{"id":"https://openalex.org/W2886663320","doi":"https://doi.org/10.1158/1538-7445.am2018-191","title":"Abstract 191: Paracrine role of endothelial cells in HER3-mediated colon cancer cell survival","display_name":"Abstract 191: Paracrine role of endothelial cells in HER3-mediated colon cancer cell survival","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2886663320","doi":"https://doi.org/10.1158/1538-7445.am2018-191","mag":"2886663320"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-191","doi":"https://doi.org/10.1158/1538-7445.am2018-191","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-191","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100431113","display_name":"Rui Wang","orcid":"https://orcid.org/0000-0001-5794-7201","observed_orcids":["https://orcid.org/0000-0001-5794-7201"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Wang","raw_affiliation_strings":["UT MD Anderson Cancer Ctr., Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT MD Anderson Cancer Ctr., Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063114221","display_name":"Rajat Bhattacharya","orcid":"https://orcid.org/0000-0001-5693-6754","observed_orcids":["https://orcid.org/0000-0001-5693-6754"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajat Bhattacharya","raw_affiliation_strings":["UT MD Anderson Cancer Ctr., Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT MD Anderson Cancer Ctr., Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fan Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fan Fan","raw_affiliation_strings":["UT MD Anderson Cancer Ctr., Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT MD Anderson Cancer Ctr., Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073510151","display_name":"Xiangcang Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiangcang Ye","raw_affiliation_strings":["UT MD Anderson Cancer Ctr., Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT MD Anderson Cancer Ctr., Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113723751","display_name":"Delphine R. Boulb\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Delphine Boulbes","raw_affiliation_strings":["UT MD Anderson Cancer Ctr., Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT MD Anderson Cancer Ctr., Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042341684","display_name":"Lee M. Ellis","orcid":"https://orcid.org/0000-0001-8082-4904","observed_orcids":["https://orcid.org/0000-0001-8082-4904"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee M. Ellis","raw_affiliation_strings":["UT MD Anderson Cancer Ctr., Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT MD Anderson Cancer Ctr., Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"191","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.05040000006556511,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8529999852180481},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.9440000057220459},{"id":"https://openalex.org/keywords/her3","display_name":"HER3","score":0.9039999842643738},{"id":"https://openalex.org/keywords/akt-pathway","display_name":"AKT pathway","score":0.7620000243186951},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9929999709129333},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9700000286102295},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5830000042915344},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6420000195503235},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.6639999747276306},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.6690000295639038},{"id":"https://openalex.org/keywords/xenograft-tumor-model","display_name":"xenograft tumor model","score":0.7630000114440918},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.9449999928474426},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.7465314865112305},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7047178745269775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6809194087982178},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5775740146636963},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5327646136283875},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.48080554604530334},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.429837167263031},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4154629111289978},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41385418176651},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3402385115623474},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.3349551558494568},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2195867896080017},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10916787385940552},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-191","doi":"https://doi.org/10.1158/1538-7445.am2018-191","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-191","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2956130107","https://openalex.org/W2888146702","https://openalex.org/W2740693072","https://openalex.org/W2608097170","https://openalex.org/W4220690591","https://openalex.org/W4282946963","https://openalex.org/W3184262091","https://openalex.org/W2324170616","https://openalex.org/W4321325417","https://openalex.org/W4393087435"],"abstract_inverted_index":{"Abstract":[0],"INTRODUCTION:":[1],"Colorectal":[2],"cancer":[3,100,419,444],"(CRC)":[4],"remains":[5],"the":[6,13,45,55,78,80,91,99,116,132,171,281,298,384,451],"second-leading":[7],"cause":[8],"of":[9,18,38,44,47,57,84,119,162,203,237,313,367,383,402,438,450],"cancer-related":[10],"death":[11],"in":[12,54,90,96,104,122,196,209,233,251,274,277,333,338,370,379,414,441],"United":[14],"States.":[15],"Median":[16],"survival":[17,50,446],"patients":[19,28,66,405],"with":[20,67,150,192,224,250,261,345,351,357,406],"metastatic":[21],"CRC":[22,48,85,105,124,146,165,190,206,220,275,334,342,380],"(mCRC)":[23],"is":[24,52,392],"~2.5":[25],"years":[26],"and":[27,127,129,144,229,239,256,272,331,374],"often":[29],"become":[30],"resistance":[31],"to":[32,113],"systemic":[33],"therapy":[34],"within":[35],"1":[36],"year":[37],"treatment.":[39],"Therefore,":[40],"a":[41,214,317,364,399],"better":[42],"understanding":[43],"regulation":[46],"cell":[49,102,125,166,182,270,329,372,445],"pathways":[51],"necessary":[53],"development":[56],"new":[58],"therapeutic":[59],"strategies":[60],"that":[61,73,311,356,409],"will":[62],"improve":[63],"outcomes":[64],"for":[65,186,388,417,454],"mCRC.":[68],"We":[69,284],"have":[70],"previously":[71],"demonstrated":[72,363],"endothelial":[74,439],"cells":[75,147,191,221,276,343,440],"(ECs)":[76],"from":[77,138,158,265],"liver,":[79],"most":[81],"common":[82],"site":[83],"metastases,":[86],"secrete":[87],"soluble":[88],"factors":[89],"conditioned":[92],"medium":[93],"(CM)":[94],"that,":[95],"turn,":[97],"increase":[98],"stem":[101],"phenotype":[103],"cells.":[106,335,381],"OBJECTIVES:":[107],"In":[108,336],"this":[109],"study,":[110],"we":[111,309],"sought":[112],"(1)":[114],"elucidate":[115],"paracrine":[117,365],"role":[118,366,437],"liver":[120,140,266,368,385],"ECs":[121,137,267,369],"mediating":[123],"growth":[126,167,208,271,288,353,373],"chemoresistance,":[128],"(2)":[130],"determine":[131],"mechanism(s)":[133],"involved.":[134],"METHODS:":[135],"Primary":[136],"non-malignant":[139],"parenchyma":[141],"were":[142,148,222],"isolated":[143],"confirmed.":[145],"incubated":[149],"either":[151,195,315],"their":[152],"own":[153],"CM":[154,157,163,198,204,228,264,347],"(control)":[155],"or":[156,199,226,320],"ECs.":[159],"The":[160,174],"effect":[161,175],"on":[164,176,205],"was":[168,178,211,244],"determined":[169,179,212],"by":[170,180,248,257,305,316,321],"MTT":[172],"assay.":[173],"chemoresistance":[177,273,332,375],"fluorescence-activated":[181],"sorting":[183],"(FACS)-based":[184],"assay":[185],"apoptosis":[187],"after":[188],"treating":[189,403],"5-fluorouracil":[193],"(5-FU)":[194],"control":[197,225,358],"EC":[200,227,306,325,346],"CM.":[201,241,307,359],"Effects":[202],"tumor":[207,218,259,340],"vivo":[210,339],"using":[213],"subcutaneous":[215],"(subQ)":[216],"xenograft":[217],"model.":[219],"pretreated":[223],"then":[230],"injected":[231],"subQ":[232],"an":[234],"inoculation":[235],"mixture":[236],"Matrigel":[238],"concentrated":[240],"Tumor":[242],"burden":[243],"assessed":[245,413],"over":[246],"time":[247],"bioluminescence":[249],"vitro":[252,278],"imaging":[253],"system":[254],"(IVIS)":[255],"measuring":[258],"volume":[260],"calipers.":[262],"RESULTS:":[263],"significantly":[268],"increased":[269],"via":[279,376],"activating":[280,377,389],"AKT":[282,327],"pathway.":[283],"identified":[285],"human":[286],"epidermal":[287],"factor":[289],"receptor":[290,300],"3":[291],"(HER3,":[292],"also":[293],"known":[294],"as":[295],"ERBB3)":[296],"being":[297,412],"only":[299],"tyrosine":[301],"kinase":[302],"(RTK)":[303],"activated":[304],"Furthermore,":[308],"found":[310],"inhibition":[312],"HER3,":[314],"HER3":[318,322,391,407],"inhibitor":[319],"siRNAs,":[323],"blocked":[324],"CM-induced":[326],"activation,":[328],"growth,":[330],"our":[337],"model,":[341],"treated":[344],"formed":[348],"larger":[349],"tumors":[350],"higher":[352],"rates":[354],"than":[355],"CONCLUSIONS:":[360],"Our":[361],"results":[362],"promoting":[371],"HER3-AKT":[378],"Identification":[382],"EC-secreted":[386],"factor(s)":[387],"CRC-associated":[390],"currently":[393],"under":[394],"study.":[395],"This":[396],"study":[397],"suggested":[398],"potential":[400],"strategy":[401],"mCRC":[404],"antibodies/inhibitors":[408],"are":[410],"already":[411],"clinical":[415],"trials":[416],"various":[418],"types.":[420],"Citation":[421],"Format:":[422],"Rui":[423],"Wang,":[424],"Rajat":[425],"Bhattacharya,":[426],"Fan":[427],"Fan,":[428],"Xiangcang":[429],"Ye,":[430],"Delphine":[431],"Boulbes,":[432],"Lee":[433],"M.":[434],"Ellis.":[435],"Paracrine":[436],"HER3-mediated":[442],"colon":[443],"[abstract].":[447],"In:":[448],"Proceedings":[449],"American":[452],"Association":[453],"Cancer":[455,468],"Research":[456],"Annual":[457],"Meeting":[458],"2018;":[459],"2018":[460],"Apr":[461],"14-18;":[462],"Chicago,":[463],"IL.":[464],"Philadelphia":[465],"(PA):":[466],"AACR;":[467],"Res":[469],"2018;78(13":[470],"Suppl):Abstract":[471],"nr":[472],"191.":[473]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2018-08-22T00:00:00"}
