{"id":"https://openalex.org/W2886717841","doi":"https://doi.org/10.1158/1538-7445.am2018-2964","title":"Abstract 2964: On-treatment changes in circulating tumor DNA (ctDNA) level as an early predictor of clinical outcome in the LOTUS randomized phase 2 trial of 1st-line ipatasertib (IPAT) + paclitaxel (PAC) for metastatic triple-negative breast cancer (mTNBC)","display_name":"Abstract 2964: On-treatment changes in circulating tumor DNA (ctDNA) level as an early predictor of clinical outcome in the LOTUS randomized phase 2 trial of 1st-line ipatasertib (IPAT) + paclitaxel (PAC) for metastatic triple-negative breast cancer (mTNBC)","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2886717841","doi":"https://doi.org/10.1158/1538-7445.am2018-2964","mag":"2886717841"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-2964","doi":"https://doi.org/10.1158/1538-7445.am2018-2964","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-2964","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001032099","display_name":"Matthew J. Wongchenko","orcid":"https://orcid.org/0000-0003-1230-7117","observed_orcids":["https://orcid.org/0000-0003-1230-7117"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew J. Wongchenko","raw_affiliation_strings":["1Genentech, Inc., South San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genentech, Inc., South San Francisco, CA;","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029183165","display_name":"Doron Lipson","orcid":"https://orcid.org/0009-0004-2738-5702","observed_orcids":["https://orcid.org/0009-0004-2738-5702"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doron Lipson","raw_affiliation_strings":["2Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000559665","display_name":"Travis A. Clark","orcid":"https://orcid.org/0000-0002-2441-2953","observed_orcids":["https://orcid.org/0000-0002-2441-2953"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Travis Clark","raw_affiliation_strings":["2Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mark Kennedy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Kennedy","raw_affiliation_strings":["2Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023279824","display_name":"Mandy Greene","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mandy Greene","raw_affiliation_strings":["2Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015108630","display_name":"Virginia Breese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia Breese","raw_affiliation_strings":["2Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090126370","display_name":"Alyssa Tsiros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alyssa Tsiros","raw_affiliation_strings":["2Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026459010","display_name":"Sung\u2010Bae Kim","orcid":"https://orcid.org/0000-0001-5588-8332","observed_orcids":["https://orcid.org/0000-0001-5588-8332"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung-Bae Kim","raw_affiliation_strings":["3Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082195410","display_name":"Cristina Saura","orcid":"https://orcid.org/0000-0001-8296-5065","observed_orcids":["https://orcid.org/0000-0001-8296-5065"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]},{"id":"https://openalex.org/I4387155398","display_name":"Vall d'Hebron Institute of Oncology","ror":"https://ror.org/054xx3904","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4387155398"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Saura","raw_affiliation_strings":["4Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona, Spain;","institution_ids":["https://openalex.org/I4210127641","https://openalex.org/I4387155398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053983312","display_name":"Mafalda Oliveira","orcid":"https://orcid.org/0000-0001-9152-8799","observed_orcids":["https://orcid.org/0000-0001-9152-8799"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]},{"id":"https://openalex.org/I4387155398","display_name":"Vall d'Hebron Institute of Oncology","ror":"https://ror.org/054xx3904","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4387155398"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mafalda Oliveira","raw_affiliation_strings":["4Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona, Spain;","institution_ids":["https://openalex.org/I4210127641","https://openalex.org/I4387155398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004300577","display_name":"Jose M Baselga","orcid":"https://orcid.org/0000-0003-1361-4063","observed_orcids":["https://orcid.org/0000-0003-1361-4063"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Baselga","raw_affiliation_strings":["5Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063009340","display_name":"Amy V. Kapp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Amy