{"id":"https://openalex.org/W2886595271","doi":"https://doi.org/10.1038/s41389-018-0072-4","title":"Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects","display_name":"Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects","publication_year":2018,"publication_date":"2018-08-10","ids":{"openalex":"https://openalex.org/W2886595271","doi":"https://doi.org/10.1038/s41389-018-0072-4","mag":"2886595271","pmid":"https://pubmed.ncbi.nlm.nih.gov/30108207","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6092349"},"language":"en","primary_location":{"id":"doi:10.1038/s41389-018-0072-4","doi":"https://doi.org/10.1038/s41389-018-0072-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41389-018-0072-4","pdf_url":"https://www.nature.com/articles/s41389-018-0072-4.pdf","source":{"id":"https://openalex.org/S4210239318","display_name":"Oncogenesis","issn_l":"2157-9024","issn":["2157-9024"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41389-018-0072-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Qianqian He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Qianqian He","raw_affiliation_strings":["Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore","School of Biological Sciences, Nanyang Technological University, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, Singapore, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064076595","display_name":"Bijin Veonice Au","orcid":"https://orcid.org/0000-0002-3670-4670","observed_orcids":["https://orcid.org/0000-0002-3670-4670"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Bijin Au","raw_affiliation_strings":["Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026857062","display_name":"Madhura Kulkarni","orcid":"https://orcid.org/0000-0002-0406-5739","observed_orcids":["https://orcid.org/0000-0002-0406-5739"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I181996519","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13","country_code":"IN","type":"education","lineage":["https://openalex.org/I181996519"]},{"id":"https://openalex.org/I4210149123","display_name":"Prashanti Cancer Care Mission","ror":"https://ror.org/04mf96963","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I4210149123"]}],"countries":["IN","SG"],"is_corresponding":false,"raw_author_name":"Madhura Kulkarni","raw_affiliation_strings":["Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore","Transnational Cancer Research Centre: Prashanti Cancer Care Mission, Indian Institute of Science Education and Research, Pune, India"],"raw_orcid":"https://orcid.org/0000-0002-0406-5739","affiliations":[{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Transnational Cancer Research Centre: Prashanti Cancer Care Mission, Indian Institute of Science Education and Research, Pune, India","institution_ids":["https://openalex.org/I181996519","https://openalex.org/I4210149123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101567723","display_name":"Yang Shen","orcid":"https://orcid.org/0000-0001-6607-7818","observed_orcids":["https://orcid.org/0000-0001-6607-7818","https://orcid.org/0000-0003-4714-0839"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yang Shen","raw_affiliation_strings":["Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I66068411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025468831","display_name":"Kah Jing Lim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kah. J. Lim","raw_affiliation_strings":["Acenzia Inc., Windsor, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acenzia Inc., Windsor, Ontario, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067817648","display_name":"Jiamila Maimaiti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiamila Maimaiti","raw_affiliation_strings":["Acenzia Inc., Windsor, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acenzia Inc., Windsor, Ontario, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001985358","display_name":"Cheng Kit Wong","orcid":"https://orcid.org/0000-0001-5205-771X","observed_orcids":["https://orcid.org/0000-0001-5205-771X"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210147916","display_name":"Institute of Medical Biology","ror":"https://ror.org/04frzv033","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210147916"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Cheng. Kit. Wong","raw_affiliation_strings":["Institute of Medical Biology, Agency for Science, Technology and Research, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Biology, Agency for Science, Technology and Research, Singapore, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210147916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044630563","display_name":"Monique Luijten","orcid":"https://orcid.org/0000-0002-1103-5204","observed_orcids":["https://orcid.org/0000-0002-1103-5204"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Monique. N. H. Luijten","raw_affiliation_strings":["Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002024919","display_name":"Han C. Chong","orcid":"https://orcid.org/0000-0002-8137-2556","observed_orcids":["https://orcid.org/0000-0002-8137-2556"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Han C. Chong","raw_affiliation_strings":["Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042322286","display_name":"Elaine Hsuen Lim","orcid":"https://orcid.org/0000-0002-4660-3187","observed_orcids":["https://orcid.org/0000-0002-4660-3187"]},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Elaine H. Lim","raw_affiliation_strings":["Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031265292","display_name":"Giulia Irene Rancati","orcid":"https://orcid.org/0000-0003-0835-0139","observed_orcids":["https://orcid.org/0000-0003-0835-0139"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210147916","display_name":"Institute of Medical Biology","ror":"https://ror.org/04frzv033","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210147916"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Giulia Rancati","raw_affiliation_strings":["Institute of Medical Biology, Agency for Science, Technology and Research, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Biology, Agency for Science, Technology and Research, Singapore, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210147916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068162387","display_name":"Indrajit Sinha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Indrajit Sinha","raw_affiliation_strings":["Acenzia