464399337769},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6167668104171753},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5873401761054993},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5775333046913147},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5023658275604248},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.432947039604187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34403181076049805},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3346690535545349},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3005416691303253}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-5072","doi":"https://doi.org/10.1158/1538-7445.am2018-5072","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-5072","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2920966583","https://openalex.org/W2171682959","https://openalex.org/W4401419737","https://openalex.org/W2605071081","https://openalex.org/W1989938817","https://openalex.org/W2000263623","https://openalex.org/W2263780012","https://openalex.org/W7131207788","https://openalex.org/W1974343136","https://openalex.org/W2489047095"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"CCRL2":[2,49,88,135,166,189,210,228,263,294],"is":[3],"a":[4,34,95,120,142,195,258,317],"presumed":[5],"member":[6],"of":[7,21,25,48,73,83,108,123,157,188,218,251,293,312,325],"the":[8,22,46,79,84,155,191,216,284,290,326],"atypical":[9,85],"chemokine":[10,86],"receptor":[11,87],"family,":[12],"whose":[13],"members":[14],"are":[15,300],"increasingly":[16],"recognized":[17],"as":[18,131,154],"key":[19],"components":[20],"regulatory":[23],"network":[24],"inflammation":[26],"and":[27,31,39,56,61,112,176],"immunity":[28],"in":[29,50,63,89,151,165,194,206,215,233,237,257,268,271,278,296,316],"cancer":[30,53,65,92,111,220,241,253,298,319],"may":[32],"have":[33,44],"major":[35],"effect":[36],"on":[37],"anti-inflammatory":[38],"immunotherapeutic":[40],"strategies.":[41],"Recent":[42],"studies":[43],"reported":[45],"expression":[47,62,81,136,158,168,229,264,295,311],"different":[51],"human":[52,90],"cell":[54],"lines":[55],"tissues.":[57],"However,":[58],"its":[59,204],"function":[60],"prostate":[64,91,110,125,196,219,240,252,318],"has":[66],"not":[67],"been":[68],"previously":[69],"addressed.":[70],"The":[71],"aim":[72],"this":[74,288],"work":[75],"was":[76,103,137,149,212,230,265],"to":[77,224,243,275],"determine":[78],"protein":[80,167,192],"profile":[82],"tissue":[93,101,115,197,247,254,259,320],"using":[94,105,141,179],"tumor":[96,221,235],"microarray":[97,102,198,260,321],"approach.":[98],"Methods:":[99],"A":[100],"constructed":[104,199],"231":[106],"cores":[107,238,244],"matched":[109,279],"benign":[113,175,225,246,281],"prostatic":[114,208],"from":[116,283],"47":[117],"patients":[118],"with":[119,200,239,245],"previous":[121],"diagnosis":[122],"localized":[124],"cancer,":[126],"which":[127],"underwent":[128],"surgical":[129],"resection":[130],"their":[132],"primary":[133],"treatment.":[134],"evaluated":[138],"by":[139,161,171],"immunohistochemistry":[140],"monoclonal,":[143],"anti-human-CCRL2":[144],"antibody.":[145],"An":[146],"H":[147],"score":[148],"calculated":[150],"each":[152],"spot":[153],"sum":[156],"intensity":[159],"(0-3+)":[160],"extent":[162],"(0%-100%).":[163],"Differences":[164],"were":[169],"assessed":[170],"comparing":[172],"H-Scores":[173],"between":[174],"cancerous":[177,272],"tissues":[178],"Mann-Whitney":[180],"test":[181],"for":[182,329],"non-Gaussian":[183],"distribution.":[184],"Results:":[185],"Immunohistochemical":[186,310],"evaluation":[187],"at":[190],"level":[193],"clinical":[201],"specimens":[202,255],"confirmed":[203],"overexpression":[205],"malignant":[207],"tissue.":[209],"staining":[211],"present":[213],"predominantly":[214],"cytoplasm":[217],"cells.":[222],"Compared":[223],"epithelial":[226,234,269,276,297],"cells,":[227],"significantly":[231,266],"higher":[232],"cells":[236,270,277,299],"compared":[242,274],"(p=0.0001).":[248],"Conclusions:":[249],"Immunohistochemistry":[250],"arrayed":[256],"revealed":[261],"that":[262],"stronger":[267],"acini":[273,282],"adjacent":[280],"same":[285],"patient.":[286],"To":[287],"point,":[289],"physiological":[291],"effects":[292],"unclear.":[301],"Citation":[302],"Format:":[303],"Niradiz":[304],"Reyes,":[305],"Ines":[306],"Benedetti,":[307],"Jan":[308],"Geliebter.":[309],"CC-chemokine":[313],"receptor-like":[314],"2/CCRL2":[315],"[abstract].":[322],"In:":[323],"Proceedings":[324],"American":[327],"Association":[328],"Cancer":[330,343],"Research":[331],"Annual":[332],"Meeting":[333],"2018;":[334],"2018":[335],"Apr":[336],"14-18;":[337],"Chicago,":[338],"IL.":[339],"Philadelphia":[340],"(PA):":[341],"AACR;":[342],"Res":[344],"2018;78(13":[345],"Suppl):Abstract":[346],"nr":[347],"5072.":[348]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2018-08-22T00:00:00"}