V. Kapp","raw_affiliation_strings":["1Genentech, Inc., South San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genentech, Inc., South San Francisco, CA;","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002812618","display_name":"Wai\u2010Yee Chan","orcid":"https://orcid.org/0000-0002-9714-0936","observed_orcids":["https://orcid.org/0000-0002-9714-0936"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Wai Y. Chan","raw_affiliation_strings":["1Genentech, Inc., South San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genentech, Inc., South San Francisco, CA;","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040489877","display_name":"Stina Mui Singel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Stina M. Singel","raw_affiliation_strings":["1Genentech, Inc., South San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genentech, Inc., South San Francisco, CA;","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085108777","display_name":"Steven B. Gendreau","orcid":"https://orcid.org/0009-0009-4599-7151","observed_orcids":["https://orcid.org/0009-0009-4599-7151"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Steven Gendreau","raw_affiliation_strings":["1Genentech, Inc., South San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genentech, Inc., South San Francisco, CA;","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056387446","display_name":"Rebecca Alexandra Dent","orcid":"https://orcid.org/0000-0001-6421-7602","observed_orcids":["https://orcid.org/0000-0001-6421-7602"]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Rebecca Dent","raw_affiliation_strings":["6National Cancer Centre, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6National Cancer Centre, Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"2964","last_page":"2964"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.028300000354647636,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.996999979019165},{"id":"https://openalex.org/keywords/ctdna-fraction","display_name":"ctDNA fraction","score":0.8119999766349792},{"id":"https://openalex.org/keywords/metastatic-triple-negative-breast-cancer","display_name":"metastatic triple-negative breast cancer","score":0.8600000143051147},{"id":"https://openalex.org/keywords/ipatasertib","display_name":"ipatasertib","score":0.9959999918937683},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9309999942779541},{"id":"https://openalex.org/keywords/akt-inhibitors","display_name":"AKT inhibitors","score":0.890999972820282},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7310000061988831},{"id":"https://openalex.org/keywords/objective-response","display_name":"objective response","score":0.9129999876022339},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.6650000214576721},{"id":"https://openalex.org/keywords/mutant-allele-frequency","display_name":"mutant allele frequency","score":0.5680000185966492},{"id":"https://openalex.org/keywords/surrogate-endpoints","display_name":"surrogate endpoints","score":0.625},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.453000009059906},{"id":"https://openalex.org/keywords/hybrid-capture-sequencing","display_name":"hybrid capture sequencing","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7045146226882935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6033638715744019},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5375895500183105},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4638526439666748},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4611419141292572},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4179691672325134},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-2964","doi":"https://doi.org/10.1158/1538-7445.am2018-2964","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-2964","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2355769538","https://openalex.org/W2081816252","https://openalex.org/W2373885168","https://openalex.org/W1966504330","https://openalex.org/W1979139803","https://openalex.org/W2112436308","https://openalex.org/W2037631372","https://openalex.org/W2030889776","https://openalex.org/W2159000141","https://openalex.org/W2362391294"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"There":[2],"is":[3,256],"high":[4],"interest":[5],"in":[6,29,62,82,104,111,127,185,191,217,228,234,374,387],"longitudinal":[7,25],"analysis":[8,26],"of":[9,16,27,40,109,147,246,249,254,259,268,384,394,410],"plasma":[10,52],"ctDNA":[11,28,63,76,93],"as":[12,98,274,380],"an":[13,275,381],"early":[14,276,382],"predictor":[15,383],"response":[17,120,209,225],"and":[18,58,123,133,197,210,226,237],"long-term":[19],"outcomes.":[20],"We":[21],"report":[22],"a":[23,65,201,220],"retrospective":[24],"the":[30,41,79,99,128,198,235,243,252,265,388,411],