{"id":"https://openalex.org/W2886546630","doi":"https://doi.org/10.3892/or.2018.6626","title":"Inhibitor of apoptosis protein\u2011like protein\u20112: A novel growth accelerator for breast cancer cells","display_name":"Inhibitor of apoptosis protein\u2011like protein\u20112: A novel growth accelerator for breast cancer cells","publication_year":2018,"publication_date":"2018-08-03","ids":{"openalex":"https://openalex.org/W2886546630","doi":"https://doi.org/10.3892/or.2018.6626","mag":"2886546630","pmid":"https://pubmed.ncbi.nlm.nih.gov/30106449","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6111458"},"language":"en","primary_location":{"id":"doi:10.3892/or.2018.6626","doi":"https://doi.org/10.3892/or.2018.6626","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2018.6626","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2018.6626/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.spandidos-publications.com/10.3892/or.2018.6626/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101545064","display_name":"Lin Zhu","orcid":"https://orcid.org/0000-0003-1383-5990","observed_orcids":["https://orcid.org/0000-0003-1383-5990"]},"institutions":[{"id":"https://openalex.org/I144581915","display_name":"Jishou University","ror":"https://ror.org/056szk247","country_code":"CN","type":"education","lineage":["https://openalex.org/I144581915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Zhu","raw_affiliation_strings":["Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan\ufffd416000, P.R.\ufffdChina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan\ufffd416000, P.R.\ufffdChina","institution_ids":["https://openalex.org/I144581915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059338233","display_name":"Weihua Zhou","orcid":"https://orcid.org/0000-0003-0259-0828","observed_orcids":["https://orcid.org/0000-0003-0259-0828"]},"institutions":[{"id":"https://openalex.org/I144581915","display_name":"Jishou University","ror":"https://ror.org/056szk247","country_code":"CN","type":"education","lineage":["https://openalex.org/I144581915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weihua Zhou","raw_affiliation_strings":["Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China","institution_ids":["https://openalex.org/I144581915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102367302","display_name":"Xidi Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144581915","display_name":"Jishou University","ror":"https://ror.org/056szk247","country_code":"CN","type":"education","lineage":["https://openalex.org/I144581915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xidi Zhu","raw_affiliation_strings":["Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China","institution_ids":["https://openalex.org/I144581915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112842290","display_name":"Siqi Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019309368","display_name":"North Minzu University","ror":"https://ror.org/05xjevr11","country_code":"CN","type":"education","lineage":["https://openalex.org/I3019309368"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siqi Xiang","raw_affiliation_strings":["Department of Bioengineering, Biological Science and Engineering School, North University of Nationalities, Yinchuan, Ningxia\ufffd750021, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Biological Science and Engineering School, North University of Nationalities, Yinchuan, Ningxia\ufffd750021, P.R. China","institution_ids":["https://openalex.org/I3019309368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100440537","display_name":"Siyuan Wang","orcid":"https://orcid.org/0000-0001-6792-7482","observed_orcids":["https://orcid.org/0000-0001-6792-7482"]},"institutions":[{"id":"https://openalex.org/I144581915","display_name":"Jishou University","ror":"https://ror.org/056szk247","country_code":"CN","type":"education","lineage":["https://openalex.org/I144581915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyuan Wang","raw_affiliation_strings":["Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China","institution_ids":["https://openalex.org/I144581915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070689473","display_name":"Peng Yingxia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144581915","display_name":"Jishou University","ror":"https://ror.org/056szk247","country_code":"CN","type":"education","lineage":["https://openalex.org/I144581915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingxia Peng","raw_affiliation_strings":["The First Affiliated Hospital, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R.\ufffdChina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R.\ufffdChina","institution_ids":["https://openalex.org/I144581915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040444787","display_name":"Bangyun Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bangyun Lu","raw_affiliation_strings":["Tumor Hospital, Xiangxi Autonomous Prefecture, Jishou, Hunan 416000, P.R.\ufffdChina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Hospital, Xiangxi Autonomous Prefecture, Jishou, Hunan 416000, P.R.