{"id":"https://openalex.org/W2886723652","doi":"https://doi.org/10.22037/ipa.v1i1.20117","title":"Nephroprotective effect of Gallic acid against mercuric chloride (HgCl2) induced damage in rats","display_name":"Nephroprotective effect of Gallic acid against mercuric chloride (HgCl2) induced damage in rats","publication_year":2018,"publication_date":"2018-03-04","ids":{"openalex":"https://openalex.org/W2886723652","doi":"https://doi.org/10.22037/ipa.v1i1.20117","mag":"2886723652"},"language":"en","primary_location":{"id":"pmh:oai:journals.sbmu.ac.ir:article/20117","doi":"https://doi.org/10.22037/ipa.v1i1.20117","is_oa":true,"landing_page_url":"https://journals.sbmu.ac.ir/acta/article/view/20117","pdf_url":"https://journals.sbmu.ac.ir/acta/article/download/20117/14419","source":{"id":"https://openalex.org/S4306514108","display_name":"International Pharmacy Acta","issn_l":null,"issn":["2645-3258","2645-3266"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2645-3258","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.sbmu.ac.ir/acta/article/download/20117/14419","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069069928","display_name":"Hadi Kalantar","orcid":"https://orcid.org/0000-0002-2765-3074","observed_orcids":["https://orcid.org/0000-0002-2765-3074"]},"institutions":[{"id":"https://openalex.org/I119939603","display_name":"Ahvaz Jundishapur University of Medical Sciences","ror":"https://ror.org/01rws6r75","country_code":"IR","type":"education","lineage":["https://openalex.org/I119939603"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Kalantar, Hadi","raw_affiliation_strings":["Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran","Department of  Toxicology  #N#   School of  Pharmacy, Ahvaz  #N#  Jundishapur University of  #N# Medical Sciences, Ahvaz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran","institution_ids":["https://openalex.org/I119939603"]},{"raw_affiliation_string":"Department of  Toxicology  #N#   School of  Pharmacy, Ahvaz  #N#  Jundishapur University of  #N# Medical Sciences, Ahvaz, Iran","institution_ids":["https://openalex.org/I119939603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048358722","display_name":"Mojtaba Kalantar","orcid":"https://orcid.org/0000-0001-9490-4702","observed_orcids":["https://orcid.org/0000-0001-9490-4702"]},"institutions":[{"id":"https://openalex.org/I4210153432","display_name":"Islamic Azad University, Shoushtar Branch","ror":"https://ror.org/04w2yhr49","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I4210153432"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Kalantar, Mojtaba","raw_affiliation_strings":["Shoushtar Faculty of Medical Sciences, Shoushtar, Iran., Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shoushtar Faculty of Medical Sciences, Shoushtar, Iran., Iran","institution_ids":["https://openalex.org/I4210153432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034845479","display_name":"Heibatullah Kalantari\u202c","orcid":"https://orcid.org/0000-0002-7912-7295","observed_orcids":["https://orcid.org/0000-0002-7912-7295"]},"institutions":[{"id":"https://openalex.org/I119939603","display_name":"Ahvaz Jundishapur University of Medical Sciences","ror":"https://ror.org/01rws6r75","country_code":"IR","type":"education","lineage":["https://openalex.org/I119939603"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Kalantari, Heibatullah","raw_affiliation_strings":["Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran","Department of  Toxicology  #N#   School of  Pharmacy, Ahvaz  #N#  Jundishapur University of  #N# Medical Sciences, Ahvaz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran","institution_ids":["https://openalex.org/I119939603"]},{"raw_affiliation_string":"Department of  Toxicology  #N#   School of  Pharmacy, Ahvaz  #N#  Jundishapur University of  #N# Medical Sciences, Ahvaz, Iran","institution_ids":["https://openalex.org/I119939603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088175575","display_name":"Mehdi Goudarzi","orcid":"https://orcid.org/0000-0002-7816-4449","observed_orcids":["https://orcid.org/0000-0002-7816-4449","https://orcid.org/0000-0001-5227-0393"]},"institutions":[{"id":"https://openalex.org/I119939603","display_name":"Ahvaz Jundishapur University of Medical Sciences","ror":"https://ror.org/01rws6r75","country_code":"IR","type":"education","lineage":["https://openalex.org/I119939603"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Goudarzi, Mehdi","raw_affiliation_strings":["Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran","Department