Inc., Windsor, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acenzia Inc., Windsor, Ontario, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058319572","display_name":"Zhiyan Fu","orcid":"https://orcid.org/0000-0002-9541-9968","observed_orcids":["https://orcid.org/0000-0002-9541-9968"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Zhiyan Fu","raw_affiliation_strings":["Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I66068411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423388","display_name":"Xiaomeng Wang","orcid":"https://orcid.org/0000-0002-1036-2764","observed_orcids":["https://orcid.org/0000-0002-1036-2764","https://orcid.org/0000-0002-1733-4109"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Xiaomeng Wang","raw_affiliation_strings":["Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore","Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]},{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John. E. Connolly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I157394403","display_name":"Baylor University","ror":"https://ror.org/005781934","country_code":"US","type":"education","lineage":["https://openalex.org/I157394403"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"John. E. Connolly","raw_affiliation_strings":["Institute of Biomedical Studies, Baylor University, Waco, TX, USA","Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore","Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Studies, Baylor University, Waco, TX, USA","institution_ids":["https://openalex.org/I157394403"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]},{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063431880","display_name":"Karen Crasta","orcid":"https://orcid.org/0000-0001-9849-6080","observed_orcids":["https://orcid.org/0000-0001-9849-6080"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["GB","SG"],"is_corresponding":true,"raw_author_name":"Karen C. Crasta","raw_affiliation_strings":["Department of Medicine, Imperial College London, London, UK. kccrasta@ntu.edu.sg","Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore. kccrasta@ntu.edu.sg","Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. kccrasta@ntu.edu.sg","School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. kccrasta@ntu.edu.sg","Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Imperial College London, London, UK. kccrasta@ntu.edu.sg","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore. kccrasta@ntu.edu.sg","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]},{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. kccrasta@ntu.edu.sg","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. kccrasta@ntu.edu.sg","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5063431880"],"corresponding_institution_ids":["https://openalex.org/I115228651","https://openalex.org/I172675005","https://openalex.org/I47508984","https://openalex.org/I75573869"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":{"value":4290,"currency":"USD","value_usd":4290},"fwci":2.538,"has_fulltext":true,"cited_by_count":77,"citation_normalized_percentile":{"value":0.89672652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"7","issue":"8","first_page":"62","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.871999979019165},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8220000267028809},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9860000014305115},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.652999997138977},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.7429999709129333},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8510000109672546},{"id":"https://openalex.org/keywords/nocodazole","display_name":"nocodazole","score":0.671999990940094},{"id":"https://openalex.org/keywords/reversine","display_name":"reversine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6340000033378601},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8790000081062317},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.880043089389801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7830450534820557},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.7535653114318848},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7272573709487915},{"id":"https://openalex.org/C2779363559","wikidata":"https://www.wikidata.org/wiki/Q2506092","display_name":"Nocodazole","level":4,"score":0.5322684049606323},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5232424139976501},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5190109014511108},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48486170172691345},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47380298376083374},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.4419114887714386},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4013639986515045},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.3725961744785309},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3217077851295471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0762997567653656},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0710040032863617},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1038/s41389-018-0072-4","doi":"https://doi.org/10.1038/s41389-018-0072-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41389-018-0072-4","pdf_url":"https://www.nature.com/articles/s41389-018-0072-4.pdf","source":{"id":"https://openalex.org/S4210239318","display_name":"Oncogenesis","issn_l":"2157-9024","issn":["2157-9024"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogenesis","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5039208","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6092349","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6092349","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6092349","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogenesis","raw_type":"Text"},{"id":"pmid:30108207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30108207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogenesis","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/210871","doi":null,"is_oa":true,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/210871","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus OA2018","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:d9f6140086aa4e03a4c398e217e8deff","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d9f6140086aa4e03a4c398e217e8deff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncogenesis, Vol 