\ufffdChina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002725242","display_name":"Peizhi Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144581915","display_name":"Jishou University","ror":"https://ror.org/056szk247","country_code":"CN","type":"education","lineage":["https://openalex.org/I144581915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peizhi Tang","raw_affiliation_strings":["The First Affiliated Hospital, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China","institution_ids":["https://openalex.org/I144581915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qian Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144581915","display_name":"Jishou University","ror":"https://ror.org/056szk247","country_code":"CN","type":"education","lineage":["https://openalex.org/I144581915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Chen","raw_affiliation_strings":["The First Affiliated Hospital, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China","institution_ids":["https://openalex.org/I144581915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101896455","display_name":"Mengjuan Wu","orcid":"https://orcid.org/0009-0006-4546-410X","observed_orcids":["https://orcid.org/0009-0006-4546-410X"]},"institutions":[{"id":"https://openalex.org/I144581915","display_name":"Jishou University","ror":"https://ror.org/056szk247","country_code":"CN","type":"education","lineage":["https://openalex.org/I144581915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengjuan Wu","raw_affiliation_strings":["Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China","institution_ids":["https://openalex.org/I144581915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101719118","display_name":"Peng Xia","orcid":"https://orcid.org/0000-0001-7448-4464","observed_orcids":["https://orcid.org/0000-0001-7448-4464"]},"institutions":[{"id":"https://openalex.org/I144581915","display_name":"Jishou University","ror":"https://ror.org/056szk247","country_code":"CN","type":"education","lineage":["https://openalex.org/I144581915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Peng","raw_affiliation_strings":["Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China","institution_ids":["https://openalex.org/I144581915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100373619","display_name":"Ziyu Chen","orcid":"https://orcid.org/0000-0001-5562-7554","observed_orcids":["https://orcid.org/0000-0001-5562-7554","https://orcid.org/0009-0002-5046-8990"]},"institutions":[{"id":"https://openalex.org/I144581915","display_name":"Jishou University","ror":"https://ror.org/056szk247","country_code":"CN","type":"education","lineage":["https://openalex.org/I144581915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyu Chen","raw_affiliation_strings":["Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China","institution_ids":["https://openalex.org/I144581915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044230333","display_name":"Ziyi Sun","orcid":"https://orcid.org/0000-0002-0621-8997","observed_orcids":["https://orcid.org/0000-0002-0621-8997"]},"institutions":[{"id":"https://openalex.org/I144581915","display_name":"Jishou University","ror":"https://ror.org/056szk247","country_code":"CN","type":"education","lineage":["https://openalex.org/I144581915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyi Sun","raw_affiliation_strings":["Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China","institution_ids":["https://openalex.org/I144581915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kunliang Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144581915","display_name":"Jishou University","ror":"https://ror.org/056szk247","country_code":"CN","type":"education","lineage":["https://openalex.org/I144581915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kunliang Yang","raw_affiliation_strings":["Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China","institution_ids":["https://openalex.org/I144581915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103012649","display_name":"Mingjun Xiang","orcid":"https://orcid.org/0000-0002-2907-0147","observed_orcids":["https://orcid.org/0000-0002-2907-0147"]},"institutions":[{"id":"https://openalex.org/I144581915","display_name":"Jishou University","ror":"https://ror.org/056szk247","country_code":"CN","type":"education","lineage":["https://openalex.org/I144581915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingjun Xiang","raw_affiliation_strings":["Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China","institution_ids":["https://openalex.org/I144581915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101736245","display_name":"Dandan Yu","orcid":"https://orcid.org/0000-0003-2578-7324","observed_orcids":["https://orcid.org/0000-0003-2578-7324"]},"institutions":[{"id":"https://openalex.org/I144581915","display_name":"Jishou University","ror":"https://ror.org/056szk247","country_code":"CN","type":"education","lineage":["https://openalex.org/I144581915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dandan Yu","raw_affiliation_strings":["Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Medical Research Center, Institute of Medicine, Jishou University, Jishou, Hunan 416000, P.R. China","institution_ids":["https://openalex.org/I144581915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103012649"],"corresponding_institution_ids":["https://openalex.org/I144581915"],"apc_list":null,"apc_paid":null,"fwci":0.1746,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.45095599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"40","issue":"4","first_page":"2047","last_page":"2055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.4115999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.4115999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.19850000739097595,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.1136000007390976,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.7210000157356262},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.5920000076293945},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7210000157356262},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6931691765785217},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6301014423370361},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