{"id":"https://openalex.org/W2886728892","doi":"https://doi.org/10.3892/ijo.2018.4510","title":"Establishment of three novel cell lines derived from African American patients with colorectal carcinoma: A unique tool for assessing racial health disparity","display_name":"Establishment of three novel cell lines derived from African American patients with colorectal carcinoma: A unique tool for assessing racial health disparity","publication_year":2018,"publication_date":"2018-07-31","ids":{"openalex":"https://openalex.org/W2886728892","doi":"https://doi.org/10.3892/ijo.2018.4510","mag":"2886728892","pmid":"https://pubmed.ncbi.nlm.nih.gov/30066857","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6086619"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.2018.4510","doi":"https://doi.org/10.3892/ijo.2018.4510","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2018.4510","pdf_url":"http://www.spandidos-publications.com/10.3892/ijo.2018.4510/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.spandidos-publications.com/10.3892/ijo.2018.4510/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073359035","display_name":"Jenny E. Paredes","orcid":"https://orcid.org/0009-0004-9341-0187","observed_orcids":["https://orcid.org/0009-0004-9341-0187"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny Paredes","raw_affiliation_strings":["Department of Medicine, Division of Gastroenterology & Hepatology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology & Hepatology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103160398","display_name":"Ping Ji","orcid":"https://orcid.org/0000-0001-7103-1507","observed_orcids":["https://orcid.org/0000-0001-7103-1507"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping Ji","raw_affiliation_strings":["Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY 11794, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY 11794, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103031666","display_name":"Joseph F. LaComb","orcid":"https://orcid.org/0000-0002-2981-1072","observed_orcids":["https://orcid.org/0000-0002-2981-1072"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Lacomb","raw_affiliation_strings":["Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086099448","display_name":"Kenneth Reed Shroyer","orcid":"https://orcid.org/0000-0001-8090-0778","observed_orcids":["https://orcid.org/0000-0001-8090-0778"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Shroyer","raw_affiliation_strings":["Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011765439","display_name":"Laura A. Martello","orcid":"https://orcid.org/0000-0002-6254-5757","observed_orcids":["https://orcid.org/0000-0002-6254-5757"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Martello","raw_affiliation_strings":["Department of Medicine, Division of Gastroenterology & Hepatology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology & Hepatology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037481758","display_name":"Jennie L. Williams","orcid":"https://orcid.org/0000-0002-0720-9523","observed_orcids":["https://orcid.org/0000-0002-0720-9523"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennie Williams","raw_affiliation_strings":["Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY 11794, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY 11794, USA","institution_ids":["https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037481758"],"corresponding_institution_ids":["https://openalex.org/I59553526"],"apc_list":null,"apc_paid":null,"fwci":0.3801,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.61952668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"53","issue":"4","first_page":"1516","last_page":"1528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.7627000212669373,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.7627000212669373,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.1615000069141388,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/african-american-patients","display_name":"African American patients","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.7490000128746033},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.6909999847412109},{"id":"https://openalex.org/keywords/mirna-overexpression","display_name":"microRNA overexpression","score":0.7730000019073486},{"id":"https://openalex.org/keywords/il-8-secretion","display_name":"IL-8 secretion","score":0.6990000009536743},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8949999809265137},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.9470000267028809},{"id":"https://openalex.org/keywords/epithelial-morphology","display_name":"epithelial morphology","score":0.5429999828338623},{"id":"https://openalex.org/keywords/primary-tumor-cell-lines","display_name":"primary tumor cell lines","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.7235443592071533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6407300233840942},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5784986019134521},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5137063264846802},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5056271553039551},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.4971041977405548},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4726540148258209},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4709150493144989},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4657351076602936},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4547812044620514},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4454897344112396},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4188048541545868},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4021203815937042},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2811501622200012},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24509423971176147},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21794745326042175},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.17787307500839233},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13998422026634216},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13671156764030457}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001741","descriptor_name":"Black or African American","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054624","descriptor_name":"Health Status Disparities","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061251","descriptor_name":"Primary Cell