7, Iss 8, Pp 1-18 (2018)","raw_type":"article"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/89120","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10220/46078","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41389-018-0072-4","doi":"https://doi.org/10.1038/s41389-018-0072-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41389-018-0072-4","pdf_url":"https://www.nature.com/articles/s41389-018-0072-4.pdf","source":{"id":"https://openalex.org/S4210239318","display_name":"Oncogenesis","issn_l":"2157-9024","issn":["2157-9024"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogenesis","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3048563442","display_name":null,"funder_award_id":"Tier 1","funder_id":"https://openalex.org/F4320320766","funder_display_name":"Nanyang Technological University"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320766","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2886595271.pdf","grobid_xml":"https://content.openalex.org/works/W2886595271.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W239602587","https://openalex.org/W1690531714","https://openalex.org/W1963941229","https://openalex.org/W1966669440","https://openalex.org/W1970442105","https://openalex.org/W2001733842","https://openalex.org/W2002246796","https://openalex.org/W2004196283","https://openalex.org/W2004273407","https://openalex.org/W2006620593","https://openalex.org/W2009891171","https://openalex.org/W2017046792","https://openalex.org/W2022527641","https://openalex.org/W2028666395","https://openalex.org/W2030202463","https://openalex.org/W2037404897","https://openalex.org/W2041353881","https://openalex.org/W2042140414","https://openalex.org/W2044341880","https://openalex.org/W2046109468","https://openalex.org/W2047687247","https://openalex.org/W2050852029","https://openalex.org/W2061169804","https://openalex.org/W2062214822","https://openalex.org/W2067239022","https://openalex.org/W2067424975","https://openalex.org/W2072520553","https://openalex.org/W2087404852","https://openalex.org/W2091369486","https://openalex.org/W2094375019","https://openalex.org/W2095486134","https://openalex.org/W2095617425","https://openalex.org/W2096000713","https://openalex.org/W2097065948","https://openalex.org/W2100305481","https://openalex.org/W2102502996","https://openalex.org/W2102922697","https://openalex.org/W2102960342","https://openalex.org/W2105571100","https://openalex.org/W2107702258","https://openalex.org/W2111553417","https://openalex.org/W2112270062","https://openalex.org/W2112612696","https://openalex.org/W2113674897","https://openalex.org/W2121212012","https://openalex.org/W2131078803","https://openalex.org/W2132406938","https://openalex.org/W2135829603","https://openalex.org/W2137220794","https://openalex.org/W2153304690","https://openalex.org/W2156372413","https://openalex.org/W2158217645","https://openalex.org/W2160345528","https://openalex.org/W2160443244","https://openalex.org/W2170008898","https://openalex.org/W2171175279","https://openalex.org/W2171385762","https://openalex.org/W2189135309","https://openalex.org/W2352719856","https://openalex.org/W2518394218","https://openalex.org/W2530549727","https://openalex.org/W2553250671","https://openalex.org/W2574604975","https://openalex.org/W2612090342","https://openalex.org/W2693925639","https://openalex.org/W2748819316","https://openalex.org/W2785862171","https://openalex.org/W4210430020"],"related_works":["https://openalex.org/W7053331692","https://openalex.org/W2519262035","https://openalex.org/W4414534019","https://openalex.org/W2006620593","https://openalex.org/W1558701786","https://openalex.org/W3110854591","https://openalex.org/W1657799595","https://openalex.org/W2971981897","https://openalex.org/W1980493852","https://openalex.org/W4312070622"],"abstract_inverted_index":{"Chromosomal":[0],"instability":[1],"(CIN),":[2],"a":[3,74,162,190],"high":[4],"rate":[5],"of":[6,30,41,44,63,68,90,121,126,138,183],"chromosome":[7,45],"loss":[8],"or":[9],"gain,":[10],"is":[11],"often":[12],"associated":[13],"with":[14,86,129],"poor":[15],"prognosis":[16],"and":[17,32,47,57,70,107,153,158,167,188,199],"drug":[18],"resistance":[19],"in":[20,73,82,132,156,159,175],"cancers.":[21],"Aneuploid,":[22],"including":[23],"near-polyploid,":[24],"cells":[25,72,85,113,128,133,198],"contain":[26],"an":[27],"abnormal":[28,91],"number":[29,125],"chromosomes":[31],"exhibit":[33],"CIN.":[34],"The":[35],"post-mitotic":[36],"cell":[37,191],"fates":[38],"following":[39],"generation":[40],"different":[42,61],"degrees":[43],"mis-segregation":[46],"aneuploidy":[48,54,166],"are":[49],"unclear.":[50],"Here":[51],"we":[52],"used":[53],"inducers,":[55],"nocodazole":[56],"reversine,":[58],"to":[59,78,84,95,206],"create":[60],"levels":[62,89],"aneuploidy.":[64],"A":[65],"higher":[66],"extent":[67],"aneuploid":[69],"near-polyploid":[71],"given":[75],"population":[76],"led":[77],"senescence.":[79],"This":[80],"was":[81,102,169],"contrast":[83],"relatively":[87],"lower":[88],"ploidy":[92],"that":[93,100,143],"continued":[94],"proliferate.":[96],"Our":[97,178],"findings":[98,179],"revealed":[99],"senescence":[101,168],"accompanied":[103],"by":[104,194],"DNA":[105,135],"damage":[106],"robust":[108],"p53":[109,122],"activation.":[110],"These":[111],"senescent":[112,127,197],"acquired":[114],"the":[115,124,172,203],"senescence-associated":[116],"secretory":[117],"phenotype":[118],"(SASP).":[119],"Depletion":[120],"reduced":[123],"concomitant":[130],"increase":[131],"undergoing":[134],"replication.":[136],"Characterisation":[137],"these":[139],"SASP":[140,200],"factors":[141],"demonstrated":[142],"they":[144],"conferred":[145],"paracrine":[146],"pro-tumourigenic":[147],"effects":[148],"such":[149],"as":[150],"invasion,":[151],"migration":[152],"angiogenesis":[154],"both":[155],"vitro":[157],"vivo.":[160],"Finally,":[161],"correlation":[163],"between":[164],"increased":[165],"observed":[170],"at":[171],"invasive":[173],"front":[174],"breast":[176],"carcinomas.":[177],"demonstrate":[180],"functional":[181],"non-equivalence":[182],"discernable":[184],"aneuploidies":[185],"on":[186],"tumourigenesis":[187],"suggest":[189],"non-autonomous":[192],"mechanism":[193],"which":[195],"aneuploidy-induced":[196],"can":[201],"affect":[202],"tumour":[204,208],"microenvironment":[205],"promote":[207],"progression.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-08-22T00:00:00"}