6092569828033447},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6031554937362671},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5879017114639282},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5739624500274658},{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.50774085521698},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.48820191621780396},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4809093475341797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46485933661460876},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.45945554971694946},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4193304777145386},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33146369457244873},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2639014720916748},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24933335185050964},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.052915722131729126},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3892/or.2018.6626","doi":"https://doi.org/10.3892/or.2018.6626","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2018.6626","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2018.6626/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5064868","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6111458","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6111458","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6111458","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncol Rep","raw_type":"Text"},{"id":"pmid:30106449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30106449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/or.2018.6626","doi":"https://doi.org/10.3892/or.2018.6626","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2018.6626","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2018.6626/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5599989030","display_name":"\u51cb\u4ea1\u6291\u5236\u86cb\u767dILP-2\u4e0e\u4e73\u817a\u764c\u751f\u957f\u7684\u5173\u7cfb\u53ca\u5206\u5b50\u673a\u5236","funder_award_id":"81360397","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322927","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884"},{"id":"https://openalex.org/F4320326960","display_name":"Jishou University","ror":"https://ror.org/056szk247"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2886546630.pdf","grobid_xml":"https://content.openalex.org/works/W2886546630.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W178526765","https://openalex.org/W1963577326","https://openalex.org/W1973558486","https://openalex.org/W1987888547","https://openalex.org/W1999660608","https://openalex.org/W2013801793","https://openalex.org/W2018403844","https://openalex.org/W2030998114","https://openalex.org/W2044779886","https://openalex.org/W2052623429","https://openalex.org/W2056654402","https://openalex.org/W2065398247","https://openalex.org/W2067215445","https://openalex.org/W2090558874","https://openalex.org/W2112069401","https://openalex.org/W2117692326","https://openalex.org/W2148463655","https://openalex.org/W2162585479","https://openalex.org/W2167521529","https://openalex.org/W2326356596","https://openalex.org/W2762689786","https://openalex.org/W4233198120"],"related_works":["https://openalex.org/W3148221577","https://openalex.org/W4205635120","https://openalex.org/W2366806348","https://openalex.org/W4283359458","https://openalex.org/W2086415754","https://openalex.org/W3177868286","https://openalex.org/W2064952474","https://openalex.org/W2016904146","https://openalex.org/W2809720551","https://openalex.org/W2773821608"],"abstract_inverted_index":{"Although":[0],"the":[1,33,122,195,205],"inhibitor":[2],"of":[3,35,75,124,158,161,181,194,207],"apoptosis":[4,179],"protein\u2011like":[5],"protein\u20112":[6],"(ILP\u20112)":[7],"has":[8],"been":[9],"shown":[10],"as":[11,83,88,90,149],"a":[12],"serological":[13],"biomarker":[14],"for":[15],"breast":[16,21,38,57,78,91,127,140,144,208],"cancer,":[17],"its":[18],"effect":[19],"on":[20,126],"cancer":[22,39,58,79,128,141,145,209],"cell":[23,40,80,93,107,129,146,159,166,186],"growth":[24,206],"remains":[25],"elusive.":[26],"The":[27,178],"present":[28],"study":[29,134],"aimed":[30],"to":[31,45,70,120],"determine":[32],"role":[34,123,203],"ILP\u20112":[36,47,76,97,125,137,172,199],"in":[37,49,77,102,139,204],"growth.":[41,130],"We":[42],"used":[43,69],"immunohistochemistry":[44],"analyze":[46],"expression":[48,73,138],"59":[50],"tissue":[51],"paraffin\u2011embedded":[52],"blocks,":[53],"which":[54],"included":[55],"35":[56],"tissues":[59,142],"and":[60,86,105,113,143,152,164,184],"24":[61],"galactophore":[62],"hyperplasia":[63],"tissues.":[64],"Western":[65],"blot":[66],"analysis":[67,117],"was":[68,98,168,173,188],"detect":[71],"protein":[72],"levels":[74],"lines":[81,147,167,187],"such":[82,148],"HCC\u20111937,":[84,103,150,162,182],"MX\u20111":[85,104,151,163,183],"MCF\u20117":[87,106,165,185],"well":[89],"gland":[92],"line":[94],"MCF":[95],"10A.":[96],"silenced":[99],"by":[100,176],"siRNA":[101],"lines.":[108],"MTT":[109],"assays,":[110],"scratch":[111],"assays":[112],"AO\u2011EB":[114],"double":[115],"staining":[116],"were":[118],"conducted":[119],"evidence":[121],"Results":[131],"from":[132],"this":[133],"showed":[135],"increased":[136,189],"MCF\u20117.":[153],"Cell":[154],"viability":[155],"or":[156],"rate":[157,180],"migration":[160],"significantly":[169],"inhibited":[170],"when":[171,190],"knocked":[174],"down":[175],"siRNA.":[177],"compared":[191],"with":[192],"that":[193],"control":[196],"group.":[197],"Thus,":[198],"plays":[200],"an":[201],"active":[202],"cells.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-22T00:00:00"}