"double-blind":[31],"placebo":[32],"(PBO)-controlled":[33],"randomized":[34,390],"phase":[35,391],"2":[36,392],"LOTUS":[37,389],"(NCT02162719)":[38],"trial":[39,278,393],"oral":[42],"Akt":[43],"inhibitor":[44],"IPAT":[45,280],"+":[46,131,136,281,284,398],"PAC":[47,282,285],"for":[48,158,401,414],"mTNBC.":[49],"Methods:":[50],"Pre-treatment":[51],"samples":[53,84,115,142,250],"were":[54,143,175],"analyzed":[55],"to":[56,188],"identify":[57],"quantify":[59],"genomic":[60],"alterations":[61],"using":[64],"hybrid-capture-based":[66],"NGS":[67],"assay":[68],"that":[69],"interrogates":[70],"62":[71],"genes":[72],"(FoundationACT).":[73],"A":[74],"narrow":[75],"panel":[77],"quantified":[78],"same":[80],"mutations":[81,174],"on-treatment":[83,112,141,160,186,192],"collected":[85],"at":[86],"8":[87],"wks":[88],"(d1,":[89],"cycle":[90,167],"3).":[91],"The":[92,107,154],"fraction":[94],"(CTF)":[95],"was":[96,116,162,205,232],"defined":[97],"highest":[100],"mutant":[101],"allele":[102],"frequency":[103],"each":[105],"sample.":[106],"ratio":[108,306,311,317],"CTF":[110,178,203,218,289],"vs":[113],"pre-treatment":[114,152],"compared":[117],"with":[118,150,207,223],"objective":[119,208,224],"(RECIST":[121],"v1.1)":[122],"progression-free":[124],"survival":[125],"(PFS)":[126],"experimental":[129,236],"(IPAT":[130],"PAC)":[132,137],"control":[134,238],"(PBO":[135],"arms.":[138],"Results:":[139],"Paired":[140],"evaluable":[144,151],"from":[145,181,242,251],"66":[146],"88":[148],"patients":[149],"samples.":[153],"most":[155],"common":[156],"reason":[157],"no":[159],"sample":[161],"disease":[163],"progression":[164],"(PD)":[165],"before":[166],"3.":[168],"In":[169,194],"81":[170],"baseline":[171],"samples,":[172],"149":[173],"identified.":[176],"Calculated":[177],"ratios":[179],"ranged":[180],"0%":[182],"(not":[183],"detected":[184],"sample)":[187],"648%":[189],"(increase":[190],"sample).":[193],"both":[195],"arms":[196,287],"pooled":[199],"population,":[200],"greater":[202],"decrease":[204],"associated":[206],"longer":[211],"PFS":[212,227],"(Table).":[213],"Conclusions:":[214],"On-treatment":[215,372],"change":[216],"shows":[219],"meaningful":[221],"association":[222],"LOTUS.":[229],"This":[230],"effect":[231],"seen":[233],"arms,":[239],"suggesting":[240],"independence":[241],"specific":[244],"mechanism":[245],"therapy.":[247],"Evaluation":[248],"time":[253],"PD":[255],"ongoing.":[257],"Inclusion":[258],"additional":[260],"timepoints":[261],"will":[262],"likely":[263],"improve":[264],"predictive":[266],"ability":[267],"CTF,":[269],"possibly":[270],"allowing":[271],"its":[272],"use":[273],"surrogate":[277],"endpoint.":[279],"(n=32)PBO":[283],"(n=34)Pooled":[286],"(n=66)Median":[288],"ratio,":[290],"%":[291],"(IQR)Confirmed":[292],"complete/partial":[293],"response(n=14)(n=14)(n=28)0.4":[294],"(0-14.3)0.2":[295],"(0-46.9)0.3":[296],"(0-17.8)Stable/progressive":[297],"disease(n=18)(n=20)(n=38)8.2":[298],"(4.4-45.9)26.9":[299],"(8.4-91.4)20.7":[300],"(4.9-67.9)Median":[301],"PFS,":[302],"months":[303],"(95%":[304,318],"CI)CTF":[305],"\u22645%(n=15)(n=14)(n=29)7.2":[307],"(3.7-NE)6.3":[308],"(3.6-NE)7.2":[309],"(5.1-12.9)CTF":[310],">5%(n=17)(n=20)(n=37)3.7":[312],"(3.5-5.3)3.7":[313],"(2.8-5.4)3.7":[314],"(3.6-5.0)PFS":[315],"hazard":[316],"CI)0.46":[319],"(0.19-1.09)0.43":[320],"(0.17-0.97)0.43":[321],"(0.23-0.78)CI":[322],"=":[323,327,331],"confidence":[324],"interval;":[325],"IQR":[326],"interquartile":[328],"range;":[329],"NE":[330],"not":[332],"estimable.":[333],"Citation":[334],"Format:":[335],"Matthew":[336],"J.":[337],"Wongchenko,":[338],"Doron":[339],"Lipson,":[340],"Travis":[341],"Clark,":[342],"Mark":[343],"Kennedy,":[344],"Mandy":[345],"Greene,":[346],"Virginia":[347],"Breese,":[348],"Alyssa":[349],"Tsiros,":[350],"Sung-Bae":[351],"Kim,":[352],"Cristina":[353],"Saura,":[354],"Mafalda":[355],"Oliveira,":[356],"Jose":[357],"Baselga,":[358],"Amy":[359],"V.":[360],"Kapp,":[361],"Wai":[362],"Y.":[363],"Chan,":[364],"Stina":[365],"M.":[366],"Singel,":[367],"Steven":[368],"Gendreau,":[369],"Rebecca":[370],"Dent.":[371],"changes":[373],"circulating":[375],"tumor":[376],"DNA":[377],"(ctDNA)":[378],"level":[379],"clinical":[385],"outcome":[386],"1st-line":[395],"ipatasertib":[396],"(IPAT)":[397],"paclitaxel":[399],"(PAC)":[400],"metastatic":[402],"triple-negative":[403],"breast":[404],"cancer":[405],"(mTNBC)":[406],"[abstract].":[407],"In:":[408],"Proceedings":[409],"American":[412],"Association":[413],"Cancer":[415,428],"Research":[416],"Annual":[417],"Meeting":[418],"2018;":[419],"2018":[420],"Apr":[421],"14-18;":[422],"Chicago,":[423],"IL.":[424],"Philadelphia":[425],"(PA):":[426],"AACR;":[427],"Res":[429],"2018;78(13":[430],"Suppl):Abstract":[431],"nr":[432],"2964.":[433]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2025-10-10T00:00:00"}