Culture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3892/ijo.2018.4510","doi":"https://doi.org/10.3892/ijo.2018.4510","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2018.4510","pdf_url":"http://www.spandidos-publications.com/10.3892/ijo.2018.4510/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5036784","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6086619","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6086619","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6086619","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Oncol","raw_type":"Text"},{"id":"pmid:30066857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30066857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.3892/ijo.2018.4510","doi":"https://doi.org/10.3892/ijo.2018.4510","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2018.4510","pdf_url":"http://www.spandidos-publications.com/10.3892/ijo.2018.4510/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749},{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.6736000180244446}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8799999952316284}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1976703146","display_name":"Phosphosulindac, miRNAs and cancer racial disparity","funder_award_id":"R01CA140487","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2334187877","display_name":"2/2 Partnership to Study Racial/Ethnic Differences in GI Cancer Biology","funder_award_id":"P20CA192996","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G540305563","display_name":"1/2: Partnership to study racial/ethnic differences in GI cancer biology","funder_award_id":"P20CA192994","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2886728892.pdf","grobid_xml":"https://content.openalex.org/works/W2886728892.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W4747736","https://openalex.org/W1897192438","https://openalex.org/W1906462579","https://openalex.org/W1908590842","https://openalex.org/W1952821838","https://openalex.org/W1963677987","https://openalex.org/W1972019822","https://openalex.org/W1974964199","https://openalex.org/W1978929052","https://openalex.org/W1994647251","https://openalex.org/W2002678771","https://openalex.org/W2007769372","https://openalex.org/W2011910063","https://openalex.org/W2019864071","https://openalex.org/W2033507828","https://openalex.org/W2033560647","https://openalex.org/W2037807421","https://openalex.org/W2040876807","https://openalex.org/W2053380684","https://openalex.org/W2053505606","https://openalex.org/W2054234261","https://openalex.org/W2056587752","https://openalex.org/W2067785242","https://openalex.org/W2074454712","https://openalex.org/W2103994421","https://openalex.org/W2110567472","https://openalex.org/W2121683681","https://openalex.org/W2133984007","https://openalex.org/W2143423494","https://openalex.org/W2145492158","https://openalex.org/W2146997231","https://openalex.org/W2151811239","https://openalex.org/W2157304020","https://openalex.org/W2157942810","https://openalex.org/W2159035726","https://openalex.org/W2160736027","https://openalex.org/W2160911230","https://openalex.org/W2167347313","https://openalex.org/W2231156824","https://openalex.org/W2249823815","https://openalex.org/W2343608608","https://openalex.org/W2581876974","https://openalex.org/W6639635034","https://openalex.org/W6639748776"],"related_works":["https://openalex.org/W2298862459","https://openalex.org/W3081923737","https://openalex.org/W205655961","https://openalex.org/W2592201999","https://openalex.org/W4385999610","https://openalex.org/W2809717583","https://openalex.org/W2977364414","https://openalex.org/W3048573071","https://openalex.org/W2343608608","https://openalex.org/W4386572423"],"abstract_inverted_index":{"The":[0,74,243],"incidence":[1],"and":[2,44,54,71,76,85,102,112,126,146,155,172,224,231,249,263,270],"mortality":[3],"rates":[4],"of":[5,37,47,78,90,131,228,240],"colorectal":[6,35],"carcinoma":[7],"(CRC)":[8],"are":[9],"higher":[10],"among":[11],"African":[12],"Americans":[13,18],"(AAs)":[14],"compared":[15,164,185,234],"with":[16,26,165,186,235],"Caucasian":[17],"(CAs).":[19],"To":[20],"assess":[21],"the":[22,48,122,129,160,166,175],"molecular":[23,45],"properties":[24],"associated":[25],"racial":[27,271],"health":[28,272],"disparity,":[29],"three":[30,38,91,204],"cell":[31,49,94,105,178,190,206,216,238,245],"lines":[32,50,95,106,163,169,179,207,217,239,246],"derived":[33,96,208],"from":[34,97,209],"tumors":[36,99],"AA":[39,92,161,176,210],"subjects":[40],"were":[41,81,100,107,113,157,213,218],"established.":[42],"Cellular":[43],"characterization":[46],"designated":[51],"CHTN06,":[52,247],"SB501":[53,248],"SB521":[55,250],"was":[56,194],"performed":[57],"using":[58],"standard":[59],"technologies,":[60],"including":[61],"immunofluorescence,":[62],"electron":[63],"microscopy,":[64],"karyotyping,":[65],"reverse":[66],"transcription-polymerase":[67],"chain":[68],"reaction,":[69],"ELISA":[70],"immunoblot":[72],"analysis.":[73],"histology":[75],"morphology":[77],"CHTN06":[79],"xenografts":[80],"examined":[82],"by":[83],"hematoxylin":[84],"eosin":[86],"staining.":[87],"A":[88],"total":[89],"CRC":[93,162,168,177,189,211,244,269],"primary":[98],"established":[101],"characterized.":[103],"These":[104,215],"successfully":[108],"cultured":[109],"without":[110],"immortalization":[111],"found":[114],"to":[115,134,199,258],"be":[116,135,256],"tumorigenic":[117],"as":[118,140,220],"mouse":[119],"xenografts.":[120],"In":[121,202],"present":[123],"study,":[124],"immunoblotting":[125],"immunofluorescence":[127],"confirmed":[128],"expression":[130,227],"proteins":[132,145],"known":[133],"dysregulated":[136],"in":[137,159,197,222,261,264],"CRC,":[138],"such":[139],"p53,":[141],"DNA":[142],"mismatch":[143],"repair":[144],"villin-1.":[147],"Oncogenic":[148],"miRNAs":[149,230],"(i.e.,":[150],"miR-17,":[151],"miR-21,":[152],"miR-182,":[153],"miR-210":[154],"miR-222)":[156],"overexpressed":[158],"CA":[167,241],"(HT-29,":[170],"HCT116":[171],"SW480).":[173],"Additionally,":[174],"exhibited":[180,225],"a":[181],"differential":[182,226],"inflammatory":[183,200,232],"profile":[184],"HT-29":[187],"(CA":[188],"line);":[191],"specifically":[192],"noted":[193],"IL-8":[195],"secretion":[196],"response":[198],"stimuli.":[201],"conclusion,":[203],"novel":[205,252],"tissues":[212],"generated.":[214],"characterized":[219],"epithelial":[221],"nature":[223],"several":[229],"responses":[233],"commercially":[236],"available":[237],"origin.":[242],"represent":[251],"tools":[253],"that":[254],"may":[255],"used":[257],"provide":[259],"diverse":[260],"vitro":[262],"vivo":[265],"models":[266],"for":[267],"studying":[268],"disparity.":[273]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-08-22T00:00:00"}