{"id":"https://openalex.org/W2886562763","doi":"https://doi.org/10.1136/heartjnl-2018-bcs.6","title":"6 Metformin regresses left ventricular hypertrophy in normotensive patients with coronary artery disease without type 2 diabetes mellitus \u2013 the met-remodel trial","display_name":"6 Metformin regresses left ventricular hypertrophy in normotensive patients with coronary artery disease without type 2 diabetes mellitus \u2013 the met-remodel trial","publication_year":2018,"publication_date":"2018-06-01","ids":{"openalex":"https://openalex.org/W2886562763","doi":"https://doi.org/10.1136/heartjnl-2018-bcs.6","mag":"2886562763"},"language":"en","primary_location":{"id":"doi:10.1136/heartjnl-2018-bcs.6","doi":"https://doi.org/10.1136/heartjnl-2018-bcs.6","is_oa":false,"landing_page_url":"https://doi.org/10.1136/heartjnl-2018-bcs.6","pdf_url":null,"source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acute Coronary Syndromes","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051932439","display_name":"Mohapradeep Mohan","orcid":"https://orcid.org/0000-0003-1665-2081","observed_orcids":["https://orcid.org/0000-0003-1665-2081"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mohapradeep Mohan","raw_affiliation_strings":["University of Dundee, Ninewells Hospital and Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Dundee, Ninewells Hospital and Medical School","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004410710","display_name":"Shaween Al-Talabany","orcid":"https://orcid.org/0000-0001-8792-5329","observed_orcids":["https://orcid.org/0000-0001-8792-5329"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shaween Al-Talabany","raw_affiliation_strings":["University of Dundee, Ninewells Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Dundee, Ninewells Hospital","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064481774","display_name":"Angela McKinnie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800860831","display_name":"NHS Tayside","ror":"https://ror.org/000ywep40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Angela McKinnie","raw_affiliation_strings":["NHS Tayside, Deparment of Radiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHS Tayside, Deparment of Radiology","institution_ids":["https://openalex.org/I2800860831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045547434","display_name":"Ify R. Mordi","orcid":"https://orcid.org/0000-0002-2686-729X","observed_orcids":["https://orcid.org/0000-0002-2686-729X"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ify Mordi","raw_affiliation_strings":["University of Dundee, Ninewells Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Dundee, Ninewells Hospital","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075118238","display_name":"Jagdeep S. Singh","orcid":"https://orcid.org/0000-0002-7358-9712","observed_orcids":["https://orcid.org/0000-0002-7358-9712"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jagdeep Singh","raw_affiliation_strings":["University of Dundee, Ninewells Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Dundee, Ninewells Hospital","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070228907","display_name":"Stephen J. Gandy","orcid":"https://orcid.org/0000-0001-6993-9671","observed_orcids":["https://orcid.org/0000-0001-6993-9671"]},"institutions":[{"id":"https://openalex.org/I2800860831","display_name":"NHS Tayside","ror":"https://ror.org/000ywep40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen Gandy","raw_affiliation_strings":["NHS Tayside Medical Physics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHS Tayside Medical Physics","institution_ids":["https://openalex.org/I2800860831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103815993","display_name":"Fatima Baig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fatima Baig","raw_affiliation_strings":["University of Dundee, Ninewells Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Dundee, Ninewells Hospital","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111306114","display_name":"Muhammed Hussain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Muhammed Hussain","raw_affiliation_strings":["University of Dundee, Ninewells Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Dundee, Ninewells Hospital","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019943407","display_name":"U Bhalraam","orcid":"https://orcid.org/0000-0003-3337-4669","observed_orcids":["https://orcid.org/0000-0003-3337-4669"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"U Bhalraam","raw_affiliation_strings":["University of Dundee, Ninewells Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Dundee, Ninewells Hospital","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024998198","display_name":"Faisel Khan","orcid":"https://orcid.org/0000-0002-9889-0229","observed_orcids":["https://orcid.org/0000-0002-9889-0229"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Faisel Khan","raw_affiliation_strings":["University of Dundee, Ninewells Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Dundee, Ninewells