of  Toxicology  #N#   School of  Pharmacy, Ahvaz  #N#  Jundishapur University of  #N# Medical Sciences, Ahvaz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran","institution_ids":["https://openalex.org/I119939603"]},{"raw_affiliation_string":"Department of  Toxicology  #N#   School of  Pharmacy, Ahvaz  #N#  Jundishapur University of  #N# Medical Sciences, Ahvaz, Iran","institution_ids":["https://openalex.org/I119939603"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060761825","display_name":"Mohsen Rashidi","orcid":"https://orcid.org/0000-0002-5693-3876","observed_orcids":["https://orcid.org/0000-0002-5693-3876"]},"institutions":[{"id":"https://openalex.org/I88085062","display_name":"Mazandaran University of Medical Sciences","ror":"https://ror.org/02wkcrp04","country_code":"IR","type":"education","lineage":["https://openalex.org/I88085062"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Rashidi, Mohsen","raw_affiliation_strings":["Department of Physiology and Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran","Department of Physiology & Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran","institution_ids":["https://openalex.org/I88085062"]},{"raw_affiliation_string":"Department of Physiology & Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran","institution_ids":["https://openalex.org/I88085062"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3703,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.54841553,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10819","display_name":"Mercury impact and mitigation studies","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gallic-acid","display_name":"gallic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/mercuric-chloride","display_name":"mercuric chloride","score":0.9829999804496765},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.8980000019073486},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.8659999966621399},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8640000224113464},{"id":"https://openalex.org/keywords/reduced-glutathione","display_name":"reduced glutathione","score":0.7590000033378601},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9039999842643738},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9169999957084656},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.906000018119812},{"id":"https://openalex.org/keywords/blood-urea-nitrogen","display_name":"blood urea nitrogen","score":0.9509999752044678},{"id":"https://openalex.org/keywords/kidney-histopathology","display_name":"kidney histopathology","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8356590270996094},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.8125078678131104},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.6924458146095276},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.688469648361206},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6522811651229858},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5879983305931091},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.549472987651825},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5398809909820557},{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.5070080757141113},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4970534145832062},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4692625403404236},{"id":"https://openalex.org/C2778362808","wikidata":"https://www.wikidata.org/wiki/Q375837","display_name":"Gallic acid","level":3,"score":0.42535510659217834},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.416983962059021},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3842487931251526},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37553492188453674},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3484840393066406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33758074045181274},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.30674707889556885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12500301003456116},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10932189226150513},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:journals.sbmu.ac.ir:article/20117","doi":"https://doi.org/10.22037/ipa.v1i1.20117","is_oa":true,"landing_page_url":"https://journals.sbmu.ac.ir/acta/article/view/20117","pdf_url":"https://journals.sbmu.ac.ir/acta/article/download/20117/14419","source":{"id":"https://openalex.org/S4306514108","display_name":"International