Hospital","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062319122","display_name":"Anna Maria Choy","orcid":"https://orcid.org/0000-0002-4052-0591","observed_orcids":["https://orcid.org/0000-0002-4052-0591"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna Maria Choy","raw_affiliation_strings":["University of Dundee, Ninewells Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Dundee, Ninewells Hospital","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080812464","display_name":"G. Houston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Graheme Houston","raw_affiliation_strings":["University of Dundee, Ninewells Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Dundee, Ninewells Hospital","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jacob George","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jacob George","raw_affiliation_strings":["University of Dundee, Ninewells Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Dundee, Ninewells Hospital","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000572520","display_name":"Allan D. Struthers","orcid":"https://orcid.org/0000-0002-2926-2528","observed_orcids":["https://orcid.org/0000-0002-2926-2528"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Allan Struthers","raw_affiliation_strings":["University of Dundee, Ninewells Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Dundee, Ninewells Hospital","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068204697","display_name":"Chim Choy Lang","orcid":"https://orcid.org/0000-0002-4530-3078","observed_orcids":["https://orcid.org/0000-0002-4530-3078"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chim Lang","raw_affiliation_strings":["University of Dundee, Ninewells Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Dundee, Ninewells Hospital","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.2759,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.94232823,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"A6.1","last_page":"A6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.03189999982714653,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.984000027179718},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":0.859000027179718},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.8709999918937683},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.5960000157356262},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8820000290870667},{"id":"https://openalex.org/keywords/thiobarbituric-acid-reactive-substances","display_name":"TBARS","score":0.9139999747276306},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.45100000500679016},{"id":"https://openalex.org/keywords/cardiomyocyte-hypertrophy","display_name":"cardiomyocyte hypertrophy","score":0.5659999847412109},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.5210000276565552},{"id":"https://openalex.org/keywords/cardiomyocyte-proliferation","display_name":"cardiomyocyte proliferation","score":0.4830000102519989},{"id":"https://openalex.org/keywords/cardiomyocyte-fibrosis","display_name":"cardiomyocyte fibrosis","score":0.47200000286102295},{"id":"https://openalex.org/keywords/cardiomyocyte-calcium-handling","display_name":"cardiomyocyte calcium handling","score":0.4259999990463257},{"id":"https://openalex.org/keywords/cardiomyocyte-contractility","display_name":"cardiomyocyte contractility","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.932542085647583},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.9293542504310608},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7471910715103149},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7077101469039917},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6544936895370483},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.6493753790855408},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6259468793869019},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5952568054199219},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5271500945091248},{"id":"https://openalex.org/C2776002628","wikidata":"https://www.wikidata.org/wiki/Q1628627","display_name":"Left ventricular hypertrophy","level":3,"score":0.5147449970245361},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5111287236213684},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.48929736018180847},{"id":"https://openalex.org/C2779668308","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Prediabetes","level":4,"score":0.47647473216056824},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4727117717266083},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.46794241666793823},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.4315902590751648},{"id":"https://openalex.org/C2776835912","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Ventricular hypertrophy","level":4,"score":0.4218248724937439},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.35489165782928467},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.22022169828414917},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08127200603485107},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/heartjnl-2018-bcs.6","doi":"https://doi.org/10.1136/heartjnl-2018-bcs.6","is_oa":false,"landing_page_url":"https://doi.org/10.1136/heartjnl-2018-bcs.6","pdf_url":null,"source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acute Coronary Syndromes","raw_type":"proceedings-article"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire_cris_publications/f7c1e0f3-7db2-45f2-9e9a-89d0294c5b64","doi":null,"is_oa":false,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/f7c1e0f3-7db2-45f2-9e9a-89d0294c5b64","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mohan, M, Al-talabany, S, Mckinnie, A, Mordi, I, Singh, J, Gandy, S, Baig, F, Hussain, M, Bhalraam, U, Khan, F, Choy, A M, Houston, G, George, J, Struthers, A & Lang, C 2018, '6\u2005Metformin regresses left ventricular hypertrophy in normotensive patients with coronary artery disease without type 2 diabetes mellitus \u2013 the met-remodel trial', Heart, vol. 104, no. Issue Suppl 6, pp. A6.1-A6. https://doi.org/10.1136/heartjnl-2018-BCS.6","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2809360368","https://openalex.org/W2903807187","https://openalex.org/W2937481281","https://openalex.org/W2124140851","https://openalex.org/W6957823858","https://openalex.org/W2371632732","https://openalex.org/W2416556152","https://openalex.org/W2944545519","https://openalex.org/W4417094610","https://openalex.org/W4414042898"],"abstract_inverted_index":{"Background":[0],"Left":[1],"ventricular":[2,144],"hypertrophy":[3],"(LVH)":[4],"is":[5,22],"highly":[6],"prevalent":[7],"in":[8,16,38,50,142,161,164,242,308],"patients":[9,55,70,309],"with":[10,56,77,314],"coronary":[11],"artery":[12],"disease":[13],"(CAD),":[14],"even":[15],"the":[17,129,134,175,235,296,303],"absence":[18],"of":[19,26,41,85,131,222,246,271,299,305],"hypertension":[20],"and":[21,52,89,122,171,219,267,286,301],"an":[23],"independent":[24],"predictor":[25],"cardiovascular":[27],"mortality.":[28],"Metformin":[29,276],"has":[30],"been":[31],"shown":[32],"to":[33,106,127,147],"regress":[34,48],"LV":[35],"mass":[36,145],"(LVM)":[37],"animal":[39],"models":[40],"LVH.":[42],"We":[43],"hypothesise":[44],"that":[45],"metformin":[46,109,132,179,240,300,307],"may":[47],"LVH":[49],"non-diabetic":[51],"normotensive":[53],"CAD":[54],"pre-diabetes":[57],"and/or":[58,94],"insulin":[59,95,100],"resistance.":[60],"Methods":[61],"In":[62,174,234],"this":[63],"randomised":[64],"double-blind":[65],"placebo":[66,115,188,197,215,253,263],"controlled":[67],"trial,":[68],"68":[69],"(mean":[71],"age":[72],"65\u00b18":[73],"y,":[74],"25%":[75],"females)":[76],"prediabetes":[78],"(defined":[79,97],"using":[80,306],"American":[81],"Diabetes":[82],"Association":[83],"criteria":[84],"HbA1c":[86],"\u226539":[87],"mmol/mol":[88],"less":[90],"than":[91],"48":[92],"mmol/mol)":[93],"resistance":[96,101],"by":[98,152,204],"fasting":[99],"index":[102],"\u22652.7)":[103],"were":[104,159],"assigned":[105],"receive":[107],"either":[108],"(2":[110],"g":[111,195,261],"daily":[112],"dose)":[113],"or":[114],"for":[116,230,295],"12":[117],"months.":[118],"An":[119],"intention-to-treat":[120],"(ITT)":[121],"per-protocol":[123],"analysis":[124,177,238],"was":[125,140],"designed":[126],"determine":[128],"effect":[130,298],"on":[133],"following":[135],"study":[136],"endpoints:":[137],"Primary":[138],"endpoint":[139],"change":[141],"left":[143],"indexed":[146],"height":[148],"1.7":[149,251],"(LVMI),":[150],"assessed":[151],"magnetic":[153],"resonance":[154],"(MRI)":[155],"imaging;":[156],"other":[157],"endpoints":[158],"changes":[160,163],"LVM,":[162,281],"body":[165,201,284],"weight,":[166],"office":[167,208,282],"blood":[168],"pressure":[169],"(BP)":[170],"biomarkers.":[172],"Results":[173],"ITT":[176],"(n=61),":[178],"treatment":[180,277],"significantly":[181,278],"reduced:":[182],"LVMI":[183,247],"(metformin":[184,193,211,248,259],"\u22122.7\u00b12.3":[185],"g/m1.7":[186],"vs":[187,196,214,252,262],"\u22121.4\u00b12.7":[189],"g/m1.7;":[190],"p=0.05),":[191,200],"LVM":[192,258],"\u22126.5\u00b15.6":[194],"\u22123.45\u00b16.5":[198],"g;":[199,265],"weight":[202,269,285],"(lowered":[203],"3.6":[205],"kgs,":[206],"p=0.002),":[207],"systolic":[209],"BP":[210],"\u22124.8\u00b115.6":[212],"mmHg":[213],"4.6\u00b115.7":[216],"mmHg;":[217],"p=0.02)":[218],"reduced":[220,279],"concentration":[221],"thiobarbituric":[223],"acid":[224],"reactive":[225],"substances":[226],"(TBARs),":[227],"a":[228,243,292],"biomarker":[229],"oxidative":[231,287],"stress":[232],"(p=0.04).":[233],"on-per":[236],"protocol":[237],"(n=56),":[239],"resulted":[241],"greater":[244,268],"reduction":[245,270],"\u22123.1\u00b11.9":[249],"g/m":[250,255],"\u22121.2\u00b12.7":[254],"1.7;":[256],"p=0.005),":[257],"\u22127.5\u00b14.6":[260],"\u22123.1\u00b16.3":[264],"p=0.005)":[266],"4.2":[272],"kgs":[273],"(p=0.001).":[274],"Conclusions":[275],"LVMI,":[280],"SBP,":[283],"stress.":[288],"These":[289],"results":[290],"reveal":[291],"novel":[293],"mechanism":[294],"cardioprotective":[297],"raise":[302],"possibility":[304],"without":[310],"type":[311],"2":[312],"diabetes":[313],"CAD.":[315]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-08-22T00:00:00"}