Pharmacy Acta","issn_l":null,"issn":["2645-3258","2645-3266"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2645-3258","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:journals.sbmu.ac.ir:article/20117","doi":"https://doi.org/10.22037/ipa.v1i1.20117","is_oa":true,"landing_page_url":"https://journals.sbmu.ac.ir/acta/article/view/20117","pdf_url":"https://journals.sbmu.ac.ir/acta/article/download/20117/14419","source":{"id":"https://openalex.org/S4306514108","display_name":"International Pharmacy Acta","issn_l":null,"issn":["2645-3258","2645-3266"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2645-3258","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2886723652.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2779639544","https://openalex.org/W2010651329","https://openalex.org/W2013328089","https://openalex.org/W2022971595","https://openalex.org/W2130461101","https://openalex.org/W2182931463","https://openalex.org/W2119792938","https://openalex.org/W2052267567","https://openalex.org/W4296499582","https://openalex.org/W2018598332"],"abstract_inverted_index":{"Introduction:":[0],"Mercury":[1],"has":[2,258],"hematotoxic,":[3],"hepatotoxic,":[4],"neurotoxic,":[5],"nephrotoxic":[6],"and":[7,47,62,71,94,103,126,140,152,157,164,199,201,206,224,226,232,274],"genotoxic":[8],"effects.":[9],"Tissue":[10],"damage":[11,264],"induced":[12],"by":[13,245,266],"mercuric":[14,38],"chloride":[15,39],"(HgCl2)":[16],"is":[17],"associated":[18],"with":[19,214],"the":[20,119,122,194,219,237,241,246,250,271,276],"promotion":[21],"of":[22,101,111,196,203,210,221,228,240,249],"oxidative":[23,147,272],"stress.":[24],"In":[25,49],"this":[26,50],"study,":[27,52],"Gallic":[28],"acid":[29],"(GA),":[30],"as":[31,136],"potent":[32],"antioxidant":[33,277],"compound,":[34],"was":[35,178,243],"examined":[36],"against":[37,261],"(HgCl2)-induced":[40],"kidney":[41,173,177],"injury":[42],"in":[43,171,193,218],"Wistar":[44],"rats.":[45],"Methods":[46],"Results:":[48],"experimental":[51],"animals":[53],"were":[54,124,129,169],"divided":[55],"into":[56],"five":[57],"groups":[58],"(n=7).":[59],"Groups":[60,92],"1":[61],"2":[63],"respectively":[64],"received":[65,83,96],"normal":[66],"saline":[67],"(2":[68],"ml/kg,":[69],"orally.)":[70],"HgCl2":[72,112,211],"(0.4":[73],"mg/kg,":[74,86,105],"orally)":[75,87],"for":[76,88,113,180],"28":[77,89,114],"consecutive":[78,90,115],"days.":[79,91,116],"Group":[80],"3":[81],"only":[82],"GA":[84,98,215,242,257],"(200":[85],"4":[93],"5":[95],"orally":[97],"at":[99],"doses":[100],"50":[102],"200":[104],"respectively,":[106],"one":[107],"hour":[108],"after":[109,208],"administration":[110],"Then":[117],"On":[118],"29th":[120],"day,":[121],"rats":[123],"sacrificed,":[125],"blood":[127,141],"samples":[128],"collected":[130],"to":[131],"determine":[132],"biochemical":[133],"parameters":[134],"such":[135],"serum":[137],"creatinine":[138],"(Cr)":[139],"urea":[142],"nitrogen":[143],"(BUN)":[144],"levels.":[145],"For":[146],"stress":[148],"evaluation,":[149],"malondialdehyde":[150],"(MDA)":[151],"reduced":[153],"glutathione":[154,161],"(GSH)":[155],"levels":[156,195,220],"also":[158],"catalase":[159],"(CAT),":[160],"peroxidase":[162],"(GPx)":[163],"superoxide":[165],"dismutase":[166],"(SOD)":[167],"activity":[168,234],"evaluated":[170],"left":[172],"tissue.":[174],"The":[175,183],"right":[176],"used":[179],"histological":[181,247],"examination.":[182],"results":[184,254],"obtained":[185],"from":[186],"our":[187],"study":[188],"showed":[189,216],"a":[190],"significant":[191],"increase":[192],"MDA,":[197,222],"Cr":[198,223],"BUN,":[200],"decrease":[202],"GSH,":[204,229],"CAT":[205],"SOD":[207,233],"ingestion":[209],"(p<0.05).":[212,235],"Pre-treatment":[213],"diminished":[217],"BUN":[225],"enhanced":[227],"CAT,":[230],"GPx":[231],"Additionally":[236],"nephroprotective":[238],"effect":[239,260],"established":[244],"evaluation":[248],"kidneys.":[251],"Conclusions:":[252],"Our":[253],"indicate":[255],"that":[256],"protective":[259],"HgCl2-induced":[262],"renal":[263],"probably":[265],"scavenging":[267],"free":[268],"radicals,":[269],"reducing":[270],"stress,":[273],"increasing":[275],"defense":[278],"mechanism.":[279]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-08-22T00:00:00"}
